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1. 发明申请

WO2022036308A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 审中-公开
公开(公告)号：WO2022036308A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/046105
申请日：2021-08-16
申请人： CASTLE BIOSCIENCES, INC.
发明人： COOK, Robert, Willis , COVINGTON, Kyle, R. , MAETZOLD, Derek , KURLEY, Sarah, J.
IPC分类号： C12Q1/6886 , C12Q1/6876 , C12Q1/6883
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).

2. 发明申请

WO2022031670A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH PIGMENTED SKIN LESIONS 审中-公开
公开(公告)号：WO2022031670A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/044299
申请日：2021-08-03
申请人： CASTLE BIOSCIENCES, INC.
发明人： COOK, Robert Willis , MAETZOLD, Derek , COVINGTON, Kyle R. , ZOLOCHEVSKA, Olga
IPC分类号： C12Q1/68 , C40B30/04 , C40B40/06 , C12Q1/6806 , C12Q1/6809 , C12Q2600/158 , C12Q2600/166 , G16B40/00 , G16B5/20
摘要： The present disclosure relates to methods for diagnosing a skin lesion as malignant or benign.

3. 发明申请

WO2021155377A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 审中-公开
公开(公告)号：WO2021155377A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/016097
申请日：2021-02-01
申请人： CASTLE BIOSCIENCES, INC. , COOK, Robert Willis , COVINGTON, Kyle R. , MAETZOLD, Derek , KURLEY, Sarah J.
发明人： COOK, Robert Willis , COVINGTON, Kyle R. , MAETZOLD, Derek , KURLEY, Sarah J.
IPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q1/6813 , C40B40/08 , C40B30/04
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).

4. 发明申请

WO2022192128A2 DETERMINING PROGNOSIS AND TREATMENT BASED ON CLINICAL-PATHOLOGIC FACTORS AND CONTINUOUS MULTIGENE-EXPRESSION PROFILE SCORES 审中-公开
公开(公告)号：WO2022192128A2
公开(公告)日：2022-09-15
申请号：PCT/US2022/019122
申请日：2022-03-07
申请人： CASTLE BIOSCIENCES, INC.
发明人： COVINGTON, Kyle, R. , SPIESS, Bernhard , QUICK, Ann , KURLEY, Sarah
IPC分类号： G06E1/00 , G16B20/00 , G16B40/20 , G16B40/30 , G16H50/30
摘要： Example embodiments relate to determining prognosis and treatment based on clinical-pathologic factors and continuous multigene-expression profile scores. An example embodiment includes a non-transitory, computer-readable medium having instructions stored thereon. The instructions, when executed by a processor, cause the processor to execute a method. The method includes obtaining a plurality of clinical-pathologic factors related to a patient. The clinical-pathologic factors are indicative of risk associated with melanoma. The method also includes obtaining a continuous multigene-expression profile score for the patient. The continuous multigene-expression profile score is based on multiple genes whose expressions are related to melanoma. Further, the method includes determining, based on the plurality of clinical-pathologic factors and the continuous multigene-expression profile score, a risk score for the patient. In addition, the method includes outputting the risk score for use in determining a prognosis and treatment plan.

5. 发明申请

WO2022036245A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 审中-公开
公开(公告)号：WO2022036245A1
公开(公告)日：2022-02-17
申请号：PCT/US2021/045981
申请日：2021-08-13
申请人： CASTLE BIOSCIENCES, INC.
发明人： COOK, Robert Willis , COVINGTON, Kyle R. , MAETZOLD, Derek , KURLEY, Sarah J.
IPC分类号： A61P35/00 , A61P35/04 , C12Q1/68 , C12Q1/6886
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis, or both in primary cutaneous squamous cell carcinoma (cSCC).

6. 发明申请

WO2019213321A1 METHODS OF DIAGNOSING AND TREATING PATIENTS WITH CUTANEOUS SQUAMOUS CELL CARCINOMA 审中-公开
公开(公告)号：WO2019213321A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030282
申请日：2019-05-01
申请人： CASTLE BIOSCIENCES, INC.
发明人： COOK, Robert Willis , COVINGTON, Kyle R. , MAETZOLD, Derek
IPC分类号： C12Q1/68 , C40B30/04 , C40B40/06
摘要： The present disclosure relates to methods for predicting the risk of recurrence and/or metastasis in primary cutaneous squamous cell carcinoma (cSCC).

7. 发明申请

WO2017210699A1 METHODS FOR PREDICTING RISK OF RECURRENCE AND/OR METASTASIS IN SOFT TISSUE SARCOMA 审中-公开
标题翻译：预测软组织肉瘤复发和/或转移风险的方法
公开(公告)号：WO2017210699A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/036015
申请日：2017-06-05
申请人： CASTLE BIOSCIENCES, INC. , COOK, Robert, Willis , SHAN, Weiwei , MAETZOLD, Derek
发明人： COOK, Robert, Willis , SHAN, Weiwei , MAETZOLD, Derek
IPC分类号： A61P35/00 , A61P35/04 , C12Q1/68
摘要： The disclosure related to the development of a gene expression profile to predict soft tissue sarcoma (STS) recurrence, distant metastasis, or both. Analyses identified a 36-gene gene expression profile able to accurately predict risk in a cohort of soft tissue sarcoma tumors independent of histologic and pathologic grade. This discovery offers an opportunity to enhance current staging of STS to identify patients who have a higher risk of recurring, distant metastasis, or both.
摘要翻译：该公开涉及开发用于预测软组织肉瘤（STS）复发，远处转移或两者的基因表达谱。分析发现36基因基因表达谱能够准确预测软组织肉瘤肿瘤队列中的风险，与组织学和病理分级无关。这一发现提供了一个机会，以加强目前的STS分期，以确定具有更高风险的复发，远处转移或两者兼有的患者。

8. 发明申请

WO2017210691A1 METHODS FOR PREDICTING RISK OF RECURRENCE AND/OR METASTASIS IN SOFT TISSUE SARCOMA 审中-公开
公开(公告)号：WO2017210691A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035984
申请日：2017-06-05
申请人： CASTLE BIOSCIENCES, INC. , COOK, Robert Willis , SHAN, Weiwei , MAETZOLD, Derek
发明人： COOK, Robert Willis , SHAN, Weiwei , MAETZOLD, Derek
IPC分类号： C12Q1/68
摘要： The disclosure related to the development of a gene expression profile to predict soft tissue sarcoma (STS) recurrence, distant metastasis, or both. Analyses identified a 36-gene gene expression profile able to accurately predict risk in a cohort of soft tissue sarcoma tumors independent of histologic and pathologic grade. This discovery offers an opportunity to enhance current staging of STS to identify patients who have a higher risk of recurring, distant metastasis, or both.

9. 发明申请

WO2014158696A9 METHODS FOR PREDICTING RISK OF METASTASIS IN CUTANEOUS MELANOMA 审中-公开
标题翻译：用于预测US US OF OF TING TING。。。。。。。。。。。。。。。。。。。。。。
公开(公告)号：WO2014158696A9
公开(公告)日：2014-12-18
申请号：PCT/US2014019326
申请日：2014-02-28
申请人： CASTLE BIOSCIENCES INC
发明人： COOK ROBERT WILLIS , MAETZOLD DEREK , OESCHLAGER KRISTEN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
摘要翻译：本文公开的本发明包括用于预测原发性皮肤黑素瘤肿瘤转移风险的方法，所述方法包括测量至少8种基因的基因表达水平，所述基因选自样品中的特定基因，其取自初级皮肤黑素瘤肿瘤; 从所述至少8个基因的基因表达水平确定基因表达谱特征; 将基因表达谱与预测训练集的基因表达谱比较; 并且当基因表达谱表明与基因表达谱相比，至少8种基因的表达水平以预测方式改变时，提供关于初级皮肤黑素瘤肿瘤是否是一定类型的转移或治疗风险的指征预测训练集。

10. 发明申请

WO2014158696A1 METHODS FOR PREDICTING RISK OF METASTASIS IN CUTANEOUS MELANOMA 审中-公开
标题翻译：预测皮肤黑色素瘤转移风险的方法
公开(公告)号：WO2014158696A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/019326
申请日：2014-02-28
申请人： CASTLE BIOSCIENCES, INC.
发明人： COOK, Robert, Willis , MAETZOLD, Derek , OESCHLAGER, Kristen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The invention as disclosed herein in encompasses a method for predicting the risk of metastasis of a primary cutaneous melanoma tumor, the method encompassing measuring the gene-expression levels of at least eight genes selected from a specific gene set in a sample taken from the primary cutaneous melanoma tumor; determining a gene-expression profile signature from the gene expression levels of the at least eight genes; comparing the gene-expression profile to the gene-expression profile of a predictive training set; and providing an indication as to whether the primary cutaneous melanoma tumor is a certain class of metastasis or treatment risk when the gene expression profile indicates that expression levels of at least eight genes are altered in a predictive manner as compared to the gene expression profile of the predictive training set.
摘要翻译：本文公开的发明包括用于预测原发性皮肤黑素瘤肿瘤转移风险的方法，所述方法包括测量选自特定基因组的至少8个基因的基因表达水平在取自原发性皮肤黑素瘤肿瘤的样品中; 根据所述至少8种基因的基因表达水平确定基因表达谱特征; 将基因表达谱与预测训练集的基因表达谱进行比较; 并且当基因表达谱表明至少8个基因的表达水平以预测的方式相比于基因表达谱的变化时，提供关于原发性皮肤黑素瘤肿瘤是否具有某类转移或治疗风险的指征预测训练集。

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