专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011063416A3 MICROFLUIDIC DEVICES FOR THE CAPTURE OF BIOLOGICAL SAMPLE COMPONENTS 审中-公开
公开(公告)号：WO2011063416A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/057894
申请日：2010-11-23
申请人： THE GENERAL HOSPITAL CORPORATION , BARBER, Thomas A. , SHAH, Ajay , WALSH, John , TONER, Mehmet , KAPUR, Ravi
发明人： BARBER, Thomas A. , SHAH, Ajay , WALSH, John , TONER, Mehmet , KAPUR, Ravi
IPC分类号： G01N35/08 , G01N33/53 , G01N33/574 , G01N33/48 , G01N1/28
摘要： Methods and systems for selectively capturing analytes, such as cells, e.g., circulating tumor cells (CTCs), from fluid samples are disclosed. The methods include contacting the sample with an analyte binding moiety that selectively binds to the analytes; optionally separating first components of the sample including a majority of the analytes bound to the binding moieties from second components of the sample using size-based separation, e.g., in a microfluidic channel; adding to the first components of the sample a plurality of binding agents under conditions that enable a plurality of the binding agents to be linked to the analyte binding moieties to form multivalent tagging agents bound to the analyte; passing the first components of the sample past a surface to which is attached a plurality of capture agents that selectively bind to the binding agents; and capturing the analytes by providing conditions that enable the multivalent tagging agents bound to the analytes to bind to one or more of the capture agents.

2. 发明申请

WO2015010019A1 SELECTIVE CAPTURE AND RELEASE OF RARE MAMMALIAN CELLS USING PHOTODEGRADABLE HYDROGELS IN A MICROFLUIDIC PLATFORM 审中-公开
标题翻译：选择性捕获和释放使用可溶性水凝胶在微流感平台中的稀有马马里亚细胞
公开(公告)号：WO2015010019A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/047195
申请日：2014-07-18
申请人： THE GENERAL HOSPITAL CORPORATION , TIBBITT, Mark, W. , ANSETH, Kristi, S. , KLOXIN, April, M. , TONER, Mehmet , OAKEY, John , SHAH, Ajay
发明人： TIBBITT, Mark, W. , ANSETH, Kristi, S. , KLOXIN, April, M. , TONER, Mehmet , OAKEY, John , SHAH, Ajay
IPC分类号： A61K41/00 , C08G73/00 , A61K47/34 , C12M1/34
CPC分类号： G01N33/57492 , A61K41/0028 , A61K47/34 , B01L3/502761 , B01L2200/0647 , B01L2300/16 , C08F222/22 , C12M47/02 , C12M47/04 , G01N33/531 , G01N33/54366 , G01N33/56966
摘要： Disclosed herein are photodegradable hydrogels and associated kits for selectively capturing and releasing cells. The hydrogels result from cross linking in the presence of a photoinitiator (1) a macromer having a polymeric backbone structure, a photo labile moiety, and a first linking moiety, and (2) a cell-binding moiety having a second linking moiety. These two components are cross-linked by a polymerization reaction of the linking moieties to form a photodegradable hydrogel incorporating the cell-binding moiety within the hydrogel. Also disclosed are methods of making the hydrogels, and methods of using the hydrogels for selectively capturing and releasing cells and for detecting cells in a fluid. Such methods can be used to detect the presence and quantity of certain rare cell types in a biological fluid.
摘要翻译：本文公开了可降解水凝胶和用于选择性捕获和释放细胞的相关试剂盒。水凝胶由光引发剂（1）具有聚合物主链结构的大分子单体，光不稳定部分和第一连接部分的存在下交联而产生，和（2）具有第二连接部分的细胞结合部分。这两个组分通过连接部分的聚合反应交联以形成在水凝胶内掺入细胞结合部分的可光降解的水凝胶。还公开了制备水凝胶的方法，以及使用水凝胶选择性捕获和释放细胞并检测流体中的细胞的方法。这种方法可用于检测生物流体中某些稀有细胞类型的存在和数量。

3. 发明申请

WO2010132795A2 SYSTEMS, DEVICES, AND METHODS FOR SPECIFIC CAPTURE AND RELEASE OF BIOLOGICAL SAMPLE COMPONENTS 审中-公开
标题翻译：用于特定捕获和释放生物样品成分的系统，设备和方法
公开(公告)号：WO2010132795A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034943
申请日：2010-05-14
申请人： THE GENERAL HOSPITAL CORPORATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SHAH, Ajay , KOTZ, Kenneth T. , TONER, Mehmet
发明人： SHAH, Ajay , KOTZ, Kenneth T. , TONER, Mehmet
IPC分类号： C12Q1/24 , C12N11/04 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/54393 , C12N11/04 , G01N33/54353
摘要： Living cells can be selectively and reversibly bound to functionalized dissolvable material (e.g., cross-linked hydrogel compositions) and subsequently released from the composition as viable cells. In some examples, the cells are released by reducing the degree of cross-linking within a functionalized hydrogel composition and/or dissolving the functionalized hydrogel composition bound to the cells. The functionalized hydrogel compositions can be adhered to silicon- and silicon-oxide containing surfaces, such as glass and aminated silicon. The living cells can be isolated from biological samples, such as blood, by selectively binding certain cells from the sample to the functionalized hydrogel, removing unbound cells and later releasing viable bound cells from the functionalized hydrogel.
摘要翻译：活性细胞可以选择性地和可逆地结合到官能化的可溶解材料（例如，交联的水凝胶组合物）上，随后从组合物中释放为活细胞。在一些实例中，通过降低功能化水凝胶组合物内的交联度和/或溶解与细胞结合的官能化水凝胶组合物来释放细胞。官能化水凝胶组合物可以粘附到含硅和氧化硅的表面，例如玻璃和胺化硅。可以通过选择性地将样品中的某些细胞与功能化的水凝胶结合，去除未结合的细胞并随后从功能化的水凝胶中释放活的结合细胞，从而将活细胞与生物样品例如血液分离。

4. 发明申请

WO2010036788A3 METHOD AND APPARATUS FOR GRAFTING OF SKIN TISSUE 审中-公开
公开(公告)号：WO2010036788A3
公开(公告)日：2010-04-01
申请号：PCT/US2009/058194
申请日：2009-09-24
申请人： THE GENERAL HOSPITAL CORPORATION , ASRANI, Falguni , FARINELLI, William, A. , SHAH, Ajay , LIU, Vincent , ANDERSON, R., Rox
发明人： ASRANI, Falguni , FARINELLI, William, A. , SHAH, Ajay , LIU, Vincent , ANDERSON, R., Rox
IPC分类号： A61B17/322 , A61F2/10 , A61B17/00
摘要： Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.

5. 发明申请

WO2012020211A1 METHOD AND SYSTEM FOR PARAMETER DETERMINATION FROM MEDICAL IMAGERY 审中-公开
标题翻译：医学图像参数确定方法与系统
公开(公告)号：WO2012020211A1
公开(公告)日：2012-02-16
申请号：PCT/GB2011/001155
申请日：2011-07-29
申请人： KING'S COLLEGE LONDON , SHAH, Ajay , PROTTI, Andrea
发明人： SHAH, Ajay , PROTTI, Andrea
IPC分类号： G06T7/00
CPC分类号： G06T7/62 , G06T7/11 , G06T7/174 , G06T7/187 , G06T2207/10088 , G06T2207/20101 , G06T2207/30048
摘要： Embodiments of the present invention provide an improved method to allow for volumes and other parameters relating to internal features and artefacts to be determined from medical imagery such as MRI images. In particular, within one embodiment of the invention a cluster-based segmentation algorithm is used that can allow voxels representing an internal feature which it is desired to measure to be segmented within multiple MRI images in parallel, and for measurements based on the segmentation thus obtained to be automatically generated. For example, in one embodiment left ventricle volume throughout the cardiac cycle can be determined by processing in parallel multiple MRI slices across multiple frames captured throughout the cycle, whereby cardiac measures such as ejection fraction, stroke volume, EDV, ESV and cardiac output may then be found quickly and easily. By determining the segmentation threshold for a single slice in advance of then applying the threshold across the whole image space, it can be certain that a threshold is used that takes into account the particular image data characteristics, such as contrast between and blood and muscle, and image brightness.
摘要翻译：本发明的实施例提供了一种改进的方法，以允许从诸如MRI图像的医学图像确定与内部特征和伪影有关的体积和其它参数。特别地，在本发明的一个实施例中，使用基于簇的分割算法，其可以允许代表期望测量的内部特征的体素在多个MRI图像内并行分割，并且基于由此获得的分割进行测量自动生成。例如，在一个实施方案中，整个心动周期的左心室体积可以通过在整个循环中捕获的跨多个帧的并行多个MRI切片进行处理来确定，由此心脏测量例如射血分数，搏动体积，EDV，ESV和心输出量快速轻松地找到。通过在整个图像空间上施加阈值之前确定单个切片的分割阈值，可以确定使用考虑特定图像数据特征（例如血液和肌肉之间的对比度）的阈值，和图像亮度。

6. 发明申请

WO2012151253A1 MINIMALLY INVASIVE SURGICAL APPLICATOR 审中-公开
标题翻译：微型外科手术器械
公开(公告)号：WO2012151253A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036081
申请日：2012-05-02
申请人： INSIGHT SURGICAL INSTRUMENTS LLC , SHAH, Ajay , MANASSERO, Jeffrey , ORWIN, Elizabeth , PAI, Vincent , JENSEN, Anne , PHILLIPS, Matthew , CHALLENER, Timothy , NGUYEN, Cassie , SCHUNTER, Kristen
发明人： SHAH, Ajay , MANASSERO, Jeffrey , ORWIN, Elizabeth , PAI, Vincent , JENSEN, Anne , PHILLIPS, Matthew , CHALLENER, Timothy , NGUYEN, Cassie , SCHUNTER, Kristen
IPC分类号： A61M5/178
CPC分类号： A61B17/8802 , A61B17/00491 , A61B90/00 , B33Y80/00
摘要： The present invention provides a minimally invasive surgical applicator device. The device is useful in the application of bone wax during surgical procedures to halt or reduce bone bleeding. The device may be sterilized for re-use or may be made disposable.
摘要翻译：本发明提供了一种微创手术敷贴器。该装置在外科手术中应用骨蜡是有用的，以阻止或减少骨渗出。该装置可以被灭菌以便重新使用或者可以被制成一次性的。

7. 发明申请

WO2012009500A3 SYNCHRONIZED DELIVERY OF INTERACTIVE CONTENT 审中-公开
公开(公告)号：WO2012009500A3
公开(公告)日：2012-01-19
申请号：PCT/US2011/043944
申请日：2011-07-14
申请人： SPOT411 TECHNOLOGIES, INC. , SHAH, Ajay
发明人： SHAH, Ajay
IPC分类号： G06F15/16
摘要： Where multiple client devices are synchronized to multiple, asynchronous instances of a time-based media presentation such as live and time- shifted views of a television broadcast, interactive content can be delivered to each one of the various devices at a particular time (or "time offset") within the presentation independent of when each instance of the time-based media presentation is viewed.

8. 发明申请

WO2010138777A1 AUTOMATIC RESOURCE RETRIEVAL AND USE 审中-公开
标题翻译：自动资源检索和使用
公开(公告)号：WO2010138777A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036493
申请日：2010-05-27
申请人： ARSH TECHNOLOGIES, LLC , SHAH, Ajay , GLITSCH, Hans, M.
发明人： SHAH, Ajay , GLITSCH, Hans, M.
IPC分类号： H04B3/00
CPC分类号： H04N21/2407 , G06F17/30026 , G06F17/30056 , H04N21/4394
摘要： A plurality of audio signals are broadcasted concurrently on a plurality of substantially separate audio channels Each of the audio channels has a center frequency greater than approximately 16 kHz. Broadcasting the audio signals causes one or more clients to automatically retπeve a resource from a resource location. The plurality of audio signals collectively encode a resource identifier that describes the resource location.
摘要翻译：多个音频信号在多个基本上独立的音频通道上同时广播。每个音频通道具有大于约16kHz的中心频率。广播音频信号导致一个或多个客户端自动从资源位置重新调出资源。多个音频信号共同编码描述资源位置的资源标识符。

9. 发明申请

WO2010138776A3 AUDIO-BASED SYNCHRONIZATION TO MEDIA 审中-公开
公开(公告)号：WO2010138776A3
公开(公告)日：2010-12-02
申请号：PCT/US2010/036492
申请日：2010-05-27
申请人： SPOT411 TECHNOLOGIES, INC. , SHAH, Ajay , GLITSCH, Hans, M.
发明人： SHAH, Ajay , GLITSCH, Hans, M.
IPC分类号： H04N9/475
摘要： An audio channel of a time-based media presentation provides a basis for synchronizing to the presentation across a variety of platforms independent of when and where the presentation is being viewed. By pre-processing the media into a series of non-unique hashes, and similarly processing an audio stream of the media captured at a client device, a comparison can be made that yields an accurate time offset within the presentation. The comparison may usefully be performed over a data network using a server that hosts data from the pre-processed media, and a variety of applications may be deployed on the client device based on the resulting synchronization.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式