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1. 发明申请

WO2019231985A1 ANTI-ADHESIVE SHEAR THINNING HYDROGELS 审中-公开
公开(公告)号：WO2019231985A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/034298
申请日：2019-05-29
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： KHADEMHOSSEINI, Ali , HERRERA, Guillermo Ulises Ruiz Esparza , WANG, Xichi , SHIN, Su Ryon , JOZEFIAK, Thomas
IPC分类号： A61K31/727 , A61K38/18 , A61K38/39
摘要： The present application relates to shear thinning hydrogel compositions which are useful for reducing and/or preventing tissue adhesion in a subject (e.g., a post-operative subject). Methods of using the compositions and kits comprising the compositions are also provided.

2. 发明申请

WO2011035185A2 A MICROFLUIDIC DEVICE AND USES THEREOF 审中-公开
标题翻译：微流体装置及其用途
公开(公告)号：WO2011035185A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049372
申请日：2010-09-17
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KHADEMHOSSEINI, Ali , KHABIRY, Masoud , CHUNG, Bong Geun , HANCOCK, Matthew , DU, Yanan
发明人： KHADEMHOSSEINI, Ali , KHABIRY, Masoud , CHUNG, Bong Geun , HANCOCK, Matthew , DU, Yanan
IPC分类号： G01N33/48 , C12Q1/02 , C12M1/34 , C12M3/00 , B81C1/00 , G01N35/00
CPC分类号： B01L3/502761 , B01L2300/0636 , B01L2300/0809 , B01L2300/087 , B01L2300/0887 , C12M23/16
摘要： Microfluidic devices and methods for using microfluidic devices for immobilizing cells, e.g., mammalian cells, suspended in a flowing fluid include selecting the geometry and dimensions of one or more multi-surface cavities disposed therein, and/or the flow direction of a cell-containing fluid therein. The cavity can comprise an upper and lower surface, and cells can be captured on either surfaces located at two different depths within a cavity. The invention includes methods for generating co-cultures of different cell populations inside a multi-surface cavity disposed within microfluidic devices as disclosed herein.
摘要翻译：用于使用微流体装置来固定悬浮在流动流体中的细胞（例如哺乳动物细胞）的微流体装置和方法包括选择设置在其中的一个或多个多表面空腔的几何形状和尺寸，和/或其中含有细胞的流体的流动方向。腔体可以包括上表面和下表面，并且细胞可以被捕获在位于腔体内两个不同深度的任一表面上。本发明包括如本文所公开的用于在设置在微流体装置内的多表面腔内产生不同细胞群的共培养物的方法。

3. 发明申请

WO2016022807A1 ELASTIC BIOPOLYMER AND USE AS A TISSUE ADHESIVE 审中-公开
标题翻译：弹性生物反应器和用作组织粘合剂
公开(公告)号：WO2016022807A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/044022
申请日：2015-08-06
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： KHADEMHOSSEINI, Ali , ANNABI, Nasim , ASSMANN, Alexander
IPC分类号： A61L24/04
CPC分类号： A61L24/104 , A61K31/137 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L2300/104 , A61L2300/404 , A61L2300/418 , A61L2400/04
摘要： The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response. Advantageously, the tissue adhesives of the present invention are low cost and easy to produce, making them a promising substance to be used as a sealant for fluid leakages in soft tissue, as well as an easily tunable platform to further optimize the adhesive characteristics.
摘要翻译：本发明提供了一种改进的组织粘合剂来修复软组织中的缺陷。根据ASTM标准测试，本发明的交联甲基丙烯酰基取代的明胶水凝胶（GelSEAL）显示出优于临床使用的纤维蛋白和聚（乙二醇）的粘合性质，即伤口闭合强度，抗剪切性和爆裂压力，的胶水。大鼠的慢性体内实验证明，GelSEAL能有效地密封大的肺部泄漏，无需额外的缝线或缝钉，与纤维蛋白和聚（乙二醇）胶相比具有改善的性能。此外，皮下植入大鼠显示出GelSEAL的高生物相容性，这是由低炎症宿主反应证明的。有利地，本发明的组织粘合剂成本低且易于生产，使得它们成为用作软组织中的流体泄漏的密封剂的有希望的物质，以及用于进一步优化粘合剂特性的容易调节的平台。

4. 发明申请

WO2009014546A2 PARYLENE-C STENCILS 审中-公开
公开(公告)号：WO2009014546A2
公开(公告)日：2009-01-29
申请号：PCT/US2007/081553
申请日：2007-10-16
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KHADEMHOSSEINI, Ali , RAJALINGAM, Bimalraj
发明人： KHADEMHOSSEINI, Ali , RAJALINGAM, Bimalraj
IPC分类号： B32B33/00 , B05D1/32
CPC分类号： C12N5/0068 , B41M1/12 , C12N5/0606 , C12N2502/13 , C12N2502/28 , C12N2533/52 , C12N2533/54 , C12N2533/70 , C12N2535/10 , G03F7/12 , Y10T428/1476
摘要： A reuseable microfabrication stencil is described that can be reversibly sealed on various substrates to pattern biomolecules and biomaterials such as proteins and cells. The stencil may be used for the generation of both static and dynamic co-cultures, and cell aggregates. A multilayer stencil is described that can be used in biological patterning and used to create static and dynamic co-cultures and cell aggregates. Processes for producing and using the microfabrication stencils are also described.
摘要翻译：描述了一种可重复使用的微制造模板，其可以可逆地密封在各种基材上以图案化生物分子和生物材料，例如蛋白质和细胞。模板可用于产生静态和动态共培养物和细胞聚集体。描述了可用于生物图案化并用于创建静态和动态共培养物和细胞聚集体的多层模板。还介绍了生产和使用微制造模板的流程。

5. 发明申请

WO2018102750A1 PULP REGENERATION COMPOSITIONS AND METHODS OF FORMING AND USING THE SAME 审中-公开
公开(公告)号：WO2018102750A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064312
申请日：2017-12-01
申请人： TRUSTEES OF TUFTS COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： YELICK, Pamela, C. , KHADEMHOSSEINI, Ali
IPC分类号： A61K35/32 , A61K35/51 , A61L27/38 , A61L27/52
CPC分类号： A61K35/51 , A61K35/32 , A61L27/16 , A61L27/222 , A61L27/38 , A61L27/3808 , A61L27/52 , A61L2400/06 , A61L2430/12 , C08L33/12
摘要： A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.

6. 发明申请

WO2017139318A1 BIOADHESIVE FOR CORNEAL REPAIR 审中-公开
标题翻译：用于角膜修复的生物渗透剂
公开(公告)号：WO2017139318A1
公开(公告)日：2017-08-17
申请号：PCT/US2017/016917
申请日：2017-02-08
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： KHADEMHOSSEINI, Ali , ANNABI, Nasim , DANA, Reza , KHEIRKHAH, Ahmad
IPC分类号： A61L27/52
CPC分类号： A61L27/52 , A61L27/222 , A61L27/3804 , A61L27/3839 , A61L2430/16
摘要： The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
摘要翻译：本发明提供了修复和重建角膜缺损和损伤的组合物和方法。

7. 发明申请

WO2017062429A1 MULTICOMPONENT AND MULTIFUNCTIONAL LIVING FIBER 审中-公开
标题翻译：多功能和多功能生活光纤
公开(公告)号：WO2017062429A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055461
申请日：2016-10-05
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC
发明人： TAMAYOL, Ali , AKBARI, Mohsen , KHADEMHOSSEINI, Ali , YAZDI, Iman , FALLAHI, Afsoon , JUNCKER, David
IPC分类号： A61L27/52 , A61L27/54 , D01D1/02 , D01D5/06 , D04H1/728
CPC分类号： A61L27/52 , A61L27/54 , D01D5/24 , D01F1/10 , D04H1/728 , D04H3/005 , D04H3/015 , D06M10/001 , D06M10/10 , D06M11/155 , D06M15/13 , D06M15/15 , D06M16/003
摘要： A method of making a composite living fiber is described that includes the steps of contacting a fiber strand with an aqueous solution comprising cells, alginate, and a non-alginate hydrogel precursor to coat the fiber; crosslinking the alginate of the coated fiber; and crosslinking the non-alginate hydrogel precursor to form a composite living fiber. Composite living fibers made by this method, and tissue scaffolds made of composite living fibers, are also described.
摘要翻译：描述了制备复合活性纤维的方法，其包括使纤维束与包含细胞，海藻酸盐和非藻酸盐水凝胶前体的水溶液接触以包覆纤维的步骤; 交联包被纤维的藻酸盐; 并交联非藻酸盐水凝胶前体以形成复合活性纤维。还描述了通过该方法制造的复合活性纤维和由复合活性纤维制成的组织支架。

8. 发明申请

WO2010057078A2 METHOD AND SYSTEM FOR GENERATING SPATIALLY AND TEMPORALLY CONTROLLABLE CONCENTRATION GRADIENTS 审中-公开
标题翻译：用于产生空间和时间可控浓度梯度的方法和系统
公开(公告)号：WO2010057078A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/064555
申请日：2009-11-16
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KHADEMHOSSEINI, Ali , DU, Yanan
发明人： KHADEMHOSSEINI, Ali , DU, Yanan
IPC分类号： G01N35/08 , G01N33/48 , C12Q1/00
CPC分类号： G01N30/34 , B01L3/50273 , B01L3/502776 , B01L2300/0816 , G01N1/405 , G01N2001/4088 , G01N2030/342 , Y10T436/2575 , G01N30/6095
摘要： The ability to rapidly generate concentration gradients of diffusible molecules has important applications in many chemical and biological studies. The present invention is directed to methods and systems for generating spatially and temporally controllable concentration gradients of molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of the concentration gradients can be initiated by an induced forward flow and further optimized during an induced backward flow. The forward and backward flows can be either passively induced and/or actively pumped. The centimeter-length gradients along the microfluidic channel can be spatially and temporally controlled by the backward flow. The gradient profile was stabilized by stopping the flow. In one example, a stabilized concentration gradient of a cardiac toxin, Alpha-cypermethrin, generated according to the invention was used to test the response of HL-1 cardiac cells in the microfluidic device, which correlated with toxicity data obtained from multi-well plates. The invention can be useful for biological and chemical processes that require rapid generation of concentration gradients in a portable microfluidic device.
摘要翻译：快速产生扩散分子的浓度梯度的能力在许多化学和生物学研究中具有重要的应用。本发明涉及用于在便携式微流体装置中产生分子（即蛋白质或毒素）的空间和时间可控浓度梯度的方法和系统。浓度梯度的形成可以通过诱导的正向流引发并且在诱导的逆流期间进一步优化。前向和后向流可以被动地被诱导和/或被主动泵送。沿着微流体通道的厘米长度梯度可以由反向流动在空间和时间上控制。通过停止流动来稳定梯度分布。在一个实例中，使用根据本发明产生的心脏毒素α-氯氰菊酯的稳定化浓度梯度来测试微流体装置中HL-1心脏细胞的反应，其与从多孔板获得的毒性数据相关。本发明可用于需要在便携式微流体装置中快速产生浓度梯度的生物和化学过程。

9. 发明申请

WO2017184839A1 SYSTEMS AND METHODS FOR IN VIVO MULTI-MATERIAL BIOPRINTING 审中-公开
标题翻译：用于体内多物质生物治疗的系统和方法
公开(公告)号：WO2017184839A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028569
申请日：2017-04-20
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： ZHANG, Yu Shrike , KHADEMHOSSEINI, Ali
IPC分类号： B33Y10/00 , B33Y30/00 , B33Y70/00 , B33Y80/00 , C12M1/00 , C12M3/00
摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi- material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.
摘要翻译：描述了用于体内多材料生物打印的系统和方法。体内多材料生物打印可以用于微创地在患者体内制造生物医学构造。该系统和方法可以利用多材料生物排印器，其包括生物相容部分。生物相容部分可以包括用于体内生物打印的单个打印头。单个打印头可以包括多个出口，每个出口连接到多个贮存器中的一个。多个容器中的每一个都可以容纳用于生物打印的不同生物链。可以激活多个出口中的每一个以释放相应的生物链接。

10. 发明申请

WO2016149615A1 POLYPEPTIDE COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：多肽组合物及其使用方法
公开(公告)号：WO2016149615A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/023121
申请日：2016-03-18
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： ANNABI, Nasim , KHADEMHOSSEINI, Ali
IPC分类号： A61L27/14 , A61L27/22 , C07K14/78 , A61P7/04
CPC分类号： C07K14/78 , A61L24/0015 , A61L24/0031 , A61L24/108 , A61L26/0047 , A61L26/0066 , A61L26/008 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/404 , A61L2300/418 , A61L2300/64 , A61L2400/04
摘要： Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG] 4 IPGVG} n , wherein n is an integer greater than 1. The polypeptides can be crosslinked to from biocompatible hydrogels with tunable and desirable mechanical properties. The polypeptides and hydrogels can be used in a variety of biomedical applications including treatment of bleeding, treatment of soft tissue injury, injectable filler, and tissue adhesives.
摘要翻译：本文公开了包含{[VPGVG] 4IPGVG} n的氨基酸序列的多肽，其中n是大于1的整数。多肽可以与可调节和期望的机械性质的生物相容性水凝胶交联。多肽和水凝胶可用于各种生物医学应用，包括出血治疗，软组织损伤治疗，可注射填充剂和组织粘合剂。

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