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1. 发明申请

WO2017144900A1 MASS SPECTROMETRY KIT 审中-公开
标题翻译：质谱分析套件
公开(公告)号：WO2017144900A1
公开(公告)日：2017-08-31
申请号：PCT/GB2017/050489
申请日：2017-02-24
申请人： THE BINDING SITE GROUP LIMITED , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： MURRAY, David L. , HARDING, Stephen , BARNIDGE, David R. , WALLIS, Gregg , MILLS, John , ASHBY, Jamie
IPC分类号： G01N33/68 , C07K16/00
CPC分类号： G01N33/6854 , C07K16/00 , G01N33/6893 , G01N2800/24
摘要： An anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method purifying an anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method of quantifying an amount of a subject analyte, or a fragment of an analyte in a sample from the subject comprising: (i) adding to the sample a predetermined amount of one or more control analytes or fragments thereof, which are distinguishable from the equivalent subject analyte or fragment; (ii) measuring the relative amount of the subject analyte or fragment and the amount of the control analyte or fragment in the sample; and (iii) comparing the relative amount of subject analyte or fragment to the relative amount of control analyte or fragment, to quantify the amount of analyte or fragment in the original subject sample.
摘要翻译：抗免疫球蛋白特异性抗体（或其片段），其特征在于所述抗体或其片段在至少一个重链或其片段与至少一个重链或其片段之间包含一个或多个非二硫键交联轻链或其抗体片段或其片段。纯化抗免疫球蛋白特异性抗体（或其片段）的方法，其特征在于所述抗体或其片段包含至少一个重链或其片段与至少一个轻链或其片段之间的一个或多个非二硫键交联的抗体或其片段。一种量化来自受试者的样品中的受试者分析物或分析物片段的量的方法，包括：（i）向样品中加入预定量的一种或多种控制分析物或其片段，其可与等效的主题分析物或片段; （ii）测量主题分析物或片段的相对量以及样品中对照分析物或片段的量; （iii）将主题分析物或片段的相对量与对照分析物或片段的相对量进行比较，以量化原始主题样品中的分析物或片段的量。

2. 发明申请

WO2017144903A1 ANTIBODIES 审中-公开
标题翻译：抗体
公开(公告)号：WO2017144903A1
公开(公告)日：2017-08-31
申请号：PCT/GB2017/050492
申请日：2017-02-24
申请人： THE BINDING SITE GROUP LIMITED
发明人： WALLIS, Gregg , ASHBY, Jamie , HARDING, Stephen
IPC分类号： G01N33/68 , C07K16/00
CPC分类号： G01N33/6854 , C07K16/00 , C07K2317/94 , G01N33/6857
摘要： The invention provides an immunoassay kit providing an immunoassay kit comprising one or more analyte specific antibodies or fragments thereof, characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the analyte- specific antibodies or fragments thereof.
摘要翻译：本发明提供免疫测定试剂盒，其提供包含一种或多种分析物特异性抗体或其片段的免疫测定试剂盒，其特征在于所述抗体或其片段包含一个或多个非二硫键交联，所述非二硫键交联位于至少一个重链或其片段以及分析物特异性抗体或其片段的至少一个轻链或片段。

3. 发明申请

WO2021019211A1 IONISATION CONTROL 审中-公开
公开(公告)号：WO2021019211A1
公开(公告)日：2021-02-04
申请号：PCT/GB2020/051758
申请日：2020-07-23
申请人： THE BINDING SITE GROUP LIMITED
发明人： HARDING, Stephen , WALLIS, Gregg , ASHBY, Jamie , MARROTT, Nia , NORTH, Simon
IPC分类号： G01N33/68
摘要： An elution buffer for eluting one or more predetermined analytes from one or more analyte-specific antibodies or fragments thereof or for eluting one or more predetermined antibodies or fragments from a target antigen, wherein: the elution buffer has a pH of 1 to 5; and the elution buffer comprises a predetermined amount of an acid stable mass spectrometry ionisation control protein. The use of the elution buffer in the detection and quantifying of analytes, for example by mass spectrometry is also described.

4. 发明申请

WO2017144896A1 IMPROVED ASSAY 审中-公开
标题翻译：改进的分析
公开(公告)号：WO2017144896A1
公开(公告)日：2017-08-31
申请号：PCT/GB2017/050485
申请日：2017-02-24
申请人： THE BINDING SITE GROUP LIMITED
发明人： HARDING, Stephen , ASHBY, Jamie
IPC分类号： G01N33/563
CPC分类号： G01N33/563
摘要： The application describes a method of quantifying a multimeric analyte in a sample comprising: (i) treating the multimeric analyte with a separating agent selected to convert at least a portion of the multimeric analyte into monomeric analyte; (ii) binding the analyte to an analyte-specific binding agent; (iii) comparing the amount of binding of the analyte to the analyte-specific binding agent to a calibration curve, wherein the calibration curve is obtained (i) by binding the analyte- specific binding agent to one or more predetermined amounts of separating agent treated analyte, prior to contacting with analyte-specific binding agent or (ii) by binding the analyte- specific binding agent to a predetermined amount of substantially monomeric analyte; and (iv) determining an amount of the multimeric analyte in the sample.
摘要翻译：本申请描述了定量样品中多聚体分析物的方法，包括：（i）用选择的分离剂处理多聚体分析物，以将多聚体分析物的至少一部分转化为单体分析物; （ii）将分析物与分析物特异性结合剂结合; （iii）将分析物与分析物特异性结合剂的结合量与校准曲线进行比较，其中（i）通过将分析物特异性结合剂与一种或多种预定量的分离剂处理的在分析物特异性结合剂接触之前或（ii）通过将分析物特异性结合剂结合到预定量的基本上单体的分析物上; 和（iv）确定样品中多聚体分析物的量。

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