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1. 发明申请

WO2004071421A3 SUSTAINED RELEASE FORMULATION OF N-(2-PROPYLPENTANOYL) GLYCINAMIDE AND RELATED COMPOUNDS 审中-公开
标题翻译： N-（2-丙酰氨基）甘氨酰胺及相关化合物的持续释放配方
公开(公告)号：WO2004071421A3
公开(公告)日：2004-11-18
申请号：PCT/US2004003281
申请日：2004-02-05
申请人： TEVA PHARMA , TEVA PHARMACEUTICAL USA INC , LICHT DANIELLA , LOVINGER IOANA , ABD-ELHAI SUHER , DAGAN-LION MAZZI , GILBERT ADRIAN , LEIBOVITCH NOA , COHEN SASSON , LEVY RUTH
发明人： LICHT DANIELLA , LOVINGER IOANA , ABD-ELHAI SUHER , DAGAN-LION MAZZI , GILBERT ADRIAN , LEIBOVITCH NOA , COHEN SASSON , LEVY RUTH
IPC分类号： A61K9/20 , A61K9/22 , A61K31/16 , A61K31/19
CPC分类号： A61K31/16 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/19
摘要： The subject provides a sustained release tablet comprising the following components: a) a uniform admixture of an active ingredient selected from the group consisting of valproic sodium acid, a pharmaceutically acceptable salt or ester of valproic acid, divalproex sodium, valpromide and a compound having the structure of formula (I) or formula (II), wherein R1, R2, and R3 are independently the same or different and are hydrogen, a C1-C6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3; and a binder, and b) a hydroxypropylmethyl cellulose, a process for manufacturing the tablet and a method of treating neuropathic pain, epilepsy, mania in bipolar disorder, a headache disorder, pain or of effecting pain prophylaxis in a subject.
摘要翻译：受试者提供了包含以下组分的持续释放片剂：a）选自丙戊酸钠，丙戊酸的药学上可接受的盐或酯，二价丙磺酸钠，valpromide和具有下列成分的化合物的活性成分的均匀混合物：式（I）或式（II）的结构，其中R 1，R 2和R 3独立地相同或不同，为氢，C 1 -C 6烷基，芳烷基或芳基，n为整数大于或等于0且小于或等于3; 和粘合剂，以及b）羟丙基甲基纤维素，制备片剂的方法以及治疗神经性疼痛，癫痫，双相情感障碍中的躁狂症，头痛障碍，疼痛或对受试者进行疼痛预防的方法。

2. 发明申请

WO2014011750A8 LAQUINIMOD FORMULATIONS WITHOUT ALKALIZING AGENT 审中-公开
标题翻译：没有碱化剂的LAQUINIMOD配方
公开(公告)号：WO2014011750A8
公开(公告)日：2014-12-04
申请号：PCT/US2013049894
申请日：2013-07-10
申请人： TEVA PHARMA , TEVA PHARMA , SARFATI GADI , LOVINGER IOANA , LICHT DANIT , SAFADI MUHAMMAD
发明人： SARFATI GADI , LOVINGER IOANA , LICHT DANIT , SAFADI MUHAMMAD
IPC分类号： A61K31/47
CPC分类号： A61K31/4704 , A61K9/0053 , A61K9/2013 , A61K9/2018 , A61K9/2095 , A61K9/4858
摘要： The subject invention provides a stable pharmaceutical composition comprising a therapeutically effective amount of laquinimod, an amount of a filler, and an amount of a lubricant, wherein the stable pharmaceutical composition is free of an alkalizing agent or an oxidation reducing agent. The subject invention also provides processes for making the stable pharmaceutical composition and sealed packages comprising the stable pharmaceutical composition. The subject invention additionally provides method for treating a subject afflicted with a form of multiple sclerosis or for alleviating a symptom of multiple sclerosis in a subject afflicted with a form of multiple sclerosis comprising administering to the subject a stable pharmaceutical composition as described herein. The subject invention further provides for use of a stable pharmaceutical composition as described herein for treating a subject afflicted with a form of multiple sclerosis or for alleviating a symptom of multiple sclerosis in a subject afflicted with a form of multiple sclerosis.
摘要翻译：本发明提供了稳定的药物组合物，其包含治疗有效量的拉喹莫德，一定量的填充剂和一定量的润滑剂，其中稳定的药物组合物不含碱化剂或氧化还原剂。本发明还提供了制备稳定的药物组合物和包含稳定的药物组合物的密封包装的方法。本发明另外提供了治疗患有多发性硬化症形式的受试者或用于减轻患有多发性硬化症形式的受试者的多发性硬化症状的方法，其包括向受试者施用如本文所述的稳定的药物组合物。本发明进一步提供了本文所述的稳定药物组合物用于治疗患有多发性硬化症形式的受试者或用于减轻患有多发性硬化症形式的受试者的多发性硬化症状的用途。

3. 发明申请

WO2006091836A8 FORMULATIONS OF LADOSTIGIL TARTRATE 审中-公开
标题翻译：抗坏血酸盐配方
公开(公告)号：WO2006091836A8
公开(公告)日：2007-04-12
申请号：PCT/US2006006636
申请日：2006-02-24
申请人： TEVA PHARMA , TEVA PHARMA
发明人： LIGHT DANIELLA , LOVINGER IOANA , CACIULARU FANNY , GILBERT ADRIAN
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2059 , A61K31/27 , A61K31/325
摘要： Disclosed are formulations of ladostigil tartrate, including pharmaceutical compositions, process for the manufacture, and use thereof.
摘要翻译：本发明公开了酒石酸放射剂，包括药物组合物，制造方法和使用方法。

4. 发明申请

WO2006091836A9 FORMULATIONS OF LADOSTIGIL TARTRATE 审中-公开
标题翻译：抗坏血酸盐配方
公开(公告)号：WO2006091836A9
公开(公告)日：2006-10-26
申请号：PCT/US2006006636
申请日：2006-02-24
申请人： TEVA PHARMA , TEVA PHARMA
发明人： LIGHT DANIELLA , LOVINGER IOANA , CACIULARU FANNY , GILBERT ADRIAN
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2059 , A61K31/27 , A61K31/325
摘要： Disclosed are formulations of ladostigil tartrate, including pharmaceutical compositions, process for the manufacture, and use thereof.
摘要翻译：本发明公开了酒石酸放射剂，包括药物组合物，制造方法和使用方法。

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