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1. 发明申请

WO2009153631A2 GENERALIZED MODELING OF THE CORNEA 审中-公开
标题翻译： CORNEA的综合建模
公开(公告)号：WO2009153631A2
公开(公告)日：2009-12-23
申请号：PCT/IB2009/005766
申请日：2009-05-28
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , RUIZ, Luis, Antonio , LOESEL, Frieder
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00
摘要： A system and method for simulating a corneal reconfiguration in response to laser surgery uses a computer-programmed, biomechanical generalized model. The generalized model has a plurality of elements; with each element being pre-programmed based on diagnostic corneal data obtained from images of respective individual collagen fibers in a cornea. Collectively these pre-programmed elements replicate biomechanical properties of the cornea. In use, designated biomechanical characteristics on a plurality of selected elements are minimized to simulate laser surgery in an actual cornea. A computer then measures the resultant reconfiguration of the cornea model to assess an actual cornea's response to laser surgery.
摘要翻译：用于模拟针对激光手术的角膜重新配置的系统和方法使用计算机编程的生物力学广义模型。广义模型有多个元素; 每个元件基于从角膜中的各个胶原纤维的图像获得的诊断角膜数据进行预编程。这些预编程元件总体上复制了角膜的生物力学性质。在使用中，将多个选定元件上的指定生物力学特性最小化以模拟实际角膜中的激光手术。然后，计算机测量角膜模型的最终重新配置，以评估实际角膜对激光手术的反应。

2. 发明申请

WO2010094999A1 SYSTEM AND METHODS FOR MINIMIZING HIGHER ORDER ABERRATIONS INTRODUCED DURING REFRACTIVE SURGERY 审中-公开
标题翻译：用于最小化折射手术时引入的高次序的系统和方法
公开(公告)号：WO2010094999A1
公开(公告)日：2010-08-26
申请号：PCT/IB2009/007903
申请日：2009-12-28
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , LOESEL, Frieder , RUIZ, Luis, Antonio
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00829 , A61F2009/00872
摘要： A system and method are provided for minimizing the adverse effects of any optical aberrations, and particularly higher order aberrations, that may be introduced into an eye during the correction of a visual defect by photoablation (i.e. removal) of corneal tissue. In accordance with the present invention, after a predetermined time interval following the photoablation of tissue (e.g. about two weeks), the eye is evaluated for aberrations. Laser Induced Optical Breakdown (LIOB) is then performed on intrastromal tissue, as needed, to correct for the introduced aberrations.
摘要翻译：提供了一种系统和方法，用于最小化在通过角膜组织的光消除（即去除）校正视觉缺陷期间可能被引入到眼睛中的任何光学像差，特别是高阶像差的不利影响。根据本发明，在组织的光消融（例如约两周）之后的预定时间间隔之后，评估眼睛的像差。然后根据需要在肿瘤内组织上进行激光诱导光学细分（LIOB），以校正引入的像差。

3. 发明申请

WO2011124646A3 SYSTEM FOR PERFORMING INTRASTROMAL REFRACTIVE SURGERY 审中-公开
公开(公告)号：WO2011124646A3
公开(公告)日：2011-10-13
申请号：PCT/EP2011/055434
申请日：2011-04-07
申请人： TECHNOLAS PERFECT VISION GMBH , BILLE, Josef, F. , RUIZ, Luis, Antonio
发明人： BILLE, Josef, F. , RUIZ, Luis, Antonio
IPC分类号： A61B18/20 , A61F9/01 , A61F9/008
摘要： A system for performing intrastromal ophthalmic laser surgery requires Laser Induced Optical Breakdown (LIOB) of stromal tissue without compromising Bowman's capsule (membrane). In detail, the system is computer-controlled to create symmetrical cuts in the stroma relative to a defined axis of the eye. Importantly, these cuts are all distanced from the axis. The actual location and number of cuts in the surgery will depend on the degree of visual aberration being corrected. Further, the system may create different types of cuts in the stroma. For example, the symmetrical cuts (by type) may include cylindrical, radial or annular layer cuts. The different type cuts may be intersecting or non-intersecting depending on the visual aberration being treated.

4. 发明申请

WO2010086692A1 SYSTEM AND METHOD FOR REFRACTIVE SURGERY WITH AUGMENTATION BY INTRASTROMAL CORRECTIVE PROCEDURES 审中-公开
标题翻译：通过内镜矫正程序进行屈光手术的系统和方法
公开(公告)号：WO2010086692A1
公开(公告)日：2010-08-05
申请号：PCT/IB2009/007897
申请日：2009-12-28
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： RUIZ, Luis, Antonio , LOESEL, Frieder , BILLE, Josef, F.
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00827 , A61F2009/00857 , A61F2009/00872
摘要： A system and method are provided for an ophthalmic surgical procedure to provide a refractive correction for an eye. Specifically, the procedure is indicated when the desired refractive correction "d reqd " exceeds the capability of a correction achievable when corneal tissue is only ablated. In accordance with the present invention, an optimized refractive correction "d 1 " is accomplished by the ablation of corneal tissue (e.g. by a PRK or LASIK procedure). The optimized correction is then followed by a complementary refractive correction "d 2 " wherein stromal tissue is weakened with Laser Induced Optical Breakdown (LIOB). Together, the optimized refractive correction (ablation) and the complementary refractive correction (LIOB) equal the desire refractive correction (d reqd = d 1 + d 2 ).
摘要翻译：提供了一种用于眼科外科手术以为眼睛提供屈光矫正的系统和方法。具体地说，当希望的屈光矫正“dreqd”超过仅消融角膜组织时可实现的矫正的能力，就会指出该过程。根据本发明，通过消融角膜组织（例如通过PRK或LASIK程序）来实现优化的屈光矫正“d1”。然后，优化的校正之后是激光诱导光学击穿（LIOB）使基质组织变弱的互补屈光矫正“d2”。一起，优化的屈光矫正（消融）和互补屈光矫正（LIOB）等于期望的屈光矫正（dreqd = d1 + d2）。

5. 发明申请

WO2010086691A1 SYSTEM AND METHOD FOR CORRECTING HIGHER ORDER ABERRATIONS WITH CHANGES IN INTRASTROMAL BIOMECHANICAL STRESS DISTRIBUTIONS 审中-公开
标题翻译：用于校正内分泌生物力学应变分布变化的高阶异常的系统和方法
公开(公告)号：WO2010086691A1
公开(公告)日：2010-08-05
申请号：PCT/IB2009/007890
申请日：2009-12-24
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , LOESEL, Frieder , RUIZ, Luis Antonio
IPC分类号： A61F9/01
CPC分类号： A61F9/00827 , A61F9/008 , A61F9/00829 , A61F2009/00857 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895 , A61F2009/00897
摘要： A method for correcting higher order aberrations in an eye requires Laser Induced Optical Breakdown (LIOB) of stromal tissue. In detail, the method identifies at least one volume of stromal tissue in the eye, with each volume defining a central axis parallel to the visual axis of the eye. Thereafter, a pulsed laser beam is focused to a focal spot in each volume of stromal tissue to cause LIOB of stromal tissue at the focal spot. Further, the focal spot is moved through the volume of stromal tissue to create a plurality of incisions centered about the respective central axis of the volume. As a result, a predetermined selective weakening of the stroma is caused for correction of the higher order aberration.
摘要翻译：用于校正眼睛中高阶像差的方法需要基质组织的激光诱导光学细分（LIOB）。详细地，该方法识别眼睛中至少一个体积的基质组织，每个体积限定平行于眼睛视轴的中心轴线。此后，将脉冲激光束聚焦到每个体积的基质组织中的焦点，以引起基质组织在焦点处的LIOB。此外，焦点移动通过基质组织的体积以产生围绕体积的相应中心轴线居中的多个切口。结果，对于高阶像差的校正，引起基质的预定选择性弱化。

6. 发明申请

WO2012025808A3 SYSTEM AND METHOD FOR MINIMIZING THE SIDE EFFECTS OF REFRACTIVE CORRECTIONS USING LINE OR DOT CUTS FOR INCISIONS 审中-公开
公开(公告)号：WO2012025808A3
公开(公告)日：2012-03-01
申请号：PCT/IB2011/001890
申请日：2011-08-16
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , HOHLA, Kristian , LOESEL, Frieder
IPC分类号： A61F9/008
摘要： A system and method for performing refractive surgery in an eye requires creating a plurality of cuts in the stroma or the lens that are randomly positioned relative to a reference axis. The geometry for each cut is unique and includes a start point in the stroma that is identified by a distance "r" from the axis, and an azimuthal angle "⊖" that is measured around the axis. A computer provides concerted control for a laser unit and an optical scanner to randomly vary the start point for each cut, to create a pattern of cuts that will implement the desired refractive surgery, yet be visually illusive.

7. 发明申请

WO2010086693A1 METHODS FOR EMPLOYING INTRASTROMAL CORRECTIONS IN COMBINATION WITH SURFACE REFRACTIVE SURGERY TO CORRECT MYOPIC/HYPEROPIC PRESBYOPIA 审中-公开
标题翻译：使用表面矫正手术联合内镜矫正的方法来纠正肌肉/超声预后
公开(公告)号：WO2010086693A1
公开(公告)日：2010-08-05
申请号：PCT/IB2009/007898
申请日：2009-12-28
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , RUIZ, Luis Antonio , LOESEL, Frieder
IPC分类号： A61F9/008 , A61F9/01
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00838 , A61F2009/00857 , A61F2009/00872 , A61F2009/00895
摘要： A system and method for correcting a vision defect (i.e. presbyopia) of a patient requires two laser units. A first laser unit is used to photoablate (i.e. remove) tissue from the cornea for the creation of a multi-focal cornea that simultaneously provides for both near and distance vision capabilities. A second laser unit can also be used to refine the shape of the cornea by weakening selected portions with LIOB. Together, the removal and weakening of corneal tissue are regulated to optimize the resultant near vision and distant vision capabilities of the patient.
摘要翻译：用于校正患者的视力缺损（即老花眼）的系统和方法需要两个激光单元。第一激光单元用于从角膜照射（即去除）组织以创建多焦点角膜，其同时提供近距离和远视力能力。第二激光单元也可用于通过用LIOB削弱所选择的部分来细化角膜的形状。一起调节角膜组织的去除和削弱，以优化患者的近视力和远视力。

8. 发明申请

WO2009147480A1 SYSTEM AND METHOD FOR RESHAPING A CORNEA USING A COMBINATION OF LIOB AND STRUCTURAL CHANGE PROCEDURES 审中-公开
标题翻译：使用LIOB和结构变化程序组合来修复角膜的系统和方法
公开(公告)号：WO2009147480A1
公开(公告)日：2009-12-10
申请号：PCT/IB2009/005661
申请日：2009-05-20
申请人： TECHNOLAS PERFECT VISION GMBH
发明人： BILLE, Josef, F. , RUIZ, Luis Antonio
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00842 , A61F2009/00872 , A61F2009/00897
摘要： A system and method for reshaping and altering the cornea of an eye employs a laser beam for two different purposes. For one, the laser beam is configured to perform Laser Induced Optical Breakdown (LIOB ) on selected tissue in the stroma of the cornea. This generally weakens the stromal tissue and allows intraocular pressure and bio-mechanical forces in the eye to reshape the cornea. For the other, the laser beam is configured to cause Permanent Structural Change (PSC) on selected tissue in the stroma of the cornea. This alters the tissue density of the selected PSC stromal tissue to change its refractive index. In combination, the LIOB and PSC provide for corrected vision.
摘要翻译：用于整形和改变眼睛角膜的系统和方法采用激光束用于两种不同的目的。一方面，激光束被配置为在角膜基质的选定组织上执行激光诱导光学细分（LIOB）。这通常削弱基质组织，并允许眼内的眼压和生物机械力重塑角膜。另一方面，激光束被配置为在角膜基质的选定组织上引起永久性结构变化（PSC）。这改变了所选PSC基质组织的组织密度以改变其折射率。结合起来，LIOB和PSC提供了矫正视力。

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