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1. 发明申请

WO2011034362A9 COMPOSITION CONTAINING SAURURUS CHINENSIS EXTRACT OR SAUCHINONE AS AN ACTIVE INGREDIENT, FOR PREVENTING AND TREATING DISEASES CAUSED BY THE OVEREXPRESSION OF LXR-? 审中-公开
标题翻译：含有苏云金芽胞杆菌提取物或SAUCHINONE作为活性成分的组合物，用于预防和治疗由过度表达LXR-引起的疾病。
公开(公告)号：WO2011034362A9
公开(公告)日：2011-06-30
申请号：PCT/KR2010006365
申请日：2010-09-16
申请人： SNU R&DB FOUNDATION , KIM SANG GEON , KIM SANG CHAN , KIM YOUNG CHOONG , KIM YOUNG WOO
发明人： KIM SANG GEON , KIM SANG CHAN , KIM YOUNG CHOONG , KIM YOUNG WOO
IPC分类号： A61K31/36 , A23L1/30 , A61K36/78 , A61P1/16
CPC分类号： A61K36/78 , A23L33/105
摘要： The present invention relates to a composition containing Saururus chinensis extract or Sauchinone as an active ingredient, which inhibits the expression or activity of liver X receptor a (LXRa) or sterol response element binding protein-1 (SREBP-1), and which can thus be used in preventing, improving, and treating diseases caused by the overexpression or activity of LXRa or SREBP-1. The composition of the present invention exhibits remarkable effects of inhibiting adipogenic gene expression, and further inhibiting the accumulation of triglycerides in liver tissue, and therefore is advantageous in treating fatty liver caused by metabolic disorders resulting from a high-fat diet. In addition, the composition of the present invention can be effectively used in preventing, improving, and treating, for example, liver diseases such as fatty liver caused by the accumulation of liver lipids, hypertriglyceridemia, hyperreninemia, renin-induced hypertension, aldosteronism, adrenoleukodystrophy, glomerulosclerosis, proteinuria, renal failure, etc.
摘要翻译：本发明涉及含有Saururus chinensis提取物或Sauchinone作为活性成分的组合物，其抑制肝X受体α（LXRα）或甾醇应答元件结合蛋白-1（SREBP-1）的表达或活性，并且因此可以用于预防，改善和治疗由LXRα或SREBP-1的过表达或活性引起的疾病。本发明的组合物显示出显着的抑制脂肪形成基因表达的效果，并进一步抑制甘油三酯在肝组织中的积聚，因此有利于治疗由高脂饮食引起的代谢紊乱引起的脂肪肝。另外，本发明的组合物可有效用于预防，改善和治疗例如由肝脏积聚引起的脂肪肝，高甘油三酯血症，高血压，肾素诱导性高血压，醛固酮增多症，肾上腺脑白质营养不良，肾小球硬化，蛋白尿，肾功能衰竭等。

2. 发明申请

WO2011034362A3 COMPOSITION CONTAINING SAURURUS CHINENSIS EXTRACT OR SAUCHINONE AS AN ACTIVE INGREDIENT, FOR PREVENTING AND TREATING DISEASES CAUSED BY THE OVEREXPRESSION OF LXR-? 审中-公开
标题翻译：含有SAURURUS CHINENSIS EXTRACT或SAUCHINONE作为活性成分的组合物，用于预防和治疗由LXR-过表达引起的疾病
公开(公告)号：WO2011034362A3
公开(公告)日：2011-09-01
申请号：PCT/KR2010006365
申请日：2010-09-16
申请人： SNU R&DB FOUNDATION , KIM SANG GEON , KIM SANG CHAN , KIM YOUNG CHOONG , KIM YOUNG WOO
发明人： KIM SANG GEON , KIM SANG CHAN , KIM YOUNG CHOONG , KIM YOUNG WOO
IPC分类号： A61K31/36 , A23L1/30 , A61K36/78 , A61P1/16
CPC分类号： A61K36/78 , A23L33/105
摘要： The present invention relates to a composition containing Saururus chinensis extract or Sauchinone as an active ingredient, which inhibits the expression or activity of liver X receptor a (LXRa) or sterol response element binding protein-1 (SREBP-1), and which can thus be used in preventing, improving, and treating diseases caused by the overexpression or activity of LXRa or SREBP-1. The composition of the present invention exhibits remarkable effects of inhibiting adipogenic gene expression, and further inhibiting the accumulation of triglycerides in liver tissue, and therefore is advantageous in treating fatty liver caused by metabolic disorders resulting from a high-fat diet. In addition, the composition of the present invention can be effectively used in preventing, improving, and treating, for example, liver diseases such as fatty liver caused by the accumulation of liver lipids, hypertriglyceridemia, hyperreninemia, renin-induced hypertension, aldosteronism, adrenoleukodystrophy, glomerulosclerosis, proteinuria, renal failure, etc.
摘要翻译：本发明涉及含有Saururus chinensis提取物或Sauchinone作为活性成分的组合物，其抑制肝X受体a（LXRa）或固醇反应元件结合蛋白-1（SREBP-1）的表达或活性，因此可以用于预防，改善和治疗由LXRa或SREBP-1的过表达或活性引起的疾病。本发明的组合物显示出显着的抑制脂肪形成基因表达的效果，进一步抑制甘油三酯在肝组织中的积聚，因此有利于治疗由高脂肪饮食引起的代谢紊乱引起的脂肪肝。此外，本发明的组合物可以有效地用于预防，改善和治疗例如由肝脂肪积聚引起的肝脏疾病，高甘油三酯血症，高肾血
氨酸血症，肾素性高血压，醛固酮增多症，肾上腺脑白质营养不良，肾小球硬化，蛋白尿，肾衰竭等

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