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1. 发明申请

WO2011018504A2 IMMUNOMODULATORY COMPOSITIONS COMPRISING A POLYMER MATRIX AND AN OIL PHASE 审中-公开
标题翻译：包含聚合物基质和油相的免疫组合物
公开(公告)号：WO2011018504A2
公开(公告)日：2011-02-17
申请号：PCT/EP2010/061791
申请日：2010-08-12
申请人： SIGMOID PHARMA LIMITED , COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo , LAVELLE, Edward Charles , ROSA, Mónica Torres
发明人： COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo , LAVELLE, Edward Charles , ROSA, Mónica Torres
IPC分类号： A61K9/16
CPC分类号： A61K39/39 , A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1652 , A61K9/1658 , A61K9/5026 , A61K2039/542 , A61K2039/55561 , A61K2039/55566 , Y02A50/465 , Y02A50/466 , Y02A50/471 , Y02A50/473 , Y02A50/475
摘要： A pharmaceutical composition comprising a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising at least one immunomodulator selected from an adjuvant, an antigen or a combination thereof.A method of manufacturing shaped compositions comprises mixing an aqueous solution of a water-soluble polymer with an oil-based liquid to form a water-in-oil emulsion, at least one of the aqueous solution and the oil-based liquid comprising an antigen or an adjuvant or a combination thereof, and then causing or allowing the resultant suspension to solidify into one or more beads or other shaped elements.
摘要翻译：一种包含水溶性聚合物基质的药物组合物，其中分散有油滴，所述组合物包含至少一种选自佐剂，抗原或其组合的免疫调节剂。1.一种制备成形组合物的方法，包括将具有油性液体的水溶性聚合物，形成油包水乳液，所述水溶液和所述油性液体中的至少一种包含抗原或佐剂或其组合，然后引起或允许产生的悬浮液固化成一个或多个珠粒或其它成形元件。

2. 发明申请

WO2016071515A1 COMPOSITIONS COMPRISING CYCLOSPORIN 审中-公开
标题翻译：包含环磷酰胺的组合物
公开(公告)号：WO2016071515A1
公开(公告)日：2016-05-12
申请号：PCT/EP2015/075984
申请日：2015-11-06
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , AVERSA, Vincenzo , ROSA, Mónica , O'DONNELL, Dáire , RENAUD OF CALHANE, Wyatt
IPC分类号： A61K9/107 , A61K9/50 , A61K38/13 , A61P1/00 , A61P1/04 , A61P35/00
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/107 , A61K9/1617 , A61K9/1658 , A61K9/5047 , A61K9/5073 , A61K45/06
摘要： The present invention relates to a formulation comprising a pharmaceutically active ingredient and coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.
摘要翻译：本发明涉及包含药物活性成分和包衣的制剂。本发明还涉及该制剂在治疗和预防胃肠道疾病中的用途。还公开了制备制剂的方法。

3. 发明申请

WO2015067762A1 FORMULATIONS COMPRISING CYCLOSPORIN A 审中-公开
标题翻译：包含环磷酰胺A的配方
公开(公告)号：WO2015067762A1
公开(公告)日：2015-05-14
申请号：PCT/EP2014/074054
申请日：2014-11-07
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , AVERSA, Vincenzo , ROSA, Monica
IPC分类号： A61K9/50 , A61K38/13
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5073
摘要： A modified release composition comprising cyclosporin A for oral administration. The composition may comprise a core and a modified release coating, wherein the core comprises a hydrogel- forming polymer matrix and cyclosporin A. The composition may be in the form of a minibead. The compositions provide a pharmacokinetic profile and dissolution profile which provides release of cyclosporin A in the lower GI tract whilst minimising systemic exposure. Also disclosed are uses of the composition in the treatment of conditions affecting the lower GI tract, particularly the colon.
摘要翻译：一种包含口服给药的环孢菌素A的改良组合物。组合物可以包含核心和改性释放包衣，其中核心包含形成水凝胶的聚合物基质和环孢菌素A.组合物可以是微型体形式。组合物提供药代动力学特征和溶出曲线，其提供在下GI胃中释放环孢菌素A，同时使全身暴露最小化。还公开了组合物在治疗影响下胃肠道，特别是结肠的病症中的用途。

4. 发明申请

WO2014128233A1 ORAL STEROID FORMULATIONS FOR USE IN THE TREATMENT OF INTESTINAL FIBROSIS 审中-公开
标题翻译：用于治疗精原细胞病变的口服甾体制剂
公开(公告)号：WO2014128233A1
公开(公告)日：2014-08-28
申请号：PCT/EP2014/053373
申请日：2014-02-20
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , AVERSA, Vincenzo
IPC分类号： A61K38/13 , A61K9/16 , A61K9/50 , A61K31/223 , A61K31/502 , A61K31/56
CPC分类号： A61K9/0053 , A61K9/16 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K9/4808 , A61K9/4891 , A61K9/50 , A61K9/5036 , A61K9/5042 , A61K31/223 , A61K31/502 , A61K31/56 , A61K31/58 , A61K38/13 , A61K2300/00
摘要： An oral steroid formulation for use in the treatment of intestinal fibrosis, the formulation being a multiple minibead formulation wherein the minibeads comprise a water soluble polymer matrix in which the steroid is distributed. The steroid may be budesonide.
摘要翻译：用于治疗肠纤维化的口服类固醇制剂，该制剂是多重小型制剂，其中微型载体包含其中分布类固醇的水溶性聚合物基质。类固醇可能是布地奈德。

5. 发明申请

WO2014006215A1 HYDROGEL VACCINE FORMULATIONS 审中-公开
标题翻译： HYDROGEL VACCINE配方
公开(公告)号：WO2014006215A1
公开(公告)日：2014-01-09
申请号：PCT/EP2013/064327
申请日：2013-07-05
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo , ROSA, Mónica
IPC分类号： A61K39/108 , A61K47/36 , A61K9/50 , A61K9/51
CPC分类号： A61K39/0258 , A61K9/06 , A61K9/146 , A61K9/50 , A61K9/5042 , A61K9/5073 , A61K9/5161 , A61K39/0002 , A61K39/0208 , A61K39/0283 , A61K39/08 , A61K39/107 , A61K39/12 , A61K39/39 , A61K47/36 , A61K2039/52 , A61K2039/521 , A61K2039/522 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/542 , A61K2039/55511 , Y02A50/474
摘要： This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.
摘要翻译：本发明涉及用于递送一种或多种活性成分的组合物，更具体地涉及组合物，例如，珠粒，其包含基质材料，该基质材料包含微生物。特别地，本发明涉及包含选自活的，灭活的，减毒的和灭活的微生物的微生物的组合物。基质材料还可以包含表面活性剂，并且还可以包含佐剂。本发明还涉及这种组合物的制造和使用以及其它主题。

6. 发明申请

WO2015176780A1 CELECOXIB FORMULATIONS USEFUL FOR TREATING COLORECTAL CANCER 审中-公开
标题翻译： CELECOXIB配方可用于治疗彩色癌
公开(公告)号：WO2015176780A1
公开(公告)日：2015-11-26
申请号：PCT/EP2014/060750
申请日：2014-05-23
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo
IPC分类号： A61K9/50 , A61K31/00
CPC分类号： A61K9/5057 , A61K9/5089 , A61K31/415
摘要： An oral celecoxib formulation, the formulation being a multiple minibead formulation wherein the minibeads comprise a hydrogel-forming polymer matrix in which are distributed celecoxib, a polyoxyethylated non-ionic surfactant and an anionic surfactant, the minibeads when combined with water being capable of releasing self-assembly structures comprising surfactant and celecoxib. The formulation may be used for treating colorectal cancer, e.g. for inhibiting, reducing or delaying the initiation and/or progression of colorectal cancer, or for use in reversing colorectal cancer, reducing the burden of colorectal cancer and/or inducing remission of colorectal cancer, or for inhibiting, reducing or delaying metastasis of a colorectal cancer.
摘要翻译：口服塞来昔布制剂，该制剂是多重小型制剂，其中微型载体包含形成水凝胶的聚合物基质，其中分布有塞来昔布，聚氧乙烯化非离子表面活性剂和阴离子表面活性剂，当与水结合时能够释放自身的微型体组合结构包括表面活性剂和塞来昔布。该制剂可用于治疗结肠直肠癌，例如，用于抑制，减少或延迟结肠直肠癌的起始和/或进展，或用于逆转结肠直肠癌，减少结肠直肠癌的负担和/或诱导结肠直肠癌的缓解，或用于抑制，减少或延迟结肠直肠的转移癌症。

7. 发明申请

WO2015067763A1 FORMULATIONS 审中-公开
标题翻译：配方
公开(公告)号：WO2015067763A1
公开(公告)日：2015-05-14
申请号：PCT/EP2014/074057
申请日：2014-11-07
申请人： SIGMOID PHARMA LIMITED
发明人： COULTER, Ivan , AVERSA, Vincenzo , MCDONALD, Bernard, Francis , ROSA, Monica
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/1658 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5073 , A61K9/5089 , A61K31/196 , A61K31/502 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/36 , A61K47/42
摘要： The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.
摘要翻译：本发明涉及包含药物活性成分和涂层的制剂。本发明还涉及该制剂在治疗和预防胃肠道疾病中的用途。还公开了制备制剂的方法。

8. 发明申请

WO2012069658A2 IMMUNOMODULATORY COMPOSITIONS 审中-公开
标题翻译：免疫组织化学
公开(公告)号：WO2012069658A2
公开(公告)日：2012-05-31
申请号：PCT/EP2011/071088
申请日：2011-11-25
申请人： SIGMOID PHARMA LIMITED , AVERSA, Vincenzo , COULTER, Ivan , ROSA, Mónica Torres , McDONALD, Bernard Francis
发明人： AVERSA, Vincenzo , COULTER, Ivan , ROSA, Mónica Torres , McDONALD, Bernard Francis
IPC分类号： A61K9/00 , A61K9/50 , A61K31/436 , A61K31/502 , A61K45/06 , A61P1/04 , A61P37/06 , A61P1/00
CPC分类号： A61K38/13 , A61K9/16 , A61K9/1658 , A61K9/167 , A61K9/5036 , A61K9/5042 , A61K9/5084 , A61K31/436 , A61K31/502 , A61K45/06 , A61K2300/00
摘要： Immunomodulator formulations for use in the treatment of disease of the Gl tract. The formulations comprise a hydroxylase inhibitor and/or an immunosuppressant. Exemplary formulations comprise hydralazine as a hydroxylase inhibitor and/or cyclosporin A as an immunosuppressant.
摘要翻译：用于治疗胃肠道疾病的免疫调节剂制剂。制剂包含羟化酶抑制剂和/或免疫抑制剂。示例性制剂包含肼屈嗪作为羟化酶抑制剂和/或环孢菌素A作为免疫抑制剂。

9. 发明申请

WO2010133609A3 COMPOSITION COMPRISING OIL DROPS 审中-公开
公开(公告)号：WO2010133609A3
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056838
申请日：2010-05-18
申请人： SIGMOID PHARMA LIMITED , COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo
发明人： COULTER, Ivan , MCDONALD, Bernard Francis , AVERSA, Vincenzo
IPC分类号： A61K9/16 , A61K9/50 , A61K9/107 , A61K38/13 , A61K31/436
摘要： A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.

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