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1. 发明申请

WO2017087710A3 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS 审中-公开
公开(公告)号：WO2017087710A3
公开(公告)日：2017-05-26
申请号：PCT/US2016/062595
申请日：2016-11-17
申请人： PROVIVI, INC. , ONDI, Levente , MEHDI, Hasan
发明人： ONDI, Levente , MEHDI, Hasan , WAMPLER, Keith M. , MEINHOLD, Peter , COELHO, Pedro , BUI, Vu
IPC分类号： C07C6/02 , C07C6/04
摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.

2. 发明申请

WO2017087710A2 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS 审中-公开
标题翻译：通过烯烃产物生产脂肪族烯烃衍生物
公开(公告)号：WO2017087710A2
公开(公告)日：2017-05-26
申请号：PCT/US2016/062595
申请日：2016-11-17
申请人： PROVIVI, INC. , ONDI, Levente , MEHDI, Hasan
发明人： ONDI, Levente , MEHDI, Hasan , WAMPLER, Keith M. , MEINHOLD, Peter , COELHO, Pedro , BUI, Vu
IPC分类号： C07C67/293 , C07C69/533
CPC分类号： B01J31/2278 , B01J2231/543 , B01J2531/64 , B01J2531/66 , C07B2200/09 , C07C6/04 , C07C29/147 , C07C45/41 , C07C67/08 , C07C67/293 , C07C67/343 , C07C2531/22 , C07C69/533 , C07C33/025 , C07C69/145 , C07C47/21 , C07C11/21
摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.
摘要翻译：本发明提供了用于合成脂肪烯烃衍生物的方法。在一些实施方案中，该方法包括：a）在足以形成复分解产物的条件下，在易位催化剂存在下，使不饱和烯烃与不饱和脂肪酸酯接触，和b）将复分解产物转化为脂肪烯烃衍生物。在某些实施方案中，复分解催化剂是钨催化剂或钼催化剂。在不同的实施方案中，脂肪烯烃衍生物是昆虫信息素。还介绍了信息素组合物及其使用方法。

3. 发明申请

WO2016210352A2 SYNTHESIS OF PHEROMONES AND OTHER OXY-FUNCTIONALIZED PRODUCTS VIA ENZYMATIC HYDROXYLATION OF CARBOXYLIC ACIDS 审中-公开
标题翻译：通过羧酸的酶促羟基化合成合成其他氧化功能产物
公开(公告)号：WO2016210352A2
公开(公告)日：2016-12-29
申请号：PCT/US2016/039399
申请日：2016-06-24
申请人： PROVIVI, INC.
发明人： BUI, Vu , COELHO, Pedro , CHEN, Mike M.Y. , MEINHOLD, Peter , HEEL, Thomas
IPC分类号： C12P7/04 , C07C27/02
CPC分类号： C12P7/04 , C07C29/147 , C07C67/08 , C07C67/327 , C07C67/343 , C12P7/24 , C12P7/6436 , C12Y114/14001 , C12Y114/15003 , C07C69/675 , C07C69/533 , C07C33/025 , C07C69/145
摘要： The present invention provides a method for synthesizing an oxyfunctionalized product. The method includes incubating an enzyme substrate with an enzyme capable of hydroxylating one terminal carbon of the enzyme substrate to form a hydroxylated product and converting at least a portion of the hydroxylated product to the oxyfunctionalized product. The enzyme substrate is an unsaturated or saturated carboxylic acid or an ester thereof, and the hydroxylated product can be a terminal hydroxy-substituted unsaturated carboxylic acid or an ester thereof. The oxy-functionalized products include insect pheromones and other useful compounds.
摘要翻译：本发明提供一种合成氧化产物的方法。该方法包括使酶底物与能够使酶底物的一个末端碳羟化的酶形成羟基化产物并将至少一部分羟基化产物转化为氧化官能化产物。酶底物是不饱和或饱和的羧酸或其酯，羟基化产物可以是末端羟基取代的不饱和羧酸或其酯。氧官能化产物包括昆虫信息素和其它有用的化合物。

4. 发明申请

WO2017087846A1 MICROORGANISMS FOR THE PRODUCTION OF INSECT PHEROMONES AND RELATED COMPOUNDS 审中-公开
标题翻译：用于生产昆虫类动物及其相关化合物的微生物
公开(公告)号：WO2017087846A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062852
申请日：2016-11-18
申请人： PROVIVI, INC.
发明人： EFFENDI, Leonard , MEINHOLD, Peter , WAMPLER, Keith , COELHO, Pedro , SHEPPARD, Micah
IPC分类号： A01M29/12 , A01N37/46 , A61K9/42 , C07C57/66 , C12N15/53 , C12N15/63 , C12P7/64
CPC分类号： A01M29/12 , A01N63/02 , C12P7/6436 , C12P7/6472
摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The C 6 -C 24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. The application further relates to recombinant microorganisms co-expressing a pheromone pathway and a pathway for the production of a toxic protein, peptide, oligonucleotide, or small molecule suitable for use in an attract-and-kill pest control approach. Also provided are methods of producing unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.
摘要翻译：本申请涉及用于生物合成不饱和C 6 -C 24脂肪醇，醛和乙酸酯的重组微生物，其可以是作为昆虫信息素，香料，香料和聚合物中间体有用。本文所述的C 6 -C 24脂肪醇，醛和乙酸酯可用作复分解反应的底物以扩展目标化合物和信息素的库。本申请还涉及共表达信息素途径的重组微生物和用于产生适用于吸引和杀灭害虫防治方法的毒性蛋白质，肽，寡核苷酸或小分子的途径。还提供了使用重组微生物生产不饱和C 6 -C 24脂肪醇，醛和乙酸酯的方法，以及包含重组微生物和/或任选的一种或多种产品醇，醛或乙酸酯。

5. 发明申请

WO2018213554A1 MICROORGANISMS FOR THE PRODUCTION OF INSECT PHEROMONES AND RELATED COMPOUNDS 审中-公开
公开(公告)号：WO2018213554A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/033151
申请日：2018-05-17
申请人： PROVIVI, INC.
发明人： SHEPPARD, Micah , HEEL, Thomas , MEINHOLD, Peter , WAMPLER, Keith , COELHO, Pedro , LEONARD, Effendi
IPC分类号： C12P7/04 , C12P7/24 , C12P7/64 , C12N9/02 , C12N9/10
摘要： The present application relates to recombinant microorganisms useful in the biosynthesis of unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates which may be useful as insect pheromones, fragrances, flavors, and polymer intermediates. The recombinant microorganisms may express enzymes or enzyme variants useful for production of and/or may be modified to down regulate pathways to shunt production toward unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates. The C 6 -C 24 fatty alcohols, aldehydes, and acetates described herein may be used as substrates for metathesis reactions to expand the repertoire of target compounds and pheromones. Also provided are methods of producing unsaturated C 6 -C 24 fatty alcohols, aldehydes, and acetates using the recombinant microorganisms, as well as compositions comprising the recombinant microorganisms and/or optionally one or more of the product alcohols, aldehydes, or acetates.

6. 发明申请

WO2015176020A1 SYNTHESIS OF OLEFINIC ALCOHOLS VIA ENZYMATIC TERMINAL HYDROXYLATION 审中-公开
标题翻译：通过酶终止羟化合成烯醇的合成
公开(公告)号：WO2015176020A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/031219
申请日：2015-05-15
申请人： PROVIVI, INC.
发明人： COELHO, Pedro , CHEN, Mike M.Y. , MEINHOLD, Peter , CHO, Catherine Mee-Hie , BUI, Vu , HEEL, Thomas
IPC分类号： C07C29/04 , C07C29/50
CPC分类号： C12P7/04 , C07C1/34 , C07C2/861 , C07C5/09 , C07C6/04 , C07C29/32 , C07C45/29 , C07C51/235 , C07C67/14 , C07C2523/44 , C07C2531/22 , C07C2531/24 , C12P5/026 , C12P7/6418 , C07C33/025 , C07C69/145 , C07C11/02 , C07C11/22
摘要： In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 ( e.g. , cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
摘要翻译：在某些方面，本发明提供通过使不饱和或饱和烃底物与羟化酶接触来制备末端羟基化的烯烃和炔烃的方法。可用于实施本发明方法的示例性末端羟化酶对烃底物的一个末端碳表现出强选择性，包括但不限于非血红素二烷基烷烃单加氧酶，细胞色素P450（例如，CYP52的细胞色素P450和 CYP153家族），以及长链烷烃羟化酶。在一些实施方案中，末端羟基化的烯烃或炔烃进一步转化成末端烯烃。在某些实施方案中，末端羟基化的烯烃和炔烃可用作改变昆虫行为的昆虫信息素。在其它实施方案中，末端羟基化的烯烃和炔烃是用于通过乙醇化部分的乙酰化或氧化产生信息素的有用中间体。

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