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1. 发明申请

WO1998001762A2 A MAGNETIC FIELD SENSOR AND METHOD OF MANUFACTURING A MAGNETIC FIELD SENSOR 审中-公开
标题翻译：磁场传感器及制造磁场传感器的方法
公开(公告)号：WO1998001762A2
公开(公告)日：1998-01-15
申请号：PCT/IB1997000657
申请日：1997-06-06
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , VAN DER ZAAG, Pieter, Jan , MUNSTERS, Hendrik, Theodorus
IPC分类号： G01R33/02
CPC分类号： B82Y25/00 , G01R33/093 , Y10S428/90 , Y10T428/1121
摘要： A method of manufacturing a magnetic field sensor having a stacked structure which comprises: a substrate (1); an exchange-biasing layer (2) comprising nickel oxide; a magnetic layer (3) which is exchange-biased with the exchange-biasing layer (2), whereby at least the exchange-biasing layer (2) is provided by sputter deposition using a sputter gas which comprises Ne and/or He. The magnetic layer (3) preferably comprises permalloy. In a particular embodiment, the magnetic layer (3) is separated from a second magnetic layer (5) by an interposed non-magnetic layer (4), so as to form a spin-valve trilayer.
摘要翻译：一种制造具有堆叠结构的磁场传感器的方法，包括：基板（1）; 包含氧化镍的交换偏置层（2）; 与交换偏置层（2）交换偏置的磁性层（3），由此至少通过使用包括Ne和/或He的溅射气体的溅射沉积提供交换偏置层（2）。磁性层（3）优选包括坡莫合金。在特定实施例中，磁性层（3）通过插入的非磁性层（4）与第二磁性层（5）分离，以便形成自旋阀三层。

2. 发明申请

WO1997028528A1 MAGNETIC HEAD WITH MAGNETORESISTIVE SENSOR, AND SCANNING DEVICE PROVIDED WITH THE MAGNETIC HEAD 审中-公开
标题翻译：具有磁传感器的磁头和磁头提供的扫描装置
公开(公告)号：WO1997028528A1
公开(公告)日：1997-08-07
申请号：PCT/IB1997000039
申请日：1997-01-20
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , RUIGROK, Jacobus, Josephus, Maria , VAN DER ZAAG, Pieter, Jan
IPC分类号： G11B05/39
CPC分类号： G11B5/3916 , G11B5/3925 , G11B5/3932
摘要： Magnetic head having a head face (1) and comprising a multilayer structure with a flux guide (7a, 7b), a magnetoresistive sensor (9) and an intermediate layer (13) present between the flux guide and said sensor. The intermediate layer comprises an anti-ferromagnetic oxide which insulates the sensor from the flux guide and also magnetically biases the sensor.
摘要翻译：磁头具有头面（1），并且包括具有通量引导件（7a，7b）的多层结构，磁阻传感器（9）和存在于所述磁通引导件和所述传感器之间的中间层（13）。中间层包括使传感器与磁通引导件绝缘的反铁磁氧化物，并且还使传感器发生磁偏置。

3. 发明申请

WO1996015078A1 MOULDING OF SINTERED HEXAGONAL FERRITE MATERIAL 审中-公开
标题翻译：烧结六角形铁素体材料
公开(公告)号：WO1996015078A1
公开(公告)日：1996-05-23
申请号：PCT/IB1995000926
申请日：1995-10-26
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , VAN DER ZAAG, Pieter, Jan , VAN DER VALK, Pieter, Johan
IPC分类号： C04B35/26
CPC分类号： H01F1/10 , C04B35/2633 , H01F1/348
摘要： The invention relates to a moulding of a sintered hexagonal ferrite material. This moulding is characterized in that the majority of the grains of the material have a monodomain structure. By virtue thereof, the loss factor tan delta of this material is much smaller than that of corresponding known materials if said material is used in the frequency range of 100 MHz or higher. The monodomain structure of this material is obtained, in particular, if the average grain size of the material is smaller than 2.8 micrometers. The average grain size preferably ranges between 1.4 micrometers and 2.5 micrometers. Preference is given, in particular, to those ferrite materials whose composition corresponds to the formula Ba3Me2Fe24O41, wherein Me stands for one or more divalent ions selected from the group formed by Co, Fe, Mn, Ni, Zn, Mg and (Li.Fe)1/2. Even at very high frequencies, these materials exhibit a small loss factor. The mouldings in accordance with the invention are extremely suitable for use in antennas.
摘要翻译：本发明涉及六方晶系烧结烧结体的成型。该成型的特征在于，该材料的大部分晶粒具有单畴结构。因此，如果所述材料在100MHz或更高的频率范围内使用，则该材料的损耗因子tanδ远小于相应的已知材料的损耗因子tanδ。获得该材料的单畴结构，特别是如果材料的平均晶粒尺寸小于2.8微米。平均粒径优选在1.4微米和2.5微米之间。特别优选组成对应于式Ba3Me2Fe24O41的那些铁氧体材料，其中Me表示选自Co，Fe，Mn，Ni，Zn，Mg和（Li.Fe）中的一种或多种二价离子）1/2。即使在非常高的频率下，这些材料表现出小的损耗因子。根据本发明的模制品非常适合用于天线。

4. 发明申请

WO1996015543A1 DEFLECTION RING OF SINTERED MgZn-FERRITE MATERIAL, CATHODE RAY TUBE COMPRISING SUCH A RING AND MOULDING MADE FROM THIS MATERIAL 审中-公开
标题翻译：烧结MgZn-铁素体材料的偏转环，包含这种环的阴极管和从该材料制成的阴极管
公开(公告)号：WO1996015543A1
公开(公告)日：1996-05-23
申请号：PCT/IB1995000920
申请日：1995-10-25
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , VAN DER ZAAG, Pieter, Jan , VAN DER VALK, Pieter, Johan , DE WIT, Hendrik, Jan
IPC分类号： H01J29/76
CPC分类号： H01F41/0246 , C04B35/2683 , H01F2041/0711 , H01J29/76 , H01J2229/7031
摘要： The invention relates to a deflection ring of sintered MgZn-ferrite material. In accordance with the invention, this deflection ring is characterized in that the majority of the grains of the sintered material have a monodomain structure. By virtue thereof, a relatively small heat dissipation occurs in the ring when it is used in a cathode ray tube. The average grain size of the sintered MgZn-ferrite material is preferably 2.8 micrometers or less. MgZn-ferrite materials whose composition corresponds to the formulaMg1-zZnzFe2-yO4, wherein 0.1
摘要翻译：本发明涉及烧结MgZn-铁氧体材料的偏转环。根据本发明，该偏转环的特征在于烧结材料的大部分晶粒具有单畴结构。因此，当在阴极射线管中使用时，在环中发生相对较小的散热。烧结的MgZn铁氧体材料的平均粒径优选为2.8微米以下。其组成对应于式Mg1-zZnzFe2-yO4的MgZn-铁氧体材料，其中0.1

5. 发明申请

WO1996008449A1 SINTERED MOULDING, TRANSFORMER CORE AND INDUCTOR OF Li(Ni)Zn FERRITE MATERIAL, AS WELL AS APPLICATIONS THEREOF 审中-公开
标题翻译：作为其应用的Li（Ni）Zn铁素体材料的烧结，变压器芯和电感器
公开(公告)号：WO1996008449A1
公开(公告)日：1996-03-21
申请号：PCT/IB1995000732
申请日：1995-09-05
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , VAN DER ZAAG, Pieter, Jan , VAN DER VALK, Pieter, Johan
IPC分类号： C04B35/26
CPC分类号： C04B35/2691 , C04B35/2658 , H01F1/344 , H01F27/255 , H01J65/048
摘要： The invention relates to a sintered moulding of Li(Ni)Zn ferrite material, a transformer core and an inductor core of this material as well as several applications of these cores. In accordance with the invention, the majority of the grains of the sintered material have a monodomain structure. This leads to a substantial reduction of the loss factor and the overall losses when these mouldings are subjected to high-frequency applications and power applications. The ferrite material preferably comprises 59-65 mol% Fe2O3, 7-11 mol% Li2CO3, 4-8 mol% MnO and 20-28 mol% ZnO. This also provides the material with a high saturation magnetization.
摘要翻译：本发明涉及这种材料的Li（Ni）Zn铁氧体材料，变压器芯和电感器芯的烧结成型，以及这些芯的几种应用。根据本发明，烧结材料的大部分晶粒具有单畴结构。当这些模制品经受高频应用和电力应用时，这导致损耗因子和总体损耗的显着降低。铁氧体材料优选包含59-65mol％Fe 2 O 3，7-11mol％Li 2 CO 3，4-8mol％MnO和20-28mol％ZnO。这也为材料提供了高饱和磁化强度。

6. 发明申请

WO1995034885A2 MAGNETO-OPTICAL RECORDING MEDIUM 审中-公开
标题翻译：磁光记录介质
公开(公告)号：WO1995034885A2
公开(公告)日：1995-12-21
申请号：PCT/IB1995000430
申请日：1995-06-06
申请人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB
发明人： PHILIPS ELECTRONICS N.V. , PHILIPS NORDEN AB , BLOEMEN, Pascal, Jean, Henri , AAN DE STEGGE, Johannes, Bernardus, Franciscus , VAN DER ZAAG, Pieter, Jan , WOLF, Ronald, Martin
IPC分类号： G11B00/00
CPC分类号： G11B11/10586 , Y10S428/90 , Y10T428/24942 , Y10T428/265
摘要： A magneto optical recording medium (2) comprising a substrate (4) and a recording layer (6), the recording layer (6) comprising a bilayer structure consisting of a first layer (8) on which a magnetic second layer (10) is deposited, the second layer (10) demonstrating perpendicular magnetic anisotropy and a saturation remanence of at least 90 %, whereby the magnetic material of the second layer (10) comprises an oxide of iron, and the first layer (8) comprises an oxidic material whose in-plane lattice parameter differs from that of the magnetic material, the growth of the second layer (10) upon the first layer (8) being at least locally epitaxial.
摘要翻译：一种包括基板（4）和记录层（6）的磁光记录介质（2），所述记录层（6）包括由第一层（8）组成的双层结构，其上磁性第二层（10）沉积的第二层（10）表现出垂直磁各向异性和至少90％的饱和剩磁，由此第二层（10）的磁性材料包含铁氧化物，第一层（8）包含氧化物其面内晶格参数不同于磁性材料的晶格参数，第二层（10）在第一层（8）上的生长至少局部地外延。

7. 发明申请

WO2012127413A1 METHOD FOR PERFORMING MOLECULAR REACTIONS BY USING IMMISCIBLE INTERMEDIATE FLUIDS 审中-公开
标题翻译：通过使用可疑中间流体进行分子反应的方法
公开(公告)号：WO2012127413A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/051319
申请日：2012-03-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WIMBERGER-FRIEDL, Reinhold , VAN DER ZAAG, Pieter, Jan , SERVOLI, Eva
发明人： WIMBERGER-FRIEDL, Reinhold , VAN DER ZAAG, Pieter, Jan , SERVOLI, Eva
IPC分类号： B01L3/00 , C12Q1/68 , B01J19/00 , G01N35/08
CPC分类号： C12Q1/6869 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/16 , B01L2300/0636 , B01L2300/088 , B01L2400/0487 , G01N35/08
摘要： The present invention relates to a method for performing molecular reactions in a device comprising the steps of (a) introducing one or more reagent solution(s) and an immiscible intermediate fluid into the device, wherein the device comprises a substrate, on which chemically or biochemically recognizable entities are immobilized; (b) performing molecular reactions between the immobilized chemically or biochemically recognizable entities and the reagent solution(s); or on the immobilized chemically or biochemically recognizable entities in the presence of the reagent solution(s); (c) displacing the reagent solution(s) present on the substrate by the immiscible intermediate fluid; (d) separating the immiscible intermediate fluid and the reagent solution(s); and reusing the reagent solution(s) and/or immiscible intermediate fluid for one or more repetitions of steps (a) to (e). The invention further relates to a device for performing a molecular reaction, comprising a reaction zone, reservoirs and liquid connections and a collection and regeneration zone wherein the immiscible intermediate fluid and the reagent solution(s) are separable by gravitational separation; or a redirection and distribution module, wherein the immiscible intermediate fluid and reagent solution(s) are separated. The invention also relates to the use of an immiscible intermediate fluid for displacing a reagent solution present in a reaction zone in a microfluidic device, as well as the use of a corresponding device for performing a sequencing reaction or a nucleic acid synthesis reaction.
摘要翻译：本发明涉及一种在器件中进行分子反应的方法，包括以下步骤：（a）将一种或多种试剂溶液和不混溶的中间体流体引入该装置，其中该装置包括基底，化学或生化鉴定实体被固定化; （b）在固定的化学或生化学可识别的实体和试剂溶液之间进行分子反应; 或在试剂溶液存在下在固定的化学或生物化学可识别的实体上; （c）通过不混溶的中间流体置换存在于基板上的试剂溶液; （d）分离不混溶的中间体液体和试剂溶液; 以及重复使用所述试剂溶液和/或不混溶的中间体流体以进行一个或多个重复的步骤（a）至（e）。本发明还涉及一种用于进行分子反应的装置，包括反应区，储存器和液体连接以及收集和再生区，其中不混溶的中间流体和试剂溶液可通过重力分离而分离; 或重定向和分配模块，其中不混溶的中间流体和试剂溶液被分离。本发明还涉及不混溶中间体液体用于置换微流体装置中反应区中存在的试剂溶液的用途，以及使用相应的装置进行测序反应或核酸合成反应。

8. 发明申请

WO2011027268A2 DEVICES AND METHODS FOR MICROARRAY SELECTION 审中-公开
标题翻译：用于微阵列选择的装置和方法
公开(公告)号：WO2011027268A2
公开(公告)日：2011-03-10
申请号：PCT/IB2010/053839
申请日：2010-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
发明人： VAN DER ZAAG, Pieter, Jan , FEITSMA, Harma, Martine , DEN TOONDER, Jacob, Marinus, Jan , WIMBERGER-FRIEDL, Reinhold
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译：本发明涉及用于特异性选择靶分子的装置，其包含：（a）至少一个包含微阵列的反应区，其中所述微阵列包含底物，一种或多种物质捕捉分子被固定，包括一个或多个温度控制和/或调节单元，用于控制和/或调节区域内的温度; （b）至少一个非反应区，其包含一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）至少一个能够产生和/或调节所述反应区（a）和包含一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的运输工具。本发明进一步涉及用于特异性选择靶分子的装置，其中固定的捕获分子以点，细长点和/或线的形式在微阵列中组织。在另一方面，本发明涉及特异性选择靶分子的方法，包括将介质引入这样的装置，在反应区中进行相互作用反应，将未相互作用或未结合的靶分子转运至允许再激活靶分子并且在反应区与再活化的靶分子进行另外的相互作用反应，以及使用这样的装置用于特异性选择靶分子，例如目标富集在文献中也被称为基于微阵列的基因组选择（MGS）。

9. 发明申请

WO2012168803A2 PROVIDING NUCLEOTIDE SEQUENCE DATA 审中-公开
标题翻译：提供核苷酸序列数据
公开(公告)号：WO2012168803A2
公开(公告)日：2012-12-13
申请号：PCT/IB2012/051920
申请日：2012-04-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , VAN DER ZAAG, Pieter, Jan , AMBERG, Ronny , VERHAEGH, Wilhelmus, Franciscus, Johannes , BEYERLEIN, Peter , BOETTCHER, Rene
发明人： VAN DER ZAAG, Pieter, Jan , AMBERG, Ronny , VERHAEGH, Wilhelmus, Franciscus, Johannes , BEYERLEIN, Peter , BOETTCHER, Rene
IPC分类号： G06F19/20 , G06F19/22 , C12Q1/68
CPC分类号： G06F19/22 , C12Q1/6874 , G06F19/20
摘要： A sequencer device generates basic nucleotide sequence data 30 comprising probe data 34 of a capture probe in the sequencer device 10 and a determined sequence of identifiers 32 of a fragment of nucleic acids captured by the probe. The sequencer device outputs enriched nucleotide sequence data 36 that is enriched with data comprising a reference to a sequence 38 that is expected for the fragment of nucleic acids.
摘要翻译：定序器装置产生包括序列发生器装置10中的捕获探针的探针数据34的基本核苷酸序列数据30以及由探针俘获的核酸片段的确定序列32。定序器装置输出富集的核苷酸序列数据36，其富含数据，该数据包括对核酸片段预期的序列38的引用。

10. 发明申请

WO2012059839A2 IN VITRO DIAGNOSTIC TESTING INCLUDING AUTOMATED BROKERING OF ROYALTY PAYMENTS FOR PROPRIETARY TESTS 审中-公开
标题翻译：在体外诊断测试中，包括自动检测专有费用的专有费用
公开(公告)号：WO2012059839A2
公开(公告)日：2012-05-10
申请号：PCT/IB2011/054735
申请日：2011-10-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER ZAAG, Pieter, Jan , DIMITROVA, Nevenka , VAN DE STOLPE, Anja , VAN HOUTEN, Hendrik
发明人： VAN DER ZAAG, Pieter, Jan , DIMITROVA, Nevenka , VAN DE STOLPE, Anja , VAN HOUTEN, Hendrik
IPC分类号： G06Q10/00 , C12Q1/68 , G06F19/00
CPC分类号： G06Q20/10 , G06F19/00 , G06F19/18 , G06Q10/00 , G06Q50/22
摘要： A method comprises: recording an electronic record of diagnostic events including the performing of in- vitro diagnostic tests; during the recording, identifying the performing of a licensed in- vitro diagnostic test for which license information is stored in a licenses database; and computing license compensation due to a licensor for the performing of the licensed in- vitro diagnostic test based on royalty calculation information stored in the licenses database. The recording, identifying, and computing operations are performed by one or more computers. The method may further include remitting the computed license compensation to the licensor, the remitting also being performed by one or more computers. The licensed in- vitro diagnostic test may comprise a licensed biomarker test, for example one obtained by DNA or RNA sequencing, and the method may further comprise: performing the licensed biomarker test using a genome sequencer, wherein the performing of the licensed biomarker test and the computing of license compensation are both performed at a single medical facility.
摘要翻译：一种方法包括：记录诊断事件的电子记录，包括进行体外诊断测试; 在记录期间，识别许可证信息被存储在许可证数据库中的许可的体外诊断测试的执行; 以及由许可人根据许可证数据库中存储的使用费计算信息执行许可的体外诊断测试的计算许可证补偿。记录，识别和计算操作由一个或多个计算机执行。该方法还可以包括将所计算的许可证补偿递交给许可方，还由一个或多个计算机执行。许可的体外诊断测试可以包括许可的生物标志物测试，例如通过DNA或RNA测序获得的测试，并且该方法可以进一步包括：使用基因组测序仪进行许可的生物标志物测试，其中执行许可的生物标志物测试和许可证补偿的计算都在单一医疗机构进行。

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