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1. 发明申请

WO2006000827A2 ELECTRODE PRECONDITIONING 审中-公开
标题翻译：电极预处理
公开(公告)号：WO2006000827A2
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002551
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , BOND, Alan, Maxwell
发明人： HYLAND, Mark , BOND, Alan, Maxwell
IPC分类号： G01N27/30
CPC分类号： G01N27/4045 , G01N27/308
摘要： An electrochemical sensing method comprising: (a) providing an electrochemical cell having a working electrode and a pseudo reference electrode; (b) providing a sample comprising a metal, the sample being in contact with the working electrode and the metal being capable of being oxidised or reduced at the working electrode when the metal is bound to the working electrode; (c) preconditioning the working electrode by (i) applying a time varying preconditioning potential between the working and pseudo reference electrodes; and/or (ii) baking the working electrode; and/or (iii) air-ageing the working electrode; and (d) applying a measuring potential between the working and pseudo reference electrodes and, during application of said measuring potential, measuring the current generated by oxidation/reduction of the metal at the working electrode.
摘要翻译：一种电化学感测方法，包括：（a）提供具有工作电极和伪参考电极的电化学电池; （b）提供包含金属的样品，所述样品与所述工作电极接触，并且所述金属在所述金属结合到所述工作电极时能够在所述工作电极处被氧化或还原; （c）通过（i）在工作参考电极和伪参考电极之间施加时变预处理电位来预处理工作电极; 和/或（ii）烘烤工作电极; 和/或（iii）对工作电极进行空气老化; 以及（d）在工作电极和伪参考电极之间施加测量电位，并且在施加所述测量电位期间，测量由工作电极上的金属氧化/还原产生的电流。

2. 发明申请

WO2006000828A3 ELECTRODE FOR ELECTROCHEMICAL SENSOR 审中-公开
公开(公告)号：WO2006000828A3
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002557
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark
发明人： HYLAND, Mark
IPC分类号： G01N27/30 , C12Q1/00
摘要： The application concerns a device comprising an electrochemical cell. The device comprises a strip having a receptacle or partial receptacle (10) formed therein. The working electrode (4) of the electrochemical cell is in a wall of the receptacle or partial receptacle, and a pseudo reference electrode (5) of the electrochemical cell is present as a layer on top of the surface of the strip. The device of the invention is useful in electrochemical sensing techniques.

3. 发明申请

WO2006030170A1 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2006030170A1
公开(公告)日：2006-03-23
申请号：PCT/GB2005/003054
申请日：2005-08-03
申请人： OXFORD BIOSENSORS LIMITED , LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark , ASKEW, Herbert, Frank , BROUGHALL, John, Morton
发明人： LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark , ASKEW, Herbert, Frank , BROUGHALL, John, Morton
IPC分类号： G01N27/416
CPC分类号： G01N27/48
摘要： In an electrochemical sensor, the potential difference applied to the electrochemical cell is raised to a measuring value at a rate determined to reduce the transient current.
摘要翻译：在电化学传感器中，施加到电化学电池的电势差以确定为减少瞬态电流的速率升高到测量值。

4. 发明申请

WO2003056319A2 MICRO-BAND ELECTRODE 审中-公开
标题翻译：微带电极
公开(公告)号：WO2003056319A2
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005911
申请日：2002-12-23
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , LORIMER, Kevin , BUTLER, Ronald, Neil , WALLACE-DAVIS, Emma, Naomi, Kathlene , ASTIER, Yann
发明人： HYLAND, Mark , LORIMER, Kevin , BUTLER, Ronald, Neil , WALLACE-DAVIS, Emma, Naomi, Kathlene , ASTIER, Yann
IPC分类号： G01N27/00
CPC分类号： G01N27/3272 , Y10T29/49002
摘要： The invention concerns an electrochemical cell which, either alone or together which a substrate onto which it is placed, is in the form of a receptacle. The electrochemical cell contains a working electrode and a counter electrode, the working electrode being in a wall of the receptacle. At least one of the electrodes has at least one dimension of less than 50µm. The electrochemical cell is principally intended for use as a micro-electrode suitable for screening water, blood, urine or other biological or non-biological fluids.
摘要翻译：本发明涉及一种电化学电池，其单独地或一起放置有放置在其上的衬底，其为容器的形式。电化学电池包含工作电极和对电极，工作电极位于容器的壁中。至少一个电极具有小于50μm的至少一个尺寸。电化学电池主要用作适用于筛选水，血液，尿液或其他生物或非生物流体的微电极。

5. 发明申请

WO2007071989A1 MICRO-FLUIDIC STRUCTURES 审中-公开
标题翻译：微流体结构
公开(公告)号：WO2007071989A1
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004802
申请日：2006-12-20
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , STEPHENSON, Peter, Kevin , CREPINEAU, Florent, Francois, Marie
发明人： HYLAND, Mark , STEPHENSON, Peter, Kevin , CREPINEAU, Florent, Francois, Marie
IPC分类号： G01N33/49
CPC分类号： G01N33/491
摘要： A micro-fluidic structure such as a bio-sensor device has a dispensing element for fluid and a destination zone in communication with, and downstream of, the dispensing element. A bridge structure extends to the dispensing element and promotes fluid passage across the bridge structure from the dispensing element toward the destination zone.
摘要翻译：诸如生物传感器装置的微流体结构具有用于流体的分配元件和与分配元件连通并且在分配元件下游的目的地区域。桥梁结构延伸到分配元件并且促进流体通过桥接结构从分配元件朝向目的地区域。

6. 发明申请

WO2006000829A2 ELECTROCHEMICAL SENSING METHOD 审中-公开
标题翻译：电化学传感方法
公开(公告)号：WO2006000829A2
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002558
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , BROUGHALL, John, Morton , BUTLER, Ronald, Neil
发明人： HYLAND, Mark , BROUGHALL, John, Morton , BUTLER, Ronald, Neil
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , Y10T29/49108
摘要： A method of confining an electroactive substance within an electrochemical cell in the form of a receptacle, said method comprising: (a) providing an electrochemical cell in the form of a receptacle, the receptacle having a first open part to allow entry of a sample into the receptacle, and a second open part to allow escape of air displaced by the entering sample, the electrochemical cell having a working electrode and a counter electrode; (b) providing an electroactive substance, which substance is contained within the receptacle; (c) providing a permeable or semi-permeable membrane, comprising one or more layers, covering the first open part of the receptacle; and (d) inserting the sample into the receptacle through the membrane, such that (1) the electroactive substance and (2) the sample, are in contact with each other and with said working electrode; wherein the electroactive substance is confined within the receptacle during step (d). Preferably, the method additionally involves electrochemically testing a sample, by applying a voltage across the cell and measuring the resulting electrochemical response.
摘要翻译：将电活性物质限制在容器形式的电化学电池内的方法，所述方法包括：（a）提供呈容器形式的电化学电池，所述容器具有第一开放部分以允许样品进入所述容器和第二开放部分，以允许由所述进入的样品排出的空气逸出，所述电化学电池具有工作电极和对电极; （b）提供电活性物质，该物质包含在容器内; （c）提供覆盖容器的第一开放部分的可渗透或半透膜，包括一层或多层; 和（d）通过膜将样品插入到容器中，使得（1）电活性物质和（2）样品彼此接触并与所述工作电极接触; 其中在步骤（d）期间电活性物质被限制在容器内。优选地，该方法还涉及通过在电池上施加电压并测量所得到的电化学响应来电化学测试样品。

7. 发明申请

WO2006000823A2 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2006000823A2
公开(公告)日：2006-01-05
申请号：PCT/GB2005/002544
申请日：2005-06-29
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , ASTIER, Yann
发明人： HYLAND, Mark , ASTIER, Yann
IPC分类号： G01N27/30
CPC分类号： G01N33/683
摘要： A composition suitable for use in an electrochemical sensing method, said composition comprising (i) a transition metal salt; (ii) an electrode area normalising agent having a current which is dependent on electrode area; and (iii) a wetting agent. Also provided is a device comprising - an electrochemical cell having a working electrode and a pseudo reference electrode; a composition according to the invention; means for applying a voltage across the cell; and means for measuring the resulting current across the cell. The device can be used in the electrochemical diagnosis of ischemia.
摘要翻译：一种适用于电化学感测方法的组合物，所述组合物包含（i）过渡金属盐; （ii）具有取决于电极面积的电流的电极区域归一化剂; 和（iii）润湿剂。还提供了一种装置，其包括 - 具有工作电极和伪参考电极的电化学电池; 根据本发明的组合物; 用于在电池上施加电压的装置; 以及用于测量跨过电池的所得电流的装置。该装置可用于缺血的电化学诊断。

8. 发明申请

WO2007028998A2 SCALING FACTOR FOR AN OUTPUT OF AN ELECTROCHEMICAL CELL 审中-公开
标题翻译：电化学电池输出的放大因子
公开(公告)号：WO2007028998A2
公开(公告)日：2007-03-15
申请号：PCT/GB2006/003316
申请日：2006-09-07
申请人： OXFORD BIOSENSORS LIMITED , HYLAND, Mark , MURPHY, Lindy , LORIMER, Kevin
发明人： HYLAND, Mark , MURPHY, Lindy , LORIMER, Kevin
IPC分类号： G01N27/416
CPC分类号： G01N27/3274
摘要： A scaling factor for scaling an output of a first electrochemical cell, is determined in order to compensate for the effect on the output caused by any variation in a value of a property of a working electrode of the first cell from a reference value of that property. A measured value for the property is obtained from a portion of material formed so as to have substantially the same value of the property as does the working electrode and the measured value is processed to generate the scaling factor.
摘要翻译：确定用于缩放第一电化学电池的输出的缩放因子，以便补偿由第一电池的工作电极的性质的值的任何变化引起的对输出的影响与该特性的参考值。从形成的材料的一部分获得该性能的测量值，以便与工作电极具有基本相同的性能值，并且处理测量值以产生缩放因子。

9. 发明申请

WO2007000596A1 ELECTRODE PRECONDITIONING 审中-公开
标题翻译：电极预处理
公开(公告)号：WO2007000596A1
公开(公告)日：2007-01-04
申请号：PCT/GB2006/002373
申请日：2006-06-28
申请人： OXFORD BIOSENSORS LIMITED , ROBLIN, Patricia, Mary, Elizabeth , HYLAND, Mark , NEWMAN, Christopher, Paul
发明人： ROBLIN, Patricia, Mary, Elizabeth , HYLAND, Mark , NEWMAN, Christopher, Paul
IPC分类号： G01N27/453 , G01N27/49 , G01N27/413 , C12Q1/00
CPC分类号： G01N27/327
摘要： A method for improving the precision of electrochemical measurements made using an electrochemical cell is provided. The method comprises preconditioning a working electrode of the cell by (i) baking the working electrode; and/or (ii) incubating the working electrode; and/or (iii) applying a preconditioning potential across the cell; and/or (iv) treating the working electrode with a UV laser.
摘要翻译：提供了使用电化学电池提高电化学测量精度的方法。该方法包括：（i）烘烤工作电极，预处理电池的工作电极; 和/或（ii）孵育所述工作电极; 和/或（iii）在细胞上施加预处理潜力; 和/或（iv）用UV激光对工作电极进行处理。

10. 发明申请

WO2006018600A2 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2006018600A2
公开(公告)日：2006-02-23
申请号：PCT/GB2005/003050
申请日：2005-08-03
申请人： OXFORD BIOSENSORS LTD , LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark
发明人： LORIMER, Kevin , GRIFFITHS, John , HYLAND, Mark
IPC分类号： G01N27/416 , G01N27/48
CPC分类号： G01N27/48
摘要： In an electrochemical sensor, a peak is detected by grouping data points in windows and detecting two or three windows between which the slope of the data changes sign. The peak can be more precisely detected by detecting the highest data point in the two or three windows.
摘要翻译：在电化学传感器中，通过对窗口中的数据点进行分组并检测两个或三个窗口来检测峰值，在这两个窗口之间数据的斜率变化。通过检测两个或三个窗口中的最高数据点可以更精确地检测峰值。

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