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1. 发明申请

WO2017116979A1 FLUID COLLECTION DEVICE AND RELATED METHODS 审中-公开
标题翻译：流体收集装置和相关方法
公开(公告)号：WO2017116979A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068288
申请日：2016-12-22
申请人： OPKO DIAGNOSTICS, LLC
发明人： TAYLOR, Jason , SINGH, Hardeep , DIRCKX, Matthew
IPC分类号： B01L3/00
CPC分类号： A61B5/150343 , A61B5/150022 , A61B5/150267 , A61B5/150755 , A61B5/151 , B01L3/502715 , B01L2200/027 , B01L2400/0406
摘要： Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.
摘要翻译：通常提供用于收集和/或促进流体转移的物品和方法。在一些实施方案中，制品包含流体收集区，用于将流体（例如样品（例如血液样品）或试剂）引入流体系统中。本文所述的制品和方法可用于促进用流体填充相对较小的通道，例如微流体装置的通道。制品和方法可以例如与患者样本（例如，血滴）或与宏观流体源（例如移液管或注射器）接口。在某些实施方案中，本文所述的制品和方法可增加从患者采集流体样品的难易程度，防止或减少流体样品的溢出，减少流体样品的污染，和/或防止或减少空气进入流体样品或设备与某些现有的流体收集设备进行比较。

2. 发明申请

WO2016094766A1 FLUIDIC SYSTEMS COMPRISING AN INCUBATION CHANNEL, INCLUDING FLUIDIC SYSTEMS FORMED BY MOLDING 审中-公开
标题翻译：包含融合通道的流体系统，包括通过成型形成的流体系统
公开(公告)号：WO2016094766A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065187
申请日：2015-12-11
申请人： OPKO DIAGNOSTICS, LLC
发明人： DIRCKX, Matthew , TAYLOR, Jason , LINDER, Vincent
IPC分类号： B01L3/00 , G01N35/08
CPC分类号： B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L2200/06 , B01L2200/0673 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/0838 , B01L2300/0858 , B01L2300/0861 , B01L2300/0867 , B01L2300/12 , B01L2300/1827 , B01L2400/0406 , B01L2400/0487 , B01L2400/0694 , G01N15/1459 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N33/54366 , G01N35/00069 , G01N2015/1006 , G01N2035/00158 , G01N2035/00356 , G01N2035/1034
摘要： Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved. In some embodiments, the controlled incubation and/or mixing of assay components in an incubation channel, as described herein, may allow for improved assay performance.
摘要翻译：提供了涉及孵育和/或混合测定组分的流体装置和方法。在一些实施方案中，可以在流体装置中进行生物和/或化学测定。流体装置可以设计成允许两个或更多个测定组分的受控孵育和/或混合。在一些这样的实施例中，流体装置可以包括具有与检测通道流体连通的相对大的横截面尺寸的孵育通道。在分析测定之前，孵育通道可以允许两种或更多种测定组分的充分混合和/或温育。在某些实施方案中，检测通道可用于提供对温育和/或混合程度的反馈。基于反馈，可以调节流体系统的一个或多个组分以允许实现必要的混合程度和/或孵育程度。在一些实施方案中，如本文所述，孵育通道中测定组分的受控孵育和/或混合可允许改进的测定性能。

3. 发明申请

WO2017100457A1 FLUIDIC SYSTEMS INVOLVING INCUBATION SAMPLES AND/OR REAGENTS 审中-公开
标题翻译：涉及孵化样品和/或试剂的流体系统
公开(公告)号：WO2017100457A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065633
申请日：2016-12-08
申请人： OPKO DIAGNOSTICS, LLC
发明人： HADDAD, Douglas M. , FAGAN, Gary J. , DONG, Yi , DIRCKX, Matthew , LINDER, Vincent
IPC分类号： G01N35/08 , G01N33/82 , G01N33/536 , G01N33/68 , B01L3/00
CPC分类号： G01N33/82 , B01L3/502707 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , G01N33/54366 , G01N33/587
摘要： Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In some embodiments, fluidic devices for performing a vitamin D assay are provided.
摘要翻译：提供涉及测定组分温育和/或混合的流体装置和方法。在一些实施例中，生物和/或化学测定可以在流体装置中执行。流体装置可以被设计成允许受控孵育和/或混合两种或更多种测定组分。在一些这样的实施例中，流体装置可以包括具有与检测通道流体连通的相对大的横截面尺寸的孵育通道。温育通道可以在分析测定之前允许两种或更多种测定组分的充分混合和/或温育。在一些实施方案中，提供了用于进行维生素D测定的流体装置。

4. 发明申请

WO2014158367A1 MIXING OF FLUIDS IN FLUIDIC SYSTEMS 审中-公开
标题翻译：流体系统中流体的混合
公开(公告)号：WO2014158367A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/015243
申请日：2014-02-07
申请人： OPKO DIAGNOSTICS, LLC
发明人： DIRCKX, Matthew , LINDER, Vincent , TAYLOR, Jason
IPC分类号： B01F5/00 , B01F13/00 , B01L3/00 , G01N35/08
CPC分类号： G01N1/38 , B01F3/04 , B01F3/08 , B01F3/0861 , B01F5/0085 , B01F13/0071 , B01F13/0084 , B01F2215/0037 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0487 , B01L2400/0694 , B01L2400/084 , G01N35/08 , G01N2001/386
摘要： Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment (5) of a fluidic device. The fluids may be in the form of, for example, at least first (10-1), second (20-2) and third (10-3) fluid plugs, composed of first (10-1A), second (20-2A), and third (10-3A) fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.
摘要翻译：提供与流体装置中的流体混合相关的流体装置和方法。在一些实施例中，一种方法可包括在流体装置的通道段（5）中混合两种或多种流体。流体可以是例如至少第一（10-1），第二（20-2）和第三（10-3）流体塞子的形式，由第一（10-1A），第二（20-） 2A）和第三（10-3A）流体。第二流体可与第一和第三流体不混溶。在某些实施例中，流体塞可以在通道段中串联流动，例如以线性顺序，使第一和第三流体混合而不使用活性组分如混合器。如本文所述的通道段中的流体的混合可以允许改进的性能和简化的依赖于流体混合的流体装置的设计和操作。

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