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1. 发明申请

WO2012055573A1 USE OF HEPCIDIN BINDING NUCLEIC ACIDS FOR DEPLETION OF HEPCIDIN FROM THE BODY 审中-公开
标题翻译：使用HEPCIDIN结合核酸从身体中去除肝素
公开(公告)号：WO2012055573A1
公开(公告)日：2012-05-03
申请号：PCT/EP2011005498
申请日：2011-10-31
申请人： NOXXON PHARMA AG , SCHWOEBEL FRANK , TURNER JOHN , KLARE NICOLA , KLUSSMANN SVEN
发明人： SCHWOEBEL FRANK , TURNER JOHN , KLARE NICOLA , KLUSSMANN SVEN
IPC分类号： C12N15/115 , A61K31/7088
CPC分类号： C07H21/02 , C07H1/06 , C12N15/115 , C12N2310/16 , C12N2310/3515
摘要： The present invention is related to a method for reducing the level of hepcidin in a body fluid from a subject, comprising a) providing a nucleic acid molecule capable of binding to hepcidin, and b) bringing the nucleic acid molecule into contact with a body fluid under conditions that allow for the binding of hepcidin to the nucleic acid molecule, thereby forming a complex of hepcidin and the nucleic acid molecule, and c) removing the complex from the body fluid or removing the hepcidin from the body fluid.
摘要翻译：本发明涉及一种用于降低受试者体液中铁调素水平的方法，包括：a）提供能与铁调素结合的核酸分子，和b）使核酸分子与体液接触在允许铁调素与核酸分子结合的条件下，从而形成铁调素和核酸分子的复合物，和c）从体液中除去复合物或从体液中除去铁调素。

2. 发明申请

WO2010124874A9 HEPCIDIN BINDING NUCLEIC ACIDS 审中-公开
标题翻译： HEPCIDIN BINDIN NUCLEIC ACIDS
公开(公告)号：WO2010124874A9
公开(公告)日：2011-10-20
申请号：PCT/EP2010002659
申请日：2010-04-30
申请人： NOXXON PHARMA AG , SELL SIMONE , MORICH FRANK , MAASCH CHRISTIAN , KLUSSMANN SVEN , DINSE NICOLE , BUCHNER KLAUS , SCHWOEBEL FRANK
发明人： SELL SIMONE , MORICH FRANK , MAASCH CHRISTIAN , KLUSSMANN SVEN , DINSE NICOLE , BUCHNER KLAUS , SCHWOEBEL FRANK
IPC分类号： C12N15/09 , A61K31/00
CPC分类号： C12N15/115 , A61K31/00 , C12N2310/16 , C12N2310/351 , C12N2320/30 , C12Q1/6876 , G01N33/5308 , G01N33/74 , G01N2333/575 , G01N2500/04
摘要： The present invention is related to a nucleic acid capable of binding to hepcidin.
摘要翻译：本发明涉及能够结合铁调素的核酸。

3. 发明申请

WO0032809A3 CLONING AND COPYING ON SURFACES 审中-公开
标题翻译：复制和克隆到曲面
公开(公告)号：WO0032809A3
公开(公告)日：2000-10-19
申请号：PCT/DE9903856
申请日：1999-11-26
申请人： NOXXON PHARMA AG , VON KIEDROWSKI GUENTER , FUERSTE JENS PETER , KLUSSMANN SVEN , KLEIN THOMAS
发明人： VON KIEDROWSKI GUENTER , FUERSTE JENS PETER , KLUSSMANN SVEN , KLEIN THOMAS
IPC分类号： G01N33/53 , C12N15/09 , C12N15/10 , C12Q1/68 , C40B30/04 , C40B60/12 , G01N33/566 , G01N37/00 , B01J19/00
CPC分类号： C12N15/10 , C12Q1/686 , Y10S977/902 , C12Q2565/543 , C12Q2565/515 , C12Q2565/125
摘要： The invention relates to a method for cloning and copying genetic material on surfaces as well as copying biological material insofar as it, in a broader sense, can be classified in a ligand receptor system. The invention thus relates, in particular, to a method for propagating ligands and receptors on at least two surfaces which comprises one or several of the following cycles: a) Immobilizing a ligand on a first surface of a solid phase; b) adding a solution of receptors and binding complementary receptors to the ligands; c) transferring the receptor to an additional surface and immobilizing the receptor at that location; d) attaching an additional ligand to the immobilized receptor; e) transferring the ligand to a surface and immobilizing the same at that location. Nucleic acids are also understood as a ligand/receptor system.
摘要翻译：本发明涉及一种将遗传物质克隆和复制到表面上的方法，但也涉及生物材料的复制，只要其可以在更广泛的意义上归入配体 - 受体系统。因此，本发明特别涉及在至少两个表面上增殖配体和受体的方法，其包括一个或多个以下循环：a）将配体固定在固相的第一表面上; b）加入受体溶液并将互补受体结合至配体; c）将受体转移至另一表面并局部固定受体; d）将另一种配体加入到固定的受体中; e）将配体转移至表面并配体局部固定。配体/受体系统也被理解为意指核酸。

4. 发明申请

WO0023616A3 METHOD FOR THE EXPONENTIAL AMPLIFICATION OF MOLECULAR MATRICES 审中-公开
标题翻译：分子矩阵指数增益的方法
公开(公告)号：WO0023616A3
公开(公告)日：2000-08-17
申请号：PCT/EP9907986
申请日：1999-10-21
申请人： NOXXON PHARMA AG , VON KIEDROWSKI GUENTER , KLUSSMANN SVEN , KLEIN THOMAS , FUERSTE JENS PETER
发明人： VON KIEDROWSKI GUENTER , KLUSSMANN SVEN , KLEIN THOMAS , FUERSTE JENS PETER
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6853 , C12Q2565/137 , C12Q2563/131 , C12Q2525/197
摘要： The invention relates to a method for the exponential amplification of molecular matrices, comprising the following steps: (a) binding the molecular matrices to the surface of a solid phase using a reversible linker on the matrix; (b) adding matrix fragments, one of the fragments having an optionally protected linker unit; (c) synthesising copies of the matrix; (d) removing excess matrix fragments and reaction auxiliaries; (e) detaching the copies from the matrices; and (f) populating free binding sites on the solid phase with synthesised matrix copies. The invention also relates to a method for chemical evolution through exponential amplification of molecular matrices, comprising one or more of the following evolution cycles: (1) selection of a subpopulation of molecular matrices from a combinatorial original library; and (2) amplification and mutation of the selective matrices for providing a mutant library, comprising one or more of the amplification cycles (a) to (f) defined above.
摘要翻译：本发明涉及分子矩阵的指数扩增方法，其包括（a）借助模板上的可逆接头将分子基质结合至固相表面; （b）加入模板片段，其中片段之一具有任选保护的接头部分; （c）模板拷贝的合成; （d）除去过量的模板片段和反应助剂; （e）将副本从矩阵中分离出来; 和（f）通过合成的模板拷贝在固相上定殖游离结合位点。本发明进一步涉及通过指数扩增包含一个或多个进化周期的分子模板的化学进化方法（1）从组合文库中选择分子模板子集; （2）选择性模板的扩增和突变以提供包含如上定义的一个或多个扩增循环（a）至（f）的突变体文库。

5. 发明申请

WO2006117217A3 NOVEL USE OF SPIEGELMERS 审中-公开
标题翻译： Spiegelmers®的新用途
公开(公告)号：WO2006117217A3
公开(公告)日：2007-08-09
申请号：PCT/EP2006004180
申请日：2006-05-04
申请人： NOXXON PHARMA AG , JAROSCH FLORIAN , MAASCH CHRISTIAN , KLUSSMANN SVEN , VATER AXEL , EULBERG DIRK , PURSCHKE WERNER , BUCHNER KLAUS
发明人： JAROSCH FLORIAN , MAASCH CHRISTIAN , KLUSSMANN SVEN , VATER AXEL , EULBERG DIRK , PURSCHKE WERNER , BUCHNER KLAUS
IPC分类号： A61K31/7088 , A61P19/02 , A61P31/00 , A61P35/00 , C12N15/115 , G01N33/50
CPC分类号： C12N15/115 , C12N2310/16 , G01N2500/04
摘要： The invention relates to the use of an L-nucleic acid as an intracellularly active substance.
摘要翻译：本发明涉及使用一个L核酸作为细胞内的活性剂。

6. 发明申请

WO2005026374A3 METHOD FOR SYNTHESIZING NUCLEIC ACIDS, AND APPLICATION THEREOF 审中-公开
标题翻译：合成核酸的方法及其用途
公开(公告)号：WO2005026374A3
公开(公告)日：2005-11-10
申请号：PCT/EP2004010268
申请日：2004-09-14
申请人： NOXXON PHARMA AG , KLUSSMANN SVEN , JAROSCH FLORIAN , VATER AXEL
发明人： KLUSSMANN SVEN , JAROSCH FLORIAN , VATER AXEL
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/102 , C12N15/1096 , C12P19/34
摘要： The invention relates to a method for synthesizing a nucleic acid comprising modified nucleotides. Said method encompasses the following steps: - a matrix strand is provided; - a primer which at least partly hybridizes on the matrix strand is provided; - nucleoside triphosphates, at least some of which are modified nucleoside triphosphates, are provided; - a polymerase activity is supplied; and - the matrix strand, the primer, and the nucleoside triphosphates are incubated so as to synthesize a nucleic acid that is substantially complementary to the matrix strand. The inventive method is characterized in that the polymerase activity represents a reverse transcriptase activity.
摘要翻译：本发明涉及合成核酸的方法，其中所述核酸包含修饰的核苷酸，所述方法包括以下步骤：提供模板链，提供至少部分与所述模板链杂交的引物; 提供核苷三磷酸酯，其中一部分核苷三磷酸酯是修饰的三磷酸核苷; 提供聚合酶活性; 和孵育模板链，引物，三磷酸核苷以合成基本上与模板链互补的核酸，其特征在于聚合酶活性是逆转录酶活性。

7. 发明申请

WO02092612A3 NUCLEIC ACIDS THAT BIND TO ENTEROTOXIN B 审中-公开
标题翻译：肠毒素B结合核酸
公开(公告)号：WO02092612A3
公开(公告)日：2003-07-10
申请号：PCT/EP0205245
申请日：2002-05-13
申请人： NOXXON PHARMA AG , LEVA SUSANNE , KLUSSMANN SVEN , PURSCHKE WERNER , WIENTGES JENS
发明人： LEVA SUSANNE , KLUSSMANN SVEN , PURSCHKE WERNER , WIENTGES JENS
IPC分类号： C12N15/10 , C12Q1/68 , C12N15/11 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12N15/1048 , C12N15/1034 , C12Q1/689
摘要： The invention relates to a nucleic acid that binds to Staphylococcal Enterotoxin B, in particular Staphylococcus aureus and to a method for producing and/or identifying nucleic acids, which bind to a target molecule, in particular an inventive nucleic acid. According to the method, a) a heterogeneous population of nucleic acids is created; b) the population in step a) is contacted; c) the nucleic acids that do not interact with the target molecule are separated; d) the nucleic acids that interact with the target molecule are optionally separated; and e) the nucleic acids that interact with the target molecule are optionally sequenced. The invention is characterised in that the target molecule comprises an amino acid sequence of Staphylococcal Enterotoxin B, preferably of Staphylococcus aureus.
摘要翻译：本发明涉及一种核酸结合到来自金肠毒素B，特别是金黄色葡萄球菌，以及用于生产和/或结合一个靶分子，特别是根据本发明的核酸的核酸识别的方法，其中a）的核酸的异源群体是生成的; b）使容纳在-步骤的人口）; c）该核酸被分离不与靶分子相互作用; d）分离的核酸，其与靶分子相互作用可选; 和e）已与靶分子相互作用的核酸待测序可选的。其特征在于，所述目标分子是来自金，优选金黄色葡萄球菌，包括肠毒素B的氨基酸序列。

8. 发明申请

WO2007093409A8 MCP-I BINDING NUCLEIC ACIDS 审中-公开
标题翻译： MCP-1结合核酸
公开(公告)号：WO2007093409A8
公开(公告)日：2011-01-20
申请号：PCT/EP2007001294
申请日：2007-02-14
申请人： NOXXON PHARMA AG , PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
发明人： PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
IPC分类号： A61K31/7088 , C12N15/115
CPC分类号： C12N15/1136 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12Q1/6813 , G01N33/566
摘要： The present invention is related to a nucleic acid, preferably binding to MCP-I, selected from the group comprising type IA nucleic acids, type IB nucleic acids, type 2 nucleic acids, type 3 nucleic acids, type 4 nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ.ID.No. 87 to 115.
摘要翻译：本发明涉及优选结合MCP-1的核酸，其选自IA型核酸，IB型核酸，2型核酸，3型核酸，4型核酸和具有根据SEQ.ID.No.中任一项的核酸序列 87至115。

9. 发明申请

WO2009040113A3 C5a BINDING NUCLEIC ACIDS 审中-公开
标题翻译： C5a结合核酸
公开(公告)号：WO2009040113A3
公开(公告)日：2009-06-11
申请号：PCT/EP2008008097
申请日：2008-09-24
申请人： NOXXON PHARMA AG , PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
发明人： PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3183 , C12N2310/323 , Y10T436/143333
摘要： The present invention is related to a nucleic acid, preferably binding to C5a, selected from the group comprising type A nucleic acids, type B nucleic acids, type C nucleic acids, type D nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ. KXNo. 73 to 79.
摘要翻译：本发明涉及选自A型核酸，B型核酸，C型核酸，D型核酸和具有根据本发明的核酸序列的核酸的核酸，优选与C5a结合的核酸 SEQ。 KXNo。 73至79。

10. 发明申请

WO2007093409A3 MCP-I BINDING NUCLEIC ACIDS 审中-公开
标题翻译： MCP-1结合核酸
公开(公告)号：WO2007093409A3
公开(公告)日：2007-12-13
申请号：PCT/EP2007001294
申请日：2007-02-14
申请人： NOXXON PHARMA AG , PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
发明人： PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN
IPC分类号： A61K31/7088 , C12N15/115
CPC分类号： C12N15/1136 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12Q1/6813 , G01N33/566
摘要： The present invention is related to a nucleic acid, preferably binding to MCP-I, selected from the group comprising type IA nucleic acids, type IB nucleic acids, type 2 nucleic acids, type 3 nucleic acids, type 4 nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ.ID.No. 87 to 115.
摘要翻译：本发明涉及选自1A型核酸，1B型核酸，2型核酸，3型核酸，4型核酸和选自下述的核酸的核酸，优选与MCP-1结合：根据SEQ.ID.No.1中任一项的核酸序列。 87至115。

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