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1. 发明申请

WO2013156514A1 PROCESS FOR MAKING BIOSENSOR 审中-公开
标题翻译：制作生物传感器的过程
公开(公告)号：WO2013156514A1
公开(公告)日：2013-10-24
申请号：PCT/EP2013/057975
申请日：2013-04-17
申请人： NOVIOSENSE B.V.
发明人： HANSSEN, Johannes Hendrikus Leonardus , WILSON, Christopher
IPC分类号： G01N33/543 , A61B5/145 , A61B5/1486
CPC分类号： H01R43/033 , A61B5/0031 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B2562/0215 , A61B2562/12 , A61N1/0563 , G01N33/487 , G01N33/543 , G01N33/54306 , G01N33/5438 , G01N33/54393 , G01N2333/904 , H01M4/137 , H01M4/1399 , H01R43/28 , Y10T29/49018 , Y10T29/49194
摘要： A process for making a biosensor comprising a hollow coil comprising wires coiled in parallel and an electronic circuit component connected to the coil, the process comprising: 1) providing a mandrel on which wires including at least a first wire, a second wire and a third wire are wound in parallel, 2a) immersing the mandrel in a first buffer solution comprising a first bioreceptor, a first monomer and optional additives, 2b) arranging the wires such that the first wire may be used as a working electrode, the second wire may be used as a counter electrode and the third wire may be used as a reference electrode of a three electrode electrochemical cell used in an electropolymerisation process, 3) passing electric current through the first wire to form a first biocompatible coating of a first polymer polymerized from the first monomer comprising the first bioreceptor on the first wire, 4) removing the coil from the mandrel, 5) connecting the wires to their respective points of the electronic circuit component such that the first wire may be used as a working electrode, the second wire may be used as a counter electrode and the third wire may be used as a reference electrode and wherein the electronic circuit component is configured such that it can generate an input signal for a wireless receiver based upon the activity of the bioreceptor and wirelessly send the input signal to the wireless receiver.
摘要翻译：一种用于制造生物传感器的方法，所述生物传感器包括包括平行盘绕的线的中空线圈和连接到所述线圈的电子电路部件，所述方法包括：1）提供心轴，其上至少包括第一线，第二线和第三线电线并联缠绕，2a）将心轴浸入包含第一生物受体，第一单体和任选的添加剂的第一缓冲溶液中，2b）布置导线，使得第一线可以用作工作电极，第二线可以用作对电极，并且第三线可以用作电聚合过程中使用的三电极电化学电池的参比电极，3）使电流通过第一线以形成第一聚合物的第一生物相容性涂层第一单体包括第一线上的第一生物受体，4）从心轴移除线圈，5）将导线连接到其各自的点上使得第一线可以用作工作电极，第二线可以用作对电极，并且第三线可以用作参考电极，并且其中电子电路部件被配置为使得其可以产生基于生物受体的活动的无线接收器的输入信号，并将输入信号无线地发送到无线接收器。

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