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1. 发明申请

WO2005006962A3 IMAGE ENHANCEMENT BY SPATIAL LINEAR DECONVOLUTION 审中-公开
公开(公告)号：WO2005006962A3
公开(公告)日：2005-01-27
申请号：PCT/US2004/023178
申请日：2004-07-19
申请人： NIRX MEDICAL TECHNOLOGIES, L.L.C. , BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling , XU, Yong
发明人： BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling , XU, Yong
IPC分类号： G06F17/10
摘要： Data from a target system (616) that exhibits a non-linear relationship between system properties and measurement data, is processed by applying a linear filter (F) to improve resolution and accuracy. The filter reduces inaccuracies that are introduced by an algorithm used to reconstruct the data. The filter is defined by assigning time varying functions, such as sinusoids (200), to elements (210) in a model (Y) of the system to perturbate the elements. The resulting data output from the model is reconstructed using the same algorithm used to subsequently reconstruct the data from the target system. The filter is defined as a matrix (F) that transforms the reconstructed data of the model (X) back toward the known properties of the model (Y). A library of filters can be pre-calculated for different applications. In an example implementation, the system is tissue that is imaged using optical tomography.

2. 发明申请

WO2003012736A3 METHOD AND SYSTEM FOR ENHANCING SOLUTIONS TO A SYSTEM OF LINEAR EQUATIONS 审中-公开
公开(公告)号：WO2003012736A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024520
申请日：2002-08-02
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NE W YORK , BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling
发明人： BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling
IPC分类号： G06K9/40
摘要： A method of significantly improving the quality of solutions to a system of linear equations. The solution to a system of linear equations is enhanced by: (1) modeling a target medium into a plurality of elements and imposing at least one localized fluctuation into the target medium; (2) measuring an output resulting from at least one localized fluctuation; and (3) processing the measured output to reconstruct a result, determining a correction filter, and applying the correction filter to the result.

3. 发明申请

WO2003012736A2 METHOD AND SYSTEM FOR ENHANCING SOLUTIONS TO A SYSTEM OF LINEAR EQUATIONS 审中-公开
标题翻译：将解决方案提升到线性方程组的方法和系统
公开(公告)号：WO2003012736A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024520
申请日：2002-08-02
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NE W YORK , BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling
发明人： BARBOUR, Randall, L. , GRABER, Harry, L. , PEI, Yaling
IPC分类号： G06N
CPC分类号： G06T11/008 , G06T5/003 , G06T5/20 , G06T2207/10101
摘要： A method of significantly improving the quality of solutions to a system of linear equations. The solution to a system of linear equations is enhanced by: (1) modeling a target medium into a plurality of elements and imposing at least one localized fluctuation into the target medium; (2) measuring an output resulting from at least one localized fluctuation; and (3) processing the measured output to reconstruct a result, determining a correction filter, and applying the correction filter to the result.
摘要翻译：一种显着提高线性方程组解的质量的方法。通过以下方式增强线性方程组的解决方案：（1）将目标介质建模成多个元素，并将至少一个局部波动施加到目标介质中; （2）测量由至少一个局部波动产生的输出; 和（3）处理测量的输出以重建结果，确定校正滤波器，以及将校正滤波器应用于结果。

4. 发明申请

WO2001020307A1 METHOD AND SYSTEM FOR ENHANCED IMAGING OF A SCATTERING MEDIUM 审中-公开
标题翻译：用于增强散射介质成像的方法和系统
公开(公告)号：WO2001020307A1
公开(公告)日：2001-03-22
申请号：PCT/US2000/025157
申请日：2000-09-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , BARBOUR, Randall, L. , PEI, Yaling
发明人： BARBOUR, Randall, L. , PEI, Yaling
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , G01N2021/1787 , G01N2021/397
摘要： The present invention recognizes that contrary to intuitive expectations, sensitivity and resolution of the data for image reconstruction can be increased by decreasing the absorption or scattering mean free path length of the imaging source energy. Methods are disclosed in this respect for enhancing sensitivity and resolution in the imaging of scattering target media (116). In one method, source energy wavelength is selected to optimize scattering and absorption of the energy while maintaining measurable and acceptable detector signals (112). In another aspect of the invention, the scattering target medium (116) is radially compressed and the imaging source wavelength is then adjusted in conjunction with the compression to improve sensitivity and resolution.
摘要翻译：本发明认识到，与直观的期望相反，可以通过降低成像源能量的吸收或散射平均自由路径长度来增加用于图像重建的数据的灵敏度和分辨率。在这方面公开了增强散射目标介质（116）的成像中的灵敏度和分辨率的方法。在一种方法中，选择源能量波长以优化能量的散射和吸收，同时保持可测量和可接受的检测器信号（112）。在本发明的另一方面，散射目标介质（116）被径向压缩，然后与压缩一起调整成像源波长，以提高灵敏度和分辨率。

5. 发明申请

WO2003088133A1 MODIFICATION OF THE NORMALIZED DIFFERENCE METHOD FOR REAL-TIME OPTICAL TOMOGRAPHY 审中-公开
标题翻译：用于实时光学测量的正则化差分方法的修改
公开(公告)号：WO2003088133A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/010524
申请日：2003-04-07
申请人： BARBOUR, Randall, L. , PEI, Yaling
发明人： BARBOUR, Randall, L. , PEI, Yaling
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G01N21/359 , G01N21/4795 , G01N21/49 , G01N2021/1787 , G01N2021/475 , G01N2201/0826 , G01N2201/0833
摘要： Computation -saving techniques and stability-adding techniques provide for fast, accurate reconstructions of a time series of images involving large scale 3D problems, such as real-time image recovery in an optical tomography imaging system. A system equation for a target medium (116) such as a tissue is solved using a Normalized Difference Method (NDM) (250). Because of the inherent stability of the NDM solutions, a weight matrix (W) of the system equation can be provided for a given point in a time series (220), then reused without recalculation at subsequent points. Further saving are achieved by decomposing W using singular value decomposition or direst matrix decomposition, transforming it to reduce its dimensions, and/or scaling it to achieve a more stable numerical solution. Values of measured energy (112) emerging from the target medium are back-substituted into the system equation for the different points to obtain the target medium properties.
摘要翻译：计算保存技术和稳定性添加技术可以快速，准确地重建涉及大规模3D问题的时间序列图像，例如光学层析成像系统中的实时图像恢复。使用归一化差分法（NDM）（250）解决诸如组织的目标介质（116）的系统方程式。由于NDM解决方案的固有稳定性，可以为时间序列（220）中的给定点提供系统方程的权重矩阵（W），然后在后续点重新计算。通过使用奇异值分解或直接矩阵分解来分解W来实现进一步节省，将其变换以减小其尺寸和/或缩放以实现更稳定的数值解。从目标介质出现的测量能量（112）的值被替代为不同点的系统方程，以获得目标介质特性。

6. 发明申请

WO2007059069A3 FUNCTIONAL IMAGING IN FREELY MOVING SUBJECT 审中-公开
公开(公告)号：WO2007059069A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/044065
申请日：2006-11-13
申请人： BARBOUR, Randall, L. , MULLER, Robert, L.
发明人： BARBOUR, Randall, L. , MULLER, Robert, L.
IPC分类号： G06K9/00 , A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
摘要： A system for monitoring brain activity in a mobile animal or human subject is disclosed which comprises a first device adapted for attaching fiber optical cables to the head of a subject. A second device is detachably coupled to the first device and holds the fiber optical cables. The fiber optic cables provide a communicating light path between a tomographic imaging device and the brain of the subject when the second device is plugged into the first device in a manner equivalent to plugging a male connector into a female connector.

7. 发明申请

WO2007059139A3 FUNCTIONAL IMAGING OF AUTOREGULATION 审中-公开
公开(公告)号：WO2007059139A3
公开(公告)日：2007-05-24
申请号：PCT/US2006/044202
申请日：2006-11-13
申请人： BARBOUR, Randall, L.
发明人： BARBOUR, Randall, L.
IPC分类号： A61B6/00
摘要： The present invention provides a method for detailed delineation of variation of autoregulation and more particularly tissue metabolism. These enhanced capabilities allow for new insights into factors impacting on body function, detection and monitoring of disease states, understanding of drug actions and other physiological effectors such as diet and physical exercise.

8. 发明申请

WO2001020546A3 IMAGING OF SCATTERING MEDIA USING RELATIVE DETECTOR VALUES 审中-公开
公开(公告)号：WO2001020546A3
公开(公告)日：2001-03-22
申请号：PCT/US2000/025156
申请日：2000-09-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , BARBOUR, Randall, L.
发明人： BARBOUR, Randall, L.
IPC分类号： G06K9/00
摘要： A method for imaging of a scattering target medium (116) using a modified perturbation formulation of the radiation transport equation wherein normalized measured values are used to recover a relative difference in absorption and/or scattering properties based on the normalized measured values with respect to a reference medium. The modified perturbation formulation provides enhanced stability, reduces the sensitivity of solution to variations between the target and reference media, produces solutions having physical units and reduces the need for absolute detector calibration. Moreover, the modified perturbation equation lends itself to the detection and imaging of dynamic properties of the scattering medium.

9. 发明申请

WO2001020306A1 SYSTEM AND METHOD FOR TOMOGRAPHIC IMAGING OF DYNAMIC PROPERTIES OF A SCATTERING MEDIUM 审中-公开
标题翻译：散射介质的动态特性的图像成像系统和方法
公开(公告)号：WO2001020306A1
公开(公告)日：2001-03-22
申请号：PCT/US2000/025155
申请日：2000-09-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , BARBOUR, Randall, L. , SCHMITZ, Christoph, H.
发明人： BARBOUR, Randall, L. , SCHMITZ, Christoph, H.
IPC分类号： G01N21/00
CPC分类号： G01N21/4795
摘要： A system and method for the detection and three dimensional imaging of absorption and scattering properties of a medium such as human tissue is described. According to one embodiment of the invention, the system directs optical energy toward a turbid medium from at least one source and detects optical energy emerging from the turbid medium at a plurality of locations uisng at least one detector (106). The optical energy emerging from the medium (102) and entering the detector (106) originates from the source (101) is scattered by the medium (102). The system then generates an image representing interior structure of the turbid medium based on the detected optical energy emerging from the medium (102). Generating the image includes a time-series analysis.
摘要翻译：描述了用于诸如人体组织的介质的吸收和散射性质的检测和三维成像的系统和方法。根据本发明的一个实施例，系统将光能从至少一个源引导到混浊介质，并且在至少一个检测器（106）上的多个位置处检测从混浊介质中出现的光能。从介质（102）出来并进入来自源（101）的检测器（106）的光能由介质（102）散射。然后，系统基于从介质（102）中出现的检测到的光能产生表示混浊介质的内部结构的图像。生成图像包括时间序列分析。

10. 发明申请

WO2001020305A1 METHOD AND SYSTEM FOR IMAGING THE DYNAMICS OF SCATTERING MEDIUM 审中-公开
标题翻译：用于成像散射介质动力学的方法和系统
公开(公告)号：WO2001020305A1
公开(公告)日：2001-03-22
申请号：PCT/US2000/025136
申请日：2000-09-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, TECHNOLOGY TRANSFER OFFICE , BARBOUR, Randall, L.
发明人： BARBOUR, Randall, L.
IPC分类号： G01N21/00
CPC分类号： G01N21/4795
摘要： A method and system for imaging the dynamics of a scattering medium (116) is provided. The method and system generates contrast and resolution enhanced images of dynamic properties of a medium having a temporal signature by using time series analysis methods on a time series of collected data or time series of images to extract and isolate dynamic properties of the medium (116).
摘要翻译：提供了一种用于对散射介质（116）的动力学进行成像的方法和系统。该方法和系统通过使用时间序列分析方法在采集的数据或时间序列图像的时间序列上生成具有时间特征的介质的动态属性的对比度和分辨率增强图像，以提取和分离介质的动态特性（116）。

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