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1. 发明申请

WO2007060246A2 A METHOD FOR HEALTH MONITORING 审中-公开
标题翻译：一种健康监测方法
公开(公告)号：WO2007060246A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006/068978
申请日：2006-11-28
申请人： NAKOSTECH SARL , POULETTY, Philippe , COHEN, Daniel
发明人： POULETTY, Philippe , COHEN, Daniel
CPC分类号： G06T7/0012 , G06T2207/30004
摘要： This invention relates to methods for monitoring the anatomy of an individual, which methods comprise the steps of : (i) subjecting a healthy or asymptomatic individual to non-invasive analysis techniques, such as imaging or acoustic techniques, to obtain images or data on determined cells, tissue(s) or organs, at different time points over a period of more than one month, preferably over years; (ii) collecting the images or data in a database; (iii) comparing the images or data to the images or data previously acquired for the same individual, in essentially the same conditions; wherein said comparison of images or data obtained at different time points allows definition of non-pathological baseline anatomy for this individual.
摘要翻译：本发明涉及用于监测个体的解剖结构的方法，所述方法包括以下步骤：（i）使健康或无症状的个体经历非侵入性分析技术，诸如成像或声学技术以在超过一个月的时间，优选超过几年的时间内在不同时间点获得确定的细胞，组织或器官上的图像或数据; （ii）收集数据库中的图像或数据; （iii）在基本上相同的条件下将图像或数据与之前针对同一个体获得的图像或数据进行比较; 其中所述在不同时间点获得的图像或数据的比较允许定义该个体的非病理性基线解剖结构。

2. 发明申请

WO2011061304A1 NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE 审中-公开
标题翻译：新型诊断工具，适用于婴幼儿疾病
公开(公告)号：WO2011061304A1
公开(公告)日：2011-05-26
申请号：PCT/EP2010/067855
申请日：2010-11-19
申请人： PHARNEXT , COHEN, Daniel , CHUMAKOV, Ilya , GUERASSIMENKO, Oxana , NABIROCHKIN, Serguei
发明人： COHEN, Daniel , CHUMAKOV, Ilya , GUERASSIMENKO, Oxana , NABIROCHKIN, Serguei
IPC分类号： G01N33/68
CPC分类号： G01N33/92 , A61K31/047 , A61K31/197 , A61K31/485 , G01N33/50 , G01N33/6812 , G01N33/6896 , G01N33/743 , G01N33/78 , G01N33/88 , G01N33/942 , G01N33/9433 , G01N2800/285 , G01N2800/52 , A61K2300/00
摘要： The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease sub-types, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder.
摘要翻译：本发明特别涉及检测Charcot-Marie-Tooth（CMT）及相关疾病的倾向或诊断和/或预后的方法。更具体地，本发明涉及新的生物标志物的开发，验证和应用，其可以用于检测CMT疾病和相关疾病的存在或风险。特别地，本发明涉及可以在生物体液中测量的代谢物，脂质，碳水化合物和蛋白质生物标志物，其可用于活检的容易获得的提取物，其可用于帮助检测，预测药物治疗和随访治疗神经变性疾病，包括CMT疾病。本发明还涉及用于鉴定CMT疾病亚型的方法，评估对治疗的反应性和治疗对具有CMT或相关病症的受试者的疗效。

3. 发明申请

WO2011013079A1 DEPTH MAPPING BASED ON PATTERN MATCHING AND STEREOSCOPIC INFORMATION 审中-公开
标题翻译：基于模式匹配和立体信息的深度映射
公开(公告)号：WO2011013079A1
公开(公告)日：2011-02-03
申请号：PCT/IB2010/053430
申请日：2010-07-28
申请人： PRIMESENSE LTD. , SHPUNT, Alexander , MEDIONI, Gerard , COHEN, Daniel , SALI, Erez , DEITCH, Ronen
发明人： SHPUNT, Alexander , MEDIONI, Gerard , COHEN, Daniel , SALI, Erez , DEITCH, Ronen
IPC分类号： G06K9/00
CPC分类号： G06T7/521 , G01B11/22 , G01B11/25 , G06T7/593 , G06T2207/10024 , G06T2207/10028 , H04N5/33 , H04N13/239 , H04N13/25 , H04N13/254 , H04N13/271 , H04N13/296
摘要： A method for depth mapping includes projecting a pattern of optical radiation onto an object (22). A first image of the pattern on the object is captured using a first image sensor (40), and this image is processed to generate pattern-based depth data with respect to the object. A second image of the object is captured using a second image sensor (46), and the second image is processed together with another image to generate stereoscopic depth data with respect to the object. The pattern-based depth data is combined with the stereoscopic depth data to create a depth map of the object.
摘要翻译：用于深度映射的方法包括将光辐射图案投影到物体（22）上。使用第一图像传感器（40）捕获对象上的图案的第一图像，并且处理该图像以生成关于对象的基于图案的深度数据。使用第二图像传感器（46）捕获对象的第二图像，并且与另一图像一起处理第二图像以生成关于对象的立体深度数据。基于图案的深度数据与立体深度数据组合以创建对象的深度图。

4. 发明申请

WO2009133141A2 NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS 审中-公开
标题翻译：通过调节血管生成来治疗阿尔茨海默病和相关疾病的新治疗方法
公开(公告)号：WO2009133141A2
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055205
申请日：2009-04-29
申请人： PHARNEXT , COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , GUERASSIMENKO, Oxana , GRAUDENS, Esther
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , GUERASSIMENKO, Oxana , GRAUDENS, Esther
IPC分类号： A61K45/06 , A61P25/28
CPC分类号： A61K31/55 , A61K31/155 , A61K31/195 , A61K31/37 , A61K31/42 , A61K31/4365 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease.
摘要翻译：本发明涉及治疗阿尔茨海默病和相关疾病的组合物和方法。更具体地，本发明涉及调节血管生成以治疗所述疾病的组合疗法。

5. 发明申请

WO2009076250A1 CHAIR AND SYSTEM FOR TRANSMITTING SOUND AND VIBRATION 审中-公开
标题翻译：发声和振动的椅子和系统
公开(公告)号：WO2009076250A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/085776
申请日：2008-12-06
申请人： BODYSOUND TECHNOLOGIES, INC. , COHEN, Daniel , COHEN, David , LEWIS, Todd
发明人： COHEN, Daniel , COHEN, David , LEWIS, Todd
IPC分类号： A47C7/62 , A61H23/02 , A47C7/72
CPC分类号： A61H23/0236 , A61H2201/0149
摘要： The present invention is a chair or similar body-supporting apparatus for sitting on, reclining on or lying upon. The chair or similar apparatus is capable of transmitting sound and vibrations generated by a sound source and/or a vibration source to a user's body. The sound and vibrations are transmitted through speakers, transducers, or a combination thereof which are connected to the chair or similar apparatus. The transmitted sound and vibrations may include translated frequencies that are generated by a translation of higher frequencies that can mainly be heard to lower frequencies that can mainly be felt. The present invention is also a method of providing vibrational energy to a user, including regulating sound and vibrations transmitted through speakers, transducers, or a combination thereof which are connected to a chair or similar body-supporting apparatus.
摘要翻译：本发明是一种椅子或类似的身体支撑装置，用于坐在，斜倚或躺着。椅子或类似装置能够将由声源和/或振动源产生的声音和振动传送到用户的身体。声音和振动通过连接到椅子或类似装置的扬声器，换能器或其组合传输。发射的声音和振动可以包括通过主要可被听到的较高频率的翻译产生的翻译的频率，其可以主要被感知到较低的频率。本发明也是向用户提供振动能量的方法，包括调节通过扬声器传播的声音和振动，换能器或其组合，其连接到椅子或类似的身体支撑装置。

6. 发明申请

WO2002066672A3 TREATMENT OF CNS DISORDERS USING D-AMINO ACID OXIDASE AND D-ASPARTATE OXIDASE ANTAGONISTS 审中-公开
公开(公告)号：WO2002066672A3
公开(公告)日：2002-08-29
申请号：PCT/IB2002/001262
申请日：2002-01-15
申请人： GENSET S.A. , COHEN, Daniel , CHUMAKOV, Ilya
发明人： COHEN, Daniel , CHUMAKOV, Ilya
IPC分类号： C12Q1/26
摘要： Compounds that are antagonists of D-amino acid oxidase and D-aspartate oxidase, methods of treating CNS disorders including bipolar disorder, psychosis and schizophrenia using the compounds, and pharmaceutically acceptable compositions that contain the antagonists are disclosed.

7. 发明申请

WO2021099839A1 COLLABORATIVE NETWORKING SYSTEMS, METHODS, AND DEVICES 审中-公开
公开(公告)号：WO2021099839A1
公开(公告)日：2021-05-27
申请号：PCT/IB2020/000974
申请日：2020-11-17
申请人： MANN, Roy , LEREYA, Daniel , HARAMATI, Tal , COHEN, Itay , MORAD, Oron , BAUMER, Shirley , MAROM, Aviram , EILON, Moshik , RADZEWSKY, Shanee , COHEN, Daniel , DORON, Omer , MOSHE, Oryan , LIBERMAN, Etay , ZEMAH, Moshe , SAFRIGIN, Sergei , GARAVANI, Edo , HERSHKOVITZ, Aviel , DAVIDI, Idan , HOLTZMAN, Ayelet , BENTOV, Dar , BADICHI, Meytal
发明人： MANN, Roy , LEREYA, Daniel , HARAMATI, Tal , COHEN, Itay , MORAD, Oron , BAUMER, Shirley , MAROM, Aviram , EILON, Moshik , RADZEWSKY, Shanee , COHEN, Daniel , DORON, Omer , MOSHE, Oryan , LIBERMAN, Etay , ZEMAH, Moshe , SAFRIGIN, Sergei , GARAVANI, Edo , HERSHKOVITZ, Aviel , DAVIDI, Idan , HOLTZMAN, Ayelet , BENTOV, Dar , BADICHI, Meytal
IPC分类号： G06F40/18 , G06F40/103
摘要： Systems, methods, and computer-readable media for collaborative work systems in tablature are disclosed. The systems and methods may involve computer-based organization, processing and analytical analysis through the integration of disparate functionalities, where the integration includes at least two of document management, chats, email, calendars, GANTT charts, location tracking, time management, control systems, cost management, capacity management, CRMs, process/order/delivery scheduling, and/or other functionalities that may assist an organization. Outputs of integrated functionalities may be presented in tablature and may involve generating and transmitting electronic notifications over a network, regulating permission access, rendering static and dynamic data, enabling display of graphs, automation tablature, enabling communications for an application, organizing status-based tasks, time tracking, enabling automatic time zone updates, converting data into moving objects, aggregating and parsing data, altering tablature via geographical interfaces, and managing resource utilization in tablature.

8. 发明申请

WO2012117076A2 BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROGICAL DISORDERS 审中-公开
标题翻译：基于BACLOFEN和ACAMPROSATE的神经病学治疗方法
公开(公告)号：WO2012117076A2
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053570
申请日：2012-03-01
申请人： PHARNEXT , COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , VIAL, Emmanuel , GUEDJ, Mickaël
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , VIAL, Emmanuel , GUEDJ, Mickaël
IPC分类号： A61K31/137
CPC分类号： A61K31/44 , A61K9/2004 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/164 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/42 , A61K31/428 , A61K31/445 , A61K31/64 , A61K45/06 , A61K2300/00
摘要： The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.
摘要翻译：本发明涉及治疗与谷氨酸兴奋毒性和淀粉样蛋白ß毒性相关的神经障碍的组合和方法。更具体地说，本发明涉及多发性硬化症，阿尔茨海默氏病，阿尔茨海默病相关病症，肌萎缩性侧索硬化症，帕金森病，亨廷顿病，神经性疼痛，酒精神经病，酒精中毒或酒精戒断或脊髓损伤的新型组合疗法在巴氯芬和Acamprosate组合。

9. 发明申请

WO2009068668A1 NEW THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS 审中-公开
标题翻译：治疗CMT和相关疾病的新治疗方法
公开(公告)号：WO2009068668A1
公开(公告)日：2009-06-04
申请号：PCT/EP2008/066468
申请日：2008-11-28
申请人： PHARNEXT , COHEN, Daniel , CHUMAKOV, Ilya , GUERASSIMENKO, Oxana , NABIROCHKIN, Serguei
发明人： COHEN, Daniel , CHUMAKOV, Ilya , GUERASSIMENKO, Oxana , NABIROCHKIN, Serguei
IPC分类号： A61K31/047 , A61K31/197 , A61K31/27 , A61K31/4164 , A61K31/4178 , A61K31/485 , A61K31/567 , A61K45/06 , A61P25/28
CPC分类号： A61K31/485 , A61K9/0095 , A61K9/08 , A61K9/4866 , A61K31/047 , A61K31/197 , A61K31/7004
摘要： The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.
摘要翻译：本发明涉及治疗Charcot-Marie-Tooth疾病和相关疾病的组合物和方法。更具体地，本发明涉及通过影响受试者中的PMP22表达来治疗所述疾病的组合疗法。

10. 发明申请

WO2009068659A2 NOVEL DISEASE TREATMENT BY PREDICTING DRUG ASSOCIATION 审中-公开
标题翻译：预防药物协会的新型疾病治疗
公开(公告)号：WO2009068659A2
公开(公告)日：2009-06-04
申请号：PCT/EP2008/066457
申请日：2008-11-28
申请人： PHARNEXT , COHEN, Daniel , CHUMAKOV, Ilya
发明人： COHEN, Daniel , CHUMAKOV, Ilya
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G06F19/00 , G06F19/18 , G06F19/326 , G06F19/3456 , Y02A90/26
摘要： The present invention relates to methods for drug repositioning. More particularly, this invention relates to methods for selecting approved drugs or combinations of approved drugs for use in new therapeutic indications. This approach is situated in a cross section between drug repositioning and disease treatment by combinations of drugs with additive or synergistic action. The invention also allows to define drugs or drug combinations for treating the unmet medical need in diseases neglected by majority of Pharma companies, such as orphan diseases.
摘要翻译：本发明涉及用于药物重新定位的方法。更具体地说，本发明涉及选择批准的药物或批准的药物组合以用于新的治疗适应症的方法。这种方法处于药物重新定位和药物联合治疗的疾病治疗之间的交叉部分，具有叠加或协同作用。本发明还允许定义用于治疗大多数制药公司忽视的疾病中未满足的医疗需求的药物或药物组合，例如孤儿疾病。

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