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1. 发明申请

WO2015175972A2 SOLUTION TARGET FOR CYCLOTRON PRODUCTION OF RADIOMETALS 审中-公开
标题翻译：解决方案用于循环生产放射性物质的目标
公开(公告)号：WO2015175972A2
公开(公告)日：2015-11-19
申请号：PCT/US2015/031140
申请日：2015-05-15
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： DEGRADO, Timothy, R. , PANDEY, Mukesh , BYRNE, John
IPC分类号： A61K47/48 , A61K38/20
CPC分类号： G21G1/10 , B01D15/08 , G21G1/001 , G21G2001/0021 , H05H6/00
摘要： Methods of producing and isolating 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99m Tc, 45 Ti, 13 N, 52 Mn, or 44 Sc and solution targets for use in the methods are disclosed. The methods of producing 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99 mTc, 45 Ti, 13 N, 52 Mn, or 44 Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 CU, 99m TC, 45 -Ti, 52 Mn, or 44 Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
摘要翻译：公开了生产和分离68Ga，89Zr，64Cu，63Zn，86Y，61Cu，99mTc，45Ti，13N，52Mn或44Sc的方法和用于该方法的溶液靶。制造68Ga，89Zr，64Cu，63Zn，86Y，61Cu，99mTc，45Ti，13N，52Mn或44Sc的方法包括用质子束照射封闭的靶系统。封闭的目标系统可以包括解决方案目标。通过离子交换层析分离制备68 Ga，89Zr，64Cu，63Zn，86Y，61CU，99mTC，45-Ti，52Mn或44Sc的方法。示例性解决方案目标包括目标主体，其包括用于接收目标材料的目标腔体; 壳体，其限定用于将粒子束引导到目标空腔的通道; 用于覆盖目标腔的开口的目标窗口; 以及设置在目标窗口上游的通道中的冷却剂气体流路。

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