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1. 发明申请

WO2010096434A3 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2010096434A3
公开(公告)日：2011-01-27
申请号：PCT/US2010024407
申请日：2010-02-17
申请人： LUDWIG INST CANCER RES , OLD LLOYD J , JONHS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , RITTER GERD , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE
发明人： OLD LLOYD J , JONHS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , RITTER GERD , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , G01N33/50 , G01N33/574
CPC分类号： C07K16/40 , A61K31/495 , A61K39/39541 , A61K39/39558 , A61K47/6871 , A61K51/103 , A61K51/1045 , A61K51/1078 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/4258 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

2. 发明申请

WO2011041319A3 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2011041319A3
公开(公告)日：2011-06-30
申请号：PCT/US2010050559
申请日：2010-09-28
申请人： LUDWIG INST CANCER RES , OLD LLOYD J , JOHNS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE , RITTER GERD
发明人： OLD LLOYD J , JOHNS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE , RITTER GERD
IPC分类号： A61K51/10 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2863 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/30 , C07K16/4266 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

3. 发明申请

WO2011041319A8 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：特异性结合蛋白及其用途
公开(公告)号：WO2011041319A8
公开(公告)日：2011-10-06
申请号：PCT/US2010050559
申请日：2010-09-28
申请人： LUDWIG INST FOR CANCER RES LTD , OLD LLOYD J , JOHNS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE , RITTER GERD
发明人： OLD LLOYD J , JOHNS TERRANCE GRANT , PANOUSIS CON , SCOTT ANDREW MARK , RENNER CHRISTOPH , JUNGBLUTH ACHIM , STOCKERT ELIZABETH , COLLINS PETER , CAVENEE WEBSTER K , HUANG HUEI-JEN SU , BURGESS ANTONY WILKS , NICE EDOUARD COLLINS , MURRAY ANNE , MARK GEORGE , RITTER GERD
IPC分类号： A61K51/10 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2863 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/30 , C07K16/4266 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：本发明涉及与扩增的表皮生长因子受体（EGFR）结合并与EGFR的de2-7 EGFR截短结合的特异性结合成员，特别是抗体及其片段。具体而言，特异性结合成员识别的表位，特别是抗体及其片段，在异常翻译后修饰时增强或明显。这些特异性结合成员可用于癌症的诊断和治疗。本发明的结合成员还可以与化学治疗剂或抗癌剂和/或其他抗体或其片段组合用于治疗。

4. 发明申请

WO2013005062A3 METHOD AND APPARATUS FOR SENSING 审中-公开
标题翻译：用于感测的方法和设备
公开(公告)号：WO2013005062A3
公开(公告)日：2013-03-07
申请号：PCT/GB2012052151
申请日：2012-09-03
申请人： RIDAIR SYSTEMS LTD , COLLINS PETER
发明人： COLLINS PETER
IPC分类号： B66B13/26
CPC分类号： G01V8/20 , B66B13/26
摘要： A method of, and apparatus for, detecting an intrusion into a volume defined relative to a path across an opening along which path a closure member for the opening can be controllably displaced to define a gap in the opening, the gap being bounded on one side by the closure member and on the other side to the one side by a boundary member; the volume including at least one threshold region on at least one side of the path; the volume having as a base the threshold region and rising above the threshold region; a first group of at least two emitters of electromagnetic signals located on either the closure member or the boundary and directed into the volume and a second group of at least two receivers for electromagnetic signals located on the opposite side of the gap to the emitters; emissions from the emitters being directed into the volume but not directly towards the receivers; the emitters and receivers forming part of a network including processing means which form a compound sensor for use in monitoring operation of the closure member and for defining sensitivity to an intrusion into a region or regions of the volume; each emitter being adapted to direct a primary beam of e.m. radiation into the volume; each receiver being adapted to receive a secondary beam generated by the reflection of a primary beam from a target intruding into the volume; the method comprising the steps of: causing at least one of the emitters to emit a primary beam along a first axis into the volume; allowing for at least one of the receivers to receive a secondary beam of radiation along a second axis from the volume; the secondary beam being generated by reflection of a primary beam from a target intruding into the volume; the secondary beam being generated in the volume by way of, but not constituted by, the or any primary beam from an emitter;and enabling one or more of the receivers to provide an output signal into the network of the compound receiver characteristic of the, or each, secondary beam detected by at least one of the receivers in the second group;and providing that where the compound sensor serves to establish: that when an excess gain ratio is relatively small in an output signal from a single receiver caused by reception by the receiver of a secondary beam and the size of the gap is relatively large then the compound sensor functions so as to increase sensitivity of detection existing within a given predetermined region of the volume by comparison with sensitivity in another region or regions in the volume; that when an excess gain ratio is relatively large in an output signal from a single receiver caused by reception by the receiver of a secondary beam and the size of the gap is reducing or small then the sensor functions so as to increase sensitivity of detection within more than one region of the volume by comparison with sensitivity in another region or regions in the volume.
摘要翻译：本发明涉及一种用于检测侵入到相对于穿过开口的路径限定的体积的方法和设备，该开口沿着该路径可以可控制地移动开口的封闭构件以限定开口中的间隙，该间隙在一侧通过封闭构件并且在另一侧由边界构件向一侧施加; 该体积在路径的至少一侧上包括至少一个阈值区域; 该体积具有作为阈值区域的基础并且升高到阈值区域之上; 第一组至少两个电磁信号发射器，其位于封闭构件或边界上并且被引导到所述体积中，并且第二组至少两个接收器用于电磁信号，所述电磁信号位于所述间隙的与发射器相反的一侧上; 来自发射器的排放物被引导到容积中，但不直接朝向接收器; 所述发射器和接收器形成网络的一部分，所述网络包括形成复合传感器的处理装置，所述复合传感器用于监测所述闭合构件的操作并且用于限定对侵入所述体积的一个或多个区域的灵敏度; 每个发射器适于引导e.m.的主要波束。辐射入体积; 每个接收器适于接收通过来自侵入所述体积中的目标的主射束的反射而产生的次级射束; 所述方法包括以下步骤：使所述发射器中的至少一个沿着第一轴线发射主束到所述体积中; 允许所述接收器中的至少一个接收从所述体积沿着第二轴的次级辐射束; 所述次级束由来自侵入所述体积的目标的主束的反射而产生; 通过但不是由来自发射器的任何主波束或由任何发射器的任何主波束构成次级波束;以及使得一个或多个接收器能够将输出信号提供到复合接收器的网络中，或每个由第二组中的接收机中的至少一个接收机检测到的辅助波束;以及在复合传感器用于建立以下情况时提供：当来自单个接收机的输出信号中的过量增益比相对较小次光束的接收器和间隙的尺寸相对较大，则复合传感器起作用，以便通过与体积中的另一个区域或区域中的灵敏度相比，增加存在于该体积的给定预定区域内的检测的灵敏度; 当由接收机接收到次级光束引起的来自单个接收机的输出信号中的过量增益比相对较大并且间隙的大小减小或小时，则传感器起作用以在更多内部增加检测灵敏度通过与体积中的另一个区域或多个区域的灵敏度相比而比该体积的一个区域更小。

5. 发明申请

WO2006005940A3 MONOCLONAL ANTI-GLUT2 ANTIBODY 审中-公开
标题翻译：单克隆抗体GLUT2抗体
公开(公告)号：WO2006005940A3
公开(公告)日：2006-04-27
申请号：PCT/GB2005002727
申请日：2005-07-13
申请人： RIVERSIDE BIOSCIENCES LTD , COLLINS PETER , ROBERSTON ARCHIE
发明人： COLLINS PETER , ROBERSTON ARCHIE
IPC分类号： C07K16/28 , G01N33/68 , C07K16/00
CPC分类号： G01N33/689 , C07K16/28
摘要： A monoclonal antibody that recognises glucose transporter 2 (GLUT2) is described, as well as a hybridoma that produces the antibody. The antibody may be used to identify or isolate embryonic or fetal cells, for example in an in vitro method of prenatal diagnosis.
摘要翻译：描述识别葡萄糖转运蛋白2（GLUT2）的单克隆抗体，以及产生抗体的杂交瘤。抗体可用于鉴定或分离胚胎或胎儿细胞，例如在体外产前诊断方法中。

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