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1. 发明申请

WO2012174177A2 SYSTEMS AND METHODS FOR IMAGING AND QUANTIFYING TISSUE MAGNETISM WITH MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用磁共振成像成像和定量组织磁体的系统和方法
公开(公告)号：WO2012174177A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042337
申请日：2012-06-14
申请人： LIU, Chunlei , WU, Bing , LI, Wei
发明人： LIU, Chunlei , WU, Bing , LI, Wei
CPC分类号： G01R33/5616 , G01R33/443 , G01R33/482 , G01R33/4822 , G01R33/4824 , G01R33/5611 , G01R33/56509 , G01R33/56536
摘要： Systems and methods for imaging and quantifying tissue magnetism with magnetic resonance imaging (MRI) are disclosed. According to an aspect, a method for MRI includes using an MRI system to acquire multiple image echoes of an object. The method also includes combining the image echoes. Further, the method includes generating an image of the object based on the combined image echoes for depicting a characteristic of the object.
摘要翻译：公开了用磁共振成像（MRI）成像和定量组织磁性的系统和方法。根据一个方面，MRI的方法包括使用MRI系统来获取对象的多个图像回波。该方法还包括组合图像回波。此外，该方法包括基于用于描绘对象的特征的组合图像回波来生成对象的图像。

2. 发明申请

WO2011139745A2 SYSTEMS AND METHODS FOR SUSCEPTIBILITY TENSOR IMAGING 审中-公开
标题翻译：用于易感性张量成像的系统和方法
公开(公告)号：WO2011139745A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034086
申请日：2011-04-27
申请人： LIU, Chunlei
发明人： LIU, Chunlei
IPC分类号： A61B5/055
CPC分类号： G01R33/54 , A61B5/0042 , A61B5/055 , G01R33/243 , G01R33/48 , G01R33/56383
摘要： The present disclosure provides a method and system for quantifying and making images of tissue anisotropy property based on magnetic resonance imaging (MRI). The systems and methods provided herein utilize orientation distribution of magnetic susceptibility to characterize magnetic susceptibility anisotropy (MSA) inside biological tissues. This MSA may be intrinsic property of the tissue or may be induced by the presence of external agents. In certain embodiments, the MSA is displayed as an orientation distribution function of susceptibility and/or may be described by mathematical quantities such as tensors (e.g., symmetric or asymmetric second order or higher order tensors) and spherical harmonics. In other embodiments, the MSA is characterized using a second order tensor named apparent susceptibility tensor (AST).
摘要翻译：本公开提供了用于基于磁共振成像（MRI）量化和制造组织各向异性性质的图像的方法和系统。本文提供的系统和方法利用磁化率的取向分布来表征生物组织内的磁化率各向异性（MSA）。这种MSA可能是组织的内在特性，或者可能是由外部因素引起的。在某些实施例中，MSA被显示为磁化率的取向分布函数和/或可以通过诸如张量的数学量（例如，对称或不对称的二阶或更高阶张量）和球谐函数来描述。在其他实施方案中，使用称为视敏感性张量（AST）的二阶张量来表征MSA。

3. 发明申请

WO2014059237A1 SYSTEMS AND METHODS FOR SUSCEPTIBILITY TENSOR IMAGING IN THE P-SPACE 审中-公开
标题翻译： P空间中可疑传感器成像的系统和方法
公开(公告)号：WO2014059237A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/064478
申请日：2013-10-11
申请人： LIU, Chunlei
发明人： LIU, Chunlei
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/443 , G01R33/4822 , G01R33/4824 , G01R33/5616 , G01R33/56536
摘要： Systems and methods for susceptibility tensor imaging in the p-space are disclosed. An example method includes using an MRI system to generate an MRI signal of an object. The method may also include conducting a multipole analysis of the MRI signal in a subvoxel Fourier spectral space (p-space). Further, the method may include sampling the p-space with pulsed field gradients to determine a set of dipole and quadrupole susceptibility tensors. The method may also include generating an image of the object based on the set of dipole and quadrupole susceptibility tensors for depicting a characteristic of the object.
摘要翻译：公开了用于p空间中的敏感性张量成像的系统和方法。示例性方法包括使用MRI系统来生成对象的MRI信号。该方法还可以包括在子体素傅里叶谱空间（p空间）中进行MRI信号的多极分析。此外，该方法可以包括用脉冲场梯度对p空间进行采样以确定一组偶极子和四极敏感度张量。该方法还可以包括基于用于描绘对象的特征的偶极子和四极易感性张量的集合来生成对象的图像。

4. 发明申请

WO2012107482A3 POWER SEMICONDUCTOR MODULE 审中-公开
公开(公告)号：WO2012107482A3
公开(公告)日：2012-08-16
申请号：PCT/EP2012/052118
申请日：2012-02-08
申请人： ABB RESEARCH LTD , KICIN, Slavo , SCHULZ, Nicola , HÄFNER, Jürgen , LIU, Chunlei , HAMIDI, Amina , FABIAN, Jan-Henning
发明人： KICIN, Slavo , SCHULZ, Nicola , HÄFNER, Jürgen , LIU, Chunlei , HAMIDI, Amina , FABIAN, Jan-Henning
IPC分类号： H01L23/62 , H01L25/07 , H01L21/60
摘要： A semiconductor device (509a, b) comprises a semiconductor chip (504a, b) comprising a bottom electrode and a top electrode and a bottom electrode- baseplate (502). The bottom electrode-baseplate (502) is electrically and thermally conductive. The semiconductor device (509a, b) comprises a top electrode- baseplate (508). The top electrode-baseplate (508) is electrically and thermally conductive. The semiconductor device (509a, b) comprises a first preform (506a, b) made of material configured for supporting a creation of an electrically conductive alloy when being melted. In order to provide a semiconductor device having enhanced characteristics, the bottom electrode of the semiconductor chip (504a, b) is thermally and electrically connected to the bottom electrode-baseplate (502) via a first bonding layer (618), the top electrode of the semiconductor chip (504a, b) is thermally and electrically connected to a first side of the first preform (506a, b) via a second bonding layer (620), and the second side of the first preform (506a, b) is thermally and electrically connected to the top electrode- baseplate (508) via a third bonding layer (624).

5. 发明申请

WO2016004281A1 POLYPEPTIDES COMPRISING A THERMAL SENSITIVE ION CHANNEL LINKED TO A DOMAIN 5 OF KININOGEN, NUCLEIC ACIDS, AND THEIR USES FOR CELL MODULATION AND TREATMENTS 审中-公开
标题翻译：包含连接到KININOGEN，NUCLEICACID及其用于细胞调节和治疗用途的5敏感性离子通道的多核苷酸
公开(公告)号：WO2016004281A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038948
申请日：2015-07-02
申请人： LIU, Chunlei , BENNER, Eric
发明人： LIU, Chunlei , BENNER, Eric
IPC分类号： C12N15/62 , C07K14/705 , C07K14/81 , A61K48/00 , A61K38/57 , A61K38/17 , C12N15/85 , A61N2/00
CPC分类号： C07K14/705 , A61N2/002 , A61N2/008 , A61N2/02 , C07K14/8139 , C07K2319/00
摘要： Disclosed herein are inventive polypeptides (e.g., comprising a thermal sensitive ion channel or variant thereof and a domain 5 of kininogen 1 or variant or fragment thereof) and nucleic acid molecules encoding inventive polypeptides. Also disclosed are methods for modulating a cell comprising administering certain compositions (e.g., pharmaceutical compositions of the nucleic acid molecule) and applying a static magnetic field or an electromagnetic field. Methods for treating diseases or disorders in an animal (e.g., a human) comprising administering certain compositions (e.g., pharmaceutical compositions of the nucleic acid molecule) and applying a static magnetic field or an electromagnetic field, are further disclosed.
摘要翻译：本文公开了本发明的多肽（例如，包含热敏离子通道或其变体和激肽原1或其变体或片段的结构域5）和编码本发明多肽的核酸分子。还公开了调节细胞的方法，包括施用某些组合物（例如，核酸分子的药物组合物）和施加静态磁场或电磁场。进一步公开了包括施用某些组合物（例如核酸分子的药物组合物）和施加静态磁场或电磁场的用于治疗动物（例如人）中的疾病或病症的方法。

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