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1. 发明申请

WO2010018926A3 METHOD FOR PREPARING N-SUBSTITUTED MALEIMIDES 审中-公开
标题翻译：制备N-取代的马来酰亚胺的方法
公开(公告)号：WO2010018926A3
公开(公告)日：2010-04-08
申请号：PCT/KR2009003405
申请日：2009-06-24
申请人： KOREA KUMHO PETROCHEM CO LTD , KIM JIN-EOK , KIM SEUNG-IL , KWAG HAN-JIN
发明人： KIM JIN-EOK , KIM SEUNG-IL , KWAG HAN-JIN
IPC分类号： C07D207/452
CPC分类号： C07D207/448
摘要： The present invention relates to a method for preparing N-substituted maleimides, and more specifically a method for preparing N-substituted maleimides, wherein unlike the existing methods wherein N-substituted maleinamide acid is prepared before N-substituted maleimides are prepared, and an organic solvent, acid catalyst, dehydration cocatalyst and stabilization agent are introduced into a reactor without separately preparing a N-substituted maleinamide acid. A primary amine is then introduced to form an amine salt, maleic acid anhydride is introduced to perform the reactions of dehydrogenation and ring closure and the water thus formed is subject to azeotropic distillation with an organic solvent so as to prepare N-substituted maleimides at high purity and high yield by effectively suppressing the formation of a maleimide polymer. In particular, the present invention has advantages that include a streamlined process, high yields, minimized side reactions, exclusion of the introduction of expensive raw materials, exclusion of a cumbersome reactant solution treatment, and significant reduction in the time required for introducing raw materials and maleic acid anhydride.
摘要翻译：本发明涉及制备N-取代的马来酰亚胺的方法，更具体地涉及制备N-取代的马来酰亚胺的方法，其中与制备N-取代的马来酰亚胺之前制备N-取代的马来酰胺酸的现有方法不同，溶剂，酸催化剂，脱水助催化剂和稳定剂引入反应器中而不单独制备N-取代的马来酰胺酸。然后引入伯胺形成胺盐，引入马来酸酐以进行脱氢和闭环反应，并且将由此形成的水与有机溶剂共沸蒸馏以在高的温度下制备N-取代的马来酰亚胺通过有效地抑制马来酰亚胺聚合物的形成而获得纯度和高收率。具体而言，本发明具有以下优点，包括简化的工艺，高收率，最小化的副反应，排除引入昂贵的原材料，排除繁琐的反应物溶液处理，以及显着缩短引入原材料所需的时间和马来酸酐。

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