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    • 4. 发明申请
    • DEVICE AND METHOD FOR NON-ENZYMATIC AND ELECTROCHEMICAL DETECTION OF GLUCOSE BIOANALYTE
    • 葡萄糖生物质的非酶化和电化学检测的装置和方法
    • WO2016038529A1
    • 2016-03-17
    • PCT/IB2015/056854
    • 2015-09-08
    • INDIAN INSTITUTE OF SCIENCE
    • KUMAR, VinayBHAT, Navakant
    • A61B5/1468
    • A61B5/1468A61B2562/0295
    • An electrochemically active device is provided for collecting and retaining a biological sample with electrodes connected to conductive tracks arranged on a substrate. The device is provided with a non- enzymatic and an electrochemically active receptor and the receptor is in chemical contact with the electrodes and a biological sample with a bioanalyte. The present invention also provides a holder and a point-of-care biosensor for the device of the present invention and a method for measuring glucose bioanalyte in a reduce volume of the biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of glucose bioanalytes by determining redox current values in the biological samples.
    • 提供了一种电化学活性器件,用于收集和保留具有连接到布置在衬底上的导电轨迹的电极的生物样品。 该装置设置有非酶和电化学活性受体,并且受体与电极化学接触,并具有生物分析物的生物样品。 本发明还提供了用于本发明的装置的保持器和点护理生物传感器以及在生物样品的减少体积中测量葡萄糖生物分析物的方法。 本发明的装置,保护点生物传感器和方法通过确定生物样品中的氧化还原电流值来促进葡萄糖生物分析物的精确测量浓度。
    • 5. 发明申请
    • DEVICE AND METHOD FOR DETECTION OF HAEMOGLOBIN AND ITS COMPLEXES
    • 检测HEMOGLOBIN及其复合物的装置和方法
    • WO2016038526A1
    • 2016-03-17
    • PCT/IB2015/056832
    • 2015-09-07
    • INDIAN INSTITUTE OF SCIENCE
    • KUMAR, VinayBHAT, Navakant
    • A61B5/1468
    • G01N27/4168A61B5/1477A61B5/726A61B2562/0295G01N33/721
    • An electrochemically active device is provided for collecting and retaining a blood sample with at least a two-electrode member connected to conductive tracks. A receptor with an integral receptor-membrane arranged on the two-electrode member, to receive non-electrochemically active heamoglobin bioanalyte and its complexes from red blood cells (RBC) of said blood sample, through a lysing agent and convert the non-electrochemically active heamoglobin bioanalyte and its complexes, into an electrochemically active bioanalyte and its electrochemically active complexes. The present invention also provides a point-of-care biosensor incorporated with the device of the present invention and method of measuring for the detection and quantitative measurement of concentrations of haemoglobin (Hb), glycated haemoglobin (GHb), methaemoglobin (MetHb) and myoglobin, in reduced volumes of blood samples, by determining redox current values in the reduced volumes of blood samples.
    • 提供了一种电化学活性器件,用于收集和保持血液样本,其中至少两个电极构件连接到导电轨道。 具有布置在双电极构件上的整体受体膜的受体,通过裂解剂从所述血液样品的红细胞(RBC)接收非电化学活性的血红蛋白生物分析物及其复合物,并转化非电化学活性 血红蛋白生物分析物及其复合物转化为电化学活性生物分析物及其电化学活性复合物。 本发明还提供了与本发明的装置结合的护理点生物传感器和测量血红蛋白(Hb),糖化血红蛋白(GHb),血红蛋白(MetHb)和肌红蛋白的浓度的检测和定量测量的方法 通过测定血样中体积减少的氧化还原电流值,减少体积的血液样本。