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1. 发明申请

WO2012135125A1 TELOMERE LENGTH MEASUREMENT IN FORMALIN-FIXED, PARAFFIN EMBEDDED (FFPE) SAMPLES BY QUANTITATIVE PCR 审中-公开
标题翻译：通过定量PCR在FORMALIN-FIXED，PARAFFIN嵌入（FFPE）样品中的TELOMERE长度测量
公开(公告)号：WO2012135125A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030581
申请日：2012-03-26
申请人： GERON CORPORATION , WANG, Hui , GO, Ning, F. , PIROT, Zhu, Zhen
发明人： WANG, Hui , GO, Ning, F. , PIROT, Zhu, Zhen
IPC分类号： G01N33/574
CPC分类号： C12Q1/6876 , C12Q1/6851 , G01N33/5088 , G01N2800/52 , C12Q2525/155 , C12Q2527/107 , C12Q2527/125 , C12Q2527/137 , C12Q2545/113
摘要： Methods of reliably quantifying telomere length in cells or tissues that have been formalin fixed and paraffin embedded (FFPE) samples by quantitative polymerase chain reaction protocol and kits for use with such various methods are provided. The methods of the present invention may be used to predetermine an individual's response to treatment with a telomerase inhibitor, a telomere damaging agent or a telomerase activator.
摘要翻译：提供了通过定量聚合酶链反应方案和用于这些各种方法的试剂盒可靠地定量已经用福尔马林固定和石蜡包埋（FFPE）样品的细胞或组织中端粒长度的方法。本发明的方法可以用于预先确定个体对用端粒酶抑制剂，端粒损伤剂或端粒酶激活剂治疗的反应。

2. 发明申请

WO2010141385A1 ASSAY FOR TELOMERASE ACTIVITY USING MICROFLUIDIC DEVICE 审中-公开
标题翻译：使用微流控器件测定TELOMERASE活性
公开(公告)号：WO2010141385A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/036719
申请日：2010-05-28
申请人： GERON CORPORATION , HARLEY, Calvin, B. , WANG, Hui , PIROT, Zhu, Zhen
发明人： HARLEY, Calvin, B. , WANG, Hui , PIROT, Zhu, Zhen
IPC分类号： G01N33/48
CPC分类号： C12Q1/48 , G01N2333/91245
摘要： Methods for determining the level of telomerase reverse transcriptase activity in mammalian cells are disclosed. A preferred measuring device is a microfluidic device that includes a spectrophotometer, a fluorescent detector, a fluorescence polarization detector or a scintillation counting device.
摘要翻译：公开了确定哺乳动物细胞中端粒酶逆转录酶活性水平的方法。优选的测量装置是包括分光光度计，荧光检测器，荧光偏振检测器或闪烁计数装置的微流体装置。

3. 发明申请

WO2014085632A1 DIAGNOSTIC MARKERS FOR TREATING CELL PROLIFERATIVE DISORDERS WITH TELOMERASE INHIBITORS 审中-公开
标题翻译：用TELOMERASE抑制剂治疗细胞增殖性疾病的诊断标记
公开(公告)号：WO2014085632A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072302
申请日：2013-11-27
申请人： GERON CORPORATION
发明人： BASSETT, Ekaterina , BURINGTON, Bart , WANG, Hui , ENG, Kevin
IPC分类号： C12Q1/68 , G01N33/533
CPC分类号： G01N33/574 , A61K31/7125 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N2333/9128 , A61K2300/00
摘要： Provided herein are methods for identifying individuals diagnosed with a cell proliferative disorder that will benefit from treatment with a telomerase inhibitor compound. Also provided herein are methods for treating these individuals with telomerase inhibitor compounds. The methods comprise identifying individuals who will benefit from said treatment based on the average relative length of telomeres in cancer cells from said individuals.
摘要翻译：本文提供了用于鉴定将被从端粒酶抑制剂化合物治疗中受益的细胞增殖性病症诊断的个体的方法。本文还提供了用端粒酶抑制剂化合物治疗这些个体的方法。所述方法包括根据来自所述个体的癌细胞中端粒的平均相对长度识别将从所述治疗中受益的个体。

4. 发明申请

WO2013173998A1 METHOD AND APPARATUS FOR PULSE ELECTROCHEMICAL POLISHING 审中-公开
标题翻译：脉冲电化学抛光方法与装置
公开(公告)号：WO2013173998A1
公开(公告)日：2013-11-28
申请号：PCT/CN2012/075990
申请日：2012-05-24
申请人： ACM RESEARCH (SHANGHAI) INC. , WANG, Jian , JIN, Yinuo , WANG, Jun , WANG, Hui
发明人： WANG, Jian , JIN, Yinuo , WANG, Jun , WANG, Hui
IPC分类号： H01L21/321 , B23H3/02 , B24B57/02 , C25F3/16
CPC分类号： H01L21/32115 , C25F3/16 , C25F3/30 , C25F7/00 , H01L22/12 , H01L22/20
摘要： A method and apparatus for pulse electrochemical polishing a wafer are disclosed. The method comprises steps of: establishing a duty cycle table showing all points on the wafer, a removal thickness corresponding to every point and a duty cycle corresponding to the removal thickness; driving a wafer chuck (5) holding and positioning the wafer (8) to move at a preset speed so that a special point on the wafer (8) is right above a nozzle (6) ejecting charged electrolyte (7) onto the wafer (8); looking up the duty cycle table and obtaining the removal thickness and the duty cycle corresponding to the special point; and applying a preset pulse power source to the wafer (8) and the nozzle (6) and the actual polishing power source for polishing the special point being equal to the duty cycle multiplying by the preset power source.
摘要翻译：公开了用于脉冲电化学抛光晶片的方法和装置。该方法包括以下步骤：建立表示晶片上所有点的占空比表，对应于每个点的去除厚度和对应于去除厚度的占空比; 驱动晶片卡盘（5），其保持并定位晶片（8）以预定速度移动，使得晶片（8）上的特殊点位于喷射带电电解质（7）到晶片上的喷嘴（6）的正上方 8）; 查找占空比表，获得与特殊点对应的去除厚度和占空比; 以及将预设的脉冲电源施加到晶片（8）和喷嘴（6）上的实际抛光功率源和用于抛光专用点的实际抛光功率等于乘以预设电源的占空比。

5. 发明申请

WO2013143116A1 FLOW CONTROL SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：流量控制系统及其方法
公开(公告)号：WO2013143116A1
公开(公告)日：2013-10-03
申请号：PCT/CN2012/073302
申请日：2012-03-30
申请人： ACM RESEARCH (SHANGHAI) INC. , WANG, Jian , ZHAO, Yu , XIE, Liangzhi , ZHANG, Xiaoyan , JIA, Shena , WANG, Hui
发明人： WANG, Jian , ZHAO, Yu , XIE, Liangzhi , ZHANG, Xiaoyan , JIA, Shena , WANG, Hui
IPC分类号： G05D7/06
CPC分类号： G05D7/0664
摘要： A flow control system and method thereof are disclosed. The flow control system includes a control valve for liquid flowing through, a pressure sensor measuring a pressure of the liquid flowing through the control valve and outputting a measuring signal, a controller receiving the measuring signal from the pressure sensor and outputting a corresponding electric current signal, an I/P converter receiving the electric current signal from the controller and outputting compressed air with corresponding pressure to the control valve to regulate the pressure of the liquid in the control valve, a flow switch measuring a flow rate of the liquid flowing into a chamber, and a needle valve regulating the flow rate to a target flow rate. The control valve, the pressure sensor, the I/P converter and the controller constitute a PID closed loop control system to provide a precise and stable liquid supply.
摘要翻译：公开了一种流量控制系统及其方法。流量控制系统包括用于液体流过的控制阀，测量流过控制阀的液体的压力并输出测量信号的压力传感器，控制器从压力传感器接收测量信号并输出相应的电流信号，I / P转换器，其接收来自控制器的电流信号，并将相应压力的压缩空气输出到控制阀，以调节控制阀中的液体的压力;流量开关，其测量流入以及将流量调节到目标流量的针阀。控制阀，压力传感器，I / P转换器和控制器构成PID闭环控制系统，提供精确稳定的液体供应。

6. 发明申请

WO2010129934A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS OF THYROID CONDITIONS 审中-公开
标题翻译：用于诊断甲状腺条件的方法和组合物
公开(公告)号：WO2010129934A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/034140
申请日：2010-05-07
申请人： VERACYTE, INC. , KENNEDY, Giulia , ANDERSON, Bonnie, H. , CHUDOVA, Darya, I. , WANG, Eric, T. , WANG, Hui , PAGAN, Moraima , RABBEE, Nusrat , WILDE, Jonathan, I.
发明人： KENNEDY, Giulia , ANDERSON, Bonnie, H. , CHUDOVA, Darya, I. , WANG, Eric, T. , WANG, Hui , PAGAN, Moraima , RABBEE, Nusrat , WILDE, Jonathan, I.
IPC分类号： C12Q1/68 , C12N15/12 , C40B40/08
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.
摘要翻译：本发明涉及用于分子谱和癌症诊断的组合物，试剂盒和方法，包括但不限于与癌症相关的基因组DNA标记。特别地，本发明提供了与甲状腺癌相关的分子谱，确定分子谱的方法和分析结果以提供诊断的方法。

7. 发明申请

WO2010111826A1 METHODS AND APPARATUS FOR CLEANING SEMICONDUCTOR WAFERS 审中-公开
标题翻译：清洗半导体波形的方法和装置
公开(公告)号：WO2010111826A1
公开(公告)日：2010-10-07
申请号：PCT/CN2009/071088
申请日：2009-03-31
申请人： ACM RESEARCH (SHANGHAI) INC. , WANG, Jian , NUCH, Sunny Voha , XIE, Liangzhi , WU, Junping , JIA, Zhaowei , HUANG, Yunwen , GAO, Zhifeng , MA, Yue , WANG, Hui
发明人： WANG, Jian , NUCH, Sunny Voha , XIE, Liangzhi , WU, Junping , JIA, Zhaowei , HUANG, Yunwen , GAO, Zhifeng , MA, Yue , WANG, Hui
IPC分类号： H01L21/00 , B08B3/12
CPC分类号： H01L21/02068 , B08B3/12 , H01L21/02063 , H01L21/67051
摘要： A method for cleaning a semiconductor substrate (1010) using an ultra/mega sonic device (1003) is provided. The method comprises holding a semiconductor substrate (1010) by using a chuck (1014); positioning an ultra/mega sonic device (1003) adjacent to the semiconductor substrate (1010); injecting chemical liquid (1032) on the semiconductor substrate (1010) and into a gap between the semiconductor substrate (1010) and the ultra/mega sonic device (1003) by using at least one nozzle (1012); and changing the gap between the semiconductor substrate (1010) and the ultra/mega sonic device (1003) for each rotation of the chuck (1014) during the cleaning process by turning the semiconductor substrate (1010) or the ultra/mega sonic device (1003) clockwise or count clockwise. An apparatus for cleaning a semiconductor substrate (1010) using an ultra/mega sonic device (1003) is also provided.
摘要翻译：提供了一种使用超声波设备（1003）清洁半导体衬底（1010）的方法。该方法包括通过使用卡盘（1014）保持半导体衬底（1010）; 定位与半导体衬底（1010）相邻的超/超声波器件（1003）; 通过使用至少一个喷嘴（1012）将半导体衬底（1010）上的化学液体（1032）注入到半导体衬底（1010）和超声波声学器件（1003）之间的间隙中; 以及通过转动所述半导体衬底（1010）或所述超/超声波器件（1010），在所述清洁过程期间，通过所述卡盘（1014）的每次旋转来改变所述半导体衬底（1010）和所述超/超声波器件（1003） 1003）顺时针或顺时针方向计数。还提供了一种使用超声波超声波设备（1003）清洁半导体衬底（1010）的设备。

8. 发明申请

WO2010039478A1 SYSTEM AND METHOD FOR DISPLAYING DETAILED INFORMATION FOR A DATA POINT 审中-公开
标题翻译：用于显示数据点的详细信息的系统和方法
公开(公告)号：WO2010039478A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/057712
申请日：2009-09-21
申请人： NELLCOR PURITAN BENNETT LLC , WANG, Hui , LI, Li , VARGAS, Steve , BOYCE, Robin , AMUNDSON, Scott , OCHS, James , MADERE, Tonia
发明人： WANG, Hui , LI, Li , VARGAS, Steve , BOYCE, Robin , AMUNDSON, Scott , OCHS, James , MADERE, Tonia
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61B5/7475 , A61B5/02416 , A61B5/14551 , A61B5/743 , A61B5/7445 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： The present disclosure may describe a system and method for displaying detailed information about a patient at a time selectable from a trend line of historic data. For example, the patient's SpO2, pulse rate, status, and so forth may be recorded over time. One or more trend lines of the recorded data over time may be displayed, and a user may select a point of interest from the trend line. Detailed data corresponding to that point of interest may then be displayed, for example, next to the trend line or on a separate screen. The detailed information may appear in the form of a pop-up box that does not obscure the trend line. In embodiments, the user may select the data point by moving a cursor or placing a pointing device on the trend line. The detailed information may be displayed automatically or may be activated by further user action.
摘要翻译：本公开可以描述用于从历史数据的趋势线可选择的时间显示关于患者的详细信息的系统和方法。例如，可以随时间记录患者的SpO2，脉搏率，状态等。随着时间的推移，可以显示记录数据的一个或多个趋势线，并且用户可以从趋势线中选择兴趣点。然后可以例如在趋势线旁边或在单独的屏幕上显示与该兴趣点对应的详细数据。详细信息可能以不会遮蔽趋势线的弹出框的形式显示。在实施例中，用户可以通过移动光标或将指示设备放置在趋势线上来选择数据点。详细信息可以自动显示，或者可以通过进一步的用户动作来激活。

9. 发明申请

WO2007143132A2 PATIENT MONITORING HELP SCREEN SYSTEM AND METHOD 审中-公开
标题翻译：患者监测帮助屏幕系统和方法
公开(公告)号：WO2007143132A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/013010
申请日：2007-05-30
申请人： NELLCOR PURITAN BENNETT LLC , WANG, Hui
发明人： WANG, Hui
CPC分类号： G16H40/63 , G06F19/00
摘要： Embodiments of the present invention relate to a patient monitoring help screen system and method. Specifically, embodiments of the present invention include a patient monitoring device (10) with an integral help screen system. The help screen system may provide context-based help, such that the help screen accessed by a help key (12) may relate to a specific display context.
摘要翻译：本发明的实施例涉及一种患者监护帮助屏幕系统和方法。具体地，本发明的实施例包括具有整体帮助屏幕系统的患者监视装置（10）。帮助屏幕系统可以提供基于上下文的帮助，使得由帮助键（12）访问的帮助屏幕可以涉及特定显示上下文。

10. 发明申请

WO2007011305A1 DEVICE FOR PROCESSING A BIOLOGICAL AND/OR CHEMICAL SAMPLE AND METHOD OF USING THE SAME 审中-公开
标题翻译：用于处理生物和/或化学样品的装置及其使用方法
公开(公告)号：WO2007011305A1
公开(公告)日：2007-01-25
申请号：PCT/SG2005/000241
申请日：2005-07-19
申请人： ATTOGENIX BIOSYSTEMS PTE LTD. , OVISO, Dominador Fortaleza, Jr. , TING, Dor Ngi , GHADESSY, Farid , WANG, Hui , LAU, Wen Jian
发明人： OVISO, Dominador Fortaleza, Jr. , TING, Dor Ngi , GHADESSY, Farid , WANG, Hui , LAU, Wen Jian
IPC分类号： C12M1/24 , C12M3/00 , B01L3/00 , A61B10/00 , G01N1/28
CPC分类号： G01N1/405 , B01L3/502 , B01L2300/0672 , B01L2300/069 , B01L2300/0832 , B01L2300/087 , B01L2400/0406 , B01L2400/0457 , B01L2400/0677 , B01L2400/0683 , G01N1/34 , Y10T436/143333 , Y10T436/25
摘要： The present invention relates to a device and an apparatus device for processing a biological and/or chemical sample. The device comprises at least one sample processing chamber having an inlet at a first end and a penetrable sealing layer at a second end that forms at least a part of an inner wall of the sample processing chamber. The sealing layer is adapted to seal off the sample processing chamber from the environment until said sealing layer is penetrated to form an outlet. The device and apparatus also includes an absorption layer, wherein upon penetration of said sealing layer, said absorption layer is in fluid contact with said sealing layer, and is capable of absorbing fluid released from said sample processing chamber, via the outlet. The present invention also relates to a fluid separation device. The fluid separation device comprises a penetrable sealing layer adapted to form a wall of a sample processing chamber of the device of the invention. The fluid separation device also comprises an absorption layer that is influid contact with the sealing layer and capable of absorbing fluid released from a sample processing chamber of the device.
摘要翻译：本发明涉及用于处理生物和/或化学样品的装置和装置装置。该装置包括至少一个样品处理室，其具有在第一端处的入口和在第二端处形成至少一部分样品处理室的内壁的可穿透密封层。密封层适于将样品处理室与环境密封，直到所述密封层被穿透以形成出口。所述装置和装置还包括吸收层，其中在所述密封层穿透时，所述吸收层与所述密封层流体接触，并且能够经由所述出口吸收从所述样品处理室释放的液体。本发明还涉及一种流体分离装置。流体分离装置包括适于形成本发明的装置的样品处理室的壁的可穿透的密封层。流体分离装置还包括吸收层，其与密封层相接触并且能够吸收从装置的样品处理室释放的流体。

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