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1. 发明申请

WO2003048185A3 ANGIOPIOETIN RELATED FACTORS 审中-公开
公开(公告)号：WO2003048185A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/037660
申请日：2002-11-21
申请人： GENVEC, INC. , KESSLER, Paul, D. , KOVESDI, Imre
发明人： KESSLER, Paul, D. , KOVESDI, Imre
IPC分类号： A61K39/00
摘要： The invention provides fusion proteins comprising a fibrinogen-like domain comprising an amino acid sequence identical or homologous to the amino acid sequence of the fibrinogen-like domain of a first wild-type angiopoietin-related factor and a coiled-coil domain comprising an amino acid sequence identical or homologous to the coiled-coil domain of a second wild-type angiopoietin-related factor, where the first and second wild-type angiopoietin related factors are different. The invention further provides polynucleotides encoding such fusion proteins, vectors comprising such polynucleotides, and methods of making and administering such fusion proteins, polynucleotides, and vectors.

2. 发明申请

WO2007027860A3 ADENOVIRAL VECTOR-BASED MALARIA VACCINES 审中-公开
公开(公告)号：WO2007027860A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033982
申请日：2006-08-31
申请人： GENVEC, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY NAVAL MEDICAL RESEARCH CENTER , BRUDER, Joseph, T. , KOVESDI, Imre , KING, C., Richter , MCVEY, Duncan, L. , ETTYREDDY, Damodar, R. , DOOLAN, Denise, Louise , CARUCCI, Daniel, John , LIMBACH, Keith
发明人： BRUDER, Joseph, T. , KOVESDI, Imre , KING, C., Richter , MCVEY, Duncan, L. , ETTYREDDY, Damodar, R. , DOOLAN, Denise, Louise , CARUCCI, Daniel, John , LIMBACH, Keith
IPC分类号： C12N15/861 , C07K14/445 , A61K39/015
摘要： The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal.

3. 发明申请

WO2003040314A2 E1-REVERTANT-FREE ADENOVIRAL COMPOSITION 审中-公开
标题翻译： E1无反应性腺病毒组合物
公开(公告)号：WO2003040314A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/034721
申请日：2002-10-31
申请人： GENVEC, INC.
发明人： BROUGH, Douglas, E. , KOVESDI, Imre
IPC分类号： C12N
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： The invention provides a composition comprising particles of an adenoviral vector comprising deficiencies in two or more gene functions required for viral replication, wherein at least one of the deficiencies is of a gene function of the E1 region of the adenoviral genome and (b) a carrier therefor, with relatively high ratios of (i) the number of particles of the adenoviral vectors to the number of particles of E1-revertant replication-deficient adenoviral vectors not comprising one or more of the deficiencies in gene functions of the E1 region of the adenoviral and (ii) the number of particles of the adenoviral vectors to the number of particles of replication-competent adenoviral vectors, as well as a method of preparing such a composition.
摘要翻译：本发明提供包含腺病毒载体颗粒的组合物，其包含病毒复制所需的两个或多个基因功能的缺陷，其中至少一个缺陷是腺病毒基因组的E1区域的基因功能，和（b）载体因此，具有相对高的比例（i）腺病毒载体的颗粒数与E1复发缺失型复制缺陷型腺病毒载体的颗粒数量不包含腺病毒E1区的基因功能的一个或多个缺陷和（ii）腺病毒载体的颗粒数与复制能力的腺病毒载体的颗粒数目，以及制备这种组合物的方法。

4. 发明申请

WO2003022311A1 ADENOVIRAL VECTOR AND RELATED SYSTEM AND METHODS OF MAKING AND USE 审中-公开
标题翻译： ADENOVIRAL VECTOR AND相关系统及其制作和使用方法
公开(公告)号：WO2003022311A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/029111
申请日：2002-09-13
申请人： GENVEC, INC. , KOVESDI, Imre
发明人： KOVESDI, Imre
IPC分类号： A61K48/00
CPC分类号： C12N7/00 , A61K48/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352 , C12N2830/002 , C12N2830/85
摘要： An adenoviral vector comprising an adenoviral genome comprising (i) at least one deletion in a region of the adenoviral genome selected from the group consisting of E1, E2A and E4, (ii) (a) at least one deletion in the VAI gene of the adenoviral genome, alone or in further combination with at least one deletion in the VAII gene of the adenoviral genome, (b) a recombinant VAI gene, alone or in further combination with a recombinant VAII gene, wherein the recombinant gene comprises either of a regulatable promoter in place of the native promoter or a mutated native promoter and 5' to the mutated native promoter, a pol II promoter, or (c) a dominant negative, double-stranded, RNA-dependent protein kinase (PKR) and, optionally, (iii) a polymerase II (pol II) construct comprising a pol II promoter operably linked to a coding region and/or a polymerase III (pol III) construct comprising a pol III promoter operably linked to a coding region, as well as a system comprising such an adenoviral vector and a cell line that complements the adenoviral vector, and related systems and methods.
摘要翻译：一种腺病毒载体，其包含腺病毒基因组，其包含（i）在选自E1，E2A和E4的腺病毒基因组的区域中的至少一个缺失，（ii）（a）在所述腺病毒基因的VAI基因中的至少一个缺失腺病毒基因组单独或与腺病毒基因组的VAII基因中的至少一个缺失进一步组合，（b）单独的或与重组VAII基因进一步组合的重组VAI基因，其中重组基因包括可调节的启动子代替天然启动子或突变的天然启动子，5'与突变的天然启动子，pol II启动子或（c）显性负双重，RNA依赖性蛋白激酶（PKR）和任选地，（iii）包含可操作地连接到编码区的pol II启动子和/或包含可操作地连接到编码区的pol III启动子的聚合酶III（pol III）构建体的聚合酶II（pol II）构建体，以及系统包括这样的腺病毒 ector和补充腺病毒载体的细胞系，以及相关系统和方法。

5. 发明申请

WO1998007877A1 A SHORT-SHAFTED ADENOVIRAL FIBER AND ITS USE 审中-公开
标题翻译：短缺的腺病毒纤维及其使用
公开(公告)号：WO1998007877A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014718
申请日：1997-08-21
申请人： GENVEC, INC.
发明人： GENVEC, INC. , WICKHAM, Thomas, J. , ROELVINK, Petrus, W. , KOVESDI, Imre
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/70546 , C07K2319/00 , C12N7/00 , C12N15/87 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/14043 , C12N2710/14143 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/6018 , C12N2810/855 , C12N2810/856 , C12N2810/859
摘要： The present invention provides a short-shafted adenoviral fiber, a recombinant adenovirus comprising a short-shafted fiber, a vector comprising a short-shafted adenoviral fiber gene, and a method of targeting attachment of a short-shafted recombinant adenovirus to a cell so as to effect entry of the short-shafted recombinant adenovirus into the cell.
摘要翻译：本发明提供一种短轴型腺病毒纤维，包含短轴纤维的重组腺病毒，包含短轴腺病毒纤维基因的载体，以及将短轴重组腺病毒连接至细胞的方法，以便以使短轴重组腺病毒进入细胞。

6. 发明申请

WO2003059292A3 COMPOSITION AND METHOD FOR MAINTAINING NON-ENVELOPED VIRAL VECTORS 审中-公开
公开(公告)号：WO2003059292A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/000831
申请日：2003-01-13
申请人： GENVEC, INC. , KOVESDI, Imre , RANSOM, Stephen, C.
发明人： KOVESDI, Imre , RANSOM, Stephen, C.
IPC分类号： C12N15/86
摘要： The invention provides a composition and a method for preserving a non-enveloped viral vector. The composition comprises (a) trehalose, (b) a divalent metal salt, a cationic polymer, or a combination thereof, (c) a multiplicity of non-enveloped viral vector particles, and (d) a liquid carrier. Non-enveloped virus particles are stable in the composition in a liquid form, at elevated temperatures, for a sustained period of time.

7. 发明申请

WO2003059292A2 COMPOSITION AND METHOD FOR MAINTAINING NON-ENVELOPED VIRAL VECTORS 审中-公开
标题翻译：用于维护非传染病毒载体的组合物和方法
公开(公告)号：WO2003059292A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/000831
申请日：2003-01-13
申请人： GENVEC, INC. , KOVESDI, Imre , RANSOM, Stephen, C.
发明人： KOVESDI, Imre , RANSOM, Stephen, C.
IPC分类号： A61K
CPC分类号： C12N7/00 , C12N2710/10351
摘要： The invention provides a composition and a method for preserving a non-enveloped viral vector. The composition comprises (a) trehalose, (b) a divalent metal salt, a cationic polymer, or a combination thereof, (c) a multiplicity of non-enveloped viral vector particles, and (d) a liquid carrier. Non-enveloped virus particles are stable in the composition in a liquid form, at elevated temperatures, for a sustained period of time.
摘要翻译：本发明提供了一种用于保存非包膜病毒载体的组合物和方法。组合物包含（a）海藻糖，（b）二价金属盐，阳离子聚合物或其组合，（c）多个非包膜病毒载体颗粒，和（d）液体载体。无包膜的病毒颗粒在液体形式的组合物中在高温下持续持续一段时间是稳定的。

8. 发明申请

WO2002083851A3 VEGF FUSION PROTEINS 审中-公开
公开(公告)号：WO2002083851A3
公开(公告)日：2002-10-24
申请号：PCT/US2002/011406
申请日：2002-04-10
申请人： GENVEC, INC. , KOVESDI, Imre , KESSLER, Paul, D.
发明人： KOVESDI, Imre , KESSLER, Paul, D.
IPC分类号： C07K14/475
摘要： The invention provides therapeutic fusion proteins which include a first peptide portion comprising a first non-heparin binding VEGF peptide portion and a second non-VEGF peptide portion covalently associated with the first peptide portion, which first and second peptide portions separately promote angiogenesesis, bone growth, wound healing, or any combination thereof. Further provided are polynucleotides, encoding such fusion proteins, vectors including such polynucleotides, methods of making such proteins, and methods of promoting angiogenesis, bone growth, and/or wound healing using such proteins, polynucleotides, and vectors.

9. 发明申请

WO2002083851A2 VEGF FUSION PROTEINS 审中-公开
标题翻译： VEGF融合蛋白
公开(公告)号：WO2002083851A2
公开(公告)日：2002-10-24
申请号：PCT/US2002/011406
申请日：2002-04-10
申请人： GENVEC, INC. , KOVESDI, Imre , KESSLER, Paul, D.
发明人： KOVESDI, Imre , KESSLER, Paul, D.
IPC分类号： C12N
CPC分类号： C12N9/16 , A61K38/00 , C07K14/475 , C07K14/50 , C07K14/515 , C07K14/52 , C07K2319/00
摘要： The invention provides therapeutic fusion proteins which include a first peptide portion comprising a first non-heparin binding VEGF peptide portion and a second non-VEGF peptide portion covalently associated with the first peptide portion, which first and second peptide portions separately promote angiogenesesis, bone growth, wound healing, or any combination thereof. Further provided are polynucleotides, encoding such fusion proteins, vectors including such polynucleotides, methods of making such proteins, and methods of promoting angiogenesis, bone growth, and/or wound healing using such proteins, polynucleotides, and vectors.
摘要翻译：本发明提供治疗性融合蛋白，其包括第一肽部分，其包含与第一肽部分共价缔合的第一非肝素结合VEGF肽部分和第二非VEGF肽部分，所述第一和第二肽部分分别促进血管生成，骨生长，伤口愈合或其任何组合。进一步提供了编码这种融合蛋白的多核苷酸，包括这种多核苷酸的载体，制备这种蛋白质的方法，以及使用这些蛋白质，多核苷酸和载体促进血管发生，骨生长和/或伤口愈合的方法。

10. 发明申请

WO1996027021A1 INTERDEPENDENT ADENOVIRAL VECTORS AND METHODS OF USING SAME 审中-公开
标题翻译：相关的ADENOVIRAL VECTORS及其使用方法
公开(公告)号：WO1996027021A1
公开(公告)日：1996-09-06
申请号：PCT/US1996002488
申请日：1996-02-22
申请人： CORNELL RESEARCH FOUNDATION, INC. , GENVEC, INC.
发明人： CORNELL RESEARCH FOUNDATION, INC. , GENVEC, INC. , HERSH, Jeff , CRYSTAL, Ronald, G. , BEWIG, Burkhard , KOVESDI, Imre
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/525 , C12N15/63 , C12N15/67 , C12N2710/10343 , C12N2830/00 , C12N2830/85
摘要： The present invention provides a method of modulating gene expression by co-infection of cells with two or more interdependent replication-deficient adenoviral vectors, in particular by introducing into a cell, in any order or simultaneously, a first replication-deficient adenoviral vector comprising a first promoter and a first nucleic acid sequence which encodes a first gene product, wherein the first promoter regulates expression of the first gene product, and (b) a second replication-deficient adenoviral vector comprising a second promoter and a second nucleic acid sequence which encodes a second gene product, wherein the second promoter regulates in cis expression of the second gene product and is regulated in trans by the first gene product, and wherein the first promoter is different from the second promoter. The present invention also provides a method of modulating gene expression to produce a gene product, e.g., protein, a method for increasing the selective targeting for gene delivery of a particular type of cells, and interdependent adenoviral vectors appropriate for use in the methods of the present invention.
摘要翻译：本发明提供了通过用两个或更多个相互依赖的复制缺陷型腺病毒载体共感染细胞来调节基因表达的方法，特别是以任何顺序或同时引入细胞，第一复制缺陷型腺病毒载体包含第一启动子和编码第一基因产物的第一核酸序列，其中第一启动子调节第一基因产物的表达，和（b）第二复制缺陷型腺病毒载体，其包含第二启动子和第二核酸序列，其编码第二基因产物，其中第二启动子以第二基因产物的顺式表达调节，并被第一基因产物反转，并且其中第一启动子不同于第二启动子。本发明还提供了调节基因表达以产生基因产物的方法，例如蛋白质，增加特定类型细胞的基因递送的选择性靶向的方法，以及适用于所述方法的相互依赖的腺病毒载体本发明。

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