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1. 发明申请

WO2016124505A1 BIOREACTOR SYSTEM FOR CELL CULTIVATION 审中-公开
标题翻译：用于细胞培养的生物反应器系统
公开(公告)号：WO2016124505A1
公开(公告)日：2016-08-11
申请号：PCT/EP2016/051970
申请日：2016-01-29
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB
发明人： PATIL, Haresh, Digambar , RAMAKRISHNA, Manoj , BHARGAV, Anoop , PAUL, Praveen , JOHN, Sebastian , PURANIK, Swapnil
IPC分类号： C12M3/06 , B01F11/00 , C12M1/00 , C12M1/34 , C12M1/36
CPC分类号： C12M41/48 , B01F11/0017 , B01F15/0085 , C12M23/04 , C12M23/14 , C12M23/38 , C12M23/52 , C12M27/16 , C12M29/10 , C12M41/12 , C12M41/14 , C12N5/0602 , C12N2523/00 , C12N2527/00
摘要： The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit(, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.
摘要翻译：本发明涉及用于细胞培养的新型生物反应器系统。更具体地，本发明涉及一种紧凑的生物反应器系统，其具有几种综合功能，并且能够在相同的生物反应器中进行小规模的静态培养以及放大的摇摆培养。生物反应器系统包括用于定位体积可调节的细胞培养袋的托盘，覆盖细胞培养袋并具有加热功能的盖子，集成灌注单元（集成单元加载单元和用于自动细胞培养取样的集成单元其中生物反应器系统由单一控制单元控制，本发明还涉及使用生物反应器系统培养治疗细胞的细胞培养方法。

2. 发明申请

WO2015043830A1 CHROMATOGRAPHY COLUMN ASSEMBLY 审中-公开
标题翻译：色谱柱组装
公开(公告)号：WO2015043830A1
公开(公告)日：2015-04-02
申请号：PCT/EP2014/067492
申请日：2014-08-15
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： RAO, Venna , RAMAKRISHNA, Manoj
IPC分类号： G01N30/60
CPC分类号： B01D15/424 , C07K1/16 , G01N30/6004 , G01N30/6021
摘要： The invention relates to a chromatography column assembly that offers an affordable self-packed column for performing chromatographic separation. The chromatography column assembly comprises a column tube having a first and a second opening at substantially opposite ends, and an end cap of either a snap fit design or a bolted design. The column assembly may further include an adaptor shaft inserted into the column through the end cap for achieving a desired bed volume. The column assembly may also include a second end cap enclosing the second opening, and an optional adaptor shaft may be inserted into the column through the second end cap, enabling further adjustment of the bed volume.
摘要翻译：本发明涉及一种色谱柱组件，其提供了用于进行色谱分离的经济实惠的自填柱。色谱柱组件包括具有在基本相对的端部处的第一和第二开口的柱管和卡扣配合设计或螺栓设计的端盖。柱组件还可以包括通过端盖插入柱中的适配器轴，以实现所需的床体积。柱组件还可以包括封闭第二开口的第二端盖，并且可选的适配器轴可以通过第二端盖插入柱中，使得能够进一步调节床体积。

3. 发明申请

WO2015155045A1 HOISTING AND HOLDING SYSTEM FOR CHROMATOGRAPHY COLUMN 审中-公开
标题翻译：色谱柱的装置和保存系统
公开(公告)号：WO2015155045A1
公开(公告)日：2015-10-15
申请号：PCT/EP2015/056863
申请日：2015-03-30
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： RAMAKRISHNA, Manoj , CHENGALVARAYAN, Kishore
IPC分类号： G01N30/60 , B01D15/22
CPC分类号： G01N30/6047 , B01D15/22 , G01N30/6021 , G01N2030/027
摘要： A holding system (100) for holding and hoisting a chromatography column (102) is disclosed. The holding system includes an upright member (116) and a plurality of holding members (118,120,122) arranged along the upright member (116) and movable along the main axis of the upright member (116). A first supporting member (106) is positioned at an end portion (103) of the chromatography column, wherein a holding member (118) may be engaged with said first supporting member (106). A second supporting member (108) is positioned at the other end portion of the chromatography column. A second, different holding member (122) is engaged with the second supporting member (108). One or more hoist assisting members (138,140) are also present. A hoist assisting member (138) is operatively connected to said holding member (118) engaged with the first supporting member (106). The hoist assisting member (138) is operable to move the holding member (118) connected to the first supporting member (106) for hoisting the chromatography column (102).
摘要翻译：公开了用于保持和提升色谱柱（102）的保持系统（100）。保持系统包括直立构件（116）和沿着直立构件（116）布置并沿着直立构件（116）的主轴线移动的多个保持构件（118,120,122）。第一支撑构件（106）位于色谱柱的端部（103）处，其中保持构件（118）可与所述第一支撑构件（106）接合。第二支撑构件（108）位于色谱柱的另一端部。第二不同的保持构件（122）与第二支撑构件（108）接合。一个或多个起重机辅助构件（138,140）也存在。升降机辅助构件（138）可操作地连接到与第一支撑构件（106）接合的所述保持构件（118）。提升辅助构件（138）可操作以移动连接到第一支撑构件（106）的保持构件（118），用于提升色谱柱（102）。

4. 发明申请

WO2015060774A1 APPARATUS FOR CONNECTION OF THERMOPLASTIC TUBING 审中-公开
标题翻译：用于连接热塑管的装置
公开(公告)号：WO2015060774A1
公开(公告)日：2015-04-30
申请号：PCT/SE2014/051240
申请日：2014-10-22
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： CHENGALVARAYAN, Kishore , RAMAKRISHNA, Manoj
IPC分类号： A61M39/18 , B29C65/20 , B29C65/74
CPC分类号： B29C65/7802 , A61M39/14 , A61M39/18 , B29C65/103 , B29C65/1412 , B29C65/16 , B29C65/2046 , B29C65/74 , B29C65/7841 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/73921 , B29C66/8414 , B29C66/857 , B29L2023/007 , B29L2031/753 , B29K2021/003 , B29K2027/06
摘要： The invention discloses an apparatus (1) for aligning and supporting a first (2) and a second (3) length of thermoplastic tubing, preparatory to and during cutting and welding of said lengths of tubing, where the apparatus comprises the following components arranged on a base support (4): a) a first holder (5) arranged to accommodate portions of the first and second lengths of tubing in a first (6) and a second (7) elongated holding space respectively, wherein the holding spaces are essentially parallel to each other and separated from each other by a first distance (8); b) a second holder (9) arranged to accommodate portions of the first and second lengths of tubing in a third (10) and a fourth (11) elongated holding space respectively, wherein the holding spaces are essentially parallel to each other and to the holding spaces in the first holder and separated from each other by a second distance (12) substantially the same as the first distance (8), and wherein said second holder is movable in a direction essentially perpendicular to the holding spaces of the first and second holders from a cutting position where said first holding space (6) is aligned with said third holding space (10) and said second holding space (7) is aligned with said fourth holding space (11) to a welding position where said first holding space (6) is aligned with said fourth holding space (11); c) cutting means (13) arranged between said first and second holders for cutting said lengths of tubing when the second holder is in the cutting position; d) aligning means arranged to abut the outside of a cut length of tubing accommodated in the first holding space (6) and the outside of a cut length of tubing accommodated in the fourth holding space (11) and to align these lengths of tubing with each other.
摘要翻译：本发明公开了一种用于对准和支撑第一（2）和第二（3）长度的热塑性管材的装置（1），其准备并在切割和焊接所述长度的管道期间，其中所述装置包括布置在基座支撑件（4）：a）第一保持器（5），其布置成分别容纳在第一和第二（7）细长的保持空间中的第一和第二管段长度的部分，其中保持空间基本上彼此平行并彼此分开第一距离（8）; b）第二保持器（9），其布置成分别容纳在第三（10）和第四（11）细长的保持空间中的第一和第二长度的管的部分，其中保持空间基本上彼此平行，在第一保持器中保持空间并且彼此分开与第一距离（8）基本相同的第二距离（12），并且其中所述第二保持器可在基本上垂直于第一和第二距离的保持空间的方向上移动保持器从所述第一保持空间（6）与所述第三保持空间（10）对准的切割位置和所述第二保持空间（7）与所述第四保持空间（11）对准到焊接位置，在所述焊接位置，所述第一保持空间（6）与所述第四保持空间（11）对准; c）当所述第二保持器处于切割位置时，设置在所述第一和第二保持器之间的切割装置（13）用于切割所述长度的管道; d）对准装置，其布置成邻接容纳在第一保持空间（6）中的管道的切割长度的外侧和容纳在第四保持空间（11）中的切割长度的管道的外部，并且将这些长度的管道与彼此。

5. 发明申请

WO2018122194A1 FAILURE RECOVERY IN CELL CULTURE BIOREACTORS 审中-公开
公开(公告)号：WO2018122194A1
公开(公告)日：2018-07-05
申请号：PCT/EP2017/084483
申请日：2017-12-22
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE UK LIMITED
发明人： RAMAKRISHNA, Manoj , BHARGAV, Anoop , PAI, Umesh
IPC分类号： C12M1/00 , C12M3/06 , C12M1/36
摘要： Disclosed is a cell culture system comprising a first cell culture bioreactor system (10) for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (20), a process controller (30), process control devices (32) which provide inputs (16) for the culture volume and culture parameter measurement devices (14), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory (36) operable to record data indicative of the progress of the control program steps. Failure of the system can be rectified by moving the bioreactor volume to another similar system which has access to data indicative of any incomplete program steps which steps may have been modified by feedback from the measurement devices.

6. 发明申请

WO2018007157A1 APPARATUS AND METHODS FOR ADJUSTABLE VOLUME CELL CULTURE 审中-公开
标题翻译：用于可调整体积细胞培养的装置和方法
公开(公告)号：WO2018007157A1
公开(公告)日：2018-01-11
申请号：PCT/EP2017/065349
申请日：2017-06-22
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE LIMITED
发明人： KONDURU, Nagaraju , RAMAKRISHNA, Manoj , PATIL, Haresh Digambar
IPC分类号： C12M1/00 , C12M3/00 , C12M1/12
摘要： Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.
摘要翻译：公开了细胞培养装置，其包括：包含柔性管的细胞培养容器; 支持桌; 以及一对相对的保持器，用于以流体密封的方式保持管的相对部分，使得流体不能通过管内的相应部分，所述一对之间的间隔是可调节的，以在管持有人对。

7. 发明申请

WO2017032829A1 IMPROVEMENTS IN AND RELATING TO BIOMANUFACTURING APPARATUS 审中-公开
标题翻译：生物制造设备的改进和相关
公开(公告)号：WO2017032829A1
公开(公告)日：2017-03-02
申请号：PCT/EP2016/070075
申请日：2016-08-25
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE LIMITED
发明人： RAMAKRISHNA, Manoj , BHARGAV, Anoop , PATIL, Haresh, Digambar , PAUL, Praveen , JOHN, Sebastian , CHOUDHARY, Manish, Uddhaorao , KUMAR, Pradeep , PHADKE, Nivedita
IPC分类号： C12M3/06 , C12M1/00
CPC分类号： C12M41/14 , C12M27/16 , C12M29/00
摘要： Disclosed is biomanufacturing apparatus 1 comprising a housing (20) including top (22) and bottom (24) faces which allow stacking of plural housings, an access door (25) at a front side of the housing, a substantially enclosed bioreactor chamber (30) inside the housing accessible via the door, and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use; at least a fluid handling portion (48,49) of at least one fluid pump device (54/58); and at least one connection (43) for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.
摘要翻译：公开了一种生物制造装置1，其包括壳体（20），该壳体包括顶部（22）和底部（24）面，其允许堆叠多个壳体，位于壳体前侧的进入门（25），基本封闭的生物反应器室），以及在所述壳体内的另一个基本上封闭的区域（36），所述壳体包含电气部件和/或电子控制部件，所述腔室（30）包括：用于支撑生物反应器的托盘（40），托盘支撑件（45）包括用于在使用中摆动托盘的机构（44,47）; 至少一个流体泵装置（54/58）的流体处理部分（48,49）; 以及用于连接到用于承载流体，气体和/或电力的导管和/或路径的至少一个连接件（43）。

8. 发明申请

WO2017032847A1 IMPROVEMENTS IN AND RELATING TO BIOMANUFACTURING APPARATUS 审中-公开
标题翻译：生物制造设备的改进和相关
公开(公告)号：WO2017032847A1
公开(公告)日：2017-03-02
申请号：PCT/EP2016/070116
申请日：2016-08-25
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE LIMITED
发明人： BHARGAV, Anoop , PATIL, Haresh, Digambar , PAUL, Praveen , JOHN, Sebastian , CHOUDHARY, Manish, Uddhaorao , KUMAR, Pradeep , PHADKE, Nivedita , RAMAKRISHNA, Manoj
IPC分类号： C12M3/06 , C12M1/00 , C12M1/34 , C12M1/36
CPC分类号： C12M27/16 , C12M41/12 , C12M41/14 , C12M41/48
摘要： Disclosed is biomanufacturing apparatus (1) comprising a housing (20), a substantially enclosed bioreactor chamber (30) inside the housing and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use the tray (40) including a heater (42) for contacting a bioreactor and heating the same, and the apparatus further comprising secondary heating (53) for heating air surrounding the tray.
摘要翻译：公开了一种生物制造设备（1），其包括壳体（20），壳体内的基本上封闭的生物反应器室（30），以及包含电气部件和/或电子控制部件的壳体内部的另外基本封闭的区域（36） 30），包括：用于支撑生物反应器的托盘（40），托盘支撑件（45），其包括用于在使用中摇动所述托盘的托架（40），所述机构包括用于接触生物反应器的加热器（42）对其加热，并且该设备还包括用于加热围绕该托盘的空气的二次加热（53）。

9. 发明申请

WO2017032831A1 IMPROVEMENTS IN AND RELATING TO BIOMANUFACTURING APPARATUS 审中-公开
标题翻译：生物制造设备的改进和相关
公开(公告)号：WO2017032831A1
公开(公告)日：2017-03-02
申请号：PCT/EP2016/070077
申请日：2016-08-25
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE LIMITED
发明人： RAMAKRISHNA, Manoj , BHARGAV, Anoop , PATIL, Haresh, Digambar , PAUL, Praveen , JOHN, Sebastian , CHOUDHARY, Manish, Uddhaorao , KUMAR, Pradeep , PHADKE, Nivedita
IPC分类号： C12M3/06 , C12M1/00
CPC分类号： C12M27/16 , C12M41/14
摘要： Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.
摘要翻译：公开了一种生物制造装置1，其包括壳体20，壳体20包括允许堆叠多个壳体的顶部22和底部24的面，位于壳体前侧的进入门25，通过门可接近的壳体内的基本封闭的生物反应器室30，以及包含电气部件和/或电子控制部件的壳体内的另一个基本上封闭的区域36，腔室30包括：用于支撑生物反应器的托盘40，托盘支撑件45，其包括用于在使用中摆动托盘的机构44,47; 托盘支撑件还包括用于确定托盘上的质量负载的变化的测力传感器（41）。

10. 发明申请

WO2017025641A1 HEATSEAL SAMPLING 审中-公开
标题翻译： HEATSEAL采样
公开(公告)号：WO2017025641A1
公开(公告)日：2017-02-16
申请号：PCT/EP2016/069299
申请日：2016-08-12
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE LIMITED
发明人： RAMAKRISHNA, Manoj , PATIL, Haresh, Digambar , JOHN, Sebastian
IPC分类号： C12M1/26 , C12M1/12 , C12M1/00
CPC分类号： C12M33/04 , C12M1/121 , C12M1/28 , C12M33/00 , C12M37/04
摘要： The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.
摘要翻译：本发明提供从细胞培养生物反应器取样的装置和方法。本发明在需要确定细胞计数，提供离线样品或去除样品的同时保持样品的不育性以进行质量控制（QC）评估时是有用的。本发明的装置允许在生物反应器中的细胞扩增期间的一个或多个时间的时间进行容易的无菌取样。

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