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1. 发明申请

WO2005025687A1 BALL LAUNCHER 审中-公开
公开(公告)号：WO2005025687A1
公开(公告)日：2005-03-24
申请号：PCT/GB2004/003922
申请日：2004-09-13
申请人： FOSS-TECH YORK LTD , THOMPSON, James
发明人： THOMPSON, James
IPC分类号： A63B69/40
CPC分类号： A63B69/406 , A63B2069/402
摘要： A ball launching apparatus including launching means (10) wherein the launching means (10) comprise a plurality of wheels (135) to impart movement onto and launching a ball (134) passing therethrough. The angle and rotational speed of the wheels (135) can be adjusted to control the trajectory of the ball (134). The apparatus can include a housing (8), rotationally mounted on movement means (126), allowing lateral and rotational movement of at least part of the apparatus to further control the trajectory of the ball (134).
摘要翻译：一种发射装置，包括发射装置（10），其中所述发射装置（10）包括多个轮（135），以使运动通过其中并通过其中的球（134）。可以调节车轮（135）的角度和转速以控制球（134）的轨迹。该装置可以包括旋转地安装在移动装置（126）上的壳体（8），允许装置的至少一部分的横向和旋转运动以进一步控制球（134）的轨迹。

2. 发明申请

WO2011103291A1 SILOXANE SURFACE-MODIFIED HYDROGEL AND HYDROGEL MICROPARTICLE COMPOSITIONS 审中-公开
标题翻译：硅氧烷表面改性水凝胶和水凝胶微球组合物
公开(公告)号：WO2011103291A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025249
申请日：2011-02-17
申请人： DOW CORNING CORPORATION , AHN, Dongchan , THOMPSON, James
发明人： AHN, Dongchan , THOMPSON, James
IPC分类号： C08F8/42
CPC分类号： C08F8/42 , C08F20/06
摘要： Embodiments of the present invention relate generally to siloxane surface-modified hydrogel microparticles and pastes, methods for their preparation, and uses thereof for delivery of personal care and healthcare active ingredients, as well as agricultural active ingredients.
摘要翻译：本发明的实施方案通常涉及硅氧烷表面改性的水凝胶微粒和糊剂，其制备方法及其用于递送个人护理和保健活性成分以及农业活性成分的用途。

3. 发明申请

WO2005095210A1 RECLINING SEAT 审中-公开
标题翻译：重新安装座椅
公开(公告)号：WO2005095210A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/003488
申请日：2005-03-30
申请人： THOMPSON, James
发明人： THOMPSON, James
IPC分类号： B64D11/06
CPC分类号： B64D11/0638 , B60N2/1695 , B60N2/1821 , B60N2/1846 , B60N2/1892 , B60N2/2209 , B60N2/224 , B60N2/3065 , B60N2/7011 , B60N3/004 , B64D11/06 , B64D11/0601 , B64D11/0606 , B64D11/064 , Y02T50/46
摘要： A reclining seat comprising a generally rigid outer shell 18 containing a seat base 16 and a back rest 14. The seat base and back rest are coupled together for movement with respect to the shell from an upright state to a reclined state by forward sliding movement to the seat base and corresponding downward movement of the top edge of the back rest. The back rest comprises a flexible diaphragm.
摘要翻译：一个倾斜座椅，包括一个包含座椅基座16和靠背14的大致刚性的外壳18.座椅底座和靠背联接在一起，以通过向前滑动运动相对于壳体从直立状态向倾斜状态移动座椅底座和靠背顶部边缘的相应向下运动。靠背包括柔性隔膜。

4. 发明申请

WO2003072705A3 RNA INTERFERENCE MEDIATED INHIBITION OF CYCLIN D1 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 审中-公开
公开(公告)号：WO2003072705A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/003662
申请日：2003-02-06
申请人： SIRNA THERAPEUTICS, INC. , THOMPSON, James , MCSWIGGEN, James , BEIGELMAN, Leonid
发明人： THOMPSON, James , MCSWIGGEN, James , BEIGELMAN, Leonid
IPC分类号： C07H21/04
摘要： The present invention concerns methods and reagents useful in modulating cyclin (e.g., cyclin D1) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against cyclin D1 gene expression. The molecules are useful in the treatment of cancer.

5. 发明申请

WO2003070885A2 RNA INTERFERENCE MEDIATED INHIBITION OF STEAROYL-CoA DESATURASE (SCD) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
标题翻译： RNA干扰介导的使用短暂干扰核酸（siNA）的硬脂酰辅酶A去饱和酶（SCD）基因表达的抑制作用
公开(公告)号：WO2003070885A2
公开(公告)日：2003-08-28
申请号：PCT/US2003/004317
申请日：2003-02-13
申请人： RIBOZYME PHARMACEUTICALS, INCORPORATED , McSWIGGEN, James , BEIGELMAN, Leonid , THOMPSON, James
发明人： McSWIGGEN, James , BEIGELMAN, Leonid , THOMPSON, James
IPC分类号： C12N
CPC分类号： C12N15/115 , A61K38/00 , A61K47/54 , C12N15/1132 , C12N15/1137 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12Y114/19001 , C12Y207/11001 , C12Y207/11013 , C12Y301/03048 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating Stearoyl-CoA desaturase (SCD) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against Steraroyl-CoA desaturase (SCD) gene expression and/or activity. The siNA molecules are useful in the treatment of diabetes (type I and/or type II), atherosclerosis, cancer, obesity, and viral infection, and any other condition that responds to modulation of SCD expression or activity.
摘要翻译：本发明涉及可用于在多种应用中调节硬脂酰辅酶A去饱和酶（SCD）基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的应用。具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA）能够介导针对Steraryl-CoA去饱和酶（SCD）基因表达和/或活性的RNA干扰（RNAi）的分子。 siNA分子可用于治疗糖尿病（I型和/或II型），动脉粥样硬化，癌症，肥胖症和病毒感染以及对SCD表达或活性调节作出反应的任何其他病症。

6. 发明申请

WO2003070744A1 RNA INTERFERENCE MEDIATED INHIBITION OF INTERLEUKIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
标题翻译： RNA干扰介导的抑制使用短暂干细胞核的白介素基因表达
公开(公告)号：WO2003070744A1
公开(公告)日：2003-08-28
申请号：PCT/US2003/004566
申请日：2003-02-11
申请人： RIBOZYME PHARMACEUTICALS, INC. , MCSWIGGEN, James , BEIGELMAN, Leonid , THOMPSON, James
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , THOMPSON, James
IPC分类号： C07H21/04
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating interleukin gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against interleukin (e.g., IL-1, IL-2, IL-5, IL-6, IL-10, IL-15, IL-16, IL-17 and IL-18 genes and genes encoding interleukin receptors of IL-1, IL-2, IL-5, IL-6, IL-10, IL-15, Il-16, IL-17 and IL-18) gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of transplant rejection, autoimmune disease, inflammatory disease, infectous disease, allergy, and any other condition that responds to modulation of interleukin expression or activity.
摘要翻译：本发明涉及可用于调节多种应用中的白细胞介素基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的用途。具体地，本发明涉及能够介导针对白细胞介素的RNA干扰RNAi的小核酸分子，例如短干扰核酸siNA，短干扰RNA siRNA，双链RNA dsRNA，微RNA miRNA和短发夹RNA shRNA分子。，IL-1，IL-2，IL-5，IL-6，IL-10，IL-15，IL-16，IL-17和IL-18基因和编码IL-1，IL-2的白介素受体的基因，IL-5，IL-6，IL-10，IL-15，II-16，IL-17和IL-18基因表达和/或活性。小核酸分子可用于治疗移植排斥反应，自身免疫性疾病，炎性疾病，感染性疾病，变态反应以及对白细胞介素表达或活性调节作出反应的任何其他病症。

7. 发明申请

WO2008141829A1 TABLE APPARATUS FOR A VEHICLE SEAT 审中-公开
标题翻译：车用座椅的装置
公开(公告)号：WO2008141829A1
公开(公告)日：2008-11-27
申请号：PCT/EP2008/004116
申请日：2008-05-23
申请人： J THOMPSON SOLUTIONS LTD , THOMPSON, James , GORDON, Philip , HANNA, Jason, Kyle
发明人： THOMPSON, James , GORDON, Philip , HANNA, Jason, Kyle
IPC分类号： B64D11/06
CPC分类号： B64D11/0638 , B60N3/001 , B64D11/06 , B64D11/0646
摘要： A table apparatus for a vehicle seat comprising a table, having at least one table leaf, and a table support mechanism, wherein the table support mechanism enables translational movement of the table between a substantially horizontal stowed configuration and a deployed configuration. In a preferred embodiment, the linkage arrangement of the table support mechanism comprises at least one substantially horizontally extending support arm extending from a table support member, the table being mounted upon a distal end of the support arm, the support arm being pivotally connected to the table support member for rotation about a first pivot axis in a substantially horizontal plane about the support member, the table being pivotally connected to said distal end of the support arm for rotation about a second pivot axis in a substantially horizontal plane, linkage means being provided for normally constraining rotational movement of the table about the second pivot axis to follow rotational movement of the support arm about the first pivot axis such that the rearmost table face remains substantially aligned to the user such that the table orientation is maintained substantially parallel to its final deployed position during movement between said stowed and deployed configurations.
摘要翻译：一种用于车辆座椅的台式装置，包括具有至少一个台面叶片的桌子和桌子支撑机构，其中桌子支撑机构使台面能够在基本上水平的收起构型和展开构型之间进行平移运动。在优选实施例中，工作台支撑机构的连接装置包括至少一个基本上水平延伸的支撑臂，其从工作台支撑构件延伸，桌子安装在支撑臂的远端上，支撑臂枢转地连接到工作台支撑构件，用于围绕支撑构件在基本水平的平面中围绕第一枢转轴线旋转，工作台枢转地连接到支撑臂的所述远端，以在基本上水平的平面内围绕第二枢转轴线旋转，提供联动装置用于通常约束围绕第二枢转轴线的工作台的旋转运动以跟随支撑臂围绕第一枢转轴线的旋转运动，使得最后面的工作台面保持基本上与使用者对准，使得工作台取向基本上平行于其最终的在所述收起和部署配置之间的移动期间展开位置 ations。

8. 发明申请

WO2004108822A1 FLUOROPLASTIC SILICONE VULCANIZATES 审中-公开
标题翻译：荧光硅胶VULCANIZATES
公开(公告)号：WO2004108822A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/018229
申请日：2004-06-04
申请人： DOW CORNING CORPORATION , CHORVATH, Igor , HARTMANN, Mark , KWAN, Kermit , OLDINSKI, Robert , ROMENESKO, David , THOMPSON, James , TONGE, Lauren , WARREN, Stephen
发明人： CHORVATH, Igor , HARTMANN, Mark , KWAN, Kermit , OLDINSKI, Robert , ROMENESKO, David , THOMPSON, James , TONGE, Lauren , WARREN, Stephen
IPC分类号： C08L27/12
CPC分类号： C08L83/10 , C08F8/42 , C08F14/18 , C08F259/08 , C08F283/12 , C08G77/16 , C08G77/20 , C08G77/24 , C08G77/44 , C08G77/442 , C08G77/70 , C08L27/12 , C08L27/18 , C08L51/003 , C08L51/085 , C08L83/04 , C08L2666/14 , C08L2666/02 , C08L2666/04 , C08F2/00 , C08L83/00
摘要： Fluoroplastics containing fluorocarbon resins and silicones are prepared by first mixing a fluorocarbon resin with a compatibilizer, then adding a curable organopolysiloxane with a radical initiator, and vulcanizing the organopolysiloxane in the mixture. The fluoroplastics can be processed by various techniques, such as extrusion, vacuum forming, injection molding, blow molding or compression molding, to fabricate plastic parts. The resulting fabricated parts can be re-processed (recycled) with little or no degradation of mechanical properties.
摘要翻译：含氟碳树脂和硅氧烷的氟塑料通过首先将氟碳树脂与增容剂混合，然后用自由基引发剂加入可固化的有机聚硅氧烷，并硫化混合物中的有机聚硅氧烷来制备。氟塑料可以通过各种技术加工，例如挤出，真空成型，注射成型，吹塑或压缩成型，以制造塑料部件。所得到的制造部件可以重新加工（再循环），很少或没有机械性能的降低。

9. 发明申请

WO2003074654A2 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 审中-公开
标题翻译： RNA干扰介导的使用短暂干扰核酸（SINA）的基因表达的抑制
公开(公告)号：WO2003074654A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/005028
申请日：2003-02-20
申请人： Sirna Therapeutics, Inc , MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
IPC分类号： C12N
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
摘要翻译：本发明涉及可用于调节各种应用中的基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的用途。具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA）能够针对靶核酸序列介导RNA干扰（RNAi）的分子。小核酸分子可用于治疗对细胞，组织或生物中的基因表达或活性的调节作出反应的任何疾病或病症。

10. 发明申请

WO2003070966A3 RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
公开(公告)号：WO2003070966A3
公开(公告)日：2003-08-28
申请号：PCT/US2003/004464
申请日：2003-02-14
申请人： SIRNA THERAPEUTICS, INC , USMAN, Nassim , POLISKY, Barry , THOMPSON, James , BEIGELMAN, Leonid
发明人： USMAN, Nassim , POLISKY, Barry , THOMPSON, James , BEIGELMAN, Leonid
IPC分类号： C07H21/02
摘要： The present invention concerns methods and reagents useful in target discovery. Specifically, the invention relates to small nucleic acid molecules capable of mediating RNA interference (RNAi), such as short interfering nucleic acid (siNA) short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods of target discovery using siRNA.

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