专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004017915A3 COMPOSITION FOR THE CARRYING AND DELIVERY OF BONE GROWTH INDUCING MATERIAL AND METHODS FOR PRODUCING AND APPLYING THE COMPOSITION 审中-公开
标题翻译：运送和输送骨骼生长诱导材料的组合物以及生产和应用组合物的方法
公开(公告)号：WO2004017915A3
公开(公告)日：2004-10-28
申请号：PCT/US0326422
申请日：2003-08-20
申请人： EXACTECH INC , GENZYME CORP , LIN STEVE T , AVILA LUIS Z , COURY ARTHUR J , KRAMER HILDEGARD M , ROTH LAURENCE A , ROBERTS REBECCA , SLY KURT
发明人： LIN STEVE T , AVILA LUIS Z , COURY ARTHUR J , KRAMER HILDEGARD M , ROTH LAURENCE A , ROBERTS REBECCA , SLY KURT
IPC分类号： A61B17/86 , A61F2/00 , A61F2/02 , A61F2/28 , A61K9/14 , A61K45/00 , A61L27/48 , A61L27/58
CPC分类号： A61L27/58 , A61B17/866 , A61F2/0077 , A61F2/28 , A61F2/30767 , A61F2002/30062 , A61F2210/0004 , A61F2310/00359 , A61L27/3608 , A61L27/48 , A61L2430/02 , C08L89/00
摘要： Various embodiments of the present invention relate to compositions for delivering bone growth inducing material (e.g., to viable bone and/or other skeletal tissues to repair defects and the like). More particularly, various embodiments of the present invention relate to delivery mechanisms for an osteotherapeutic material (e.g., osteoinductive and/or osteoconductive materials), including (but not limited to) demineralized bone matrix ("DBM") and cortical-cancellous bone chips ("CCC"). Certain compositions according to various embodiments of the present invention may comprise mixtures of a physiologically acceptable biodegradable carrier, an osteoinductive material, and/or an osteoconductive material (e.g., DBM and CCC). The compositions may thus be applied (for example, to defective bone tissue and/or other viable tissue) to induce formation of new bone. Other embodiments of the present invention relate to the preparation of compositions and methods of using such compositions.
摘要翻译：本发明的各种实施例涉及用于递送骨生长诱导材料（例如，递送至活骨和/或其他骨骼组织以修复缺陷等）的组合物。更具体地说，本发明的各种实施方式涉及用于骨质治疗材料（例如骨诱导性和/或骨传导性材料）的递送机制，其包括（但不限于）脱矿质骨基质（“DBM”）和皮质松质骨碎片 “CCC”）。根据本发明各种实施方式的某些组合物可以包含生理上可接受的生物可降解载体，骨诱导材料和/或骨传导材料（例如DBM和CCC）的混合物。因此可以将组合物施用（例如，对有缺陷的骨组织和/或其他有活力的组织）以诱导新骨的形成。本发明的其他实施方案涉及组合物的制备和使用这种组合物的方法。

2. 发明申请

WO2005115489A3 ADHERENT POLYMERIC COMPOSITIONS 审中-公开
标题翻译：附加聚合物组合物
公开(公告)号：WO2005115489A3
公开(公告)日：2006-04-27
申请号：PCT/US2005018159
申请日：2005-05-23
申请人： GENZYME CORP , JARRETT PETER K , MILLER ROBERT J , MESSIER KENNETH A , PHILBROOK C MICHAEL , KRAMER HILDEGARD M , KABLIK J JEFFREY , JOHNSTON ERIKA E , AVILA LUIS Z , COURY ARTHUR J
发明人： JARRETT PETER K , MILLER ROBERT J , MESSIER KENNETH A , PHILBROOK C MICHAEL , KRAMER HILDEGARD M , KABLIK J JEFFREY , JOHNSTON ERIKA E , AVILA LUIS Z , COURY ARTHUR J
IPC分类号： A61L15/16 , A61L24/00 , A61L24/04 , A61L27/34 , A61L31/06 , A61L31/10
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/043 , A61L27/34 , A61L31/10 , C08L71/02
摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.
摘要翻译：本文描述的是粘合聚合物组合物和使用该组合物的方法。组合物附着在所施加的表面上。在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特征。例如，特定的大分子单体可用于所施用组合物的靶向生物再吸收速率和/或降解速率。

3. 发明申请

WO2011156590A4 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 审中-公开
标题翻译：抗微生物，抗血栓形成组合物
公开(公告)号：WO2011156590A4
公开(公告)日：2012-07-05
申请号：PCT/US2011039792
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/14 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附。

4. 发明申请

WO2011156589A4 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 审中-公开
标题翻译：非污染，抗微生物，抗血栓形成的移植物从组合物
公开(公告)号：WO2011156589A4
公开(公告)日：2012-06-28
申请号：PCT/US2011039790
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L29/08 , A61L29/02 , A61L29/04 , A61L29/14 , A61L29/16
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37 C in 70 µg/mL fibrinogen derived from human plasma containing 1.4 µg/mL I-125 radiolabeled fibrinogen.
摘要翻译：用于制备和生成的制品的方法包括具有表面，表面下的块体和基体表面上的接枝聚合物层的基材，基材表面和接枝聚合物层组合构成改性表面，所述改性表面具有在纤维蛋白原结合试验中纤维蛋白原吸附小于约125ng / cm 2，其中修饰的表面在37℃下在70μg/ mL源自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

5. 发明申请

WO2011156603A3 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开
标题翻译：具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039806
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层

6. 发明申请

WO2011156603A2 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开
标题翻译：具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A2
公开(公告)日：2011-12-15
申请号：PCT/US2011039806
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层

7. 发明申请

WO2011156589A3 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 审中-公开
标题翻译：非反应性，抗微生物，抗组氨酸衍生物
公开(公告)号：WO2011156589A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039790
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L29/08 , A61L29/02 , A61L29/04 , A61L29/14 , A61L29/16
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37 C in 70 µg/mL fibrinogen derived from human plasma containing 1.4 µg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中，纤维蛋白原吸附小于约125ng / cm 2，其中将修饰的表面在37℃下在来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的70μg/ mL纤维蛋白原中温育60分钟。

8. 发明申请

WO2011156590A2 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 审中-公开
标题翻译：抗微生物，抗血栓形成组合物
公开(公告)号：WO2011156590A2
公开(公告)日：2011-12-15
申请号：PCT/US2011039792
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/14 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式