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1. 发明申请

WO03102538A2 COMBINATORIAL CHEMICAL LIBRARY II 审中-公开
标题翻译：组合化学图书馆二
公开(公告)号：WO03102538A2
公开(公告)日：2003-12-11
申请号：PCT/US0316898
申请日：2003-05-30
申请人： EUROPEAN MOLECULAR BIOLOGY LAB EMBL , WILLIAMS KATHLEEN M , SERRANO LUIS , GONZALES CAYETANO , BEJARANO LUIS
发明人： SERRANO LUIS , GONZALES CAYETANO , BEJARANO LUIS
IPC分类号： A61K38/00 , C07K1/04 , C07K7/64 , G01N
CPC分类号： C07K7/64 , A61K38/00 , C07K1/047
摘要： A chemical library comprising two or more different cyclic peptide mimetic compounds each independently having a structure represented by the following formula is disclosed. Individual compounds from which the library is comprised are also disclosed. The chemical library is useful in screening of pharmaceutically active compounds, in particular antibacterial compounds.
摘要翻译：公开了包含两个或多个不同的环肽模拟化合物的化学文库，其各自独立地具有由下式表示的结构。还公开了包含文库的单个化合物。化学文库可用于筛选药物活性化合物，特别是抗菌化合物。

2. 发明申请

WO2004006854A3 METHOD FOR IDENTIFICATION OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：用于鉴定生物活性剂的方法
公开(公告)号：WO2004006854A3
公开(公告)日：2004-10-14
申请号：PCT/US0322033
申请日：2003-07-14
申请人： BAYLOR COLLEGE MEDICINE , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , ENVIVO PHARMACEUTICALS INC , BOTAS JUAN , GONZALES CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FALT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
发明人： BOTAS JUAN , GONZALES CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FALT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
IPC分类号： A61K20060101 , A61K49/00 , C12Q1/00 , C12Q1/68 , G06K9/00 , G06T7/00 , G06T7/20
CPC分类号： G06T7/20 , G06T7/0012 , G06T2207/30004
摘要： The present invention provides a method for screening for the effect of a test on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.
摘要翻译：本发明提供了一种用于筛选测试对生物标本群体（优选昆虫）的影响的方法，其包括以下步骤：提供一组标本，向群体施用至少一种测试试剂，产生显示测量人员的运动，测量人员的至少一个特征，由测试人员的影响。本发明还提供了制备用于治疗哺乳动物疾病的药物的方法。

3. 发明申请

WO2012085891A2 TNF FAMILY LIGAND VARIANTS 审中-公开
标题翻译：肿瘤坏死因子家族配体变异
公开(公告)号：WO2012085891A2
公开(公告)日：2012-06-28
申请号：PCT/IB2011055937
申请日：2011-12-23
申请人： UNIV GRONINGEN , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , FUNDACIO PRIVADA CT DE REGULACIO GENOMICA , INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ICREA , QUAX WILHELMUS JOHANNES , TUR VICENTE R , SERRANO LUIS , VAN DER SLOOT ALBERT MARTINUS , COOL ROBBERT H , ASSEN AART H G VAN
发明人： QUAX WILHELMUS JOHANNES , TUR VICENTE R , SERRANO LUIS , VAN DER SLOOT ALBERT MARTINUS , COOL ROBBERT H , ASSEN AART H G VAN
IPC分类号： C07K14/435 , C07K14/00
CPC分类号： C07K14/525 , C07K14/435
摘要： The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.
摘要翻译：本发明涉及已经在配体三聚界面突变的TNF家族配体的变体，使得它们不能组装成三聚体，并且组装成二聚体或保持为单体。这种配体结合TNF受体但不能活化它，有效地起到竞争性抑制剂的作用。本发明还涉及编码TNF家族配体的变体的核酸，包含该核酸的载体和宿主细胞以及用于治疗与通过TNF受体的异常信号传导相关的疾病的方法。

4. 发明申请

WO2004006985A3 ASSAYING AND IMAGING SYSTEM IDENTIFYING TRAITS OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：测试和成像系统识别生物样本的性状
公开(公告)号：WO2004006985A3
公开(公告)日：2004-04-08
申请号：PCT/US0321784
申请日：2003-07-14
申请人： BAYLOR COLLEGE MEDICINE , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , ENVIVO PHARMACEUTICALS INC , BOTAS JUAN , GONZALEZ CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FAELDT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
发明人： BOTAS JUAN , GONZALEZ CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FAELDT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
IPC分类号： A61B5/00 , A61M20060101 , C12Q1/68 , G01N31/00 , G01N33/48 , G01N33/483 , G01N33/50 , G06F20060101 , G06F1/00 , G06F3/00 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/20
CPC分类号： G06T7/20 , G06T7/0012 , Y02A90/24 , Y02A90/26
摘要： A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.
摘要翻译：提供了用于分析样本的系统方法。结合这样的系统或方法，在给定采样周期的不同对应时间点获得多个视场的多像素目标图像。使用多组目标图像获得背景图像。对于一系列时间点，将背景图像从目标图像中移除以产生相应的背景去除目标图像。使用至少一部分相应的背景去除的目标图像来执行分析以识别样本的可见特征。提供一个固定结构来固定一组离散的标本容器。提供定位机构来定位多个容器子集，以将运动样本放置在容器的多个子集内，位于照相机的视场内。

5. 发明申请

WO0073460A2 MODIFIED CYTOKINE 审中-公开
标题翻译：改良的细胞因子
公开(公告)号：WO0073460A2
公开(公告)日：2000-12-07
申请号：PCT/IB0000769
申请日：2000-05-23
申请人： EUROPEAN MOLECULAR BIOLOGY LAB EMBL , BAYER AG , DOMINGUES HELENA , OSCHKINAT HARTMUT , SERRANO LUIS , PETERS JOERG
发明人： DOMINGUES HELENA , OSCHKINAT HARTMUT , SERRANO LUIS , PETERS JOERG
IPC分类号： A01K67/027 , A61K38/00 , A61P37/08 , C07K14/54 , C12N15/09 , C12N15/24 , C12P21/02 , A61K38/20 , C07K1/22 , C07K14/715 , G01N33/68
CPC分类号： C07K14/5406 , A01K2217/05 , A61K38/00
摘要： The invention relates to methods for the stabilisation of cytokines and to cytokines generated by such methods. The methods of the invention involve mutating the amino acid sequence of a cytokine so as to remove solvent-exposed hydrophobic residues, and/or mutating the amino acid sequence of the cytokine so as to stabilise one or more secondary structure elements in the molecule. These steps have the effect of destabilising intermediates that are formed during the folding process, relative to the stability of the cytokine in its naturally folded state, so increasing the yield of the cytokine as produced in vitro .
摘要翻译：本发明涉及稳定细胞因子和通过这些方法产生的细胞因子的方法。本发明的方法包括突变细胞因子的氨基酸序列，以除去溶剂暴露的疏水残基，和/或突变细胞因子的氨基酸序列，以稳定分子中一个或多个二级结构元件。这些步骤具有相对于细胞因子在其天然折叠状态下的稳定性而在折叠过程中形成的中间体不稳定的作用，因此提高了在体外产生的细胞因子的产量。

6. 发明申请

WO2005056596B1 IMPROVED CYTOKINE DESIGN 审中-公开
标题翻译：改善细胞因子设计
公开(公告)号：WO2005056596B1
公开(公告)日：2005-10-27
申请号：PCT/IB2004004335
申请日：2004-12-06
申请人： UNIV GRONINGEN , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , NAT UNIV IRELAND , TUR VICENTE R , VAN DER SLOOT ALBERT MARTINUS , MULLALLY MARGARET M , COOL ROBERT H , SZEGEZDI EVA E , SAMALI AFSHIN , FERNANDEZ-BALLESTER GREGORIO , SERRANO LUIS , QUAX WILHELMUS J
发明人： TUR VICENTE R , VAN DER SLOOT ALBERT MARTINUS , MULLALLY MARGARET M , COOL ROBERT H , SZEGEZDI EVA E , SAMALI AFSHIN , FERNANDEZ-BALLESTER GREGORIO , SERRANO LUIS , QUAX WILHELMUS J
IPC分类号： C07K14/705 , G06F19/16 , G06F19/22 , G06F19/00
CPC分类号： G06F19/16 , C07K14/70575 , G06F19/22
摘要： The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
摘要翻译：本发明涉及设计蛋白质，特别是细胞因子的新方法。这些方法允许稳定这些细胞因子，以及修饰它们的同源受体的选择性/特异性。本发明还涉及通过本发明的方法设计的各种改性蛋白质。

7. 发明申请

WO2004008279A3 COMPUTER USER INTERFACE FACILITATING ACQUIRING AND ANALYZING OF BIOLOGICAL SPECIMEN TRAITS 审中-公开
标题翻译：计算机用户界面促进生物样本获取和分析
公开(公告)号：WO2004008279A3
公开(公告)日：2005-10-13
申请号：PCT/US0321731
申请日：2003-07-14
申请人： BAYLOR COLLEGE MEDICINE , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , ENVIVO PHARMACEUTICALS INC , BOTAS JUAN , GONZALEZ CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FALT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
发明人： BOTAS JUAN , GONZALEZ CAYETANO , SERRANO LUIS , ZOGHBI HUDA Y , FALT EDWARD , CUMMINGS CHRISTOPHER J , BOULIN CHRISTIAN
IPC分类号： A61B5/00 , A61M20060101 , C12Q1/68 , G01N31/00 , G01N33/48 , G01N33/483 , G01N33/50 , G06F20060101 , G06F1/00 , G06F3/00 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/20
CPC分类号： G06T7/20 , G06T7/0012 , Y02A90/24 , Y02A90/26
摘要： Tools are provided for obtaining and assessing data concerning the physical or behavioral traits of a biological specimen population for the purpose of identifying, treating, or gathering intelligence on the condition of the specimen population. In one aspect, a computer system is provided to assess a condition of a biological specimen by studying the physical traits of a sample that comprises a number of specimens. The condition may comprise a human central nervous system condition. A user interface is provided that comprises a computer screen, an input interface portion, and a processing mechanism. The user interface may further comprise a specimen information input mechanism. The specimen information input mechanism may comprise a specimen type input that allows the user to specify, through the computer screen input, the type of specimen to be studied.
摘要翻译：提供工具用于获取和评估有关生物样本人群的物理或行为特征的数据，以便在标本人群的状况下识别，处理或收集情报。一方面，提供一种计算机系统，用于通过研究包含多个样本的样品的物理性状来评估生物样品的状况。该病症可能包括人类中枢神经系统疾病。提供了一种包括计算机屏幕，输入接口部分和处理机构的用户界面。用户界面还可以包括标本信息输入机构。样本信息输入机构可以包括样本类型输入，其允许用户通过计算机屏幕输入来指定要研究的样本的类型。

8. 发明申请

WO0116810A3 A COMPUTER-BASED METHOD FOR MACROMOLECULAR ENGINEERING AND DESIGN 审中-公开
标题翻译：一种用于大分子工程和设计的基于计算机的方法
公开(公告)号：WO0116810A3
公开(公告)日：2002-05-02
申请号：PCT/EP0008504
申请日：2000-08-31
申请人： EUROPEAN MOLECULAR BIOLOGY LAB EMBL , LACROIX EMMANUEL , SERRANO LUIS
发明人： LACROIX EMMANUEL , SERRANO LUIS
IPC分类号： C07K1/00 , G06F17/50
CPC分类号： C07K1/00 , G06F19/16
摘要： The present invention relates to a system and method for engineering and designing a macromolecule. An experimentally determined or de novo atomic structure that corresponds to the macromolecule is identified. The atomic structure is composed of building blocks. When the macromolecule is a peptide or a protein, the building blocks are amino acid residues. A target subset of the building blocks in the atomic structure to be optimized is identified. The coordinates of those building blocks that are not in the target subset are fixed. For each building block in the target subset, a large number of potential conformers is sampled. Each conformer to be sampled is substituted into the atomic structure and tested against an energy function that includes the equivalent energy of the conformer in a reference state and comprises at least one entropic term. Combinations of conformers that best satisfy an interaction energy function are identified.
摘要翻译：本发明涉及一种用于工程设计大分子的系统和方法。确定对应于大分子的实验确定的或从未确定的原子结构。原子结构由构建块组成。当大分子是肽或蛋白质时，构建单元是氨基酸残基。识别要优化的原子结构中的构建块的目标子集。不在目标子集中的构件块的坐标是固定的。对于目标子集中的每个构建块，对大量潜在构象进行采样。要采样的每个构象异构体被替换为原子结构，并针对包括构象异构体在参考状态中的等效能量的能量函数进行测试，并且包括至少一个熵项。确定最能满足相互作用能量函数的构象异构体的组合。

9. 发明申请

WO2009077857A2 TRAIL VARIANTS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的TRAIL变量
公开(公告)号：WO2009077857A2
公开(公告)日：2009-06-25
申请号：PCT/IB2008003720
申请日：2008-12-17
申请人： FUNDACIO PRIVADA CT DE REGULAC , ICREA , NAT UNIV IRELAND , UNI MEDISCH CT GRONINGEN , UNIV GRONINGEN , SAMALI AFSHIN , SZEGEZDI EVA , MAHALINGHAM DEVALINHAM , DE VRIES EMMA GEERTRUIDA ELISABETH , DUIKER EVELIEN WILMA , DE JONG STEVEN , RODRIGUES DOS REIS CARLOS RICARDO , DE RUIJTER MARIEKE , COOL ROBBERT HANS , QUAX WILHELMUS JOHANNES , VAN DER SLOOT ALBERT MARTINUS , SERRANO LUIS
发明人： SAMALI AFSHIN , SZEGEZDI EVA , MAHALINGHAM DEVALINHAM , DE VRIES EMMA GEERTRUIDA ELISABETH , DUIKER EVELIEN WILMA , DE JONG STEVEN , RODRIGUES DOS REIS CARLOS RICARDO , DE RUIJTER MARIEKE , COOL ROBBERT HANS , QUAX WILHELMUS JOHANNES , VAN DER SLOOT ALBERT MARTINUS , SERRANO LUIS
CPC分类号： C07K14/70575 , A61K9/0019 , A61K33/24 , A61K38/191 , A61K2300/00
摘要： The present invention relates to the use of a mutant TRAIL protein to treat various cancers in mammals. The invention provides a variant TRAIL protein, which has superior selectivity for the death receptor 5, for treating a mammal diagnosed with cancer.
摘要翻译：本发明涉及使用突变型TRAIL蛋白来治疗哺乳动物中的各种癌症。本发明提供了一种对死亡受体5具有优异选择性的变体TRAIL蛋白，用于治疗诊断为癌症的哺乳动物。

10. 发明申请

WO9925732A3 DESIGN OF COILED-COIL DIMER DERIVED ANTAGONISTS OF 4-HELIX BUNDLE CYTOKINE SPECIFIC RECEPTORS 审中-公开
标题翻译： 4螺旋组织细胞因子特异性受体的线圈二极体衍生拮抗剂的设计
公开(公告)号：WO9925732A3
公开(公告)日：1999-09-02
申请号：PCT/EP9807286
申请日：1998-11-13
申请人： EUROP LAB MOLEKULARBIOLOG , DOMINGUES HELENA , CREGUT DAVID , SEBALD WALTER , OSCHKINAT HARTMUT , SERRANO LUIS
发明人： DOMINGUES HELENA , CREGUT DAVID , SEBALD WALTER , OSCHKINAT HARTMUT , SERRANO LUIS
IPC分类号： A61K38/00 , A61K38/20 , C07K14/395 , C07K14/54
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/395 , C07K2319/00 , Y10S514/826 , Y10S514/885
摘要： The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.
摘要翻译：公开了4螺旋束细胞因子特异性受体的拮抗剂的设计，能够作为这种拮抗剂的模拟肽及其作为药剂的用途。

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