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1. 发明申请

WO2018112203A1 ELECTROSPUN STENTS, FLOW DIVERTERS, AND OCCLUSION DEVICES AND METHODS OF MAKING THE SAME 审中-公开
公开(公告)号：WO2018112203A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066421
申请日：2017-12-14
申请人： ELUM TECHNOLOGIES, INC. , NANOFIBER SOLUTIONS, INC.
发明人： KRESSLEIN, McKenzie Jacob , BORJA, Brandon Javier , JOHNSON, Jed , GROEHL, Tyler Matthew , OHST, Devan , TRAN, Quang Quoc , NELSON, Kevin J.
IPC分类号： A61B17/12 , A61F2/82 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/00 , A61L27/34 , A61L27/28 , A61L27/14 , A61L31/10 , A61L31/04
CPC分类号： A61F2/90 , A61B17/12109 , A61B17/12113 , A61B17/12172 , A61B17/12177 , A61B2017/00004 , A61B2017/00526 , A61F2/06 , A61L31/022 , A61L31/041 , A61L31/08 , A61L31/14 , A61L31/146 , A61L31/148 , A61L2430/36 , D01D5/003 , D01D5/0038 , D01D5/0076 , D01D5/0084
摘要： The instant disclosure is directed to medical devices having a lattice framework. The lattice framework may comprise a plurality of interconnected polymeric electrospun fiber members, or may comprise one or more wires formed into a plurality of interconnected members. The lattice framework may be substantially tubular, or may have a bowtie or cone configuration. The medical devices described herein may find particular uses as stents, flow diverters, and occlusive devices. The instant disclosure is also directed to methods of making such medical devices, using electrospinning and processing techniques.

2. 发明申请

WO2017024263A1 KINK-RESISTANT ELECTROSPUN FIBER MOLDS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：抗振动电极纤维模具及其制造方法
公开(公告)号：WO2017024263A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045875
申请日：2016-08-05
申请人： NANOFIBER SOLUTIONS, INC.
发明人： JOHNSON, Jed , GROEHL, Tyler
IPC分类号： D01D5/253 , A61F2/82 , A61L27/14 , D04H1/728
CPC分类号： D01D5/0076 , A61F2/04 , A61F2/06 , A61L27/14 , D04H1/728
摘要： A mandrel for forming a mold may comprise a rod having an outer surface, and a spiral component disposed around the outer surface of the rod, wherein the mandrel may be configured to receive an electrospun fiber. A method of making a kink-resistant electrospun fiber mold may comprise configuring such a mandrel to receive an electrospun fiber, applying a charge to one or more of the rod, the spiral component, and a polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the mandrel. A mold formed from such a method may comprise an inner wall extending axially, and an outer wall adjacent to the inner wall, having a plurality of axially adjacent, outwardly extending peaks separated by a plurality of valleys.
摘要翻译：用于形成模具的心轴可以包括具有外表面的杆和围绕杆的外表面设置的螺旋部件，其中心轴可以被配置为接收电纺纤维。制造耐扭结电纺纤维模具的方法可以包括配置这样的心轴以接收静电纺纤维，向棒，螺旋部件和聚合物注射系统中的一个或多个施加电荷，并且沉积聚合物溶液从聚合物注射系统到心轴。由这种方法形成的模具可以包括轴向延伸的内壁和与内壁相邻的外壁，具有由多个谷分开的多个轴向相邻的向外延伸的多个峰。

3. 发明申请

WO2017079328A1 ELECTROSPUN FIBERS HAVING CONTRAST AGENTS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：具有造影剂的电纺丝纤维及其制造方法
公开(公告)号：WO2017079328A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060157
申请日：2016-11-02
申请人： NANOFIBER SOLUTIONS, INC.
发明人： JOHNSON, Jed , OHST, Devan , CHAKROFF, Jason
IPC分类号： A61L27/14 , A61L27/38
CPC分类号： A61K47/34 , A61K49/0002 , A61K49/0409 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/58 , D01D5/0038 , D01F1/09 , D01F1/10 , C08L67/04
摘要： A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.
摘要翻译：纤维可以包含电纺聚合物和造影剂。制造电纺丝纤维的方法可包括配置接收表面以接收聚合物纤维，将电荷施加到接收表面，聚合物注射系统和从聚合物注入系统喷射的聚合物溶液中的一个或多个，并沉积聚合物溶液从聚合物注射系统喷射到接收表面上。聚合物溶液可以包含聚合物和造影剂。

4. 发明申请

WO2016176559A1 MULTI-COMPONENT ELECTROSPUN FIBER SCAFFOLDS 审中-公开
标题翻译：多组分电纺纤维SCAFFOLDS
公开(公告)号：WO2016176559A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030058
申请日：2016-04-29
申请人： NANOFIBER SOLUTIONS, INC.
发明人： JOHNSON, Jed
IPC分类号： A61L27/14 , A61L27/38
CPC分类号： D04H1/728 , A61L15/40 , A61L15/64 , A61L27/38 , A61L27/48 , A61L27/58 , D04H1/4266 , D04H1/435
摘要： A scaffold may comprise a first polymeric electrospun fiber comprising a first material having a first degradation rate, and a second polymeric electrospun fiber comprising a second material having a second degradation rate different from the first degradation rate. The first degradation rate may substantially correspond to a cell infiltration rate, and the second degradation rate may be slower than the first degradation rate. Such a scaffold may be manufactured by electrospinning a first polymer fiber having a first degradation rate by ejecting a first polymer solution from a first polymer injection system onto a mandrel, and electrospinning a second polymer fiber having a second degradation rate different from the first degradation rate by ejecting a second polymer solution from a second polymer injection system onto a mandrel. Wound healing may be improved by applying such a scaffold to a portion of a wound.
摘要翻译：支架可以包括包含具有第一降解速率的第一材料的第一聚合电纺丝纤维和包含具有与第一降解速率不同的第二降解速率的第二材料的第二聚合物电纺丝纤维。第一降解速率可以基本上对应于细胞浸润速率，并且第二降解速率可能比第一降解速率慢。可以通过将第一聚合物溶液从第一聚合物注射系统喷射到心轴上，通过静电纺丝具有第一降解速率的第一聚合物纤维来制造，并且静电纺丝具有与第一降解速率不同的第二降解速率的第二聚合物纤维通过将第二聚合物溶液从第二聚合物注射系统喷射到心轴上。通过将这样的支架应用于伤口的一部分可以改善伤口愈合。

5. 发明申请

WO2015153011A1 ELECTROSPUN BIOCOMPATIBLE FIBER COMPOSITIONS 审中-公开
标题翻译：电极生物成分纤维组合物
公开(公告)号：WO2015153011A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/016973
申请日：2015-02-20
申请人： NANOFIBER SOLUTIONS, INC.
发明人： JOHNSON, Jed , KAYUHA, Ross
IPC分类号： A61L17/08
CPC分类号： A61L17/005 , A61B17/12022 , A61B17/12186 , A61B2017/00526 , A61F2/0063 , A61F2/04 , A61F2002/046 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2400/12 , D01D5/0007 , D01D5/0023 , D01D11/00 , D01F11/00 , D04C1/02 , D04C1/12
摘要： A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber. Also disclosed is a method for making a biocompatible suture, comprising electrospinning a polymer solution onto a receiving surface, forming one or more non-overlapping nanofiber threads, removing the nanofiber threads from the receiving surface, and cutting the nanofiber threads into one or more biocompatible sutures.
摘要翻译：公开了一种组合物，其包含多个包含至少一种聚合物的电纺纤维片段，多个包含至少一种聚合物的电纺丝纤维片段和任选的载体介质。还公开了一种试剂盒，其包含多个电纺纤维碎片的第一组分和载体介质的第二组分。还公开了包含多个微粉化电纺纤维片段，载体介质和任选的多个细胞的组合物。还公开了包含多个微粉化电纺纤维片段的生物相容性织物。还公开了包含至少一种电纺纤维的生物相容性缝合线。还公开了一种制备生物相容性缝合线的方法，其包括将聚合物溶液电纺丝到接收表面上，形成一个或多个非重叠的纳米纤维线，从接收表面去除纳米纤维线，以及将纳米纤维线切割成一个或多个生物相容性缝线。

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