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1. 发明申请

WO2018112024A1 THIOLATED AROMATIC BLOCKING STRUCTURES FOR EAB BIOSENSORS 审中-公开
公开(公告)号：WO2018112024A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066069
申请日：2017-12-13
申请人： ECCRINE SYSTEMS, INC.
发明人： BERTRAND, Jacob, A. , HANLEY, Brian , SAFAZADEH HAGHIGHI, Leila , BROTHERS, Michael
IPC分类号： G01N33/543 , C12N15/115 , H01L23/532
摘要： The present invention provides self-assembled monolayers (SAM) configured for use with electrochemical aptamer-based biosensors, which allow sensing devices to detect very low concentrations of target analytes in a biofluid sample. Embodiments of the disclosed invention include SAMs with improved long-term stability in sweat through persistent thiolate bonds between the sensor electrode and disclosed blocker groups, or between the sensor electrode and aptamer sensing elements via disclosed binder molecules. Embodiments of the invention also include blocker groups configured to form densely packed and persistent SAMs on sensor electrodes.

2. 发明申请

WO2017070640A1 DEVICES CAPABLE OF SAMPLE CONCENTRATION FOR EXTENDED SENSING OF SWEAT ANALYTES 审中-公开
标题翻译：可用于样品浓度的设备用于扩展SWEAT分析的检测
公开(公告)号：WO2017070640A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058356
申请日：2016-10-23
申请人： ECCRINE SYSTEMS, INC. , UNIVERSITY OF CINCINNATI
发明人： HEIKENFELD, Jason , BERTRAND, Jacob, A. , BROTHERS, Michael , JAJACK, Andrew
IPC分类号： A61B5/00 , A61B5/05 , A61B5/053 , A61B10/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4266 , A61B5/0002 , A61B5/14517 , A61B5/14521 , A61B5/14546 , A61B5/1468 , A61B5/6833 , A61B10/0012 , A61B10/0064 , A61B2010/0016 , G01N33/50
摘要： The disclosed invention provides a sweat sensing device and method capable of collecting a sweat sample, concentrating the sample with respect to a target analyte, and measuring the target analyte in the concentrated sample. The invention is also capable of determining the change in molarity of the sweat sample with respect to the target analyte, as the sample is concentrated by the device.
摘要翻译：所公开的发明提供了能够收集汗液样品，相对于目标分析物浓缩样品并测量浓缩样品中的目标分析物的汗液感测装置和方法。当样品被装置浓缩时，本发明还能够测定汗样品相对于目标分析物的摩尔浓度的变化。

3. 发明申请

WO2019143923A1 SALINITY-STABILIZED EAB BIOSENSORS 审中-公开
公开(公告)号：WO2019143923A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/014175
申请日：2019-01-18
申请人： ECCRINE SYSTEMS, INC.
发明人： BERTRAND, Jacob, A. , HANLEY, Brian , BROTHERS, Michael
IPC分类号： C23C16/00 , G01N21/75
摘要： Embodiments of the disclosed invention provide devices that mitigate salinity-based EAB sensor output variability by improving aptamer structural rigidity or sensing performance through the pretreatment of aptamers with ions or buffering molecules. Other embodiments provide devices that mitigate salinity- based EAB sensor output variability through the pretreatment of additional device components with ions or buffering molecules thereby reducing ion uptake from, or output to, a biofluid sample.

4. 发明申请

WO2018067521A1 BIOSENSORS WITH PH-INDEPENDENT REDOX MOIETIES 审中-公开
标题翻译：具有PH独立的氧化还原时间的生物传感器
公开(公告)号：WO2018067521A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/054875
申请日：2017-10-03
申请人： ECCRINE SYSTEMS, INC.
发明人： BERTRAND, Jacob, A. , HANLEY, Brian , BROTHERS, Michael
IPC分类号： G01N27/26 , C12Q1/68 , A61B5/05 , A61B5/1468
摘要： An electrochemical sensor is provided for use in a wearable device for measuring analytes in a pH- variable biofluid. The sensor includes a plurality of aptamer sensing elements which have biorecognition elements, such as aptamers, that experience a conformational change on interaction with a target analyte in the biofluid. Each aptamer sensing element forms a first configuration before target analyte capture and a second configuration after target analyte capture. A redox moiety is paired with each aptamer sensing element. The redox moiety has a reaction potential that is at least partially independent of a pH value of the biofluid. The EAB sensor further includes an electrode operative in conjunction with the plurality of aptamer sensing elements to produce a variable signal depending upon the configuration of the aptamer sensing elements.
摘要翻译：提供电化学传感器用于可穿戴设备中，用于测量pH可变生物流体中的分析物。该传感器包括多个适体感应元件，其具有生物识别元件，例如适体，其经历与生物流体中的目标分析物相互作用时的构象变化。每个适体传感元件在目标分析物捕获之前形成第一配置并且在捕获目标分析物之后形成第二配置。氧化还原部分与每个适体感应元件配对。氧化还原部分具有至少部分独立于生物流体的pH值的反应电位。 EAB传感器还包括与多个适体感应元件一起操作的电极，以根据适体感应元件的配置产生可变信号。

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