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    • 5. 发明申请
    • SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND TEMPURATURE MEASUREMENT
    • 纳米颗粒用于成像和温度测量的系统和方法
    • WO2009008956A3
    • 2009-07-23
    • PCT/US2008007626
    • 2008-06-19
    • MARY HITCHCOCK MEMORIAL HOSPITWEAVER JOHN BBAKER IANHANSEN ERIC W
    • WEAVER JOHN BBAKER IANHANSEN ERIC W
    • A61B5/05
    • A61B5/05A61B5/0515B82Y25/00H01F1/0045
    • This invention provides a system and method that improves the sensitivity and localization capabilities of Magnetic Particle Imaging (MPI) by using combinations of time- varying and static magnetic fields. Combinations of magnetic fields can be used to distribute the signals coming from the magnetic particles among the harmonics and other frequencies in specific ways to improve sensitivity and to provide localization information to speed up or improve the signal-to-noise ratio (SNR) of imaging and/or eliminate the need for saturation fields currently used in MPI. In various embodiments, coils can be provided to extend the sub-saturation region in which nanoparticles reside; to provide a static field offset to bring nanoparticles nearer to saturation; to introduce even and odd harmonics that can be observed; and/or to introduce combinations of frequencies for more-defined observation of signals from nanoparticles. Further embodiments provide for reading of the signal produced by cyclically saturated magnetic nanoparticles in a sample so as to provide a measurement of the temperature of those nanoparticles. The spectral distribution of the signal generated provides estimates of the temperature of the nanoparticles. Related factors may also be estimated - binding energies of the nanoparticles, phase changes, bound fraction of the particles or stiffness of the materials in which the nanoparticles are imbedded.
    • 本发明提供了一种通过使用时变磁场和静磁场的组合来提高磁性粒子成像(MPI)的灵敏度和定位能力的系统和方法。 可以使用磁场组合来以特定方式分配来自谐波和其他频率之中的磁性粒子的信号以提高灵敏度并提供定位信息以加速或改善成像的信噪比(SNR) 和/或消除目前在MPI中使用的饱和场的需要。 在各种实施例中,可提供线圈以延伸纳米颗粒所在的亚饱和区; 以提供静态场偏移以使纳米粒子更接近饱和; 引入可观察到的偶数和奇数谐波; 和/或引入频率的组合以用于来自纳米粒子的信号的更加定义的观察。 进一步的实施方式提供了由样品中的循环饱和磁性纳米颗粒产生的信号的读取,以提供这些纳米颗粒的温度的测量。 产生的信号的光谱分布提供了纳米颗粒温度的估计。 还可以估计相关因素 - 纳米颗粒的结合能,相变,颗粒的结合部分或纳米颗粒所嵌入的材料的硬度。