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1. 发明申请

WO2009037264A3 COLONIC DELIVERY OF ANTIMICROBIAL AGENTS 审中-公开
标题翻译：抗菌药物的殖民地交付
公开(公告)号：WO2009037264A3
公开(公告)日：2009-10-29
申请号：PCT/EP2008062317
申请日：2008-09-16
申请人： DA VOLTERRA , ANDREMONT ANTOINE , DE GUNZBURG JEAN
发明人： ANDREMONT ANTOINE , DE GUNZBURG JEAN
IPC分类号： A61K38/00 , A61K9/14 , A61K9/50 , A61K38/43 , A61K39/00 , A61P1/00 , A61P31/00
CPC分类号： A61K9/1652 , A61K9/2846 , A61K9/5026 , A61K9/5073 , A61K31/7036 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： Antimicrobial compositions for oral delivery, and administration to the colon, distal ileum, or other portion of the gastrointestinal tract other than the stomach, of bacteriophage, phage proteins, antimicrobial peptides, or antimicrobial aptamers, are disclosed. In one embodiment, the active agent is capable of lysing the bacterial cell wall. In another embodiment, the active agent is capable of interacting with a receptor or enzyme in the bacteria. In some embodiments, the active agents selectively act on one or more harmful bacteria, such as Clostridium dificile, and either do not act, or act to a lesser extent, on helpful bacteria, such as bifidobacteria. When the agents are not delivered directly to the colon, they active agents ultimately enter the colon and affect the bacteria that are present in the colon. The compositions can include beads of pectin in the form of a cationic salt enclosing the active agent, or other types of drug delivery systems designed for targeted delivery to the desired portion of the gastrointestinal tract.
摘要翻译：公开了用于口服递送的抗微生物组合物，以及对结肠，回肠末端或除了胃之外的胃肠道的其它部分，噬菌体，噬菌体蛋白，抗微生物肽或抗微生物适体体的给药。在一个实施方案中，活性剂能够裂解细菌细胞壁。在另一个实施方案中，活性剂能够与细菌中的受体或酶相互作用。在一些实施方案中，活性剂选择性地作用于一种或多种有害细菌，例如梭菌（Clostridium dificile），并且不会对有用的细菌例如双歧杆菌起作用或在较小程度上起作用。当试剂不直接递送到结肠时，它们的活性剂最终进入结肠并影响结肠中存在的细菌。组合物可以包括呈封闭活性剂的阳离子盐形式的果胶珠或设计用于靶向递送至胃肠道所需部分的其它类型的药物递送系统。

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