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1. 发明申请

WO1996027021A1 INTERDEPENDENT ADENOVIRAL VECTORS AND METHODS OF USING SAME 审中-公开
标题翻译：相关的ADENOVIRAL VECTORS及其使用方法
公开(公告)号：WO1996027021A1
公开(公告)日：1996-09-06
申请号：PCT/US1996002488
申请日：1996-02-22
申请人： CORNELL RESEARCH FOUNDATION, INC. , GENVEC, INC.
发明人： CORNELL RESEARCH FOUNDATION, INC. , GENVEC, INC. , HERSH, Jeff , CRYSTAL, Ronald, G. , BEWIG, Burkhard , KOVESDI, Imre
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/525 , C12N15/63 , C12N15/67 , C12N2710/10343 , C12N2830/00 , C12N2830/85
摘要： The present invention provides a method of modulating gene expression by co-infection of cells with two or more interdependent replication-deficient adenoviral vectors, in particular by introducing into a cell, in any order or simultaneously, a first replication-deficient adenoviral vector comprising a first promoter and a first nucleic acid sequence which encodes a first gene product, wherein the first promoter regulates expression of the first gene product, and (b) a second replication-deficient adenoviral vector comprising a second promoter and a second nucleic acid sequence which encodes a second gene product, wherein the second promoter regulates in cis expression of the second gene product and is regulated in trans by the first gene product, and wherein the first promoter is different from the second promoter. The present invention also provides a method of modulating gene expression to produce a gene product, e.g., protein, a method for increasing the selective targeting for gene delivery of a particular type of cells, and interdependent adenoviral vectors appropriate for use in the methods of the present invention.
摘要翻译：本发明提供了通过用两个或更多个相互依赖的复制缺陷型腺病毒载体共感染细胞来调节基因表达的方法，特别是以任何顺序或同时引入细胞，第一复制缺陷型腺病毒载体包含第一启动子和编码第一基因产物的第一核酸序列，其中第一启动子调节第一基因产物的表达，和（b）第二复制缺陷型腺病毒载体，其包含第二启动子和第二核酸序列，其编码第二基因产物，其中第二启动子以第二基因产物的顺式表达调节，并被第一基因产物反转，并且其中第一启动子不同于第二启动子。本发明还提供了调节基因表达以产生基因产物的方法，例如蛋白质，增加特定类型细胞的基因递送的选择性靶向的方法，以及适用于所述方法的相互依赖的腺病毒载体本发明。

2. 发明申请

WO2003091271A1 ALTERNATIVELY SPLICED NUCLEIC ACID MOLECULES 审中-公开
标题翻译：交替分离的核酸分子
公开(公告)号：WO2003091271A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012709
申请日：2003-04-24
申请人： CORNELL RESEARCH FOUNDATION, INC. , CRYSTAL, Ronald, G. , HACKETT, Neil, R.
发明人： CRYSTAL, Ronald, G. , HACKETT, Neil, R.
IPC分类号： C07H21/04
CPC分类号： C07K14/52
摘要： The invention provides an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence of at least 1877 contiguous nucleotides of (a) SEQ ID NO: 1 or (b) a nucleotide sequence encoding an angiogenic factor, wherein the nucleotide sequence comprises cDNA comprising exons 1-5 of a vascular endothelial growth factor (VEGF) joined to genomic DNA comprising introns 5, 6, and 7 and exons 6, 7, and 8 of VEGF and further comprising a mutation in one or more of the splice donor, branch point, and splice acceptor regions contained in an exon selected from the group consisting of exons 5, 6, 7, and 8, wherein the mutation promotes the production of one isoform of VEGF as compared to another isoform of VEGF. Expression constructs, compositions, and cells comprising such a nucleic acid molecule also are provided by the invention.
摘要翻译：本发明提供了分离或纯化的核酸分子，其基本上由（a）SEQ ID NO：1的至少1877个连续核苷酸的核苷酸序列组成，或（b）编码血管生成因子的核苷酸序列，其中所述核苷酸序列包含血管内皮生长因子（VEGF）的外显子1-5连接到包含内含子5,6和7以及VEGF的外显子6,7和8的基因组DNA上，并且还包含一个或多个剪接供体，分支包含在选自外显子5,6,7和8的外显子中的位点和剪接受体区，其中与VEGF的另一同工型相比，突变促进VEGF的一种同工型的产生。包含这种核酸分子的表达构建体，组合物和细胞也由本发明提供。

3. 发明申请

WO2008109773A2 CHRONIC OBSTRUCTIVE PULMONARY DISEASE SUSCEPTIBILITY AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：慢性阻塞性肺疾病易感性及相关成分及方法
公开(公告)号：WO2008109773A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/056091
申请日：2008-03-06
申请人： CORNELL RESEARCH FOUNDATION, INC. , CRYSTAL, Ronald, G. , HACKETT, Neil, R. , HEGUY, Adriana , HARVEY, Ben-gary , LEOPOLD, Philip, L. , TILLEY, Ann, E. , O'CONNOR, Timothy
发明人： CRYSTAL, Ronald, G. , HACKETT, Neil, R. , HEGUY, Adriana , HARVEY, Ben-gary , LEOPOLD, Philip, L. , TILLEY, Ann, E. , O'CONNOR, Timothy
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides a method of determining the likelihood that a smoker will or will not develop chronic obstructive pulmonary disease (COPD) by obtaining a sample from the smoker, analyzing the sample for the expression of a set of biomarkers associated with COPD, and comparing the expression pattern determined in the sample with a standard expression pattern to determine the likelihood that the smoker will or will not develop COPD. The invention further provides a composition, a method of treatment, and methods of determining the efficacy of treatment for COPD.
摘要翻译：本发明提供了一种通过从吸烟者获得样品来分析吸烟者将会或不会发展成慢性阻塞性肺病（COPD）的可能性的方法，分析样品与COPD相关的一组生物标志物的表达，并比较用标准表达模式在样本中确定表达模式，以确定吸烟者将或不会发展COPD的可能性。本发明还提供了一种组合物，治疗方法和确定COPD治疗功效的方法。

4. 发明申请

WO2001010315A1 GENE THERAPY PLATFORMED NEEDLE AND METHOD OF ADMINISTERING A THERAPEUTIC SOLUTION TO A HEART 审中-公开
标题翻译：基因治疗平台针和将治疗方案应用于心脏的方法
公开(公告)号：WO2001010315A1
公开(公告)日：2001-02-15
申请号：PCT/US2000/021399
申请日：2000-08-04
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： ROSENGART, Todd, K. , CRYSTAL, Ronald, G.
IPC分类号： A61B17/34
CPC分类号： A61M5/46 , A61B17/34 , A61B2017/00044 , A61B2017/00247 , A61B2017/3492 , A61B2018/00392 , A61B2090/036 , A61M5/3287
摘要： The invention provides a device for the delivery of a therapeutic solution, in particular, an angiogenesis-promoting substance into a heart. The device includes an elongated needle (10) having a stop, or platform (44), spaced from the distal needle tip (42) to limit the depth of penetration and stabilize the needle in the cardiac tissue. The elongated needle body (30) is flexible enough to maneuver around thoracic and cardiac geometry, yet sufficiently rigid to facilitate such maneuvering. This minimally invasive procedure allows for delivery of the solution "at a distance" through small incisions.
摘要翻译：本发明提供了用于将治疗溶液，特别是促进血管生成物质递送到心脏中的装置。该装置包括具有与远侧针尖（42）间隔开的止动器（或平台）（44）的细长针（10），以限制穿透深度并将针稳定在心脏组织中。细长的针体（30）具有足够的柔韧性，以围绕胸部和心脏的几何形状进行操纵，但足够刚性以便于这种操纵。这种微创手术允许通过小切口在一定距离处输送溶液。

5. 发明申请

WO1997012986A3 NON-GROUP C ADENOVIRAL VECTORS 审中-公开
公开(公告)号：WO1997012986A3
公开(公告)日：1997-04-10
申请号：PCT/US1996015274
申请日：1996-09-24
申请人： CORNELL RESEARCH FOUNDATION, INC.
发明人： CORNELL RESEARCH FOUNDATION, INC. , FALCK-PEDERSEN, Erik, S. , CRYSTAL, Ronald, G. , MASTRANGELI, Andrea , ABRAHAMSEN, Karil
IPC分类号： C12N15/86

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