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    • 6. 发明申请
    • A NOVEL PROCESS FOR THE PREPARATION OF SODIUM GAMMA-HYDROXYBUTYRATE
    • 制备羟基 - 羟基丁酸钠的新方法
    • WO2009129350A3
    • 2009-12-10
    • PCT/US2009040727
    • 2009-04-15
    • NORAC INCLEVIN DANIELLUCHI JAMES
    • LEVIN DANIELLUCHI JAMES
    • C07F1/04C07D307/04C11D1/26C11D15/02
    • C07D307/04
    • The present invention is directed to a process for the preparation of the saponification products of lactones, preferably three- to eight-membered lactones. The present invention is also directed to a process for the preparation of compounds having general formula (I): wherein M is selected from the group consisting of cationic species, preferably metal cations (even more preferably Na), from a compound having the formula (II): comprising reacting a compound having formula (II) with a suitable hydroxide salt (M-OH) (III) such as, preferably, sodium hydroxide, in an aqueous medium. The reaction preferably utilizes a continuous process method for the substantial consumption of reagent and continuous, semi-continuous, and/or batch-wise processing for final consumption of reagent.
    • 本发明涉及制备内酯,优选三至八元内酯的皂化产物的方法。 本发明还涉及制备具有通式(I)的化合物的方法:其中M选自具有式(I)的化合物的阳离子种类,优选金属阳离子(甚至更优选Na) II):包括在水性介质中使具有式(II)的化合物与合适的氢氧化物盐(M-OH)(III),例如优选氢氧化钠反应。 反应优选利用连续的方法来大量消耗试剂和连续,半连续和/或分批处理以最终消耗试剂。