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    • 1. 发明申请
      WO2002072614A3 ALGORITHMIC DESIGN OF PEPTIDES FOR BINDING AND/OR MODULATION OF THE FUNCTIONS OF RECEPTORS AND/OR OTHER PROTEINS 审中-公开
    • ALGORITHMIC DESIGN OF PEPTIDES FOR BINDING AND/OR MODULATION OF THE FUNCTIONS OF RECEPTORS AND/OR OTHER PROTEINS
    • WO2002072614A3
    • 2002-09-19
    • PCT/US2002/003914
    • 2002-01-23
    • CIELO INSTITUTE , MANDELL, Arnold, J. , SELZ, Karen, A. , SHLESINGER, Michael, F.
    • MANDELL, Arnold, J. , SELZ, Karen, A. , SHLESINGER, Michael, F.
    • G06F19/00
    • Method of designing protein-targeted peptides or peptide analogues whose sequences are derived from the target protein sequences, using target protein sequence, analytically derived templates, and relevant distributions of amino acids for weighted random assignments to those templates. The templates are derived from eigenvectors of the autocovariance matrices of the physicochemically-transformed amino acid sequence of the target proteins; wavelet subsequence templates derived from wavelet transformations of the physicochemically-transformed amino acid sequence of the target proteins; and/or non-overlapping redundant subsequent templates computed from the physicochemically-transformed target protein amino acid sequence. The protein targets include cell receptors; transporters; enzymes; chaperonins; antibodies; surface proteins of infectious agents; and any protein involved in protein-protein interactions. The peptides are designed to bind to and/or otherwise modulate the function of the target protein. Partitioned amino acid distributions for weighted random assignments to the similarly partitioned templates are derived from a variety of physiologically relevant amino acid pools or regions in the target protein sequence relevant to the construction of the templates. Sequential pattern ("mode") matches between candidate peptides and their target proteins are designed such that when examined by maximum entropy, all poles power spectral transformations and/or wavelet transformations, they yield peaks of wavenumbers that differ by 10% of the larger wavenumber value. Also provided are examples of such mode-matched peptides, as well as methods for their use in elucidating sites on proteins for drug design and testing, detection of disease conditions or contaminants, and as therapeutics for protein function modulation in disease treatment.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 2. 发明申请
      WO2002072614A2 ALGORITHMIC DESIGN OF PEPTIDES FOR BINDING AND/OR MODULATION OF THE FUNCTIONS OF RECEPTORS AND/OR OTHER PROTEINS 审中-公开
    • ALGORITHMIC DESIGN OF PEPTIDES FOR BINDING AND/OR MODULATION OF THE FUNCTIONS OF RECEPTORS AND/OR OTHER PROTEINS
    • 用于结合和/或调节受体和/或其他蛋白质功能的肽的算法设计
    • WO2002072614A2
    • 2002-09-19
    • PCT/US2002/003914
    • 2002-01-23
    • CIELO INSTITUTE , MANDELL, Arnold, J. , SELZ, Karen, A. , SHLESINGER, Michael, F.
    • MANDELL, Arnold, J. , SELZ, Karen, A. , SHLESINGER, Michael, F.
    • C07K1/00
    • G06F19/22 , C07K1/00 , C07K1/047 , C07K7/08 , C07K7/083 , C07K14/53 , C07K14/585 , G06F19/16
    • Method of designing protein-targeted peptides or peptide analogues whose sequences are derived from the target protein sequences, using target protein sequence, analytically derived templates, and relevant distributions of amino acids for weighted random assignments to those templates. The templates are derived from eigenvectors of the autocovariance matrices of the physicochemically-transformed amino acid sequence of the target proteins; wavelet subsequence templates derived from wavelet transformations of the physicochemically-transformed amino acid sequence of the target proteins; and/or non-overlapping redundant subsequent templates computed from the physicochemically-transformed target protein amino acid sequence. The protein targets include cell receptors; transporters; enzymes; chaperonins; antibodies; surface proteins of infectious agents; and any protein involved in protein-protein interactions. The peptides are designed to bind to and/or otherwise modulate the function of the target protein. Partitioned amino acid distributions for weighted random assignments to the similarly partitioned templates are derived from a variety of physiologically relevant amino acid pools or regions in the target protein sequence relevant to the construction of the templates. Sequential pattern ("mode") matches between candidate peptides and their target proteins are designed such that when examined by maximum entropy, all poles power spectral transformations and/or wavelet transformations, they yield peaks of wavenumbers that differ by 10% of the larger wavenumber value. Also provided are examples of such mode-matched peptides, as well as methods for their use in elucidating sites on proteins for drug design and testing, detection of disease conditions or contaminants, and as therapeutics for protein function modulation in disease treatment.
    • 设计蛋白质靶向肽或肽类似物的方法，其序列来源于目标蛋白质序列，使用靶蛋白质序列，分析衍生的模板以及相关氨基酸分布进行加权随机分配给这些模板。 模板衍生自目标蛋白的物理化学转化氨基酸序列的自协方差矩阵的特征向量; 衍生自靶蛋白的物理化学转化氨基酸序列的小波变换的小波子序列模板; 和/或从物理化学转化的靶蛋白氨基酸序列计算的非重叠冗余后续模板。 蛋白质靶标包括细胞受体; 运输; 酶; 分子伴侣; 抗体; 感染因子的表面蛋白; 和涉及蛋白质 - 蛋白质相互作用的任何蛋白质。 肽被设计为结合和/或以其他方式调节靶蛋白的功能。 对类似分配的模板的加权随机分配的分割氨基酸分布来自与模板构建相关的目标蛋白质序列中的多种生理相关氨基酸池或区域。 候选肽之间的序列模式（“模式”）匹配，并且它们的靶蛋白被设计成使得当通过最大熵检测时，所有极功率谱变换和/或小波变换，它们产生由 << / u> 10％的较大波数值。 还提供了这种模式匹配肽的实例，以及它们用于阐明用于药物设计和测试的蛋白质上的位点，疾病状况或污染物的检测以及疾病治疗中用于蛋白质功能调节的治疗剂的方法。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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