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1. 发明申请

WO2007076294A2 METHOD OF SCREENING THE ACTIVITY OF THE SMOOTHENED RECEPTOR TO IDENTIFY THERAPUTIC MODULATION AGENTS OR DIAGNOSE DISEASE 审中-公开
标题翻译：筛选光滑受体的活性以鉴别治疗调节剂或诊断疾病的方法
公开(公告)号：WO2007076294A2
公开(公告)日：2007-07-05
申请号：PCT/US2006062102
申请日：2006-12-14
申请人： CHEN WEI , BARAK LAWRENCE S , CARON MARC G , LEFKOWITZ ROBERT J
发明人： CHEN WEI , BARAK LAWRENCE S , CARON MARC G , LEFKOWITZ ROBERT J
CPC分类号： G01N33/5011 , G01N33/57492
摘要： The invention relates to a screening method for the Smoothened receptor for testing compositions as potential Smoothened receptor ligands, either agonist or antagonist activity, by use of an arrestin-reporter molecule conjugate. It also relates to testing cells and individuals by administering a smoothened receptor ligand-reporter molecule conjugate and observing locations where the ligand binds and then using an increased number of surface Smoothened receptors compared to a pre- established criteria as an indication of a cancerous growth or tumor.
摘要翻译：本发明涉及用于通过使用抑制蛋白 - 报道分子缀合物测试组合物作为潜在的平滑受体配体（激动剂或拮抗剂活性）的平滑受体的筛选方法。它还涉及通过施用平滑受体配体 - 报道分子缀合物并观察配体结合的位置，然后使用增加数量的表面平滑受体与作为癌症生长指征的预先建立的标准相比较来测试细胞和个体，或者瘤。

2. 发明申请

WO2009155283A3 RADIOLABLED CYCLOPAMINE ASSAY FOR THE SMOOTHENED RECEPTOR 审中-公开
标题翻译：放射性CYPOPAMINE测定用于平滑受体
公开(公告)号：WO2009155283A3
公开(公告)日：2010-03-11
申请号：PCT/US2009047497
申请日：2009-06-16
申请人： UNIV DUKE , CHEN WEI , BARAK LAWRENCE S , JIANGBO WANG , LEFKOWITZ ROBERT J , LEYRLY HERBERT KIM
发明人： CHEN WEI , BARAK LAWRENCE S , JIANGBO WANG , LEFKOWITZ ROBERT J , LEYRLY HERBERT KIM
IPC分类号： G01N33/60 , G01N33/534
CPC分类号： G01N33/566 , G01N33/60 , G01N2500/04
摘要： The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.
摘要翻译：本发明公开了筛选对平滑化受体的激动剂和拮抗剂活性的组合物的新方法。该测定使用环巴胺结合和超高受体表达测试配体对受体活性。

3. 发明申请

WO2014186361A3 PHARMACOGENOMIC BIOMARKERS FOR B CELL MALIGNANCIES AND METHODS OF USE THEREOF 审中-公开
标题翻译： B细胞恶性病原体生物标志物及其使用方法
公开(公告)号：WO2014186361A3
公开(公告)日：2015-01-08
申请号：PCT/US2014037848
申请日：2014-05-13
申请人： CHEN WEI
发明人： CHEN WEI
IPC分类号： C07K14/715
CPC分类号： C12Q1/6886 , A61K38/2066 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates to the discovery that deletion and mutation of the IL10RA gene on chromosome 11q23 avert CpG ODN drug-induced apoptosis of human B-CLL cells. The IL10RA gene encodes a protein IL-10R1 precursor, where the IL-10R1 precursor contains a 21 amino acid signal peptide at the N-terminal. IL-10R1 precursor turns into IL-10R1 by posttranslational modification after the 21 amino acid signal peptide is cleaved off. These new biomarkers are useful as pharmacogenomic biomarker classifiers. These biomarkers can be used to select, stratify, or exclude patients with B cell malignancies for certain therapies and can be used to predict clinical outcomes.
摘要翻译：本发明涉及染色体11q23上的IL10RA基因的缺失和突变，避免CpG ODN药物诱导的人B-CLL细胞凋亡。 IL10RA基因编码蛋白质IL-10R1前体，其中IL-10R1前体在N-末端含有21个氨基酸的信号肽。在21个氨基酸信号肽被切除后，IL-10R1前体通过翻译后修饰变成IL-10R1。这些新的生物标志物作为药物基因组生物标志物分类是有用的。这些生物标志物可用于选择，分层或排除某些治疗B细胞恶性肿瘤患者，并可用于预测临床结果。

4. 发明申请

WO2011113675A3 METHOD OF TREATING HAIR 审中-公开
标题翻译：处理头发的方法
公开(公告)号：WO2011113675A3
公开(公告)日：2012-05-31
申请号：PCT/EP2011052733
申请日：2011-02-24
申请人： UNILEVER PLC , UNILEVER NV , UNILEVER HINDUSTAN , BATCHELOR STEPHEN NORMAN , BIRD JAYNE MICHELLE , CHEN WEI , TAO QINGSHENG , WANG JINFANG
发明人： BATCHELOR STEPHEN NORMAN , BIRD JAYNE MICHELLE , CHEN WEI , TAO QINGSHENG , WANG JINFANG
IPC分类号： A61K8/81 , A61Q5/06
CPC分类号： A61Q5/065 , A61K8/8152 , A61K2800/57
摘要： A method for colouring hair, comprising the step of applying to the hair a composition comprising a dye polymer in which the dye polymer is obtainable by the reaction of a NH2 group directly and covalently bound to an aromatic ring of a dye i) with a reactive group of a monomeric compound ii) in which the reactive group is selected from the group consisting of isocyanate; oxazolone; ester and epoxide, followed by polymerising the resulting dye monomer to form a dye polymer iii).
摘要翻译：一种毛发着色方法，包括以下步骤：向毛发施用包含染料聚合物的组合物，其中染料聚合物可通过直接与NH 2基团反应并共价结合到具有反应性的染料i）的芳环上获得一组单体化合物ii），其中反应性基团选自异氰酸酯; 恶唑酮; 酯和环氧化物，然后聚合所得染料单体以形成染料聚合物iii）。

5. 发明申请

WO2011113677A3 COMPOSITION 审中-公开
标题翻译：组成
公开(公告)号：WO2011113677A3
公开(公告)日：2012-05-03
申请号：PCT/EP2011052737
申请日：2011-02-24
申请人： UNILEVER PLC , UNILEVER NV , UNILEVER HINDUSTAN , BATCHELOR STEPHEN NORMAN , BIRD JAYNE MICHELLE , CHEN WEI , DAS JULIE ROSALYN , TAO QINGSHENG , WANG JINFANG
发明人： BATCHELOR STEPHEN NORMAN , BIRD JAYNE MICHELLE , CHEN WEI , DAS JULIE ROSALYN , TAO QINGSHENG , WANG JINFANG
IPC分类号： A61K8/81 , A61K8/91 , A61Q5/06
CPC分类号： A61Q5/065 , A61K8/8152 , A61K8/8158 , A61K2800/57 , A61Q5/02 , A61Q5/12
摘要： Hair composition and method for dying hair using a composition comprising a polymer dye, said polymer dye obtainable by polymerizing: (a) a first dye monomer which has a structure according to Formula (I) where Y is selected from -CONH- or -CH2CH(OH)CH2-NH- and R1 is selected from H, alkyl; aryl; benzyl; halogen; ester; acid amide; and, CN, and (b) a second monomer according to a structure according to Formula (II) where X is an organic bridging group covalently connecting the amine to the alkene moiety of the monomer, preferably X is -CO2(CH2)n- where n = 1 to 6; where R5 is selected from: H, alkyl; aryl; benzyl; halogen; ester; acid amide; and, CN, preferably R5 is CH3 or H; and where R2, R3, and R4 are independently selected from H or alkyl, preferably at least two of R2, R3, and R4 are alkyl.
摘要翻译：使用包含聚合物染料的组合物染色头发的头发组合物和方法，所述聚合物染料可通过聚合获得：（a）具有根据式（I）的结构的第一染料单体，其中Y选自-CONH-或-CH2CH （OH）CH 2 -NH-，并且R 1选自H，烷基; 芳基; 苄基; 卤素; 酯; 酰胺; 和CN，和（b）根据式（II）的结构的第二单体，其中X是共价连接胺与单体烯烃部分的有机桥基，优选X是-CO 2（CH 2）n - 其中n = 1至6; 其中R 5选自：H，烷基; 芳基; 苄基; 卤素; 酯; 酰胺; CN，优选R 5为CH 3或H; 并且其中R 2，R 3和R 4独立地选自H或烷基，优选R 2，R 3和R 4中的至少两个为烷基。

6. 发明申请

WO2011046964A3 INHIBITORS OF BRUTON'S TYROSINE KINASE 审中-公开
标题翻译： BRUTON的酪氨酸激酶抑制剂
公开(公告)号：WO2011046964A3
公开(公告)日：2011-08-25
申请号：PCT/US2010052377
申请日：2010-10-12
申请人： PHARMACYCLICS INC , CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
发明人： CHEN WEI , LOURY DAVID J , MODY TARAK D , VERNER ERIK , SMYTH MARK STEPHEN , LUO WENCHEN
IPC分类号： C07D487/04 , A61K31/519 , A61P19/02 , A61P19/10 , C07D401/04 , C07D401/14
CPC分类号： C07D487/04 , C07D519/00
摘要： Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate inhibitor of a protein, including a kinase.
摘要翻译：本文描述的是激酶抑制剂化合物，用于合成这种抑制剂的方法，以及在治疗疾病中使用这些抑制剂的方法。本文进一步描述了用于测定包括激酶在内的蛋白质的适当抑制剂的方法，测定和系统。

7. 发明申请

WO2008106245A8 METHOD OF FORMING SOFT LITHOGRAPHIC MOLDS WITH FLUORINE MODIFIED ELASTOMERS 审中-公开
标题翻译：用氟改性弹性体形成软光刻胶的方法
公开(公告)号：WO2008106245A8
公开(公告)日：2009-11-12
申请号：PCT/US2008051124
申请日：2008-01-16
申请人： DOW CORNING , SHIM ANNE , DRAKE ROB , SURGENOR AVRIL , CHEN WEI , HARKNESS BRIAN , AHN DONGCHAN , REED SAMANTHA
发明人： SHIM ANNE , DRAKE ROB , SURGENOR AVRIL , CHEN WEI , HARKNESS BRIAN , AHN DONGCHAN , REED SAMANTHA
IPC分类号： G03F7/00 , G03F7/004 , G03F7/075
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G03F7/0046 , G03F7/0757
摘要： The present invention provides an elastomeric stamp or mold. The elastomeric stamp or mold may be formed by a process including depositing a curable fluorine-containing polyalkylmethylsiloxane composition adjacent a master pattern and curing, at least partially, the curable fluorine-containing polyalkylmethylsiloxane composition. The process may also include removing the at least partially cured fluorine-containing polyalkylmethylsiloxane composition from the master pattern.
摘要翻译：本发明提供一种弹性体印模或模具。弹性体印模或模具可以通过包括在主图案上沉积可固化的含氟聚烷基甲基硅氧烷组合物并至少部分地固化可固化的含氟聚烷基甲基硅氧烷组合物的方法形成。该方法还可以包括从主图案除去至少部分固化的含氟聚烷基甲基硅氧烷组合物。

8. 发明申请

WO2007044804A3 PIPERIDINE DERIVATIVES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007044804A3
公开(公告)日：2009-05-07
申请号：PCT/US2006039713
申请日：2006-10-11
申请人： CHEMOCENTRYX INC , ZHANG PENGLIE , PENNELL ANDREW M K , CHEN WEI , GREENMAN KEVIN LLOYD , LI LIANFA , SULLIVAN EDWARD J
发明人： ZHANG PENGLIE , PENNELL ANDREW M K , CHEN WEI , GREENMAN KEVIN LLOYD , LI LIANFA , SULLIVAN EDWARD J
IPC分类号： A61K38/00 , A61K31/33
CPC分类号： C07D401/06 , C07D211/42 , C07D211/52 , C07D211/56 , C07D211/60 , C07D211/64 , C07D401/14 , C07D413/14 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

9. 发明申请

WO2008103930A3 DISPLAY SYSTEM 审中-公开
标题翻译：显示系统
公开(公告)号：WO2008103930A3
公开(公告)日：2008-10-23
申请号：PCT/US2008054764
申请日：2008-02-22
申请人： APPLE INC , CHUNG JERRY , YAO WEI , CHEN WEI
发明人： CHUNG JERRY , YAO WEI , CHEN WEI
IPC分类号： G06F3/038
CPC分类号： G09G3/3258 , G09G3/2014 , G09G3/2081 , G09G3/3426 , G09G2320/0242 , G09G2320/064
摘要： A display system is provided including forming a display array, connecting a control block to the display array, configuring a communication protocol between the display array and the control block, and operating the display array with the communication protocol.
摘要翻译：提供了一种显示系统，包括：形成显示阵列;将控制块连接到显示阵列;配置显示阵列和控制块之间的通信协议;以及利用通信协议操作显示阵列。

10. 发明申请

WO2007126619A3 SHELL AND TUBE EVAPORATOR 审中-公开
标题翻译：壳和蒸气蒸发器
公开(公告)号：WO2007126619A3
公开(公告)日：2008-10-09
申请号：PCT/US2007006822
申请日：2007-03-19
申请人： AAF MCQUAY INC , CHEN WEI
发明人： CHEN WEI
IPC分类号： F28F9/22
CPC分类号： F25B41/00 , F25B39/02 , F25B2339/0242 , F28D7/16 , F28D2021/0071 , F28F9/0268 , F28F13/12 , Y10T29/49396
摘要： An evaporator for use in a refrigeration system, the evaporator having a shell defining an interior volume enclosing a tube bundle comprising a plurality of elongate tubes, a water inlet in fluid communication with a first end of the of the tube bundle for directing water to the first end of the tube bundle and a water outlet in fluid communication with a second end of the tube bundle for passing water received from the second end of the tube bundle out from the interior volume, includes a plurality of fluid deflectors in fluid communication with a refrigerant inlet for promoting mixing of incoming refrigerant in various states and distributing such mixed refrigerant generally evenly throughout the interior volume. A method of forming an evaporator is further included.
摘要翻译：一种用于制冷系统的蒸发器，所述蒸发器具有壳体，所述壳体限定包围管束的内部容积，所述管束包括多个细长管，所述水入口与所述管束的第一端流体连通，用于将水引导到管束的第一端和与管束的第二端流体连通的水出口，用于将从管束的第二端接收的水从内部空间排出，包括多个流体连通的流体导流器制冷剂入口，用于促进各种进入的制冷剂的混合，并将这种混合的制冷剂一般均匀地分布在整个内部容积中。还包括形成蒸发器的方法。

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