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1. 发明申请

WO2022144461A1 IMAGE ANALYSIS AND NON-INVASIVE DATA COLLECTION FROM CELL CULTURE DEVICES 审中-公开
公开(公告)号：WO2022144461A1
公开(公告)日：2022-07-07
申请号：PCT/EP2022/050072
申请日：2022-01-04
申请人： CELVIVO APS
发明人： FEY, Stephen John , JOCHUMSEN, Hans Henrik , WRZESINSKI, Krzysztof
IPC分类号： C12M3/04 , C12M1/00 , C12M1/34 , C12M1/36
摘要： An incubator system configured to illuminate at least one or more cell culture chamber devices and to rotate them about a respective predetermined axis, each cell culture chamber device comprising an enclosure, the enclosure configured to contain a cell culture media, and at least one viewing area configured to allow inspection of at least a part of the cell culture media, the incubator system further comprising at least one illumination device and at least one monitoring device, the at least one monitoring device configured to provide one or more monitoring signals of at least part of an illuminated cell culture media or an illuminated cell culture chamber, illuminated, by at least one of the at least one illumination device, with a signal of electromagnetic radiation, preferably incoherent or coherent ultraviolet, visible, infrared, and/or near- infrared light of broad or narrow wavelength spectrum, and wherein the incubator system further comprises or is in connection with one or more processing units configured to extract and/or derive data from the one or more monitoring signals, said data representing one or more aspects of the cell culture chamber device itself and/or the cellular activity occurring within.

2. 发明申请

WO2021245117A1 A CELL CULTURE CHAMBER DEVICE FOR CELL AND TISSUE GROWTH 审中-公开
公开(公告)号：WO2021245117A1
公开(公告)日：2021-12-09
申请号：PCT/EP2021/064742
申请日：2021-06-02
申请人： CELVIVO APS
发明人： WRZESINSKI, Krzysztof , JOCHUMSEN, Hans Henrik , FEY, Stephen John
IPC分类号： C12M3/00 , C12M1/24 , C12M1/00 , C12M1/04 , C12M21/08 , C12M23/08 , C12M23/20 , C12M23/22 , C12M23/24 , C12M23/38 , C12M29/04
摘要： This invention relates to a cell culture chamber device (100) for the growing of cell cultures and tissues, the cell culture chamber device (100) comprising - an enclosure (110) configured to contain a cell culture media, and - a first end (111), a second end (112), and at least one connecting wall (114) connecting the first and the second ends (111, 112), where the first end (111), the second end (112), and the at least one connecting wall (114) at least in part defines the enclosure (110), wherein the first end (111), or a part or window (113) thereof, is substantially transparent and the second end (112) and/or at least one of the at least one connecting wall (114), or a respective part or window (113) thereof, is/are substantially transparent or is/are substantially translucent, where the first end or the part or window thereof (111, 113) is configured to be optically aligned, at least for some period of time or periodically, with the second end or the part or window thereof (112, 113) and/or with the at least one of the at least one connecting wall or the part or window thereof (114, 113) so that light (703) or another illumination or visualisation signal, transmitted through or by the second end or the part or window thereof (112, 113) and/or through or by the at least one of the at least one connecting wall or the part or window thereof (114, 113) into the enclosure (110) is transmitted through the cell culture media and out through the first end or the part or window thereof (111, 113) to outside the enclosure (110), and e.g. to outside the cell culture chamber device (100).

3. 发明申请

WO2022008292A1 AN INCUBATOR FOR RECEIVING A NUMBER OF CELL CULTURE CHAMBER DEVICES 审中-公开
公开(公告)号：WO2022008292A1
公开(公告)日：2022-01-13
申请号：PCT/EP2021/067777
申请日：2021-06-29
申请人： CELVIVO APS
发明人： JOCHUMSEN, Hans Henrik , WRZESINSKI, Krzysztof , FEY, Stephen John
IPC分类号： C12M1/00 , C12M3/00 , C12M3/04 , C12M1/36
摘要： This invention relates to an incubator (200, 200') configured to receive a predetermined number, at least one or a plurality, of cell culture chamber devices (100), each cell culture chamber device (100) comprising an enclosure (110) configured to contain a cell culture media, the incubator (200, 200') comprising a housing (210) comprising an incubation chamber (201) configured to contain at least a respective part of the cell culture chamber devices (100) when received by the incubator (200, 200'), and at least one registration and/or detection device (220) being integrated with the incubator (200, 200') and being configured to register and/or detect an illumination or visualisation signal (703) after passing, reflecting, or propagating through at least a part of the enclosure (110) of at least one of the predetermined number of cell culture chamber devices (100) when received by the incubator (200, 200').

4. 发明申请

WO2021001472A1 BIOREACTOR AND BIOREACTOR SYSTEM FOR CELL AND TISSUE GROWTH 审中-公开
公开(公告)号：WO2021001472A1
公开(公告)日：2021-01-07
申请号：PCT/EP2020/068632
申请日：2020-07-02
申请人： CELVIVO APS
发明人： WRZESINSKI, Krzysztof W. , FEY, Stephen John
IPC分类号： C12M1/12 , C12M1/00 , C12M3/04
摘要： The invention relates to a bioreactor (10, 10', 100) adapted for rotation, the bioreactor comprising: a vessel (12) comprising: a first end (24) and a second end (26) which define a central axis (28) of the vessel (12) extending along a first direction, e.g. a length direction, of the vessel (12) from said first (24) to said second end (26), at least one wall (18, 18', 20) running along the first direction of the vessel (12), at least one media conduit (22, 22') defining a volume for receiving fresh or spent media; an inner chamber defined by at least a part of a space confined within said at least one wall (18, 18', 20) and comprising a fresh media chamber (14) and a spent media chamber (16); a cell culture chamber (30) in fluid communication with said at least one media conduit (22, 22') and said fresh (14) and/or spent media chamber (16); and a movable wall (38) configured, within said inner chamber, to separate said fresh media chamber (14) from said spent media chamber (16) within said inner chamber.

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