专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023004436A1 METHODS AND SYSTEMS FOR EARLY DETECTION OF OCULAR AND/OR NEUROLOGICAL CONDITIONS 审中-公开
公开(公告)号：WO2023004436A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/074083
申请日：2022-07-22
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： KORONYO, Maya , DOUSTAR, Jonah , KORONYO, Yosef , BLACK, Keith L.
IPC分类号： G06K9/00 , G06N20/00 , G06V10/82 , A61B3/14 , A61B5/00
摘要： The present invention describes systems and method for the detection, diagnosis and monitoring of neurological and/or ocular disease, such as cognitive impairment and Alzheimer's disease. In one example, a method includes differentiating between vein vessels and artery vessels in one or more retinal images of a superior-temporal region of the retina, identifying distal vein branches downstream from a primary vein branch, and quantifying an amount of venular-adjacent amyloid-beta deposits in a venular-adjacent region corresponding to the distal vein branches, wherein the distal vein branches include one or more of secondary veins, secondary vein branches, and tertiary veins. The method further comprises diagnosing the neurological and/or ocular disease based on the amount of venular-adjacent amyloid-beta deposits.

2. 发明申请

WO2020055455A1 TARGETED NANOPARTICLES FOR DIAGNOSING, DETECTING, AND TREATING CANCER 审中-公开
公开(公告)号：WO2020055455A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/028196
申请日：2019-04-18
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PEREZ, J. Manuel , CHUNG, Leland , ZHANG, Yi , BLACK, Keith L.
IPC分类号： A61B5/00 , A61B6/00 , A61K31/131 , A61K31/335 , A61K31/382 , A61K31/542
摘要： The present invention provides a nanoparticle, comprising: a core, wherein the core comprises at least one iron oxide; a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one targeting moiety attached to the shell, wherein the nanoparticle does not comprise boron, for use in methods for detecting and treating cancer in a subject.

3. 发明申请

WO2017201539A1 METHODS OF TREATING OR PREVENTING ALZHEIMER'S DISEASE AND ASSOCIATED CONDITIONS 审中-公开
标题翻译：治疗或预防阿尔茨海默病和相关病症的方法
公开(公告)号：WO2017201539A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033875
申请日：2017-05-22
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： KORONYO, Maya , RENTSENDORJ, Altanchimeg , KORONYO, Yosef , BLACK, Keith L.
IPC分类号： A61K31/00 , A61K31/7052 , A61K35/12 , A61K38/00 , A61K38/17 , A61K38/18
摘要： The present invention describes a method of treating, preventing, reducing the likelihood of or alleviating a symptom of Alzheimer's disease and associated conditions by increasing OPN expression. The invention further provides for a method of improving cognitive function in a subject in need thereof.
摘要翻译：本发明描述了通过增加OPN表达来治疗，预防，减少阿尔茨海默病和相关病症的可能性或减轻其可能性的方法。本发明还提供了改善有此需要的受试者的认知功能的方法。

4. 发明申请

WO2017152054A1 POLYMALIC ACID BASED NANOIMMUNOCONJUGATES AND USES THEREOF 审中-公开
标题翻译：基于多元酸的纳米无机复合物及其应用
公开(公告)号：WO2017152054A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020666
申请日：2017-03-03
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： LJUBIMOVA, Julia Y. , BLACK, Keith L. , HOLLER, Eggehard , LJUBIMOV, Alexander , DING, Hui
IPC分类号： A61K39/395 , A61K31/713 , A61K38/19 , A61K38/16 , A61K47/10 , A61P35/00 , A61P35/04
摘要： Nanoimmunoconjugates including a polymalic acid-based molecular scaffold, targeting ligands, anti-tumor immune response stimulators and anti-cancer agents are provided. Methods for treating cancer in a subject by administering the nanoimmunoconjugates that provide both systemic and local immune responses and synergistic anticancer effect are described.
摘要翻译：提供了包括基于聚苹果酸的分子支架，靶向配体，抗肿瘤免疫应答刺激剂和抗癌剂的纳米免疫缀合物。描述了通过施用提供全身和局部免疫应答以及协同抗癌作用的纳米免疫缀合物来治疗受试者的癌症的方法。

5. 发明申请

WO2023283637A2 A METHOD TO DETECT RETINAL AMYLOIDOSIS AND TAUOPATHY USING SNAP HYPERSPECTRAL IMAGING AND/OR SNAP HYPERSPECTRAL OPTICAL COHERENCE TOMOGRAPHY 审中-公开
公开(公告)号：WO2023283637A2
公开(公告)日：2023-01-12
申请号：PCT/US2022/073558
申请日：2022-07-08
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： KORONYO, Maya , KORONYO, Yosef , BLACK, Keith L. , MIRZAEI, Nazanin , GAO, Liang
IPC分类号： A61B3/14 , G01N21/25 , G01J3/02 , G01J3/45 , A61B3/102 , A61B3/12 , G16H30/00
摘要： The present invention describes systems and method for the detection, diagnosis and monitoring of cognitive impairment and Alzheimer's disease. In one example, an integrated system comprising a full-field Fourier domain optical coherence tomography and an image mapping spectrometry is used for generating spectrally resolved volumetric images at wavelengths that show difference in spectral signatures of normal cells compared to spectral signatures of amyloid beta and pTau deposits, and also image inner retinal layers where amyloid beta and pTau deposits may aggregate.

6. 发明申请

WO2022031606A2 COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：WO2022031606A2
公开(公告)日：2022-02-10
申请号：PCT/US2021/044195
申请日：2021-08-02
申请人： CEDARS-SINAI MEDICAL CENTER , FORTEM NEUROSCIENCES, INC.
发明人： KORONYO, Maya , BLACK, Keith L. , KAVANAUGH, Jack
IPC分类号： A61K31/202 , A61K31/232 , A61K31/27 , A61P25/28 , A61K31/547
摘要： Provided herein are compositions and methods that improve cognition in individuals having or at risk of having Alzheimers disease, including familial Alzheimers disease, early-onset Alzheimers disease, and middle to late stage Alzheimers disease.

7. 发明申请

WO2019204645A1 NANOPARTICLES FOR BORON NEUTRON CAPTURE THERAPY AND FOR DIAGNOSING, DETECTING, AND TREATING CANCER 审中-公开
公开(公告)号：WO2019204645A1
公开(公告)日：2019-10-24
申请号：PCT/US2019/028179
申请日：2019-04-18
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： PEREZ, J. Manuel , SPOKOYNY, Alexander M. , TEH, James , BERNIER, Nicholas , BLACK, Keith L. , CHUNG, Leland , ZHANG, Yi
IPC分类号： A61K9/14 , A61K9/51 , A61K31/704 , A61K47/36 , A61K49/00 , A61N1/40 , A61P35/00
摘要： The invention provides a nanovehicle, comprising: a core, wherein the core comprises at least one iron oxide: a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one boron cluster. The invention provides a method of treating a disease, disorder, or disease condition in a subject, comprising administering a therapeutically effective amount of the nanovehicle to the subject; and radiating the nanovehicle with neutrons. In various embodiments, the invention provides a method for detecting a cancer in a subject, comprising administering an effective amount of at least one nanoparticle of the present invention to the subject. The invention also provides the nanovehicles (e.g., nanoparticles) described herein in the form of various pharmaceutical formulations. The invention provides a kit, the kit comprises: a quantity of the nanovehicle (e.g., nanoparticle) described herein..

8. 发明申请

WO2019070645A1 METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY THROUGH MULTIPLE BIO BARRIERS 审中-公开
公开(公告)号：WO2019070645A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/053873
申请日：2018-10-02
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： HOLLER, Eggehard , LJUBIMOVA, Julia Y. , BLACK, Keith L.
IPC分类号： A61K38/00 , A61K47/48 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435
摘要： Mini nanodrugs that include a polymalic-based molecular scaffold with one or more peptides capable of crossing the blood-brain barrier, one or more plaque-binding peptides and one or more therapeutic agents attached to the scaffold are provided. Methods of treating brain diseases or abnormal conditions, and imaging of the same in a subject by administering the mini nanodrugs are described. Methods for reducing formation of amyloid plaques in the brain of a subject are disclosed.

9. 发明申请

WO2012139030A1 POLYMALIC ACID BASED NANOCONJUGATES FOR IMAGING 审中-公开
标题翻译：基于聚合酸的纳米颗粒成像
公开(公告)号：WO2012139030A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032573
申请日：2012-04-06
申请人： CEDARS-SINAI MEDICAL CENTER , BLACK, Keith L. , LJUBIMOVA, Julia Y. , LJUBIMOV, Alexander V. , HOLLER, Eggehard
发明人： BLACK, Keith L. , LJUBIMOVA, Julia Y. , LJUBIMOV, Alexander V. , HOLLER, Eggehard
IPC分类号： A61K49/00 , C07C211/00
CPC分类号： A61K49/16 , A61K47/593 , A61K49/128
摘要： Nanoconjugates include a polymalic-based molecular scaffold with one or more imaging moiety and one or more targeting modules attached to the scaffold. At least one imaging moiety and at least one targeting module is conjugated to the polymalicacid based molecular scaffold. Methods of synthesizing the nanoconjugate involve providing a polymalic acid having a plurality of pendant carboxyi groups. The method reacts a compound containing sulfhydryl groups and amino acid groups through the pendant carboxyi groups to add sulfhydryl groups to the polymalic acid to form an activated polymalic acid. The method reacts at least one imaging moiety containing a sulfhydryl binding group to the activated polymalic acid to form a preconjugate. The method may involve administering to the subject a nanoconjugate that includes a polymalic acid-based molecular scaffold, at least one imaging moiety, and at least one targeting module.
摘要翻译：纳米缀合物包括具有一个或多个成像部分和连接到支架的一个或多个靶向模块的基于聚丙烯的分子支架。至少一个成像部分和至少一个靶向模块与基于聚缩水甘油的分子支架缀合。合成纳米缀合物的方法涉及提供具有多个侧链羧基的聚丙酸。该方法通过侧基羧基将含有巯基和氨基酸的化合物反应，以向聚丙酸中加入巯基以形成活化的聚丙酸。该方法将含有巯基结合基团的至少一个成像部分与活化的聚丙酸反应形成预共轭物。该方法可以包括向受试者施用包括基于聚丙酸的分子支架，至少一个成像部分和至少一个靶向模块的纳米缀合物。

10. 发明申请

WO2017210645A1 VISUAL STIMULI MAZE TEST FOR DETECTING VISUAL ABNORMALITIES IN PRODROMAL ALZHEIMER'S DISEASE AND IN ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于检测阿尔茨海默病和阿尔茨海默病视觉异常的视觉刺激试验
公开(公告)号：WO2017210645A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035835
申请日：2017-06-02
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： KORONYO, Maya , KORONYO, Yosef , BLACK, Keith L.
IPC分类号： A01K1/03 , A01K15/00 , A01K15/02 , A01K29/00 , A61K35/12 , A61K35/30
CPC分类号： A61B5/4088 , A01K1/031 , A01K15/02 , A01K2267/0312 , A61B3/0091 , A61B3/022 , A61B3/06 , A61B2503/40
摘要： Disclosed herein is a rodent and human behavioral test for evaluating visual dysfunctions associated with the retinal changes in Alzheimer disease progression. In one example, the inventors developed a maze that tests rodent's ability to identify (1) specific contrasts, (2) specific colors, (3) certain items in the visual field, and (4) other 'non-typical' peripheral and night vision functions associated with AD. For instance, the inventors developed a maze the tests the rodents ability to avoid certain colors or contrasts gradients. The maze may include certain rooms with specific visual markers (e.g., colors, contrasts, objects or other visual features) that also contain shock plates.
摘要翻译：本文公开了用于评估与阿尔茨海默病进展中的视网膜变化相关的视觉功能障碍的啮齿动物和人类行为测试。在一个例子中，发明人开发了测试啮齿动物识别（1）特定对比度，（2）特定颜色，（3）视野中的某些项目，和（4）其他“非典型”外围和夜间的能力的迷宫与AD相关的视觉功能。例如，发明人开发了迷宫测试啮齿动物避免某些颜色或对比度梯度的能力。迷宫可包括具有特定视觉标记（例如，颜色，对比度，物体或其他视觉特征）的某些房间，其也包含震动板。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式