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    • 10. 发明申请
    • PROCESS OF PREPARING BROMOPICRIN
    • 制备溴米亭的方法
    • WO2007023496A2
    • 2007-03-01
    • PCT/IL2006/000978
    • 2006-08-22
    • BROMINE COMPOUNDS LTD.OREN, JakobGOLAN, LeahFRIM, Ron
    • OREN, JakobGOLAN, LeahFRIM, Ron
    • C07C205/11
    • C07C201/12C07C205/08
    • Process of preparing high purity bromopicrin, and high purity bromopicrin produced therefrom. Providing a mixture of nitromethane and bromine, and preferably water, and absent of organic solvent. Adding an aqueous solution of an alkaline substance to the mixture, thereby providing a reaction mixture containing bromopicrin, the adding performed such that no excess of the alkaline substance occurs in the reaction mixture during the adding. Collecting the organic phase (containing the bromopicrin) from the reaction mixture. No need for subjecting the organic phase of the reaction mixture to distillation or extraction, for obtaining near quantitative yield of bromopicrin having purity of at least equal to or greater than 96 weight percent. Process parameters controlling selectivity of reaction forming bromopicrin are molar ratio of bromine and nitromethane in the mixture; reaction temperature while bromopicrin is formed; concentration of the alkaline substance in the aqueous solution; and reaction time.
    • 制备高纯度溴苦苷的方法以及由其生产的高纯度溴化苦。 提供硝基甲烷和溴的混合物,优选水,并且不含有机溶剂。 向混合物中加入碱性物质的水溶液,由此提供含有溴代苦味酸的反应混合物,进行加入使得在加入期间在反应混合物中不会出现过量的碱性物质。 从反应混合物中收集有机相(含有溴化苦)。 不需要对反应混合物的有机相进行蒸馏或萃取,以获得纯度至少等于或大于96重量%的溴化苦的几乎定量产率。 控制形成溴化苦的反应的选择性的工艺参数是混合物中溴和硝基甲烷的摩尔比; 反应温度,同时形成溴化苦; 碱性物质在水溶液中的浓度; 和反应时间。