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1. 发明申请

WO2014205447A2 MICROFLUIDIC SYSTEM WITH FLUID PICKUPS 审中-公开
标题翻译：具有流体PICKUPS的微流控系统
公开(公告)号：WO2014205447A2
公开(公告)日：2014-12-24
申请号：PCT/US2014/043715
申请日：2014-06-23
申请人： BIO-RAD LABORATORIES, INC. , MAKAREWICZ, Anthony, J., Jr. , BOUSSE, Luc , SCHIAFFINO, Stefano
发明人： MAKAREWICZ, Anthony, J., Jr. , BOUSSE, Luc , SCHIAFFINO, Stefano
IPC分类号： B01L3/00 , C12N15/10
CPC分类号： B01L3/502784 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/50853 , B01L7/52 , B01L2200/027 , B01L2300/04 , B01L2300/041 , B01L2300/044 , B01L2300/046 , B01L2300/0672 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2400/0457 , B01L2400/0487 , B01L2400/049 , B01L2400/0655 , B01L2400/0677 , B01L2400/084 , C12N15/1075 , C12Q1/6806 , Y10T436/2575
摘要： Microfluidic system, including methods and apparatus, for processing fluid, such as by droplet generation. In some embodiments, the system may include a well and a channel component attached to the well. The channel component may include (a) a body, (b) an input tube (a "fluid pickup") projecting from a bottom surface of the body and having an open bottom end disposed in the input well, (c) a microchannel, and (d) a passage extending through the input tube and the body and connecting the well to the microchannel. The system may be configured to receive a sample- containing fluid in the well and retain the sample-containing fluid below a top end of the passage, until a pressure differential is created that drives at least a portion of the sample-containing fluid from the well via the passage and through the microchannel.
摘要翻译：微流体系统，包括用于处理流体的方法和装置，例如通过液滴产生。在一些实施例中，系统可以包括井和连接到井的通道部件。通道部件可以包括（a）主体，（b）从主体的底表面突出并具有设置在输入孔中的敞开的底端的输入管（“流体拾取器”），（c）微通道，和（d）延伸穿过输入管和主体并将井连接到微通道的通道。该系统可以被配置为在井中接收含样品的流体并将含样品的流体保持在通道的顶端下方，直到形成压力差，从而将含有样品的流体的至少一部分从通过通道和通过微通道。

2. 发明申请

WO2014018562A1 DROPLET GENERATION SYSTEM WITH FEATURES FOR SAMPLE POSITIONING 审中-公开
标题翻译：具有样本定位特征的DROPLET生成系统
公开(公告)号：WO2014018562A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051735
申请日：2013-07-23
申请人： BIO-RAD LABORATORIES, INC.
发明人： CAULEY, Thomas, H., III , BRACKBILL, Timothy , BOUSSE, Luc , PETERSEN, Jon
IPC分类号： B01F3/08 , B01L3/00 , B01J19/00
CPC分类号： G01N1/28 , B01F3/0807 , B01F13/0062 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/084 , Y10T436/25
摘要： System, including methods and apparatus, for forming droplets of an emulsion. The system may include a channel junction at which a stream of sample fluid is divided into droplets by a dividing flow of carrier fluid. The system also may include one or more features configured to position sample fluid for reduced contact between the sample fluid and one or more surface regions of the channel junction, which may improve the consistency of droplet formation. In exemplary embodiments, sample fluid may be positioned by a step member produced by an increase in channel depth, and/or by directing flow of carrier fluid to form a barrier layer between sample fluid and a wall region, such as a ceiling region or floor region, of a channel network.
摘要翻译：用于形成乳液液滴的系统，包括方法和装置。该系统可以包括通道结，在该通道连接处，样品流体流通过载体流体的分流被分成液滴。该系统还可以包括被配置为定位样品流体以减少样品流体和通道结的一个或多个表面区域之间的接触的一个或多个特征，这可以提高液滴形成的一致性。在示例性实施例中，样品流体可以由通过增加通道深度产生的台阶构件定位，和/或通过引导载体流体的流动来形成样品流体和壁区域之间的阻挡层，例如天花板区域或地板区域，通道网络。

3. 发明申请

WO2013155531A2 SAMPLE HOLDER WITH A WELL HAVING A WICKING PROMOTER 审中-公开
标题翻译：样品夹具有一个有一个WICKING PROMOTER的井
公开(公告)号：WO2013155531A2
公开(公告)日：2013-10-17
申请号：PCT/US2013/036649
申请日：2013-04-15
申请人： BIO-RAD LABORATORIES, INC.
发明人： CAULEY III, Thomas, H. , BOUSSE, Luc , PETERSEN, Jon , NESS, Kevin, D. , ROMINE, Steven
IPC分类号： G01N1/00 , B32B38/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/502746 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/161 , B01L2400/0406 , B01L2400/086 , B01L2400/088 , B32B38/0012 , G01N1/00 , Y10T156/10 , Y10T156/1002
摘要： Sample holding system, including methods and apparatus, including a holder defining a well having a wicking promoter that encourages flow of a sample to the bottom of the well. Methods of making and using the holder are also disclosed.
摘要翻译：样品保持系统，包括方法和装置，包括定义具有促进样品流到孔的底部的芯吸促进剂的阱的保持器。还公开了制造和使用保持器的方法。

4. 发明申请

WO2004094994A2 MICROFLUIDIC DEVICES AND METHODS 审中-公开
标题翻译：微流体装置和方法
公开(公告)号：WO2004094994A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/006918
申请日：2004-03-04
申请人： PREDICANT BIOSCIENCES, INC. , HELLER, Jonathan , STULTS, John , SRINIVASAN, Uthara , BOUSSE, Luc , ZHAO, Mingqi , NI, Jing
发明人： HELLER, Jonathan , STULTS, John , SRINIVASAN, Uthara , BOUSSE, Luc , ZHAO, Mingqi , NI, Jing
IPC分类号： G01N
CPC分类号： H01J49/0018 , H01J49/165 , Y10T137/0402 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224 , Y10T137/7036 , Y10T436/2575
摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.
摘要翻译：微流体装置向质谱仪提供物质。微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

5. 发明申请

WO2007089884A2 OPTIMIZED SAMPLE INJECTION STRUCTURES IN MICROFLUIDIC SEPARATIONS 审中-公开
标题翻译：微流控分离优化的样品注射结构
公开(公告)号：WO2007089884A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002721
申请日：2007-01-31
申请人： PATHWORK DIAGNOSTICS, INC. , NGUYEN, Michael , BOUSSE, Luc
发明人： NGUYEN, Michael , BOUSSE, Luc
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： C07K1/26 , G01N27/44791 , Y10T436/2575
摘要： The invention herein provides improved sample injection systems and related methods to create microfluidic devices with symmetrical channel configurations that can produce relatively large sample volumes. An embodiment of the invention provides microfluidic structures with different geometries that are symmetrical from the perspective of a sample load channel and a sample waste channel, which essentially eliminates issues of time offset and other problems commonly associated with twin-T sample formation techniques. A split-injection approach and related methods of sample plug formation are therefore provided.
摘要翻译：本文的发明提供了改进的样品注射系统和相关方法，以产生具有对称通道配置的微流体装置，其可产生相对大的样品体积。本发明的一个实施例提供具有不同几何形状的微流体结构，其从样品装载通道和样品废物通道的角度来看是对称的，其基本上消除了时间偏移和通常与双T样品形成技术相关的其他问题的问题。因此提供了分流注射方法和相关的样品塞形成方法。

6. 发明申请

WO2021030353A1 ISOELECTRIC FOCUSING DEVICES AND FIXTURES 审中-公开
公开(公告)号：WO2021030353A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/045775
申请日：2020-08-11
申请人： INTABIO, INC. , GENTALEN, Erik , MACK, Scott , GWERDER, Eric , BOUSSE, Luc
发明人： GENTALEN, Erik , MACK, Scott , GWERDER, Eric , BOUSSE, Luc
IPC分类号： B01D57/02 , B01L3/00 , C12Q1/68 , C12Q1/70 , G01N27/447 , G01N33/68 , H01J49/04
摘要： Methods, devices, and systems for performing isoelectric focusing reactions are described. The systems or devices disclosed herein may comprise fixtures that have a membrane. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. Two or more isoelectric focusing reactions may be performed in parallel. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.

7. 发明申请

WO2008154036A1 MICROCHIP LARGE-VOLUME PCR WITH INTEGRATED REAL-TIME CE DETECTION 审中-公开
标题翻译： MICROCHIP大容量PCR与一体化实时检测
公开(公告)号：WO2008154036A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/007359
申请日：2008-06-11
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD. , BOUSSE, Luc , ZHANG, Jian-ping
发明人： BOUSSE, Luc , ZHANG, Jian-ping
IPC分类号： C12P19/34 , G01N30/00
CPC分类号： G01N27/44791 , B01L3/502746 , B01L3/502753 , B01L7/52 , B01L2300/0816 , B01L2400/0421 , G01N27/44721
摘要： A microfluidic device is provided with appropriate integrated structures to conduct large volume PCR and end-point or real-time capillary electrophoresis detection The microfluidic device includes a substrate having an amplification chamber of a volume of nucleic acid, wells disposed on the substrate, flow channels connecting the wells and the chamber in the substrate to allow for solution flow through the chamber, and one or more separation channels provided in the substrate and connected to the chamber for separating and detecting a fraction of the amplified nucleic acid The chamber, the flow channels, and the one or more separation channels are configured such that the hydrodynamic flow resistance of the chambers and the flow channels combined is at least 10Λ3 times smaller than the hydrodynamic flow resistance in the one or more separation channels The microfluidic device can achieve a very high sensitivity in detection while being highly cost effective
摘要翻译：微流体装置具有适当的集成结构以进行大容量PCR和终点或实时毛细管电泳检测微流体装置包括具有一定体积核酸的扩增室的底物，设置在基底上的阱，流路将所述孔和所述腔室连接在所述基底中以允许溶液流过所述腔室，以及设置在所述基底中并连接到所述腔室的一个或多个分离通道，用于分离和检测所述扩增的核酸的一部分所述腔室，所述流动通道并且所述一个或多个分离通道被构造成使得所述腔室和所述流动通道组合的流体动力学流动阻力比所述一个或多个分离通道中的流体动力学流动阻力小至少10〜3倍。所述微流体装置可以实现检测灵敏度非常高，而且成本效益高

8. 发明申请

WO2008121803A1 METHOD OF CLEANING MICRO-FLOW PASSAGES 审中-公开
标题翻译：清洁微流通道的方法
公开(公告)号：WO2008121803A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058624
申请日：2008-03-28
申请人： FUJIFILM CORPORATION , WAKO PURE CHEMICAL INDUSTRIES, LTD. , SETO, Yoshihiro , BOUSSE, Luc , LI, Chen
发明人： SETO, Yoshihiro , BOUSSE, Luc , LI, Chen
IPC分类号： B08B9/00
CPC分类号： B08B9/0321 , B08B9/035
摘要： To improve cleansing quality of wall surfaces of micro-flow channels in a micro-flow channel cleansing method. During cleansing of wall surfaces of micro-flow channels having at least one branching channel, by causing cleansing fluid to flow therethrough, the cleansing fluid is caused to flow through the at least one branching channel such that there is no residual fluid on the wall surfaces thereof.
摘要翻译：以微流通道清洗方式提高微流通道壁表面的清洁质量。在清洁具有至少一个分支通道的微流动通道的壁表面之间，通过使清洁流体流过其中，使净化流体流过至少一个分支通道，使得在壁表面上不存在残留流体它们。

9. 发明申请

WO2008082670A2 METHOD AND SYSTEM FOR INTERNAL STANDARDIZATION OF ASSAYS 审中-公开
标题翻译：内部标准化测定方法与系统
公开(公告)号：WO2008082670A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/026523
申请日：2007-12-27
申请人： WAKO PURE CHEMICHAL INDUSTRIES, LTD. , WADA, Henry G. , KAWABATA, Tomohisa , BOUSSE, Luc
发明人： WADA, Henry G. , KAWABATA, Tomohisa , BOUSSE, Luc
IPC分类号： G01N27/28
CPC分类号： G01N27/447 , G01N21/274 , G01N21/278 , G01N33/582 , G01N2001/2893
摘要： Internal standard concentration is normalized as an independent parameter through measuring a buffer conductance in a system with characterized reagents and in a defined assay device. The conductivity of a fresh internal standard solution is measured whether in isolation or as part of a system that is subject to a uniform variation such as evaporation or condensation. Collected conductance measurements may be used to normalize assay signals that are dependent upon fluidic channel dimensions, such as fluorescence assay signal measurement.
摘要翻译：通过在具有特征的试剂和定义的测定装置的系统中测量缓冲电导，将内标浓度归一化为独立参数。无论是隔离还是作为受到均匀变化如蒸发或冷凝的系统的一部分，测量新鲜内标溶液的电导率。收集的电导测量可用于标准化依赖于流体通道尺寸的测定信号，例如荧光测定信号测量。

10. 发明申请

WO2008147428A1 SYSTEMS AND METHODS FOR ACTIVE MICROFLUIDIC CELL HANDLING 审中-公开
标题翻译：用于活性微流控细胞处理的系统和方法
公开(公告)号：WO2008147428A1
公开(公告)日：2008-12-04
申请号：PCT/US2007/080483
申请日：2007-10-04
申请人： NANOPOINT, INC. , HIGASHI, Len , BOUSSE, Luc , RUDOFF, Roger , ALLEY, Ray , GIFFIN, Maile
发明人： HIGASHI, Len , BOUSSE, Luc , RUDOFF, Roger , ALLEY, Ray , GIFFIN, Maile
IPC分类号： C12M1/00
CPC分类号： C12M23/40 , B01L3/5027 , C12M23/12 , C12M29/10
摘要： A method and system for providing a cell support system are described. The method and system include providing a first block, a second block coupled to the first block, and a plurality of microfluidic channels. The first block includes a plurality of cell wells therein. The second block includes a plurality of through holes therethrough. The plurality of holes are in fluid communication with at least one corresponding cell well of the plurality of cell wells. The plurality of microfluidic channels are in fluid combination with at least a portion of the plurality of cell wells and are configured to provide an active fluid flow with the portion of the plurality of cell wells.
摘要翻译：描述了一种用于提供小区支持系统的方法和系统。该方法和系统包括提供第一块，耦合到第一块的第二块和多个微流体通道。第一块在其中包括多个单元阱。第二块包括穿过其中的多个通孔。多个孔与多个细胞孔的至少一个对应的细胞井流体连通。多个微流体通道与多个单元阱的至少一部分流体组合并且被配置为提供与多个单元阱的一部分的活性流体流。

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