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1. 发明申请

WO2019006190A1 SYSTEM AND METHOD FOR DROPLET DETECTION 审中-公开
公开(公告)号：WO2019006190A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040125
申请日：2018-06-28
申请人： BIO-RAD LABORATORIES, INC. , STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICK, Anthony, J., Jr. , SIMONIAN, Smitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
发明人： STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICK, Anthony, J., Jr. , SIMONIAN, Smitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
IPC分类号： B01L3/02 , G01N35/10
摘要： Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.

2. 发明申请

WO2019006190A8 SYSTEM AND METHOD FOR DROPLET DETECTION 审中-公开
公开(公告)号：WO2019006190A8
公开(公告)日：2019-01-03
申请号：PCT/US2018/040125
申请日：2018-06-28
申请人： BIO-RAD LABORATORIES, INC. , STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICZ, Anthony, J., Jr. , SIMONIAN, Dmitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
发明人： STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICZ, Anthony, J., Jr. , SIMONIAN, Dmitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
IPC分类号： B01L3/02 , G01N35/10
摘要： Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.

3. 发明申请

WO2017117490A1 DROPLET ASSAY SYSTEM WITH AUTOMATIC CALIBRATION 审中-公开
标题翻译：带自动校准的液滴测定系统
公开(公告)号：WO2017117490A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069393
申请日：2016-12-30
申请人： BIO-RAD LABORATORIES, INC.
发明人： DZENITIS, John , SCHIAFFINO, Stefano
IPC分类号： G01N35/10
CPC分类号： B01L3/502784 , B01L3/0241 , B01L3/545 , B01L2200/12 , B01L2200/147 , B01L2200/148 , B01L2300/021 , B01L2300/0663 , B01L2300/0864 , B01L2400/049
摘要： The present disclosure provides systems and methods for performing droplet assays with automatic calibration. An exemplary assay system may comprise a cartridge including a plurality of droplet generators to form emulsions of droplets having a same nominal volume. A tag may be associated with the cartridge and may encode calibration data or an identifier thereof. The calibration data may include a respective value specific to each droplet generator. The system further may include a detection system to detect a signal representing an analyte from droplets of each emulsion, and a reader to read the calibration data or the identifier from the tag. The system still further may include a processor configured to receive the signal and the calibration data and to calculate, for each emulsion, a concentration of an analyte using at least the signal and the respective value specific to the droplet generator that formed the emulsion.
摘要翻译：本公开提供了用于利用自动校准来执行液滴测定的系统和方法。示例性测定系统可以包括盒，该盒包括多个液滴发生器以形成具有相同标称体积的液滴的乳剂。标签可以与盒子相关联并且可以对校准数据或其标识符进行编码。校准数据可以包括特定于每个液滴生成器的相应值。该系统还可以包括用于检测表示来自每种乳剂的液滴的分析物的信号的检测系统和用于从标签读取校准数据或标识符的读取器。该系统还可以包括处理器，该处理器被配置为接收信号和校准数据并且使用至少信号和对形成乳液的液滴生成器特定的相应值来针对每种乳液计算分析物的浓度。 / p>

4. 发明申请

WO2018148693A1 SYSTEM, METHOD, AND DEVICE FOR FORMING AN ARRAY OF EMULSIONS 审中-公开
公开(公告)号：WO2018148693A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017883
申请日：2018-02-12
申请人： BIO-RAD LABORATORIES, INC. , CAULEY, Trey , DZENITIS, John , HOBBS, Steve , SCHIAFFINO, Stefano
发明人： CAULEY, Trey , DZENITIS, John , HOBBS, Steve , SCHIAFFINO, Stefano
IPC分类号： B01L3/00 , A61K9/107
摘要： Systems, methods, and devices for forming an array of emulsions. An exemplary device comprises a frame and at least one or a plurality of separate microfluidic modules mounted to the frame and each configured to form an array of emulsions. In some embodiments, each module may be mounted by snap-fit attachment. The device also may include the same sealing member bonded to a top side of each module and hermetically sealing each of the modules. Another exemplary microfluidic device for forming an array of emulsions comprises a stack of layers bonded together. The stack may comprise a port layer forming a plurality of ports. Each port may have a top rim formed by a protrusion that encircles the central axis of the port. The rims may be coplanar with one another to facilitate bonding of a sealing member to each rim.

5. 发明申请

WO2018140808A1 ASSAY PERFORMANCE SYSTEMS INCLUDING AQUEOUS SAMPLE STABILIZATION 审中-公开
公开(公告)号：WO2018140808A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/015573
申请日：2018-01-26
申请人： BIO-RAD LABORATORIES, INC. , CATER, Sean , DZENITIS, John , SCHIAFFINO, Stefano , SHAH, Pallavi , UTADA, Andrew
发明人： CATER, Sean , DZENITIS, John , SCHIAFFINO, Stefano , SHAH, Pallavi , UTADA, Andrew
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/686 , B01F3/08 , G01N35/02
摘要： An assay performance system may include modules configured to store aqueous sample plates, conduct droplet generation or emulsification of aqueous samples, and to perform thermocycling and droplet reading functions. One or more samples may be emulsified and stored in an emulsified state for extended times prior to thermocycling. Accordingly, the assay performance system may include material handling systems and methods to accommodate the storage function.

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