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1. 发明申请

WO02059102A3 UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE 审中-公开
标题翻译：尿素衍生物，其制备方法，用作药物，药物组合物和用途
公开(公告)号：WO02059102A3
公开(公告)日：2003-01-09
申请号：PCT/FR0200279
申请日：2002-01-23
申请人： AVENTIS PHARMA SA , DEPREZ PIERRE , PATEK MARCEL
发明人： DEPREZ PIERRE , PATEK MARCEL
IPC分类号： C07D243/08 , A61K31/17 , A61K31/175 , A61K31/36 , A61K31/495 , A61K31/496 , A61K31/551 , A61P1/00 , A61P3/14 , A61P5/18 , A61P9/00 , A61P9/12 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07C273/18 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/34 , C07C275/42 , C07D295/12 , C07D295/13 , C07D295/18 , C07D317/58 , C07D333/20 , C07D407/12 , C07C275/30 , C07D295/20
CPC分类号： C07D295/13 , C07C275/24 , C07C275/34 , C07D407/12 , Y02P20/55
摘要： The invention concerns novel products of formula (I) wherein: Y represents oxygen or sulphur; Z represents C=CH2, CH-CH3 or CH2; R1 represents hydrogen, morpholinyl or the radical (II) wherein the two nitrogen atoms are linear or form a cyclic radical; X represents carbonyl, alkylene or alkenylene, linear or branched containing not more than 6 carbon atoms optionally oxygen- or sulphur-interrupted; R4, R5 and R6 represent hydrogen, a nitrogen-protecting, alkyl, cycloalkyl, aryl and arylalkyl group optionally substituted; R2 represents alkyl optionally substituted by aryl, heteroaryl or -NR4R5; R3 represents alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl optionally substituted. Said products are all in the form of isomers and the salts as medicines.
摘要翻译：本发明涉及式（I）的新产物，其中：Y表示氧或硫; Z表示C = CH 2，CH-CH 3或CH 2; R1表示氢，吗啉基或其中两个氮原子是直链或形成环状基团的基团（II）; X代表羰基，亚烷基或亚烯基，直链或支链含有不超过6个碳原子，任选被氧或硫中断; R4，R5和R6代表氢，任选被取代的氮保护基，烷基，环烷基，芳基和芳基烷基; R 2表示任选被芳基，杂芳基或-NR 4 R 5取代的烷基; R3表示任选取代的烷基，环烷基，芳基，杂芳基，芳基烷基或杂芳基烷基。所述产物均为异构体的形式，其盐为药物。

2. 发明申请

WO2004070050A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS 审中-公开
标题翻译：新型循环尿素衍生物，其制备方法及其作为激酶抑制剂的药物应用
公开(公告)号：WO2004070050A2
公开(公告)日：2004-08-19
申请号：PCT/FR2004000188
申请日：2004-01-28
申请人： AVENTIS PHARMA SA
发明人： PATEK MARCEL , NAIR ANIL , HITTINGER AUGUSTIN , NEMECEK CONCEPTION , BOND DANIEL , HARLOW GREG , BOUCHARD HERVE , MAUGER JACQUES , MALLERON JEAN-LUC , PALERMO MARK , AL-OBEIDI FAHAD , FAITG THOMAS , STROBEL HARTMUT , RUF SVEN , RITTER KURT , EL-AHMAD YOUSSEF , LESUISSE DOMINIQUE , BENARD DIDIER
IPC分类号： A61P3/00 , A61P7/02 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P35/00 , C07D401/06 , C07D401/14 , C12Q
CPC分类号： C07D401/06 , C07D401/14
摘要： The invention relates to novel products having formula (I), wherein: p denotes 0 to 2; R and R1 denote O or NH; R2 and R3 denote hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, or R2 and R3, together with the carbon atom to which they are bound, form a carbocyclic or heterocyclic radical, all of said radicals being optionally substituted; A1 denotes a single bond, alkyl, allyl and propynyl; Y and Y1 denote H, OCF3, S(O)nCF3, S(O)nAlk, SO2CHF2, SO2CF2CF3, -O-CF2-CHF2, -O-CHF2, -O-CH2-CF3, SF5 and SO2NR5R6, whereby R5 and R6 are selected from among hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl, which are optionally substituted, or R5 and R6, together with N to which they are bound, form a heterocyclic radical; A2 denotes Al, CO and SO2; B2 denotes a heterocyclic radical which is optionally substituted with one or more substituents which are selected from the values of Y2; Y2 denotes hydrogen, halogen, hydroxyl, cyano, alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -O-alkenyl, -O-alkynyl, O-cycloalkyl, S(O)n-alkyl, -S(O)n-alkenyl, -S(O)n-alkynyl, S(O)n-cycloalkyl, -COOR13,-OCOR13, NR5R6, CONR5R6, S(O)n-NR5R6,-NR10-CO-R13, -NR10-SO2-R13, -NH-SO2-NR5R6, -NR10-CO-NR5R6, -NR10-CS-NR5R6, -NR10-COOR13, all of said radicals being optionally substituted; and n denotes an integer of between 0 and 2. The aforementioned products are in all the isomeric forms and the salts thereof for use as medicaments.
摘要翻译：本发明涉及具有式（I）的新产品，其中：p表示0至2; R和R1表示O或NH; R 2和R 3表示氢，烷基，烯基，炔基，环烷基，芳基和杂芳基，或者R 2和R 3与它们所连接的碳原子一起形成碳环或杂环基，所有基团都是任选被取代的; A1表示单键，烷基，烯丙基和丙炔基; Y和Y1表示H，OCF3，S（O）nCF3，S（O）nAlk，SO2CHF2，SO2CF2CF3，-O-CF2-CHF2，-O-CHF2，-O-CH2-CF3，SF5和SO2NR5R6， R 6选自任选取代的氢，烷基，烯基，环烷基，环烯基，杂环烷基，芳基和杂芳基，或R 5和R 6与它们所连接的N一起形成杂环基; A2表示Al，CO和SO2; B2表示任选被一个或多个选自Y2的取代基取代的杂环基; 环烷基，杂环烷基，芳基，杂芳基，-O-烯基，-O-炔基，O-环烷基，S（O）n - 烷基，-S（O）n - 烯基，-S（O）n - 炔基，S（O）n-环烷基，-COOR 13，-OCOR 13，NR 5 R 6，CONR 5 R 6，S（O）n -NR 5 R 6，-NR 10 -CO-R 13，-NR 10 -SO 2 - R13，-NH-SO2-NR5R6，-NR10-CO-NR5R6，-NR10-CS-NR5R6，-NR10-COOR13，所有所述基团任选被取代; 并且n表示0和2之间的整数。上述产物是全部异构形式及其盐，用作药物。

3. 发明申请

WO2008065282A3 SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE 审中-公开
标题翻译：取代的吡唑，包含这些的组合物，生产方法和用途
公开(公告)号：WO2008065282A3
公开(公告)日：2008-07-31
申请号：PCT/FR2007001851
申请日：2007-11-09
申请人： SANOFI AVENTIS , BJERGARDE KIRSTEN , DODSON MARK , MAUGER JACQUES , NAIR ANIL , PATEK MARCEL , TABART MICHEL
发明人： BJERGARDE KIRSTEN , DODSON MARK , MAUGER JACQUES , NAIR ANIL , PATEK MARCEL , TABART MICHEL
IPC分类号： C07D231/38 , A61K31/415 , A61P35/00
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The present invention relates to new chemical compounds, particularly to substituted pyrazoles, compositions containing these, and their use as drugs.
摘要翻译：本发明涉及新的化合物，特别涉及取代的吡唑，含有这些化合物的组合物以及它们作为药物的用途。

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