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1. 发明申请

WO2010091287A1 PROCESS FOR PURIFYING GUAR 审中-公开
标题翻译：净化手段
公开(公告)号：WO2010091287A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023369
申请日：2010-02-05
申请人： ALCON RESEARCH, LTD. , DAVIS, James W. , KETELSON, Howard Allen , MEADOWS, David L. , BAKER, John C.
发明人： DAVIS, James W. , KETELSON, Howard Allen , MEADOWS, David L. , BAKER, John C.
IPC分类号： C08B37/00 , A61K9/00 , A61K47/36
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译：本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理该水溶液以诱导纯化的瓜尔胶的沉淀。本发明的另一个实施方案涉及包含通过所述方法制备的纯化的瓜尔胶的眼用制剂。

2. 发明申请

WO2011068955A1 OPHTHALMIC EMULSION 审中-公开
标题翻译： OPHTHALMIC乳液
公开(公告)号：WO2011068955A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058703
申请日：2010-12-02
申请人： ALCON RESEARCH, LTD. , KETELSON, Howard Allen , MEADOWS, David L.
发明人： KETELSON, Howard Allen , MEADOWS, David L.
IPC分类号： A61K9/00 , A61K9/107 , A61K47/24 , A61K47/36 , A61K47/02
CPC分类号： A61K9/107 , A61K9/0048 , B01F17/0028 , B01F17/0064 , B01F17/0085
摘要： The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
摘要翻译：本发明涉及眼用乳液。该乳液具有促进乳液中小油滴的稳定性的成分的独特组合。乳剂还包括有助于将脂质输送到眼表面的粘膜粘附聚合物。

3. 发明申请

WO2005008220A1 SYSTEM AND METHOD FOR DYNAMIC CONTACT ANGLE MEASUREMENT 审中-公开
标题翻译：用于动态接触角测量的系统和方法
公开(公告)号：WO2005008220A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/022360
申请日：2004-07-14
申请人： ALCON, INC. , KETELSON, Howard Allen , MEADOWS, David L.
发明人： KETELSON, Howard Allen , MEADOWS, David L.
IPC分类号： G01N13/02
CPC分类号： G01N13/02 , G01N2013/0208 , G01N2013/0241
摘要： A system and method for dynamic contact angle measurement on a curved material are disclosed. One embodiment of the method comprises: initializing a video-based contact angle measuring apparatus; preparing the curved material for contact angle measurement; performing a sessile drop procedure to deposit a drop of liquid on the curved material; capturing an image of the drop on the curved material at a preset time; determining a drop-curved material interface on the image; determining a drop profile on the image; and calculating a set of dynamic contact angles based on the drop-curved material interface and the drop profile. The contact angle measuring apparatus can further comprise a processor for executing software instructions, a software module comprising processor-executable software instructions for performing at least some of the steps of the method and a memory, operably coupled to the processor, for storing the processor-executable software instructions. Further, the steps of determining the drop-curved material interface, determining the drop profile, capturing an image, initializing the contact angle-measuring apparatus and calculating the set of dynamic contact angles can each be at least partially performed via software running on the processor. The contact angle measuring apparatus can also include a camera and a digital frame-grabber for capturing an image. As a further aspect of the present invention, the curved material can be a hydrogel contact lens either mounted on an external sample stage or in a patient's eye for in vivo contact angle measurements.
摘要翻译：公开了一种用于弯曲材料上的动态接触角测量的系统和方法。该方法的一个实施例包括：初始化基于视频的接触角测量装置; 准备用于接触角测量的弯曲材料; 执行固定滴落程序以将一滴液体沉积在弯曲的材料上; 在预设时间捕获弯曲材料上的液滴的图像; 确定图像上的下落曲线材料界面; 确定图像上的丢弃轮廓; 并且基于液滴曲线材料界面和液滴轮廓计算一组动态接触角。接触角测量装置还可以包括用于执行软件指令的处理器，软件模块，包括用于执行可操作地耦合到处理器的方法和存储器的至少一些步骤的处理器可执行软件指令，用于存储处理器 - 可执行软件说明。此外，可以通过在处理器上运行的软件至少部分地执行确定落下曲线材料界面，确定液滴轮廓，拍摄图像，初始化接触角测量装置和计算动态接触角集合的步骤。接触角测量装置还可以包括用于捕获图像的相机和数字帧抓取器。作为本发明的另一方面，弯曲材料可以是安装在外部样品台上或患者眼睛中的水凝胶隐形眼镜，用于体内接触角测量。

4. 发明申请

WO2013119974A1 AQUEOUS PHARMACEUTICAL COMPOSITION WITH ENHANCED STABILITY 审中-公开
标题翻译：具有增强稳定性的水性药物组合物
公开(公告)号：WO2013119974A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025376
申请日：2013-02-08
申请人： ALCON RESEARCH, LTD.
发明人： MEADOWS, David L. , KETELSON, Howard Allen , DAVIS, James W. , CHIOU, Jang-Shing
IPC分类号： A61K9/00 , A61K9/08 , A61K47/36 , A61K47/48 , A61K47/02
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/08 , A61K31/335 , A61K31/551 , A61K47/02 , A61K47/186 , A61K47/34 , A61K47/36 , A61K47/40
摘要： The present invention is an aqueous pharmaceutical composition that includes an ionized therapeutic agent, an ionic component and guar gum. The guar gum is present in the composition a concentration sufficient to limit interactions between the ionized therapeutic agent and the ionic component thereby imparting stability to the composition. The composition is preferably at or near physiologic pH. The aqueous pharmaceutical composition has been found particularly useful as an aqueous ophthalmic, otic or nasal composition. The pharmaceutical composition, due to its characteristics, is particularly suitable as an ophthalmic composition.
摘要翻译：本发明是一种水性药物组合物，其包含电离治疗剂，离子组分和瓜耳胶。瓜尔胶在组合物中存在足以限制电离治疗剂和离子组分之间的相互作用的浓度，从而赋予组合物稳定性。组合物优选处于或接近生理pH。已经发现水性药物组合物特别可用作眼科，耳鼻喉或鼻腔组合物。由于其特性，药物组合物特别适合作为眼用组合物。

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