专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023033729A2 A METHOD OF DETECTING A POPULATION OF MACROPHAGES 审中-公开
公开(公告)号：WO2023033729A2
公开(公告)日：2023-03-09
申请号：PCT/SG2022/050619
申请日：2022-08-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , AOUADI, Myriam
发明人： BLERIOT, Camille , GINHOUX, Florent
IPC分类号： G01N33/50 , A01K67/027 , C12Q1/00
摘要： There is provided a method of detecting a population of macrophage in a sample comprising detecting and/or determining the expression of Cdh5 in the macrophage in the sample. Also disclosed is a kit for detecting and/or separating and/or depleting a population of a macrophage, a method of depleting a population of a macrophage, a method of improving the health of an obese and/or overweight subject, a method of determining the risk of obesity and/or a metabolic impairment related to obesity in a subject, and an animal model thereof.

2. 发明申请

WO2018044238A1 METHODS FOR THE IDENTIFICATION, TARGETING AND ISOLATION OF HUMAN DENDRITIC CELL (DC) PRECURSORS "PRE-DC" AND THEIR USES THEREOF 审中-公开
标题翻译：人类树突状细胞（DC）前体“PRE-DC”的鉴定，靶向和分离方法及其用途
公开(公告)号：WO2018044238A1
公开(公告)日：2018-03-08
申请号：PCT/SG2017/050435
申请日：2017-08-31
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： GINHOUX, Florent , SEE, Chi Ee Peter
IPC分类号： G01N33/50 , G01N33/68 , G01N33/564 , A61K39/395 , A61K35/15 , A61P31/12 , A61P3/04 , A61P29/00 , A61P35/00 , A61P37/00
摘要： Biomarkers for the detection and identification of a precursor of conventional dendritic cell (cDC) (pre-DC) and its cell subsets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also disclosed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer.
摘要翻译：定义了用于检测和鉴定常规树突细胞（cDC）（pre-DC）前体和其细胞亚群（pre-cDC1或pre-cDC2）的生物标志物，其包括CD169， CD327，AXL，CD271，CD324及其组合，用于检测前DC。用于检测疾病或病症，现有疾病或病症的预后的方法包括测定与对照相比受试者样品中的前DC细胞的数量，以及治疗患者的方法，所述方法包括给予抗CD169，CD327 ，AXL，CD271，CD324及其组合也被公开。另外，包含对一种或多种靶标疾病的生物标记或抗原和/或一种或多种选自早期前DC，前cDC1和前cDC2的细胞具有特异性的一种或多种结合分子的免疫原性组合物是也被公开用于引发针对传染性疾病或癌症的免疫应答。

3. 发明申请

WO2016114723A1 DIFFERENTIATION OF MACROPHAGES FROM PLURIPOTENT STEM CELLS 审中-公开
标题翻译：来自大脑干细胞的巨噬细胞的分化
公开(公告)号：WO2016114723A1
公开(公告)日：2016-07-21
申请号：PCT/SG2016/050018
申请日：2016-01-18
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： LIM, Hwei-In Shawn , HUBER, Tara , GINHOUX, Florent
IPC分类号： C12N5/0786 , G01N33/50 , A61K35/15 , A61P17/02
CPC分类号： C12N5/0645 , A61K35/15 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/165 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/415 , C12N2501/727 , C12N2506/02 , C12N2506/45 , C12N2533/90 , G01N33/5055 , G01N33/5058 , G01N33/5073
摘要： The present invention relates to a method of culturing primitive-like macrophages from stem cells, a kit when used in the method thereof and uses of the primitive like macrophage for in-vitro disease models and for screening compounds for therapy. One embodied culture method comprises contacting and incubating embryonic stem cells or induced pluripotent stem cells with a serum-free culture media comprising a GSK3 inhibitor to differentiate stem cells into cells of the mesoderm lineage, followed by incubation with a culture media comprising Dickkopf-related protein 1 (DKK1) to differentiate the mesoderm into cells of hematopoietic lineage, maturing hematopoietic cells and incubating these cells with a culture media comprising M-CSF to drive differentiation into primitive-like macrophages. Another embodiment comprises incubating the stem cells with serum-free culture media comprising FGF2 and BMP4 to induce differentiation into cells of the mesoderm lineage, followed by incubating the cells with a culture media comprising FGF2, BMP4, Activin A and VEGF to differentiate the cells of the mesoderm lineage into cells of the hematopoietic cell lineage, maturing the cells of the hematopoietic cell lineage and lastly, incubating the matured hematopoietic cells with culture media comprising M-CSF to drive the differentiation of hematopoietic cells into primitive-like macrophages.
摘要翻译：本发明涉及一种从干细胞中培养原始样巨噬细胞的方法，用于其方法中的试剂盒以及诸如巨噬细胞之类原子用于体外疾病模型和筛选用于治疗的化合物的用途。一种具体的培养方法包括使含有GSK3抑制剂的无血清培养基与胚胎干细胞或诱导的多能干细胞接触并孵育，以将干细胞分化成中胚层谱系的细胞，然后与包含Dickkopf相关蛋白 1（DKK1）将中胚层分化成造血谱系细胞，成熟造血细胞并用包含M-CSF的培养基孵育这些细胞以驱动分化为原始状巨噬细胞。另一个实施方案包括将干细胞与包含FGF2和BMP4的无血清培养基一起孵育以诱导分化成中胚层谱系的细胞，随后用包含FGF2，BMP4，活化素A和VEGF的培养基孵育细胞以分化细胞造血细胞谱系细胞的中胚层谱系，成熟造血细胞谱系的细胞，最后，将含有M-CSF的培养基培养成熟的造血细胞，以驱动造血细胞分化为原始状巨噬细胞。

4. 发明申请

WO2013122544A2 IL-1β NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES 审中-公开
标题翻译： IL-1beta中和人类单克隆抗体
公开(公告)号：WO2013122544A2
公开(公告)日：2013-08-22
申请号：PCT/SG2013/000057
申请日：2013-02-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： WANG, Cheng-I , GOH, Angeline , YEO, Siok Ping , MORTELLARO, Alessandra , BISWAS, Subhra Kumar , GINHOUX, Florent , ZHONG, Pingyu
IPC分类号： C07K16/24
CPC分类号： C07K16/245 , A61K39/3955 , A61K2039/505 , C07K2317/10 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.
摘要翻译：本发明涉及抗原结合蛋白，尤其涉及IL-1β抗原结合蛋白。本发明还提供了包含抗原结合蛋白的组合物，抗原结合蛋白的用途和生产方法。

5. 发明申请

WO2021251908A1 NEUTROPHIL PROGENITORS AND RELATED METHODS AND USES 审中-公开
公开(公告)号：WO2021251908A1
公开(公告)日：2021-12-16
申请号：PCT/SG2021/050342
申请日：2021-06-11
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： NG, Lai Guan , KWOK, Immanuel, Weng Han , TAN, De Li, Leonard , GINHOUX, Florent
IPC分类号： G01N33/50 , C12N5/0787 , A61K35/15 , A61P7/00 , C12N5/06 , G01N33/5005
摘要： There is provided a method of identifying a neutrophil progenitor, the method comprising: determining an expression of at least one biomarker selected from the group consisting of: CD71, LOX-1, CD164, CD112, CD181, TACSTD2, CD11b and CD49d in a cell. In various embodiments, the cell is identified as a neutrophil progenitor when it is determined to have at least one of the following expression profiles: CD71hi/+, LOX-1int/lo/-, CD164hi/+, CD112hi/+, CD181int/lo/-, TACSTD2hi/+, CD11blo/- and/or CD49dint/hi/+. Also disclosed are a method of sorting and/or separating neutrophil progenitors from a cell population, a composition that is enriched in neutrophil progenitors and related uses and methods.

6. 发明申请

WO2020263192A1 METHOD OF IDENTIFYING PRO-INFLAMMATORY DENDRITIC CELLS 审中-公开
公开(公告)号：WO2020263192A1
公开(公告)日：2020-12-30
申请号：PCT/SG2020/050369
申请日：2020-06-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： GINHOUX, Florent , DUTERTRE, Charles Antoine
IPC分类号： G01N33/68
摘要： There is provided a method of identifying pro-inflammatory dendritic cells, the method comprising: determining an expression of CD5, CD14 and/or CD163 in cells, wherein CD5 - , CD14 + and/or GD163 + cells are identified as pro- inflammatory dendritic cells. Also disclosed is a method of characterising inflammation and/or inflammatory disease in a subject, the method comprising: determining a proportion of CD5 - , CD14 + and/or GD163 + dendritic cells in the subject's sample, wherein the proportion positively correlates with the level of inflammation and/or the severity of inflammatory disease in the subject.

7. 发明申请

WO2018203833A1 METHODS FOR THE STIMULATION OF DENDRITIC CELL (DC) PRECURSOR POPULATION "PRE-DC" AND THEIR USES THEREOF 审中-公开
公开(公告)号：WO2018203833A1
公开(公告)日：2018-11-08
申请号：PCT/SG2018/050219
申请日：2018-05-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： GINHOUX, Florent , SEE, Chi Ee Peter
IPC分类号： A61K39/39 , A61K31/7056 , A61P31/00 , A61P35/00 , A61P37/04 , G01N33/50
摘要： The present invention relates to a method of treating or preventing an infection, a neoplastic disease or an immune-related disease in a subject in need thereof, the method comprising contacting a therapeutically effective or immuno-effective amount of an TLR9 agonist, specifically CpG oligodeoxynucleotide 2216 (CpG ODN), with a precursor dendritic cell (pre-DC), wherein the TLR9 agonist stimulates the pre-DC to secrete one or more cytokines such as TNF-alpha and IL-12p40, to thereby activate or increase the subject's immune response for treating or preventing the infection, the neoplastic disease or the immune-related disease. The present invention also relates to immunogenic or adjuvant compositions comprising the TLR9 agonist. A method of diagnosing a deficient immune system in a subject, comprising contacting a sample comprising pre-DC from the subject with one or more TLR 9 agonists and kits thereof are also disclosed.

8. 发明申请

WO2013122544A9 IL-1β NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES 审中-公开
公开(公告)号：WO2013122544A9
公开(公告)日：2013-08-22
申请号：PCT/SG2013/000057
申请日：2013-02-13
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： WANG, Cheng-I , GOH, Angeline , YEO, Siok Ping , MORTELLARO, Alessandra , BISWAS, Subhra Kumar , GINHOUX, Florent , ZHONG, Pingyu
IPC分类号： C07K16/24
摘要： The present invention is directed to antigen binding proteins and in particular to IL-1β antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.

9. 发明申请

WO2022031234A1 CHARACTERISING MACROPHAGES AND METHODS THEREOF 审中-公开
公开(公告)号：WO2022031234A1
公开(公告)日：2022-02-10
申请号：PCT/SG2021/050458
申请日：2021-08-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： BLERIOT, Camille , GINHOUX, Florent , SHARMA, Ankur
IPC分类号： G01N33/50
摘要： There is provided a method of characterising a macrophage in a tissue of a subject, wherein the method comprises determining an expression of one or more biomarkers in the macrophage, wherein the one or more biomarkers is selected from the group consisting of Folr2, SerpinaSi, Nid2, Slc27a6, SemaSa, Cdh13, Bcl6b, C6, Klf15, Marco, Cd209d, Tshz3, Bmprla, Tln2, Coro2b, Ackr2, 1110046J04Rik, Pcdhac2, Gm2253, Vsig4, Phactrt, NpM, CpneS, Angptl7, Gm26714, Auts2, Cxcl13, Sgce, 2900052N01 Rik, Cd209b, Timd4, Cd209g, Mrd (CD206), Spp1, Il22ra2, Gm24112, Gm23010, Ighv7-1, Gm23628, Gm24620, Gm23058, Arhgef37, Gad1-ps, Gm26397, lghv2-5, Chil3, Mir1934, 1810012K08Rik, Ighv1 -59, Gm14119, Gm19620 and Snord71. In one embodiment, the macrophage can be an embryo-derived macrophage and/or a long-lived tissue resident macrophage. In another embodiment, the macrophage can be a monocyte-derived macrophage. Also disclosed are methods of diagnosing a disease in a subject, methods of treating a disease, and kits for use thereof relating to a macrophage determined to express one or more of the said biomarkers.

10. 发明申请

WO2018224614A1 VEGF INHIBITORS FOR USE FOR PREVENTING AND/OR TREATING ACNE 审中-公开
公开(公告)号：WO2018224614A1
公开(公告)日：2018-12-13
申请号：PCT/EP2018/065080
申请日：2018-06-07
申请人： GALDERMA RESEARCH & DEVELOPMENT , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： VIAL, Emmanuel , OUVRY, Gilles , HACINI-RACHINEL, Fériel , GINHOUX, Florent , JANELA, Baptiste
IPC分类号： A61K31/395 , A61K31/495 , A61P17/10
CPC分类号： A61K31/713 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K39/395 , A61K2039/505 , A61P17/10 , A61P31/04 , C07K16/22 , C07K2317/76
摘要： The present invention relates to the use of a VEGF inhibitor for use for preventing and/or treating acne.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式