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1. 发明申请

WO2017042636A1 NITRIC OXIDE INHALATION THERAPY FOR INFANTS WITH BRONCHIOLITIS 审中-公开
标题翻译：含有BRONCHIOLITIS的婴儿的氮氧化物吸入治疗
公开(公告)号：WO2017042636A1
公开(公告)日：2017-03-16
申请号：PCT/IB2016/001447
申请日：2016-09-09
申请人： ADVANCED INHALATION THERAPIES (AIT) LTD.
发明人： AV-GAY, Yossef , GREENBERG, David , TAL, Asher
IPC分类号： A61P9/00 , A61K31/198
CPC分类号： A61K33/00 , A61K2300/00
摘要： The present invention provides a method for treating bronchiolitis in an infant in need thereof, wherein the method comprises repeatedly administering to the infant a gas mixture comprising nitric oxide at a concentration from about 144 to about 176 ppm for a first period of time, followed by a gas mixture containing no nitric oxide for a second period of time, wherein the administration is repeated for a time sufficient to: a) reduce the length of time of hospitalization required to achieve oxygen saturation greater than or equal to 92% in room air; b) reduce the length of time of hospitalization required to achieve a clinical score of less than or equal to 5; c) reduce the length of time of hospitalization required to be discharged; or d) any combination thereof, as compared to an infant that is not subjected to the repeated administration of nitric oxide.
摘要翻译：本发明提供了治疗有需要的婴儿的细支气管炎的方法，其中所述方法包括向婴儿反复施用含有浓度为约144至约176ppm的一氧化氮的气体混合物，持续第一时间段，随后是在第二时间段内不含一氧化氮的气体混合物，其中重复给药足够的时间：a）在室内空气中减少达到氧饱和度所需的时间长度大于或等于92％; b）减少实现临床评分小于或等于5的住院时间; c）减少需要出院的住院时间; 或d）与未经受重复施用一氧化氮的婴儿相比的任何组合。

2. 发明申请

WO2015037002A2 SYSTEM FOR NITRIC OXIDE INHALATION 审中-公开
标题翻译：氮氧化物吸入系统
公开(公告)号：WO2015037002A2
公开(公告)日：2015-03-19
申请号：PCT/IL2014/050811
申请日：2014-09-11
申请人： ADVANCED INHALATION THERAPIES (AIT) LTD.
发明人： AV-GAY, Yossef , GREENBERG, David , VIZMAN, Racheli , LEVI, Einav
CPC分类号： A61M16/12 , A61M16/0057 , A61M16/0081 , A61M16/0627 , A61M16/122 , A61M16/20 , A61M16/208 , A61M2016/0015 , A61M2016/0027 , A61M2016/1025 , A61M2016/1035 , A61M2202/0208 , A61M2202/0275 , A61M2202/0283 , A61M2205/3351 , A61M2205/3389 , A61M2205/3393 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/84 , A61M2240/00 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A system for inhalation, comprising gas supply apparatus configured to separately supply at least NO, and a carrier gas mixture which contains O 2 ; a mixer apparatus configured for receiving gases from the supply apparatus and mixing the NO with the carrier gas mixture to provide a therapeutic mixture; an inhaler device configured for receiving the therapeutic mixture and releasing the therapeutic mixture in an enclosed space of the inhaler device; a chemical sensing assembly configured for providing data pertaining to a concentration of at least NO 2 in the inhaler device; and a controller configured for controlling flow of the therapeutic mixture responsively to the data.
摘要翻译：一种用于吸入的系统，包括被配置为分别供应至少NO的气体供应装置和包含O 2的载气混合物; 混合器装置，被配置为从所述供应装置接收气体并将所述NO与所述载气混合物混合以提供治疗混合物; 吸入器装置，被配置为接收治疗混合物并将治疗混合物释放在吸入器装置的封闭空间中; 化学感测组件，被配置为提供与吸入器装置中至少NO 2浓度有关的数据; 以及控制器，被配置为响应于所述数据控制治疗混合物的流动。

3. 发明申请

WO2014136111A2 INHALATION OF NITRIC OXIDE FOR TREATING RESPIRATORY DISEASES 审中-公开
标题翻译：吸入氧化氮用于治疗呼吸道疾病
公开(公告)号：WO2014136111A2
公开(公告)日：2014-09-12
申请号：PCT/IL2014/050225
申请日：2014-03-06
申请人： ADVANCED INHALATION THERAPIES (AIT) LTD.
发明人： AV-GAY, Yossef , GREENBERG, David , VIZMAN, Racheli
IPC分类号： A61M16/12
CPC分类号： A61K33/00 , A61B5/1455 , A61K9/007 , A61M16/10 , A61M16/12 , A61M2202/0275 , A61M2205/33 , A61M2230/205 , A61M2230/432 , A61M2230/435 , A61M2230/437 , G01N33/0036 , G01N33/004 , G01N33/497 , G01N33/6863 , G01N33/84 , G01N33/86 , G01N2033/4975 , G01N2800/12 , G01N2800/52

4. 发明申请

WO2017130066A1 METHODS OF TREATMENT OF RESPIRATORY TRACT INFECTIONS AND CYSTIC FIBROSIS 审中-公开
标题翻译：呼吸道感染和囊性纤维化的治疗方法
公开(公告)号：WO2017130066A1
公开(公告)日：2017-08-03
申请号：PCT/IB2017/000118
申请日：2017-01-27
申请人： ADVANCED INHALATION THERAPIES (AIT) LTD.
发明人： GREENBERG, David , TAL, Asher , AV-GAY, Yossef
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K31/04
摘要： The present invention provides a method for treating cystic fibrosis in a human subject in need thereof, wherein the method comprises repeatedly administering to the human subject a gas mixture comprising nitric oxide at a concentration from about 144 to about 176 ppm for a first period of time, followed by a gas mixture containing no nitric oxide for a second period of time, wherein the administration is repeated for a time sufficient to: a) reduce the level of at least one inflammatory biomarker in the human subject when compared to the level of the inflammatory biomarker prior to the administration; b) reduce the microbial density by 1 to 2 log units as measured by colony forming units in the human subject when compared to the microbial density prior to the administration; or c) a combination thereof.
摘要翻译：本发明提供了治疗有此需要的人类受试者中的囊性纤维化的方法，其中所述方法包括向人类受试者重复施用包含一氧化氮浓度为约144至约在第一段时间内接触176ppm，随后在第二段时间内不含一氧化氮的气体混合物，其中给药重复足够的时间以：a）降低人体中至少一种炎性生物标志物的水平当与施用前的炎性生物标志物的水平相比较时受试者; b）当与施用前的微生物密度相比时，通过人类受试者中的菌落形成单位测量，将微生物密度降低1至2个对数单位; 或c）其组合。

5. 发明申请

WO2017130062A1 SYSTEMS FOR INHALATION OF THERAUPEUTIC AND DIAGNOSTIC GAS AND METHODS OF USE THEREOF 审中-公开
标题翻译：吸入胸腔积液和诊断气体的系统及其使用方法
公开(公告)号：WO2017130062A1
公开(公告)日：2017-08-03
申请号：PCT/IB2017/000112
申请日：2017-01-27
申请人： ADVANCED INHALATION THERAPIES (AIT) LTD.
发明人： FIGLEY, Curtis , EINAV, Levi , OPHIR, Atai , AV-GAY, Yossef
IPC分类号： A61M16/00
CPC分类号： A61M16/024 , A61M16/0051 , A61M16/0078 , A61M16/06 , A61M16/0833 , A61M16/085 , A61M16/0875 , A61M16/12 , A61M16/122 , A61M16/208 , A61M2016/0033 , A61M2016/1025 , A61M2016/1035 , A61M2202/0208 , A61M2202/0225 , A61M2202/025 , A61M2202/0275 , A61M2206/11 , A61M2210/0618
摘要： In one embodiment, the present invention provides a system to deliver at least one therapeutic gas to a spontaneously breathing patient, wherein the rate of delivery of the at least one therapeutic gas exceeds the patient's inspiratory flow rate, and the amount of the at least one therapeutic gas that is wasted is minimized or eliminated.
摘要翻译：在一个实施例中，本发明提供了一种将至少一种治疗气体输送到自主呼吸患者的系统，其中至少一种治疗气体的输送速率超过患者的吸气流速，并且浪费的至少一种治疗气体的量被最小化或消除。

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