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1. 发明申请

WO2022147496A1 ANALYTE SENSORS WITH METAL-CONTAINING REDOX MEDIATORS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2022147496A1
公开(公告)日：2022-07-07
申请号：PCT/US2022/011026
申请日：2022-01-03
申请人： ABBOTT DIABETES CARE INC.
发明人： LE, Phu , LATOUR, John, V. , WALLIS, Kevin, P. , HOSS, Udo
IPC分类号： C12Q1/00
摘要： The present disclosure provides redox mediators having two tridentate ligands and analyte sensors comprising such redox mediators. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject.

2. 发明申请

WO2019035073A3 SYSTEMS, DEVICES, AND METHODS RELATED TO THE INDIVIDUALIZED CALIBRATION AND/OR MANUFACTURING OF MEDICAL DEVICES 审中-公开
公开(公告)号：WO2019035073A3
公开(公告)日：2019-02-21
申请号：PCT/IB2018/056223
申请日：2018-08-17
申请人： ABBOTT DIABETES CARE INC.
发明人： SCOTT, Steven , BENNELL, Christopher J. , BHOGAL, Claire , CRANFIELD, Katie A. , TAUB, Marc B. , WINTER, Bree M. , REYNOLDS, Owen D. , BABKA, Jean-Pierre , PATEL, Dharmendra S. , THOMAS, Christopher A. , HOSS, Udo , YAHNKE, Mark S. , KAHN, Tahir S.
IPC分类号： A61B5/145 , A61B5/1495
摘要： Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.

3. 发明申请

WO2019018838A1 DEVICES, SYSTEMS, AND METHODS FOR DELIVERY OF SOLID FORMULATIONS 审中-公开
公开(公告)号：WO2019018838A1
公开(公告)日：2019-01-24
申请号：PCT/US2018/043240
申请日：2018-07-23
申请人： ABBOTT DIABETES CARE INC.
发明人： HOSS, Udo
IPC分类号： A61B5/145 , A61K9/48 , A61K9/50 , A61K9/51 , A61M5/00
摘要： The disclosed technology provides delivery devices for therapeutic agents, where the delivery devices are configured to be worn on a patient's body, and where the delivery devices deliver a solid formulation of a therapeutic agent subcutaneously to the patient. The delivery devices may in one embodiment be part of an integrated system comprising both a solid formulation delivery device and an analyte sensing device.

4. 发明申请

WO2013086007A2 ELECTRODES WITH CONDUCTIVE POLYMER UNDERLAYER 审中-公开
标题翻译：导电聚合物底层电极
公开(公告)号：WO2013086007A2
公开(公告)日：2013-06-13
申请号：PCT/US2012/067965
申请日：2012-12-05
申请人： ABBOTT DIABETES CARE INC.
发明人： HOSS, Udo , HELLER, Adam
IPC分类号： G01N27/30
CPC分类号： A61B5/1468 , A61B5/14532 , G01N27/3272
摘要： The disclosure provides method and materials for preparing biosensors (e.g., in vitro test strips and in vivo sensors) with improved mechanical properties. In some aspects, for example, the electrochemical sensors have improved durability and are better able to withstand mechanical and electrochemical stresses such as those encountered during manufacturing, transportation, storage, and use (e.g., in vivo positioning, in vivo operation, or in vitro operation). Also for example, in some aspects the electrochemical sensors are less susceptible to pinholes and other manufacturing defects that degrade performance in traditional sensors.
摘要翻译：本公开提供了用于制备具有改进的机械性能的生物传感器（例如，体外测试条和体内传感器）的方法和材料。在一些方面，例如，电化学传感器具有改善的耐久性，并且能够更好地承受诸如在制造，运输，储存和使用期间遇到的机械和电化学应力（例如，体内定位，体内操作或体外操作）。同样例如，在一些方面，电化学传感器较不易受针孔和其他制造缺陷的影响，这些缺陷降低了传统传感器的性能。

5. 发明申请

WO2011130545A1 ANALYTE MONITORING DEVICE AND METHODS 审中-公开
标题翻译：分析监测装置和方法
公开(公告)号：WO2011130545A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032542
申请日：2011-04-14
申请人： ABBOTT DIABETES CARE INC. , HOSS, Udo , FELDMAN, Benjamin, J. , LIU, Zenghe , CHO, Hyun , RUSH, Benjamin, M.
发明人： HOSS, Udo , FELDMAN, Benjamin, J. , LIU, Zenghe , CHO, Hyun , RUSH, Benjamin, M.
IPC分类号： A61B5/00
CPC分类号： A61B5/1473 , A61B5/1451 , A61B5/14532 , A61B5/1468 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B2560/0252 , A61B2560/0443
摘要： Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.
摘要翻译：用于确定实时分析物浓度的方法和系统，包括分析物传感器，所述分析物传感器具有与皮肤层下面的间质液体流体接触的部分;体内电子器件，包括耦合到分析物传感器并被配置用于定位在皮肤层上的壳体，在壳体上包括多个电触头的体内电子壳体; 以及数据分析单元，其具有在壳体上的数据分析单元壳体和多个探针。每个探针被配置为当数据分析单元与体内电子器件物理接触地定位时电耦合到相应的电接触。探针上的一个或多个信号对应于基本上实时监测的分析物浓度水平（MACL），预定时间段内的MACL或MACL的变化率或其组合中的一个或多个。

6. 发明申请

WO2011011643A1 CONTINUOUS ANALYTE MEASUREMENT SYSTEMS AND SYSTEMS AND METHODS FOR IMPLANTING THEM 审中-公开
标题翻译：连续分析仪测量系统及其系统和方法
公开(公告)号：WO2011011643A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/042974
申请日：2010-07-22
申请人： ABBOTT DIABETES CARE INC. , HOSS, Udo , MAZZA, John, Charles , LE, Phu
发明人： HOSS, Udo , MAZZA, John, Charles , LE, Phu
IPC分类号： A61B5/1468
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B2562/227
摘要： Low profile continuous analyte measurement systems and systems and methods for implantation within the skin of a patient are provided.
摘要翻译：提供了用于植入患者皮肤内的低分子连续分析物测量系统和系统和方法。

7. 发明申请

WO2009124095A1 SHALLOW IMPLANTABLE ANALYTE SENSOR WITH RAPID PHYSIOLOGICAL RESPONSE 审中-公开
标题翻译：具有快速生理反应的可剥离分析传感器
公开(公告)号：WO2009124095A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039044
申请日：2009-03-31
申请人： ABBOTT DIABETES CARE INC. , FELDMAN, Benjamin, J. , HOSS, Udo , CHO, Hyun
发明人： FELDMAN, Benjamin, J. , HOSS, Udo , CHO, Hyun
IPC分类号： G01F1/64
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B5/685 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2562/0295
摘要： Methods and devices to detect analyte in body fluid are provided Embodiment include analyte sensors designed so that at least a portion of the sensor is positionable beneath the skin One or more working electrodes may be placed intradermal^ under the skin layer A detected signal from the implanted portion of the analyte sensor is associated with an analyte level of the user.
摘要翻译：用于检测体液中分析物的方法和装置实施例包括分析物传感器，其被设计成使得传感器的至少一部分可定位在皮肤下面。一个或多个工作电极可以被皮内层下皮内放置。来自植入物的检测信号分析物传感器的一部分与用户的分析物水平相关联。

8. 发明申请

WO2022147512A1 AN ANALYTE SENSOR AND SHARP FOR DELIVERING A THERAPEUTIC AGENT IN CLOSE PROXIMITY TO AN ANALYTE SENSOR AND METHODS THEREFORE 审中-公开
公开(公告)号：WO2022147512A1
公开(公告)日：2022-07-07
申请号：PCT/US2022/011058
申请日：2022-01-03
申请人： ABBOTT DIABETES CARE INC.
发明人： CLARY, Jacob , LATOUR, John, V. , HOSS, Udo , OU, Junli , CANNADY, Nolan, R.
IPC分类号： A61B5/145 , A61B5/1486 , A61M5/14
摘要： The present disclosure provides therapeutic compositions and methods for delivering a therapeutic agent in close proximity to an analyte sensor. In certain embodiments, the present disclosure provides analyte sensors including one or more therapeutic agents, e.g, covalently-bound therapeutic agents. In certain embodiments, the present disclosure further provides therapeutic releasing compositions and methods of delivering such therapeutic releasing compositions.

9. 发明申请

WO2022010620A1 ANALYTE SENSORS FEATURING ENHANCEMENTS FOR DECREASING INTERFERENT SIGNAL 审中-公开
公开(公告)号：WO2022010620A1
公开(公告)日：2022-01-13
申请号：PCT/US2021/037307
申请日：2021-06-15
申请人： ABBOTT DIABETES CARE INC.
发明人： OJA, Stephen , FOX, Cade, Brylee , TRAN, Lam, N. , LIU, Zenghe , FELDMAN, Benjamin, J. , HOSS, Udo , YAHNKE, Mark, Stephen , KHAN, Tahir, S. , BABKA, Jean-Pierre , REYNOLDS, Owen, Daniel
IPC分类号： A61B5/1486 , A61B5/1468 , G01N33/487 , A61B5/14532 , A61B5/14865
摘要： Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode comprising an active area disposed thereon and electrode asperities laser planed therefrom. Some analyte sensors may comprise an interferent-reactant species incorporated therewith. Some analyte sensors may comprise an interferent scrubbing electrode. Combinations of these enhancements may additionally be employed.

10. 发明申请

WO2021133903A1 ANALYTE SENSORS AND SENSING METHODS FEATURING LOW-POTENTIAL DETECTION 审中-公开
公开(公告)号：WO2021133903A1
公开(公告)日：2021-07-01
申请号：PCT/US2020/066826
申请日：2020-12-23
申请人： ABBOTT DIABETES CARE INC.
发明人： LATOUR, John, V. , MCCANLESS, Jonathan, D. , OJA, Stephen , OUYANG, Tianmei , WALLIS, Kevin, Paul , FELDMAN, Benjamin, J. , HOSS, Udo , QIAN, Suyue
IPC分类号： G01N27/327 , A61B5/145 , G01N33/66 , A61B5/14532 , A61B5/14865 , C12Q1/004 , C12Q1/006 , G01N27/3272 , G01N27/3277 , G01N27/3278
摘要： Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of (I) wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.

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