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1. 发明申请

WO2009024121A2 SOFT-TISSUE IMPLANT HAVING ANTIBACTERIAL EFFECT 审中-公开
标题翻译：具有抗菌作用的软组织植入物
公开(公告)号：WO2009024121A2
公开(公告)日：2009-02-26
申请号：PCT/DE2008001310
申请日：2008-08-05
申请人： FRIEDRICH BAUR GMBH , KOKOTT ANDREAS , HOFFMANN BETTINA , FELDMANN MARTINA , ZIEGLER GUENTER , PRANTL LUKAS , EISSENMANN-KLEIN MARITA
发明人： KOKOTT ANDREAS , HOFFMANN BETTINA , FELDMANN MARTINA , ZIEGLER GUENTER , PRANTL LUKAS , EISSENMANN-KLEIN MARITA
IPC分类号： A61L27/14 , A61L27/54
CPC分类号： A61L27/54 , A61L2300/406
摘要： The invention relates to a soft-tissue implant having an antibacterial effect in the medical field. The aim of the invention to provide a soft-tissue implant, such as a breast implant, having an antibacterial effect that avoids the disadvantages of prior art in that the bacterial contamination of implants, particularly breast implants, as a result of the deposition of bacteria and the formation of biofilms is prevented and/or reduced is achieved in that one or more active ingredients/substances can be released across a surface, wherein the release occurs by means of at least two different release mechanisms and/or by a release in two different release regions.
摘要翻译：本发明涉及具有在医学领域抗菌活性的软组织植入物。本发明的目的是提供一种软组织植入物，例如，乳房植入物，具有抗菌作用的指示，其通过植入物的细菌污染避免了现有技术的缺点，特别是乳房植入物，在细菌和生物膜形成的附接的结果防止或减少是，在一种或多种活性成分实现/物质是平释放，其中所述释放是通过至少两种不同的释放机制和/或由两个不同类型的释放区域的释放进行。

2. 发明申请

WO2008017719A3 A POROUS SOLID BODY WITH BIMODAL PORE SIZE DISTRIBUTION AND A METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：具有双峰尺寸分布的多孔固体及其生产方法
公开(公告)号：WO2008017719A3
公开(公告)日：2008-04-24
申请号：PCT/EP2007058314
申请日：2007-08-10
申请人： FRIEDRICH BAUR GMBH , DITTERT BERND , ZIEGLER GUENTER , HEIDENAU FRANK
发明人： DITTERT BERND , ZIEGLER GUENTER , HEIDENAU FRANK
IPC分类号： C04B35/00 , A61K33/00 , A61L24/00 , A61L27/00 , C04B38/00
CPC分类号： A61L24/0036 , A61K33/00 , A61K33/06 , A61K33/28 , A61K33/30 , A61K33/34 , A61K33/38 , A61L24/02 , A61L27/306 , A61L27/54 , A61L27/56 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , B82Y30/00 , C04B35/111 , C04B35/447 , C04B35/46 , C04B35/486 , C04B35/624 , C04B35/6316 , C04B38/0045 , C04B2103/67 , C04B2111/00836 , C04B2235/3212 , C04B2235/3281 , C04B2235/3291 , C04B2235/3418 , C04B2235/449 , C04B2235/5454 , C04B38/0054 , C04B38/0064 , C04B35/10 , C04B35/14 , C04B35/48 , A61K2300/00
摘要： The present invention discloses an antimicrobial, porous solid body with bimodal pore size distribution, a granulate made of this solid body, a mold comprising the solid body or the granulate, the use of the solid body, the granulate, or the mold, a method for the production of the mold, a method for the production of the porous solid body, and a body coated with the porous solid body. In this process, inorganic or organic particles and metal cations are inserted into an oxidic matrix.
摘要翻译：在本发明公开了一种抗微生物剂，具有双峰孔径分布的多孔固体，该固体本体，一模制体，其包括固体本体或颗粒剂中，使用固体的，颗粒的或模制的，用于生产模制品的方法，所制备的处理的颗粒的多孔固体和涂覆有多孔固体的涂层体。在这种情况下，无机或有机颗粒和金属阳离子被引入氧化物基质中。

3. 发明申请

WO2007025496A3 MATERIAL PRIMARILY FOR MEDICAL, LONG-TERM IN VIVO USE 审中-公开
标题翻译：医用材料的大部分，长期在体内使用
公开(公告)号：WO2007025496A3
公开(公告)日：2007-11-29
申请号：PCT/DE2006001334
申请日：2006-07-27
申请人： FRIEDRICH BAUR GMBH , UNIV REGENSBURG KLINIKUM , KOKOTT ANDREAS , HOFFMANN BETTINA , ZIEGLER GUENTER , BEHR MICHAEL , ROSENTRITT MARTIN
发明人： KOKOTT ANDREAS , HOFFMANN BETTINA , ZIEGLER GUENTER , BEHR MICHAEL , ROSENTRITT MARTIN
IPC分类号： A61K6/097 , A61K6/083 , A61L27/34
CPC分类号： A61K6/087 , A61K6/083 , A61K6/097 , A61L27/34 , A61L27/427 , A61L27/54 , A61L2300/404 , A61L2300/606 , C08B37/003 , C08L5/08 , C09D5/1662 , C08L33/10
摘要： The invention relates to a material that is used primarily for medical, long-term in vivo purposes, e.g. as a filling material in dentistry. The aim of the invention is to create a material primarily for medical, long-term in vivo use which does not have the disadvantages of materials used in prior art, is initiated without releasing active substances, and endures after the material has been removed or when the shape thereof is modified. Said aim is achieved by the fact that the material is made of polymers and filling agents which are embodied as polymer-coated, chemically modified particles that carry hydroxyl groups and are surrounded by a matrix of another polymer. The coating polymer develops an antimicrobial effect.
摘要翻译：本发明涉及用于主要医疗，长期的体内使用，例如作为材料，如在牙科填充材料。本发明的目的是提供一种材料用于体内使用的主要医疗，长期，其避免了现有技术的缺点，并且没有一个药物释放被启动，并且在去除材料之后或者尽管在材料形式变化的持续存在，这样实现，即该材料由聚合物和填料,,其中涂有聚合物的填料，化学改性的，带有羟基的颗粒，其是由另一种聚合物的基体所包围，其中所述涂层聚合物部署抗微生物效果的。

4. 发明申请

WO2005007212A3 INDIVIDUALLY ADJUSTABLE ACTIVE SUBSTANCE-RELEASING SYSTEM 审中-公开
标题翻译：单独可调释放系统
公开(公告)号：WO2005007212A3
公开(公告)日：2005-03-31
申请号：PCT/DE2004001512
申请日：2004-07-06
申请人： FRIEDRICH BAUR GMBH , KOKOTT ANDREAS , FELDMANN MARTINA , DETSCH RAINER , SCHNABELRAUCH MATTHIAS , ZIEGLER GUENTER , VOGT SEBASTIAN
发明人： KOKOTT ANDREAS , FELDMANN MARTINA , DETSCH RAINER , SCHNABELRAUCH MATTHIAS , ZIEGLER GUENTER , VOGT SEBASTIAN
IPC分类号： A61B17/00 , A61B17/68 , A61B17/72 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/54 , A61L31/16
CPC分类号： A61L31/16 , A61B17/68 , A61B17/72 , A61B17/8605 , A61B17/864 , A61B17/8685 , A61B2017/00004 , A61F2002/2839 , A61F2002/30062 , A61F2002/30677 , A61F2002/3068 , A61F2210/0004 , A61F2250/0068 , A61L27/54 , A61L2300/61
摘要： The invention relates to an active substance-releasing system. The aim of the invention is to create a topically effective active substance-releasing system which allows for a patient-specific combination of active substances while also being able to perform mechanical functions. Said aim is achieved by an individually adjustable system comprising a dimensionally stable, load-bearing basic member made of a non-resorbable and/or resorbable material, at least two visually distinguishable active substance carriers (A-M) which are made of resorbable and/or non-resorbable material, are mounted in a spatially separated manner in cavities that are externally accessible and/or on the surface of the basic member, and can be reversibly and/or irreversibly inserted into and/or applied onto the basic member, each of the active substance carriers containing a different pharmaceutical agent, application aids for inserting and/or applying the active substance carriers into and/or onto the basic member, and application aids for implanting and explanting the basic members loaded with the active substance carriers.
摘要翻译：本发明涉及一种药物递送系统。本发明的目的是提供一种一方面局部作用的药物释放系统的制剂允许患者特异性结合，在另一方面满足机械功能是这样实现的尺寸稳定的，最后优秀基本由非可再吸收的和/主体的可定制的系统或可再吸收材料是由至少两个视觉上可区分的活性成分的载体（AM），其由可吸收的和/或不可再吸收的材料制成的，其中的每一个含有至少一种其它药学活性剂，其中，在访问向外腔和/或在表面上的药物载体在基体的安装间隔，使活性成分的载体可逆和/或不可逆引入所述基体和/或在基体上和/或可应用，应用助剂的引入和/或Aufbr 在和/或在基体上的药物载体，和用于植入和与活性成分的碱explanting加载的载体，有输送装置的基因。

5. 发明申请

WO2008025840A3 STRUCTURED COATINGS FOR IMPLANTS AND METHOD FOR PRODUCTION THEREOF 审中-公开
标题翻译：结构化涂料用于生产植入物和方法
公开(公告)号：WO2008025840A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007059115
申请日：2007-08-31
申请人： FRIEDRICH BAUR GMBH , HEIDENAU FRANK , ZIEGLER GUENTER
发明人： HEIDENAU FRANK , ZIEGLER GUENTER
IPC分类号： A61L27/32 , A61L27/44
CPC分类号： A61L27/32 , A61L27/306 , A61L27/446 , A61L27/46 , A61L27/56 , A61L27/60
摘要： The invention relates to a method for producing a powder-filled ceramic coating made from a precursor ceramic compound (for example, a sol-gel), said coating having an advantageous surface roughness and wherein active ingredients may be eluted from the matrix or filler under physiological conditions and to an implant which can be produced according to the claimed method.
摘要翻译：本发明涉及一种用于一precursorkeramischen化合物（例如，溶胶 - 凝胶）的基础上，制备粉末填充的陶瓷涂层，所述涂层具有良好的表面粗糙度和从矩阵的和填料物质在生理条件下洗脱，以及根据本发明的方法可生产的植入物。

6. 发明申请

WO2008011876A3 ARRANGEMENT FOR ON-LINE MEASUREMENTS ON CELLS 审中-公开
标题翻译：安排在线测量对细胞
公开(公告)号：WO2008011876A3
公开(公告)日：2008-04-03
申请号：PCT/DE2007001326
申请日：2007-07-23
申请人： FRIEDRICH BAUR GMBH , SEITZ DANIEL , MAYR HELMAR , ZIEGLER GUENTER , VONAU WINFRIED , GERLACH FRANK , HERRMANN SIGRUN
发明人： SEITZ DANIEL , MAYR HELMAR , ZIEGLER GUENTER , VONAU WINFRIED , GERLACH FRANK , HERRMANN SIGRUN
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/5438 , B01L3/502707 , B01L2200/02 , B01L2300/0627 , B01L2300/0645 , B01L2300/163 , C12M41/32 , C12M41/34
摘要： The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for di measurement of soluble analytes and dissolved gases on samples in a sample area. The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and in the process can be integrated in a microfluidic system, is achieved in that the arrangement comprises a substrate (1), at least one sensor (2) a space (4) and a membrane (5) with the substrate (1) holding the sensor (2) or the sensors and the membrane (5) in such a way that a space (4) is generated between the sensor (2) and the sensors and the membrane (5), with the membrane (5) having the capability to be connected in a biocompatible form and to a cell culture space (7) with the sensor (2) or the sensors being electrochemical sensors, and in which the space (4) can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor (2) or the sensors is or are fitted with operating circuits (8) via which downstream electronics can be coupled.
摘要翻译：本发明涉及一种装置（测定装置），用于对细胞在线测量，特别是用于可溶性分析物和在本发明的一个Probenraum.Die对象样品中溶解的气体的二测量以提供用于在线测量侦察和代谢的监视的布置表示活细胞，避免了现有技术的缺点，并因此可以被集成到微流体系统，指示是这样达到的，该装置包括一个基底（1），至少一个传感器（2），一个空间（4）和一个膜（5），其中所述基板（1）支撑所述传感器（2）或传感器和所述膜（5）以这样的方式即（所述传感器（2）或传感器和所述膜（5）的空间之间 4）被产生，其特征在于，所述膜（5）是生物相容的与细胞培养室（7）连接到所述传感器（2）和所述传感器是电化学传感器，所述空间（4）具有填充转印介质和在流体系统可以被集成，并且所述传感器（2）或传感器操作的电路（8）携带，可以经由电子nachschaltbare耦合。

7. 发明申请

WO2004101841A2 METHOD FOR PRODUCING CERAMIC GRADIENT LAYERS ON A METALLIC SUBSTRATE BY MEANS OF AN IN SITU REACTION WITH NON-OXIDISING PRECURSOR IN A SI-C-N (M) SYSTEM 审中-公开
标题翻译：用于生产金属基体上陶瓷梯度层通过与IN SYSTEM的Si-C-N的非氧化物前体原位反应（M）
公开(公告)号：WO2004101841A2
公开(公告)日：2004-11-25
申请号：PCT/EP2004005209
申请日：2004-05-14
申请人： FRIEDRICH BAUR GMBH , FELDMANN MARTINA , MOTZ GUENTER , ZIEGLER GUENTER
发明人： FELDMANN MARTINA , MOTZ GUENTER , ZIEGLER GUENTER
IPC分类号： C23C12/02 , C23C26/00
CPC分类号： C23C26/00 , C23C12/02
摘要： The invention relates to a method for producing metallic substrates provided with superficial gradient layers and to a metallic substrate provided with a superficial gradient layer which is producible by said method. Said invention also relates to the use of said metallic substrate provided with a superficial gradient layer in the form of an element implatable into a human or animal body.
摘要翻译：本发明涉及一种用于生产具有表面梯度的金属基板，和与表面梯度层，由所述方法得到的金属基板的方法。本发明还涉及使用该金属基板的与表面梯度如在人或动物体的元件。

8. 发明申请

WO2007118848A2 METHOD FOR PRODUCTION OF A BIOCOMPATIBLE STRUCTURE IN PARTICULAR FOR PRODUCTION OF AN IMPLANT 审中-公开
标题翻译：一种用于生产生物相容的支架，尤其是用于制造植入物
公开(公告)号：WO2007118848A2
公开(公告)日：2007-10-25
申请号：PCT/EP2007053610
申请日：2007-04-13
申请人： FRIEDRICH BAUR GMBH , ZIEGLER GUENTER , DETSCH RAINER , DEISINGER ULRIKE , HAMISCH SABINE
发明人： ZIEGLER GUENTER , DETSCH RAINER , DEISINGER ULRIKE , HAMISCH SABINE
IPC分类号： A61L27/28 , A61L27/54
CPC分类号： B29C64/106 , B29L2031/7532
摘要： The invention relates to a method for production of a biocompatible structure, in particular, for production of an implant, comprising the following method steps: preparation of a metering nozzle, comprising at least two separate chambers, a first chamber being filled with a biocompatible matrix material and at least open second chamber being filled with at least one biocompatible and/or bioactive coating material and a tube at least partly integrated in the metering nozzle, a first end section of the tube being coupled to the first chamber to form a first strand of the matrix material and a second end section of the tube is coupled to an outlet opening of the metering nozzle, the second chamber at least partly enclosing a side wall of the tube which has at least one opening for coating the first strand of the matrix material with at least one coating material and production of a second strand by means of the metering nozzle made of the matrix material coated with the coating material and production of the structure from the second strand based on given data which may be stored in a databank.
摘要翻译：本发明涉及一种方法，用于制造生物相容的支架，特别是用于制造的植入物，其包括以下步骤：提供具有至少两个分开的腔中，具有biokompatiblcn基质材料和至少一个第二腔室与至少一种生物相容的和/第一腔室中的分注喷嘴或生物活性涂层材料被填充并具有至少部分地集成在计量喷嘴管，其特征在于，与所述第一腔室中的管的第一端部以形成所述基质材料的第一链和所述管的第二端部被联接到所述分注喷嘴的排出开口，其中所述第二腔室具有的管，其具有用于所述基质材料的与至少一种涂覆材料至少部分地包围，并提供介质的第二链与第一链的涂层的至少一个开口的侧壁期从经涂覆的基体材料用涂层材料，并产生从所述第二链作为可以被存储在数据存储器中的规定数据的功能结构中的分注喷嘴的。

9. 发明申请

WO2005030990A1 QUANTIFICATION SCHEMES FOR QUANTIFYING NUCLEIC ACIDS 审中-公开
标题翻译：定量核酸的量化方案
公开(公告)号：WO2005030990A1
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010712
申请日：2004-09-24
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ZIEGLER, Guenter , BABIEL, Reiner , FRANKEN, Norbert , LEYING, Hermann , PINSL-OBER, Judith , VESS, Thomas
发明人： ZIEGLER, Guenter , BABIEL, Reiner , FRANKEN, Norbert , LEYING, Hermann , PINSL-OBER, Judith , VESS, Thomas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2537/165
摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic valuc of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
摘要翻译：方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物的量相关的测量结果确定对照的进展参数的特征值; 以及使用至少所述目标的特征值，根据预定义或选择的量化方案量化原始目标量。

10. 发明申请

WO2004026346A3 ANTI-INFECTIOUS, BIOCOMPATIBLE TITANIUM OXIDE COATINGS FOR IMPLANTS, AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：用于植入物的抗感染，生物相容性氧化钛涂层及其生产方法
公开(公告)号：WO2004026346A3
公开(公告)日：2004-05-06
申请号：PCT/EP0310334
申请日：2003-09-17
申请人： BIOCER ENTWICKLUNGS GMBH , ZIEGLER GUENTER , GOLLWITZER HANS , HEIDENAU FRANK , MITTELMEIER WOLFRAM , STENZEL FRAUKE
发明人： ZIEGLER GUENTER , GOLLWITZER HANS , HEIDENAU FRANK , MITTELMEIER WOLFRAM , STENZEL FRAUKE
IPC分类号： A61L27/30 , A61L27/50 , A61L28/00 , A61L29/10 , A61L31/08
CPC分类号： A61L27/306 , A61L27/50
摘要： The invention relates to a method for producing a biocompatible titanium oxide coating containing metal ions, on an implant. Said metal ions can be eluted under physiological conditions and are homogeneously distributed in the coating. The invention also relates to an implant which can be produced according to the inventive method.
摘要翻译：本发明涉及一种用于生产含有在植入物上的二氧化钛涂层的生物相容性金属离子，其中所述的金属离子溶出和在涂层中的生理条件，以及根据本发明的方法的植入物可制造的下均匀地分布的方法。

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