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    • 2. 发明申请
    • CONCURRENT OPTIMIZATION IN SELECTION OF PRIMER AND CAPTURE PROBE SETS FOR NUCLEIC ACID ANALYSIS
    • 选择核酸分析初始化和捕获探针组的同时优化
    • WO2005010200A3
    • 2005-08-25
    • PCT/US2004022781
    • 2004-07-15
    • BIOARRAY SOLUTIONS LTDSEUL MICHAELVENER TATIANAXIA XIONGWU
    • SEUL MICHAELVENER TATIANAXIA XIONGWU
    • C12Q20060101C12Q1/68G01N33/48
    • C12Q1/6876C12Q2600/16G06F19/20G06F19/22
    • Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe ("primer"), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a "degree of matching" score on the basis of position­ weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence.
    • 公开了一种迭代优化两个(或多个)相互关联的探针组的方法,用于多步分析指定序列组,每个这样的序列需要用于转化的至少一个转化探针(“引物”),并且每个转化 用于检测至少一个捕获探针的序列。 本文公开的用于并行优化引物和探针选择的迭代方法调用快速逻辑串匹配函数以执行探针序列和靶序列的完全互相关。 得分函数根据本文介绍的位置加权汉明距离函数将每个探针 - 目标对齐分配给“匹配度”。 最终选择中的一对探针在几个位置可能有所不同,而其他探针对只能在一个位置上不同。 并不是所有这样的位置都是同等重要的,并且引入了分数函数,反映了探针序列内不匹配的位置。
    • 4. 发明申请
    • METHODS AND APPARATUS PROVIDING LOCAL SEARCH ENGINE
    • 提供本地搜索引擎的方法和设备
    • WO2005111787A2
    • 2005-11-24
    • PCT/US2005/015435
    • 2005-05-04
    • XIA, Xiongwu
    • XIA, Xiongwu
    • G06F7/00
    • G06F17/3087G06F17/30241G06F17/30312Y10S707/99933Y10S707/99937Y10S707/99945Y10S707/99948
    • A local search engine geographically indexes information for searching by identifying a geocoded web page of a web site and identifying at least one geocodable web page of the web site. The system identifies a geocode contained within content of the geocoded web page of the web site. The geocode indicates a physical location of an entity associated with the web site. The system indexes content of the geocoded web page and content of the geocodable web page. The indexing including associating the geocode contained within content of the geocoded web page to the indexed content of the geocoded web page and the geocodable web page to allow geographical searching of the content of the web pages.
    • 本地搜索引擎通过识别网站的地理编码的网页并且识别该网站的至少一个地理编码网页来地理上地索引用于搜索的信息。 该系统识别包含在网站的地理编码网页的内容中的地理编码。 地理编码表示与网站相关联的实体的物理位置。 系统对地理编码网页的内容和可编址网页的内容进行索引。 索引包括将包含在地理编码网页的内容内的地理编码与地理编码网页的索引内容和可编辑地理标识的网页相关联,以允许对网页的内容进行地理搜索。
    • 6. 发明申请
    • CONCURRENT OPTIMIZATION IN SELECTION OF PRIMER AND CAPTURE PROBE SETS FOR NUCLEIC ACID ANALYSIS
    • 基于核酸分析的捕获和捕获探针选择的并行优化
    • WO2005010200A2
    • 2005-02-03
    • PCT/US2004/022781
    • 2004-07-15
    • BIOARRAY SOLUTIONS, LTD.SEUL, MichaelVENER,TatianaXIA, Xiongwu
    • SEUL, MichaelVENER,TatianaXIA, Xiongwu
    • C12Q
    • C12Q1/6876C12Q2600/16G06F19/20G06F19/22
    • Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe ("primer"), and each converted sequence requiring, for detection, at least one capture probe. The iterative method disclosed herein for the concurrent optimization of primer and probe selection invokes fast logical string matching functions to perform a complete cross-correlation of probe sequences and target sequences. The score function assigns to each probe-target alignment a "degree of matching" score on the basis of position­ weighted Hamming distance functions introduced herein. Pairs of probes in the final selection may differ in several positions, while other pairs of probes may differ in only a single position. Not all such positions are of equal importance, and a score function is introduced, reflecting the position of the mismatch within the probe sequence.
    • 公开了迭代地优化用于多组指定序列的多步分析的两个(或更多)相互关联的探针组的方法,每个这样的序列为了转换需要至少一个转换探针( “引物”),并且每个转换的序列为了检测需要至少一个捕获探针。 本文公开的用于引物和探针选择的同时优化的迭代方法调用快速逻辑串匹配函数以执行探针序列和靶序列的完全互相关。 得分函数为每个探测 - 目标比对分配一个“匹配程度” 在位置和害羞的基础上得分; 这里介绍的加权汉明距离函数。 最终选择中的成对探针可能在几个位置上有所不同,而其他成对的探针可能仅在一个位置上有所不同。 并非所有这些位置都具有同等重要性,并且引入了分数函数,反映了探针序列内不匹配的位置。