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1. 发明申请

WO2012040168A3 BIOMARKERS FOR DIFFERENTIATING MELANOMA FROM BENIGN NEVUS IN THE SKIN 审中-公开
标题翻译：生物标志物用于鉴别皮肤良性黑色素瘤中的黑色素瘤
公开(公告)号：WO2012040168A3
公开(公告)日：2012-07-12
申请号：PCT/US2011052305
申请日：2011-09-20
申请人： ADVANCED CELL DIAGNOSTICS INC , MA XIAO-JUN , WU XINGYONG , LUO YULING
发明人： MA XIAO-JUN , WU XINGYONG , LUO YULING
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma.
摘要翻译：本发明公开了一种用于诊断人类受试者中黑素瘤的方法，以及一种用于对处于发展中的黑素瘤复发风险的人类受试者提供预后的方法以及一种用于确定受试者中黑素瘤阶段的方法，该方法包括步骤：单独测定磷酸酶和肌动蛋白调节因子1（PHACTR1）基因或其片段的表达水平，或者与分泌的整联蛋白结合磷蛋白（SPP1）的表达水平组合，优先在黑素瘤中表达的抗原（PRAME），生长分化因子15（GDF15）和趋化因子CXC基序配体10（CXCL10）基因。此外，本发明涉及诊断试剂盒，其包含至少一种用于检测PHACTR1或其片段的表达的至少一种物质，其单独或与检测SPP1，PRAME，GDF15和CXCL10组合用于诊断或预后黑色素瘤。

2. 发明申请

WO2012054795A1 AN ULTRA SENSITIVE METHOD FOR IN SITU DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于检测核酸的超敏感方法
公开(公告)号：WO2012054795A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057202
申请日：2011-10-21
申请人： ADVANCED CELL DIAGNOSTICS, INC. , WU, Xingyong , WANG, Huei-Yu Fay , SU, Nan , WANG, Li-Chong , LUO, Yuling
发明人： WU, Xingyong , WANG, Huei-Yu Fay , SU, Nan , WANG, Li-Chong , LUO, Yuling
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q1/6818 , C12Q1/682 , C12Q2563/131 , C12Q2537/143 , C12Q2537/125
摘要： Disclosed is a method for in situ detection of one or more target nucleic acids based on a combination of RNAscope® method and a general ISH signal amplification method. This new method produces high signal intensity and while keeps low background noise of signal amplification. The result can be consistently reproduced and the method can be easily adopted for routine clinic diagnostic use. Further, the invention relates to a kit, comprising the components of RNAscope® assay and a general ISH signal amplification assay, for sensitive detection of one or more target nucleic acids.
摘要翻译：公开了一种基于RNA检测方法和一般ISH信号扩增方法的组合来原位检测一种或多种靶核酸的方法。这种新方法产生高信号强度，同时保持低信号放大的背景噪声。结果可以一贯重现，该方法可以方便地用于常规诊所诊断。此外，本发明涉及一种试剂盒，其包含用于灵敏检测一种或多种靶核酸的RNA检测和一般ISH信号扩增测定的组分。

3. 发明申请

WO2012040168A2 BIOMARKERS FOR DIFFERENTIATING MELANOMA FROM BENIGN NEVUS IN THE SKIN 审中-公开
标题翻译：用于从皮肤中的新陈代谢来分化MELANOMA的生物标记物
公开(公告)号：WO2012040168A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052305
申请日：2011-09-20
申请人： ADVANCED CELL DIAGNOSTICS, INC. , MA, Xiao-Jun , WU, Xingyong , LUO, Yuling
发明人： MA, Xiao-Jun , WU, Xingyong , LUO, Yuling
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma.
摘要翻译：公开了一种用于诊断人类受试者中的黑素瘤的方法，以及用于对患有黑色素瘤复发风险的人类受试者提供预后的方法，以及用于确定人类受试者的黑色素瘤阶段的方法，包括单独或与分泌的整联蛋白结合磷蛋白（SPP1）的表达水平相结合的磷酸酶和肌动蛋白调节剂1（PHACTR1）基因或其片段的表达水平的测定步骤，优先表达黑素瘤抗原（PRAME），生长分化因子15（GDF15）和趋化因子CXC基序配体10（CXCL10）基因。此外，本发明涉及一种诊断试剂盒，其包含至少一种用于检测PHACTR1或其片段的表达的物质，或者与检测SPP1，PRAME，GDF15和CXCL10一起或与SPP1，PRAME，GDF15和CXCL10的检测结合用于诊断或预后的黑色素瘤。

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