专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO0147510A3 METHODS AND COMPOSITIONS RELATED TO MODULATORS OF ANNEXIN AND CARTILAGE HOMEOSTASIS 审中-公开
标题翻译：与安氏素调节剂相关的方法和组合物和卡培他滨
公开(公告)号：WO0147510A3
公开(公告)日：2002-02-21
申请号：PCT/US0034936
申请日：2000-12-21
申请人： GLAXO GROUP LTD , RUSH PRESBYTERIAN ST LUKE , CHUBINSKAYA SUSAN , HUTCHINS JEFF , MOLLENHAUER JUERGEN , TAVARES FRANCIS X , WORLEY JENNINGS F , THOMSON STEPHEN A
发明人： CHUBINSKAYA SUSAN , HUTCHINS JEFF , MOLLENHAUER JUERGEN , TAVARES FRANCIS X , WORLEY JENNINGS F , THOMSON STEPHEN A
IPC分类号： A61K31/00 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K31/7088 , A61K45/00 , A61K48/00 , A61K49/00 , A61P3/14 , A61P19/02 , A61P19/08 , A61P43/00 , C07D243/24 , C07D403/12 , C07D417/12 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5044 , A61K31/00 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K49/0004 , G01N33/5008 , G01N33/5017 , G01N33/502 , G01N33/5088 , G01N33/6887 , G01N2500/00 , G01N2510/00 , G01N2800/102 , G01N2800/105
摘要： The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function. The present invention also provides a composition comprising isolated chondrocytes, an agent that attenuates annexin function, and collagen fragments or other means for challenging chondrocytes, including for example, collagen fragments, collagen peptides, or immune mediators.
摘要翻译：本发明提供一种治疗患有关节炎或关节炎疾病的受试者或预防受试者中的关节炎或关节炎疾病的方法，其包括向受试者施用治疗有效量的减毒膜联蛋白功能的药剂。还提供了筛选增加胶原合成，减少胶原降解或减少或延缓凋亡的试剂和基因的各种方法，以及使用鉴定的试剂或核酸获得或维持软骨体内平衡，促进软骨修复，增加胶原合成的方法，减少胶原蛋白降解，或减少或延缓细胞凋亡。本发明还提供减少来自软骨细胞的囊泡的矿化作用和促进软骨内骨生长的方法。本发明还提供了包含分离的软骨细胞，减弱膜联蛋白功能的试剂以及用于挑战软骨细胞的胶原碎片或其他方法，包括例如胶原片段，胶原肽或免疫介体的组合物。

IPRDB

热门服务

关于我们

友情链接

联系方式