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1. 发明申请

WO2007109228A1 APPARATUS FOR MICROARRAY BINDING SENSORS HAVING BIOLOGICAL PROBE MATERIALS USING CARBON NANOTUBE TRANSISTORS 审中-公开
标题翻译：具有碳纳米管晶体管的生物探针材料微型结合传感器的装置
公开(公告)号：WO2007109228A1
公开(公告)日：2007-09-27
申请号：PCT/US2007/006809
申请日：2007-03-19
申请人： NATIONAL INSTITUTES OF HEALTH , UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION , GOMEZ, Romel, Del Rosario , KHAN, Javed , PANDANA, Herman , ASCHENBACH, Konrad , FUHRER, Michael , WEI, Jun
发明人： GOMEZ, Romel, Del Rosario , KHAN, Javed , PANDANA, Herman , ASCHENBACH, Konrad , FUHRER, Michael , WEI, Jun
IPC分类号： C12Q1/68
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , Y10S977/702 , Y10S977/92 , Y10S977/938
摘要： A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capability of miniaturization.
摘要翻译：提供一种微阵列装置，其包含至少一个芯片，其具有位于碳纳米管晶体管阵列上的源极和漏极，其允许电子检测核酸杂交，从而提供增加的灵敏度和小型化的能力。

2. 发明申请

WO2014062985A1 DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF AMINOACIDOPATHIES 审中-公开
标题翻译：使用装置检测氨基酸残留的装置和方法
公开(公告)号：WO2014062985A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/065548
申请日：2013-10-17
申请人： UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION , CHILDREN'S NATIONAL MEDICAL CENTER , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
发明人： AYYUB, Omar Bilal , BEHRENS, Adam Michael , KOFINAS, Peter , SUMMAR, Marshall Lynn , CABRERA-LUQUE, Juan Manuel , CUNNINGHAM, Gary , SIMEONOV, Anton , MARUGAN, Juan
IPC分类号： G01N17/04 , G01F1/64 , C12N9/00 , C12N11/00
CPC分类号： C12Q1/005 , C12N9/0018 , C12N9/0071 , C12N11/04 , C12N11/10 , G01N27/3277 , G01N33/6812 , G01N2800/04 , G01N2800/52
摘要： The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.
摘要翻译：本发明涉及能够使用包含由水凝胶改性的电极的无试剂系统来测量一种或多种氨基酸的总浓度的生物传感器，该电极包含至少一种氧化至少一种至少一种至少一种底物的酶一个氨基酸。在一些实施方案中，生物传感器包含包含藻酸盐的水凝胶。在一些实施方案中，生物传感器包括使用固定或附着在水凝胶上的嗜热细菌代谢酶。

3. 发明申请

WO2007084700A3 SYSTEM AND METHOD FOR THREAD HANDLING IN MULTITHREADED PARALLEL COMPUTING OF NESTED THREADS 审中-公开
公开(公告)号：WO2007084700A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/001501
申请日：2007-01-19
申请人： UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION , WEN, Xingzhi , VISHKIN, Uzi, Yehoshua
发明人： WEN, Xingzhi , VISHKIN, Uzi, Yehoshua
IPC分类号： G06F9/48
摘要： An Explicit Multi-Threading (XMT) system and method is provided for processing multiple spawned threads associated with SPAWN-type commands of an XMT program. The method includes executing a plurality of child threads by a plurality of TCUs including a first TCU executing a child thread which is allocated to it; completing execution of the child thread by the first TCU; announcing that the first TCU is available to execute another child thread; executing by a second TCU a parent child thread that includes a nested spawn-type command for spawning additional child threads of the plurality of child threads, wherein the parent child thread is related in a parent-child relationship to the child threads that are spawned in conjunction with the nested spawn-type command; assigning a thread ID (TID) to each child thread, wherein the TID is unique with respect to the other TIDs; and allocating a new child thread to the first TCU.

4. 发明申请

WO2014160136A1 ADVANCED FUNCTIONAL BIOCOMPATIBLE POLYMER PUTTY USED AS A HEMOSTATIC AGENT FOR TREATING DAMAGED TISSUE AND CELLS 审中-公开
标题翻译：用作治疗损伤组织和细胞的HEMOSTATIC AGENT的高级功能生物可分解聚合物
公开(公告)号：WO2014160136A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/025896
申请日：2014-03-13
申请人： UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION
发明人： DIEHN, Kevin , DOWLING, Matthew , RAGHAVAN, Srinivasa R. , KING, David R.
IPC分类号： C09K3/00
CPC分类号： A61K31/734 , A61K31/717 , A61K31/722 , A61K38/39
摘要： A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.
摘要翻译：公开了用于治疗各种伤口形态的止血腻子，包括但不限于高度三维伤口，例如枪伤和刺痛。油灰由弱交联或未交联的基质聚合物组成，使得形成粘弹性基质。腻子的粘弹性可以通过组合物调节，并使油灰符合各种伤口形貌。同样地，在该基质中包含止血聚合物，例如壳聚糖或疏水改性的壳聚糖，以在腻子上提供止血性质和组织粘合剂。所公开的止血聚合物防止微生物感染，并且适合于正常伤口代谢期间所需的氧传递。

5. 发明申请

WO2017177190A1 SYSTEMS AND METHODS FOR DETERMINATION OF HEALTH INDICATORS USING RANK CORRELATION ANALYSIS 审中-公开
标题翻译：用相关分析确定健康指标的系统和方法
公开(公告)号：WO2017177190A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026692
申请日：2017-04-07
申请人： UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION
发明人： JAMESON, Noel J. , AZARIAN, Michael,
IPC分类号： G06F11/00
摘要： A system that is a target of health monitoring via a computational system, the computational system, and corresponding method for determining health indicators using rank correlation analysis are disclosed. The target system includes a computational system that includes a computing device that acquires data from the target system, generate at least two features from the data acquired from the target system, computes, for each feature, rank correlation of the feature with time, computes the absolute value of each rank correlation coefficient for each feature, confining the range of the absolute value rank correlation coefficients to that from 0 to 1; and chooses at least one feature with a higher relative absolute value rank correlation coefficient as a health or condition indicator for the target system. The target system or the computational system or the method may perform health or condition monitoring on the target system.
摘要翻译：公开了一种系统，该系统是经由计算系统进行健康监测的目标，该计算系统以及使用等级相关分析来确定健康指标的相应方法。目标系统包括计算系统，该计算系统包括计算装置，该计算装置从目标系统获取数据，根据从目标系统获取的数据生成至少两个特征，针对每个特征计算特征与时间的相关性，计算每个特征的每个等级相关系数的绝对值，将绝对值等级相关系数的范围限制为从0到1的范围; 并选择具有较高的相对绝对值等级相关系数的至少一个特征作为目标系统的健康或状况指标。目标系统或计算系统或方法可以在目标系统上执行健康状况或状况监视。

6. 发明申请

WO2015077742A3 QUICK-DRYING, TACKY POLYMER FILM 审中-公开
公开(公告)号：WO2015077742A3
公开(公告)日：2015-05-28
申请号：PCT/US2014/067215
申请日：2014-11-25
申请人： UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION
发明人： DIEHN, Kevin , ARYA, Chandamany , ENGEL, Karl , FURSTENBURG, Matthew , RAGHAVAN, Srinivasa
IPC分类号： C09J101/02 , C09J105/08 , C09K3/14
摘要： A formulation for coating surfaces, for example gloves, with a tacky film comprises a hydrophobically modified biopolymer, where the hydrophobic modifications of the biopolymer correspond to between 1 and 90% of available functional groups, a plasticizer, and a volatile solvent. The formulation quickly dries into a tacky film that provides an enhanced friction of the surface.

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